Changes in cerebrospinal fluid neurochemistry during pregnancy

Altemus, Margaret; Fong, Jill; Yang, Ruirong; Damast, Shari; Luine, Victoria; Ferguson, Deveroux

doi:10.1016/j.biopsych.2004.06.002

Cited by 83Maternal Mental Health During Pregnancy and PostpartumPregnancy-related medical researchNeuroendocrine regulation and behavior

Changes in cerebrospinal fluid neurochemistry during pregnancy

Altemus, Margaret, Fong, Jill, Yang, Ruirong, Damast, Shari, Luine, Victoria, Ferguson, Deveroux·2004·Biological Psychiatry

DOI 10.1016/j.biopsych.2004.06.002

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Abstract

Background Little is known about changes in brain function that may occur during pregnancy. Studies in rodents and sheep suggest that several brain neurotransmitter and neurohormonal systems known to modulate anxiety may be altered during pregnancy.Methods Cerebrospinal fluid (CSF) and plasma samples were obtained from 21 women (during weeks 38-39 of pregnancy) who were undergoing elective cesarean section and from 22 healthy nonpregnant women.Results The CSF levels of g-aminobutyric acid (GABA) and 3-methoxy-4-hydroxyphenylglycolwere reduced in pregnant women. There were no changes in CSF glutamate, 5-hydroxyindoleactic acid, and homovanillic acid. There was a large increase in CSF prolactin in pregnant women and also a trend toward an elevation in CSF oxytocin. Levels of prolactin, but not oxytocin, in CSF and plasma were correlated in pregnant women.Conclusions These results suggest that pregnancy alters regulation of brain GABA, norepinephrine, and prolactin, which may play a role in changes in vulnerability to anxiety and depression during pregnancy and postpartum. Prolactin circulating in the bloodstream seems to be the major source of CSF prolactin during pregnancy.

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In pregnant women, there is no correlation between plasma and CSF OT levels.
“a high quality study in pregnant women showing no correlation between plasma and CSF OT levels (Altemus et al., 2004)”
From Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers (2014) · cites this paper as Altemus et al., 2004

Rates and risk of postpartum depression – a meta-analysis
O'hara, M. W., & Swain, A. M. (1996) · International Review of Psychiatry · doi:10.3109/09540269609037816 · Cited by 3,116 · see citing works
A Controlled Study of the Onset, Duration and Prevalence of Postnatal Depression
Cox, J., Murray, D., & Chapman, G. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.1.27 · Cited by 754 · see citing works
Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors
Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 495 · see citing works
Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II
Harris, B. L., Lovett, L. M., Newcombe, R. G., Read, G. F., Walker, R., & Riad-Fahmy, D. (1994) · BMJ · doi:10.1136/bmj.308.6934.949 · Cited by 487 · see citing works
Non-Psychotic Psychiatric Disorder After Childbirth: A Prospective Study of Prevalence, Incidence, Course and Nature
Cooper, P. J., Campbell, E. A., Day, A., Kennerley, H., & Bond, A. (1988) · British Journal of Psychiatry · doi:10.1192/bjp.152.6.799 · Cited by 425 · see citing works
Brain oxytocin: differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats
Neumann, I. D., Torner, L., & Wigger, A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00433-9 · Cited by 402 · see citing works
Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder
Epperson, C. N., Haga, K. K., Mason, G. F., Sellers, E. M., Gueorguieva, R. V., Zhang, W., Weiss, E. L., Rothman, D. L., & Krystal, J. H. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.851 · Cited by 402 · see citing works
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus, M. M., Deuster, P. A., Galliven, E., Carter, C. S., & Gold, P. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559880 · Cited by 383 · see citing works
Onset and Persistence of Postpartum Depression in an Inner-City Maternal Health Clinic System
Yonkers, K. A., Ramin, S. M., Rush, A. J., Navarrete, C. A., Carmody, T. J., March, D., Heartwell, S., & Leveno, K. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1856 · Cited by 358 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
GABA levels in CSF of patients with psychiatric disorders
Gold, B. I., Bowers, M. B., Roth, R. H., & Sweeney, D. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.3.362 · Cited by 270 · see citing works
Anxiolytic and Anti-Stress Effects of Brain Prolactin: Improved Efficacy of Antisense Targeting of the Prolactin Receptor by Molecular Modeling
Torner, L., Toschi, N., Pohlinger, A., Landgraf, R., & Neumann, I. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03207.2001 · Cited by 266 · see citing works
Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function
Bitran, D., Purdy, R. H., & Kellogg, C. K. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90260-z · Cited by 260 · see citing works
High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
Uvnäs‐Moberg, K., Ahlenius, S., Hillegaart, V., & Alster, P. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90462-6 · Cited by 254 · see citing works
A Receptor-Mediated Mechanism for the Transport of Prolactin from Blood to Cerebrospinal Fluid*
Walsh, R. J., Slaby, F., & Posner, B. I. (1987) · Endocrinology · doi:10.1210/endo-120-5-1846 · Cited by 252 · see citing works
Correlations between aminergic metabolites simultaneously obtained from human CSF and brain
Stanley, M., Träskman‐Bendz, L., & Dorovini-Zis, K. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90242-5 · Cited by 247 · see citing works
Links Between Early Post-partum Mood and Post-natal Depression
Hannah, P., Adams, D., Lee, A., Glover, V. A. S., & Sandler, M. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.6.777 · Cited by 237 · see citing works
Serum Allopregnanolone Levels in Pregnant Women: Changes during Pregnancy, at Delivery, and in Hypertensive Patients
Luisi, S., Petraglia, F., Benedetto, C., Nappi, R. E., Bernardi, F., Fadalti, M., Reis, F. M., Luisi, M., & Genazzani, A. R. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6675 · Cited by 237 · see citing works
Simultaneous microdialysis in blood and brain: oxytocin and vasopressin release in response to central and peripheral osmotic stimulation and suckling in the rat
Neumann, I., Ludwig, M., Engelmann, M., Pittman, Q. J., & Landgraf, R. (2008) · Neuroendocrinology · doi:10.1159/000126604 · Cited by 236 · see citing works
Breast-feeding is associated with reduced perceived stress and negative mood in mothers
Mezzacappa, E. S., & Katkin, E. S. (2002) · Health Psychology · doi:10.1037/0278-6133.21.2.187 · Cited by 232 · see citing works
Oxytocin and Vasopressin Gene Expression in the Hypothalamo-Neurohypophyseal System of the Rat During the Estrous Cycle, Pregnancy, and Lactation
Tol, H. H. M. V., Bolwerk, E., LlU, B., & Burbach, J. P. H. (1988) · Endocrinology · doi:10.1210/endo-122-3-945 · Cited by 226 · see citing works
Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats
Moos, F., Poulain, D. A., Rodriguez, F., Guern�, Y., Vincent, J. D., & Richard, P. (1989) · Experimental Brain Research · doi:10.1007/bf00248916 · Cited by 221 · see citing works
Increased hypothalamic expression of prolactin in lactation: involvement in behavioural and neuroendocrine stress responses
Torner, L., Toschi, N., Nava, G., Clapp, C., & Neumann, I. D. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01965.x · Cited by 221 · see citing works
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls
Gerner, R. H., Fairbanks, L. A., Anderson, G. M., Young, J. G., Scheinin, M., Linnoila, M., Hare, T. A., Shaywitz, B. A., & Cohen, D. J. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.12.1533 · Cited by 212 · see citing works
Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman, J. F. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950100030003 · Cited by 209 · see citing works
Postnatal depression and elation among mothers and their partners: Prevalence and predictors
Lane, A., Keville, R., Morris, M., Kinsella, A., Turner, M. J., & Barry, S. (1997) · The British Journal of Psychiatry · doi:10.1192/bjp.171.6.550 · Cited by 202 · see citing works
The corticotrophin releasing hormone test in late pregnancy: lack of adrenocorticotrophin and cortisol response
SCHULTE, H. M., WEISNER, D., & ALLOLIO, B. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00470.x · Cited by 199 · see citing works
The relationship between GABA concentrations in brain and cerebrospinal fluid
Böhlen, P., Huot, S., & Palfreyman, M. G. (1979) · Brain Research · doi:10.1016/0006-8993(79)90824-2 · Cited by 188 · see citing works
Responses to laboratory psychosocial stress in postpartum women
Altemus, M., Redwine, L. S., Leong, Y.-M., Frye, C. A., Porges, S. W., & Sue Carter, C. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200109000-00015 · Cited by 187 · see citing works
Cerebrospinal fluid levels of acetylcholinesterase, monoamines and oxytocin during labour, parturition, vaginocervical stimulation, lamb separation and suckling in sheep
Kendrick, K. M., Keverne, E. B., Baldwin, B. A., & Sharman, D. F. (2008) · Neuroendocrinology · doi:10.1159/000124638 · Cited by 187 · see citing works
Intracranial dialysis measurement of oxytoxin, monoamine and uric acid release from the olfactory bulb and substantia nigra of sheep during parturition, suckling, separation from lambs and eating
Kendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91455-2 · Cited by 175 · see citing works
HORMONAL ASPECTS OF POSTPARTUM DEPRESSION
Abou‐Saleh, M. T. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00022-5 · Cited by 168 · see citing works
Serum allopregnanolone in women with postpartum “blues”
Nappi, R. (2001) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(00)01112-1 · Cited by 166 · see citing works
Psychiatric Diagnosis: Exploration of Biological Predictors
Andreasen, N. C. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.3.362 · Cited by 161 · see citing works
Oxytocin and vasopressin gene expression during gestation and lactation
Zingg, H. H., & Lefebvre, D. L. (1988) · Molecular Brain Research · doi:10.1016/0169-328x(88)90011-3 · Cited by 151 · see citing works
Oxytocin, amino acid and monoamine release in the region of the medial preoptic area and bed nucleus of the stria terminalis of the sheep during parturition and suckling
Kendrick, K. M., Keverne, E. B., Hinton, M. R., & Goode, J. A. (1992) · Brain Research · doi:10.1016/0006-8993(92)90631-i · Cited by 150 · see citing works
Plasma catecholamine responses to physiologic stimuli in normal human pregnancy
Barron, W. M., MUJAIS, S. K., Zinaman, M. J., Bravo, E. L., & Lindheimer, M. D. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90397-2 · Cited by 148 · see citing works
Prolactin in human and rat serum and cerebrospinal fluid
Login, I. S., & MacLeod, R. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90196-2 · Cited by 119 · see citing works
Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders.
Kasa, K., Otsuki, S., Yamamoto, M., Sato, M., Kuroda, H., & Ogawa, N. (1982) · PubMed · Cited by 117 · see citing works
CSF oxytocin in anorexia nervosa and bulimia nervosa: clinical and pathophysiologic considerations
Demitrack, M. A., Lesem, M. D., LISTWAK, S. J., Brandt, H., Jimerson, D. C., & Gold, P. W. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.7.882 · Cited by 116 · see citing works
Septal and Hippocampal Release of Oxytocin, but not Vasopressin, in the Conscious Lactating Rat During Suckling
Neumann, I. D., & Landgraf, R. (1989) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1989.tb00120.x · Cited by 109 · see citing works
Low cerebrospinal fluid corticotropin-releasing hormone concentrations in eucortisolemic depression
Geracioti, T. D., Loosen, P. T., & Orth, D. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00312-5 · Cited by 105 · see citing works
Autonomic cardiovascular control in pregnancy
Ekholm, E. M. K., & Erkkola, R. (1996) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0301-2115(95)02255-4 · Cited by 97 · see citing works
Increased Prolactin Receptor Immunoreactivity in the Hypothalamus of Lactating Rats
Pi, P., & Grattan, D. R. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00386.x · Cited by 96 · see citing works
Pregnancy Alters Blood Pressure Responses to Psychological and Physical Challenge
Matthews, K. A., & Rodin, J. (1992) · Psychophysiology · doi:10.1111/j.1469-8986.1992.tb01691.x · Cited by 95 · see citing works
Changes in Oxytocin Immunoreactivity and mRNA Expression in the Sheep Brain during Pregnancy, Parturition and Lactation and in Response to Oestrogen and Progesterone
Broad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00505.x · Cited by 90 · see citing works
Reduced Noradrenergic Tone to the Hypothalamic Paraventricular Nucleus Contributes to the Stress Hyporesponsiveness of Lactation
Toufexis, D. J., Thrivikraman, Plotsky, P. M., Morilak, D. A., Huang, N., & Walker, C. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00223.x · Cited by 84 · see citing works
Determination of monoamines in brain nuclei by high performance liquid chromatography with electrochemical detection : Young vs. middle aged rats
Renner, K. J., & Luine, V. N. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90320-5 · Cited by 84 · see citing works
Cerebrospinal Fluid Norepinephrine and Acetylcholine Concentrations During Acute Pain
Eisenach, J. C., Detweiler, D. J., Tong, C., DʼAngelo, R., & Hood, D. D. (1996) · Anesthesia & Analgesia · doi:10.1097/00000539-199603000-00034 · Cited by 83 · see citing works
Effect of pregnancy on panic attacks
George, D. T., Ladenheim, J. A., & Nutt, D. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.8.1078 · Cited by 78 · see citing works
Psychophysiological Response of Breast‐ and Bottle‐Feeding Mothers to Their Infants' Signals
Wiesenfeld, A. R., Malatesta, C. Z., Whitman, P. B., Granrose, C. S., & Uili, R. M. (1985) · Psychophysiology · doi:10.1111/j.1469-8986.1985.tb01563.x · Cited by 75 · see citing works
Neuroactive Ring A-Reduced Metabolites of Progesterone in Human Plasma during Pregnancy: Elevated Levels of 5α-Dihydroprogesterone in Depressed Patients during the Latter Half of Pregnancy
Murphy, B. E. P., Steinberg, S. I., Hu, F.-Y., & Allison, C. M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8122 · Cited by 74 · see citing works
Sympatho‐adrenal and cardiovascular reactivity in pregnancy‐induced hypertension. I. Responses to isometric exercise and a cold pressor test
Nisell, H., Hjemdahl, P., Linde, B., & Lunell, N. O. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01455.x · Cited by 68 · see citing works
Reduced Response of the Hypothalamo-Pituitary-Adrenal Axis toα 1-Agonist Stimulation during Lactation*
Windle, R. J., Brady, M. M., Kunanandam, T., Costa, A. P. C., Wilson, B. C., Harbuz, M. S., Lightman, S. L., & Ingram, C. D. (1997) · Endocrinology · doi:10.1210/endo.138.9.5405 · Cited by 67 · see citing works
Prolactin in Human Cerebrospinal Fluid*
Assies, J., SCHELLEKENS, A. P. M., & TOUBER, J. L. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-4-576 · Cited by 66 · see citing works
The effects of pregnancy on preexisting panic disorder.
Villeponteaux, V. A., Lydiard, R. B., Laraia, M. T., Stuart, G. W., & Ballenger, J. C. (1992) · PubMed · Cited by 66 · see citing works
THE ROLE OF PROLACTIN IN THE DEPRESSED OR 'BUFFERED' ADRENOCORTICOSTEROID RESPONSE OF THE RAT
SCHLEIN, P. A., ZARROW, M. X., & Denenberg, V. H. (1974) · Journal of Endocrinology · doi:10.1677/joe.0.0620093 · Cited by 63 · see citing works
Preliminary look at the effects of pregnancy on the course of panic disorder.
Klein, D. F., Skrobala, A. M., & Garfinkel, R. S. (1997) · PubMed · Cited by 63 · see citing works
Plasma and CSF Gaba in Affective Illness
Berrettini, W. H., Nürnberger, J. I., Hare, T. A., Gershon, E. S., & Post, R. M. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.141.5.483 · Cited by 62 · see citing works
Offspring control of cerebrospinal fluid GABA concentrations in lactating rats
Qureshi, G. A., Hansen, S., & Södersten, P. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90080-2 · Cited by 62 · see citing works
Relationship of psychiatric illness to childbearing status: a hospital-based epidemiologic study
Wisner, K. L., Peindl, K., & Hanusa, B. H. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90075-u · Cited by 62 · see citing works
Intrahypothalamic 5,7-dihydroxytryptamine: Temporal analysis of effects on 5-hydroxytryptamine content in brain nuclei and on facilitated lordosis behavior
Frankfurt, M., Renner, K. J., Azmitia, E. C., & Luine, V. N. (1985) · Brain Research · doi:10.1016/0006-8993(85)90781-4 · Cited by 61 · see citing works
Gonadal hormones alter hypothalamic GABA and glutamate levels
Luine, V. N., Grattan, D. R., & SELMANOFF, M. K. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01255-3 · Cited by 56 · see citing works
Panic disorder during pregnancy
Cowley, D. S., & Roy‐Byrne, P. (1989) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674828909016694 · Cited by 55 · see citing works
Preliminary look at the effects of pregnancy on the course of panic disorder
Klein, D. F., Skrobala, A. M., & Garfmkel, R. S. (1994) · Anxiety · doi:10.1002/anxi.3070010507 · Cited by 54 · see citing works
Cerebrospinal Fluid Norepinephrine and Acetylcholine Concentrations During Acute Pain
Eisenach, J. C., Detweiler, D. J., Tong, C., et al. (1996) · Anesthesia & Analgesia · doi:10.1213/00000539-199603000-00034 · Cited by 53 · see citing works
Responses to Corticotropin-Releasing Hormone and Its Bound and Free Forms in Pregnant and Nonpregnant Women*
Suda, T., Iwashita, M., USHIYAMA, T., TOZAWA, F., Sumitomo, T., NAKAGAMI, Y., Demura, H., & SHIZUME, K. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-38 · Cited by 52 · see citing works
Cerebrospinal Fluid Prolactin: A Reflection of Abnormal Prolactin Secretion in Patients with Pituitary Tumors
Schroeder, L., Johnson, J. C., & Malarkey, W. B. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-6-1255 · Cited by 50 · see citing works
Oxytocin in the Cerebrospinal Fluid and Plasma of Pregnant and Nonpregnant Subjects
Takagi, T., Tanizawa, O., Otsuki, Y., Sugita, N., Haruta, M., & Yamaji, K. (1985) · Hormone and Metabolic Research · doi:10.1055/s-2007-1013526 · Cited by 46 · see citing works
Postpartum onset of panic disorder: a coincidental event?
Sholomskas, D. E., Wickamaratne, P. J., Dogolo, L., O'Brien, D. W., Leaf, P. J., & Woods, S. W. (1993) · PubMed · Cited by 46 · see citing works
Regional Variation in γ‐Aminobutyric Acid Turnover: Effect of Castration on γ‐Aminobutyric Acid Turnover in Microdissected Brain Regions of the Male Rat
Grattan, D. R., & SELMANOFF, M. K. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03512.x · Cited by 44 · see citing works
Significant correlation between cerebrospinal fluid and brain levels of norepinephrine, serotonin and acetylcholine in anesthetized rats
Matsumoto, M., Togashi, H., Yoshioka, M., Morii, K., Hirokami, M., Tochihara, M., Ikeda, T., Saito, Y., & Saito, H. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90098-v · Cited by 42 · see citing works
Monoamine neurotransmitters and metabolites during the estrous cycle, pregnancy, and the postpartum period
Desan, P. H., Woodmansee, W. W., Ryan, S., Smock, T., & Maier, S. F. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90066-4 · Cited by 41 · see citing works
A preliminary study of breast-feeding and maternal symptomatology
Mezzacappa, E. S., Guethlein, W., Vaz, N. M., & Bagiella, E. (2000) · Annals of Behavioral Medicine · doi:10.1007/bf02895170 · Cited by 38 · see citing works
GABAergic Regulation of Lordosis: Influence of Gonadal Hormones on Turnover of GABA and Interaction of GABA with 5-HT
Luine, V. N., Wu, V., Hoffman, C. S., & Renner, K. J. (1999) · Neuroendocrinology · doi:10.1159/000054447 · Cited by 38 · see citing works
Cerebrospinal Fluid GABA as an Index of Brain GABA Activity
Grove, J., Palfreyman, M. G., & Schechter, P. J. (1983) · Clinical Neuropharmacology · doi:10.1097/00002826-198309000-00004 · Cited by 36 · see citing works
Release of Oxytocin into Blood and into Cerebrospinal Fluid Induced by Naloxone in Anaesthetized Morphine‐Dependent Rats: The Role of the Paraventricular Nucleus
Coombes, J. E., Robinson, I. C. A. F., Antoni, F. A., & Russell, J. A. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00316.x · Cited by 36 · see citing works
The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid
Hill, K. K., West, S. A., Ekhator, N. N., Bruce, A., Wortman, M. D., Baker, D. G., & Geracioti, T. D. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00778-8 · Cited by 35 · see citing works
Analgesic effect of prolactin: Possible mechanism of action
Ramaswamy, S., Pillai, N. P., & Bapna, J. S. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90548-4 · Cited by 31 · see citing works
Postpartum Onset of Panic Disorder
Beck, C. T. (1998) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.1998.tb01267.x · Cited by 31 · see citing works
Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy.
Podell, M., & Hadjiconstantinou, M. (1997) · PubMed · Cited by 30 · see citing works
Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans
Eisenach, J. C., Dobson, C. E., Inturrisi, C. E., Hood, D. D., & Agner, P. B. (1990) · Pain · doi:10.1016/0304-3959(90)91067-s · Cited by 29 · see citing works
Prolactin in cerebrospinal fluid and dopamine function in man
Jimerson, D. C., Post, R. M., Skyler, J. S., & Bunney, W. E. (1976) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1976.tb04072.x · Cited by 26 · see citing works
Cerebrospinal fluid γ-aminobutyric acid and glutamate values in dogs with epilepsy
Podell, M., & Hadjiconstantinou, M. (1997) · American Journal of Veterinary Research · doi:10.2460/ajvr.1997.58.05.451 · Cited by 26 · see citing works
Pituitary and Placentally Derived Hormones in Cerebrospinal Fluid during Normal Human Pregnancy*
Peake, G. T., Buckman, M. T., Davis, L. E., & Standefer, J. C. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-1-46 · Cited by 25 · see citing works
Alterations in regional brain GABA concentration and turnover during pregnancy
Smolen, A., Smolen, T. N., & Han, P. C. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90281-w · Cited by 23 · see citing works
Central serotonergic function in parasuicide
Coccaro, E. F., & Astill, J. L. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90037-h · Cited by 23 · see citing works
Gestational changes of GABA levels and GABA binding in the human uterus
Erdö, S. L., Villányi, P., & László, Á. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90346-9 · Cited by 21 · see citing works
The effect of propranolol treatment in schizophrenia on CSF amine metabolites and prolactin
Belmaker, R. H., Ebstein, R. P., Dasberg, H. H., Levy, A. C., Sedvall, G., & van Praag, H. M. (1979) · Psychopharmacology · doi:10.1007/bf00433565 · Cited by 20 · see citing works
Rat brain monoamine and serotonin S2 receptor changes during pregnancy
Glaser, J., Russell, V. A., de Villiers, A. S., Searson, A., & Taljaard, J. J. F. (1990) · Neurochemical Research · doi:10.1007/bf00965738 · Cited by 19 · see citing works
Catecholamine Concentrations in Venous Plasma and Cerebrospinal Fluid in Normal and Complicated Pregnancy
Tinkanen, H., Rorarius, M. G. F., & Metsä-Ketelä, T. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000292654 · Cited by 18 · see citing works
Association of GABAA receptor subunit genes with childhood absence epilepsy
Scharfetter, J., Feucht, M., Fuchs, K., Füreder, T., Gößler, R., Cvetkovic, N., Pichlbauer, E., Sieghart, W., Kasper, S. F., & Aschauer, H. N. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)87569-5 · Cited by 17 · see citing works
Rat brain hypothalamic and hippocampal monoamine and hippocampal β-adrenergic receptor changes during pregnancy
Glaser, J., Russell, V. A., & Taljaard, J. J. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90286-i · Cited by 14 · see citing works
Alterations in brain catecholamines during pregnancy
Smolen, A., Smolen, T. N., & van de Kamp, J. L. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90174-2 · Cited by 13 · see citing works
Could Reduced Cerebrospinal Fluid (CSF) Galanin Contribute to Restricted Eating in Anorexia Nervosa?
Frank, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00251-7 · Cited by 13 · see citing works
Prolactin levels in the cerebrospinal fluid of patients with HIV infection and AIDS
Montero, A., Fernandez, M., Cohen, J., Luraghi, M. R., & Sen, L. (1998) · Neurological Research · doi:10.1080/01616412.1998.11740475 · Cited by 11 · see citing works
Cerebrospinal Fluid Monoamine Metabolites and Neuropeptides in Patients with Panic Disorder
Lepola, U. M., Jolkkonen, J., Pitkänen, A., Riekkinen, P. J., & Rimón, R. (1990) · Annals of Medicine · doi:10.3109/07853899009148933 · Cited by 8 · see citing works
Pituitary-adrenal function during lactation and after LTH (prolactin) administration in the rat.
Endröczi, E., & Nyakas, C. J. (1972) · PubMed · Cited by 5 · see citing works

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Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518 · see citing works
The expectant brain: adapting for motherhood
Brunton, P. J., & Russell, J. A. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2280 · Cited by 407 · see citing works
Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment
Levine, A., Zagoory-Sharon, O., Feldman, R., & Weller, A. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.016 · Cited by 315 · see citing works
Sex differences in depression and anxiety disorders: Potential biological determinants
Altemus, M. M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.031 · Cited by 314 · see citing works
Approaching the biology of human parental attachment: Brain imaging, oxytocin and coordinated assessments of mothers and fathers
Swain, J. E., Kim, P., Spicer, J., Ho, S. S., Dayton, C. J., Elmadih, A., & Abel, K. M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.007 · Cited by 290 · see citing works
Glutamatergic Dysfunction in OCD
Chakrabarty, K., Bhattacharyya, S., Christopher, R., & Khanna, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300733 · Cited by 344 · see citing works
The Role of Oxytocin in Mother-Infant Relations: A Systematic Review of Human Studies
Galbally, M., Lewis, A. J., van IJzendoorn, M., & Permezel, M. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.549771 · Cited by 260 · see citing works
Regulation of anxiety during the postpartum period
Lonstein, J. S. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.05.002 · Cited by 229 · see citing works
Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212 · see citing works
A spatiotemporal profile of in vivo cerebral blood flow changes following intranasal oxytocin in humans
Paloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children
Carson, D. S., Berquist, S. W., Trujillo, T. H., Garner, J. P., Hannah, S. L., Hyde, S. A., Sumiyoshi, R. D., Jackson, L. P., Moss, J. K., Strehlow, M. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.132 · Cited by 196 · see citing works
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Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder
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Macbeth, A. H., & Luine, V. N. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.011 · Cited by 169 · see citing works
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Lonstein, J. S., Lévy, F., & Fleming, A. S. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.011 · Cited by 151 · see citing works
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“In humans no correlation was found between central and plasma OT in pregnant women (Altemus et al., 2004) and suicide attempters (Jokinen et al., 2012).”
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143 · see citing works
Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
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Martin, J., Kagerbauer, S. M., Gempt, J., Podtschaske, A., Hapfelmeier, A., & Schneider, G. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12596 · Cited by 122 · see citing works
Chronic intracerebral prolactin attenuates neuronal stress circuitries in virgin rats
Donner, N. C., Bredewold, R., Maloumby, R., & Neumann, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05416.x · Cited by 114 · see citing works
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Duan, C., Cosgrove, J., & Deligiannidis, K. M. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0824-4 · Cited by 59 · see citing works
Emotion Reactivity Is Increased 4-6 Weeks Postpartum in Healthy Women: A Longitudinal fMRI Study
Gingnell, M., Bannbers, E., Moes, H. R., Engman, J., Sylvén, S. M., Skalkidou, A., Kask, K., Wikström, J., & Poromaa, I. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128964 · Cited by 57 · see citing works
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A sensitive and selective LC-differential mobility-mass spectrometric analysis of allopregnanolone and pregnanolone in human plasma
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Parenting Behavior
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Sequential serotonin and noradrenalin associated processes involved in postpartum blues
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Godoy, D. A., Robba, C., Paiva, W. S., & Rabinstein, A. A. (2021) · Neurocritical Care · doi:10.1007/s12028-021-01333-x · Cited by 43 · see citing works
Oxytocin alters cell fate selection of rat neural progenitor cells in vitro
Palanisamy, A., Kannappan, R., Xu, Z., Martino, A., Friese, M. B., Boyd, J. D., Crosby, G. J., & Culley, D. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191160 · Cited by 36 · see citing works
Prefrontal activity during response inhibition decreases over time in the postpartum period
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Social Cognition
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Is There A Connection Between Autism, Prader‐Willi Syndrome, Catatonia, And GABA?
Dhossche, D. M., Song, Y., & Liu, Y. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)71009-6 · Cited by 30 · see citing works
Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum disorder?
Althaus, M., Groen, Y., Wijers, A. A., Noltes, H., Tucha, O. M., Sweep, F. C. G. J., Calcagnoli, F., & Hoekstra, P. J. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4339-1 · Cited by 27 · see citing works
GABA+ levels in postmenopausal women with mild-to-moderate depression
Wang, Z., Aiying, Z., Zhao, B., Gan, J., Wang, G., Gao, F., Liu, B., Gong, T., Liu, W., & Edden, R. A. E. (2016) · Medicine · doi:10.1097/md.0000000000004918 · Cited by 26 · see citing works
Plasma oxytocin and personality traits in psychiatric outpatients
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Changes in Amino Acids and Nitric Oxide Concentration in Cerebrospinal Fluid During Labor Pain
Sethuraman, R., Lee, T., Chui, J.-W., & Tachibana, S. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9133-8 · Cited by 22 · see citing works
Depression and Related Disorders during the Female Reproductive Cycle
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Positive correlation between rat brain glutamate concentrations and mitochondrial 2-oxoglutarate dehydrogenase activity
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Fast Delivery
Douglas, A. J., & Meddle, S. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374285-8.00014-7 · Cited by 19 · see citing works
The role of central serotonergic markers and estradiol changes in perinatal mental health
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Hale, J. E., Gelfanova, V., You, J., Knierman, M. D., & Dean, R. A. (2008) · Methods in molecular biology · doi:10.1007/978-1-60327-210-0_5 · Cited by 18 · see citing works
Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle
Vigod, S. N., Strasburg, K., Daskalakis, Z. J., & Blumberger, D. M. (2014) · Archives of Women s Mental Health · doi:10.1007/s00737-013-0403-6 · Cited by 16 · see citing works
Childbirth pain and postpartum depression
Kwok, S. C., Moo, D., Sia, S. T., Razak, A. S., & Sng, B. L. (2015) · Trends in Anaesthesia and Critical Care · doi:10.1016/j.tacc.2015.04.003 · Cited by 15 · see citing works
Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin
Zagoory‐Sharon, O., Schroeder, M., Levine, A., Moran, T. H., & Weller, A. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.58 · Cited by 14 · see citing works
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Preconception planning to reduce the risk of perinatal depression and anxiety disorders
Avni-Barron, O., Hoagland, K., Ford, C., & Miller, L. J. (2010) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.10.27 · Cited by 11 · see citing works
Oxytocin regulation of maternal behavior
Pedersen, C. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139017855.012 · Cited by 11 · see citing works
Approche GABAergique de la dépression du post-partum : une revue critique translationnelle
Verbe, J., Dubertret, C., El‐Hage, W., Bonnet‐Brilhault, F., & Duriez, P. (2019) · L Encéphale · doi:10.1016/j.encep.2019.09.007 · Cited by 10 · see citing works
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Anxiety and Sleep Disorders, Psychopharmacology, and Pregnancy
Gentile, S. (2014) · Springer eBooks · doi:10.1007/978-3-642-54562-7_7 · Cited by 10 · see citing works
Atypical Presentations of Pregnancy-Specific Generalized Anxiety Disorders in Women Without a Previous Psychiatric Background
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Hot flashes during pregnancy: a comparative study
Hanisch, L. J., Bennett, I. M., Freeman, E. W., & Coyne, J. C. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.03.021 · Cited by 5 · see citing works
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Howland, M. A., & Cicchetti, D. (2021) · Springer eBooks · doi:10.1007/978-3-030-60159-1_14 · Cited by 5 · see citing works
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Norholt, H. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.590051 · Cited by 4 · see citing works
The complex interplay between psychosocial and biological factors in pregorexia nervosa — a rapid review
Vasiliu, O. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1168696 · Cited by 4 · see citing works
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Altemus, M. M. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.01.008 · Cited by 4 · see citing works
The Perinatal Microbiota-Gut-Brain Axis: Implications for Postpartum Depression
Armbruster, M., & Forsythe, P. (2025) · NeuroImmunoModulation · doi:10.1159/000543691 · Cited by 5 · see citing works
Causal Links Between Cerebrospinal Fluid Metabolites and Postpartum Depression: A Bidirectional Mendelian Randomization Study
Long, Y., Liu, H., Ban, R., Xu, Z., & Xu, T. (2025) · International Journal of Women s Health · doi:10.2147/ijwh.s540467 · Cited by 1 · see citing works
Maternal and Neonatal Oxytocin Levels During Cesarean Section With or Without Labor Pain and Puerperal Complications
Sayyah-Melli, M., Alizadeh, M., & Noubar, M. R. (2006) · Intern J Endocrinol Metab · Cited by 1 · see citing works
Beta-amyloid peptides(1–42) and (1–40) in the cerebrospinal fluid during pregnancy: a prospective observational study
Alomar-Dominguez, C., Dostal, L., Thaler, J., Putz, G., Humpel, C., & Lederer, W. (2020) · Archives of Women s Mental Health · doi:10.1007/s00737-020-01072-6 · Cited by 1 · see citing works
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Enderli, T. (2017) · Cited by 1 · see citing works
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Hellgren, C. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Authors: Altemus, M., Fong, J., Yang, R., Damast, S., Luine, V., & Ferguson, D.
Affiliations: Cornell University (US)
City University of New York (US)
Corresponding author: Altemus, Margaret
ORCID: Altemus, Margaret
Damast, Shari
Ferguson, Deveroux
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2004-09
Volume: 56
Issue: 6
Pages: 386-392
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2004.06.002
OpenAlex: W1968793849
Cited by: 83
References: 97
Citations by year: 2025: 2 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 2
FWCI: 4.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (M01770047)
National Institute on Drug Abuse (R24DA012136)
National Institute of General Medical Sciences (R25GM060665)
National Center for Research Resources (G12RR003037)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy-related medical research
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: pregnancy, GABA, MHPG, prolactin, oxytocin, glutamate, homovanillic acid, norepinephrine, anxiety, depression, postpartum period
MeSH terms: Adult, Cerebrospinal Fluid, Female, gamma-Aminobutyric Acid, Humans, Methoxyhydroxyphenylglycol, Neurochemistry, Oxytocin, Pregnancy, Prolactin, Radioimmunoassay, Spinal Puncture, Neurotransmitter Agents, Pregnant People

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Changes in cerebrospinal fluid neurochemistry during pregnancy

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