The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis
Abstract
Articular chondrocyte production of nitric oxide (NO) and other inflammatory mediators, such as eicosanoids and cytokines, are increased in human osteoarthritis. The excessive production of nitric oxide inhibits matrix synthesis and promotes its degradation. Furthermore, by reacting with oxidants such as superoxide anion, nitric oxide promotes cellular injury and renders the chondrocyte susceptible to cytokine-induced apoptosis. PGE(2) exerts anabolic and catabolic effects on chondrocytes, depending on the microenvironment and physiologic condition. The increased expression of inducible NOS (iNOS) and cyclo-oxygenase-2 (COX-2) in OA chondrocytes is largely due to the increased expression of pro-inflammatory cytokines, particularly IL-1, which act in an autocrine/paracrine fashion to perpetuate a catabolic state that leads to progressive destruction of articular cartilage. The initiating factors for the production of inflammatory mediators include altered biomechanical forces; their continued production may be augmented by an increase in extracellular matrix proteins acting through ligation of surface integrins.
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“Articular cartilage of patients with OA shows features of senescence, including increased expression of nitric oxide, pro-inflammatory cytokines, particularly IL-1β [8]; p16 [9]; activated DNA damage response; ROS secretion and SA-β-Gal activity [10].”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [8]
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Cites
Biochemistry of nitric oxide and its redox-activated forms
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Glucosamine therapy for treating osteoarthritis
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Research works printed but not linked: 2
- Attur MG, Dave M, Stuchin S, et al.: Osteopontin: an intrinsic inhibitor of inflammation in cartilage. Arthritis Rheum 2001, 44:578–584. · DOI · Paper page
- PK, Hummel KM, Schedel J, et al.: Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts. Arthritis Rheum 2001, 43:15971–1605.
Cited by
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Moreland, L. W. (2003) · Arthritis Research · doi:10.1186/ar623 · Cited by 669
The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis
Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 655
Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes
Largo, R., Alvarez-Soria, M. A., Dı́ez-Ortego, I., Calvo, E., Sánchez‐Pernaute, O., Egido, J., & Herrero‐Beaumont, G. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00028-1 · Cited by 393
Pearle, A. D., Scanzello, C. R., George, S., Mandl, L. A., DiCarlo, E. F., Peterson, M., Sculco, T. P., & Crow, M. K. (2007) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.10.010 · Cited by 362
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 356
Metadata
- Authors
- Abramson, S. B., Attur, M., Amin, A. R., & Clancy, R.
- Affiliations
- NYU Langone Health (US)
- Venue
- Current Rheumatology Reports
- Published
- 2001-12
- Volume
- 3
- Issue
- 6
- Pages
- 535-541
- ISSN
- 1523-3774 (ISSN-L)
- 1534-6307
- OpenAlex
- W2081577257
- Cited by
- 261
- References
- 63
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 13 · 2016: 15 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 12
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Rheumatology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- osteoarthritis, nitric oxide, articular chondrocytes, inflammatory mediators, inducible nitric oxide synthase, cyclooxygenase-2, prostaglandin E2, interleukin-1, inflammatory cytokines, apoptosis, cartilage degeneration, extracellular matrix, integrins, biomechanical forces, autocrine and paracrine signaling
- MeSH terms
- Cartilage, Articular, Humans, Nitric Oxide, Osteoarthritis, Cytokines, Inflammation Mediators, Nitric Oxide Synthase, Nitric Oxide Synthase Type II
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