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Cited by 59Maternal Mental Health During Pregnancy and PostpartumFunctional Brain Connectivity StudiesNeurological Complications and Syndromes

Understanding Peripartum Depression Through Neuroimaging: a Review of Structural and Functional Connectivity and Molecular Imaging Research

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Duan, Christy, Cosgrove, Jessica, Deligiannidis, Kristina M.·2017·Current Psychiatry Reports
DOI 10.1007/s11920-017-0824-4PMC PMC5617352
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Abstract

Purpose of review Imaging research has sought to uncover brain structure, function, and metabolism in women with postpartum depression (PPD) as little is known about its underlying pathophysiology. This review discusses the imaging modalities used to date to evaluate postpartum depression and highlights recent findings. Recent findings Altered functional connectivity and activity changes in brain areas implicated in executive functioning and emotion and reward processing have been identified in PPD. Metabolism changes involving monoamine oxidase A, gamma-aminobutyric acid, glutamate, serotonin, and dopamine have additionally been reported. To date, no studies have evaluated gray matter morphometry, voxel-based morphometry, surface area, cortical thickness, or white matter tract integrity in PPD. Recent imaging studies report changes in functional connectivity and metabolism in women with PPD vs. healthy comparison women. Future research is needed to extend these findings as they have important implications for the prevention and treatment of postpartum mood disorders.

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  • The pathophysiology of postpartum depression is likely multifactorial, with evidence supporting a role for disruption of perinatal GABA signaling.

    “The pathophysiology of PPD is likely multifactorial,26,27 with evidence supporting a role for disruption of perinatal γ-aminobutyric acid (GABA) signaling, the major inhibitory signaling pathway of the central nervous system.28”

    From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [27]

    The Molecular Imaging section identifies GABA as the main inhibitory neurotransmitter in the central nervous system. The References list studies of GABA levels in puerperal women and GABAergic neuroactive steroids in postpartum depression, but the retrieved passages do not establish that disrupted perinatal GABA signaling plays a role in postpartum depression. The multifactorial clause is attached to other citations in the citing sentence. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Duan, C., Cosgrove, J., & Deligiannidis, K. M.
Affiliations
Northwell Health (US)
Corresponding author
Deligiannidis, Kristina M.
ORCID
Deligiannidis, Kristina M.
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2017-08-19
Volume
19
Issue
10
Pages
70-70
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-017-0824-4
PMC
PMC5617352
OpenAlex
W2746169007
Cited by
59
References
23
Citations by year
2026: 9 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (5K23MH097794)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords
postpartum depression, perinatal depression, functional connectivity, brain metabolism, monoamine oxidase A, GABA, glutamate, serotonin, dopamine, executive function, reward processing, emotional processing, white matter integrity, postpartum mood disorders
MeSH terms
Brain, Female, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Depression, Postpartum, Positron-Emission Tomography, Molecular Imaging, Peripartum Period, Neuroimaging

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