Juvenile fibromyalgia: different from the adult chronic pain syndrome?
Abstract
While a majority of research has focused on adult fibromyalgia (FM), recent evidence has provided insights into the presence and impact of FM in children and adolescents. Commonly referred as juvenile fibromyalgia (JFM), youths, particularly adolescent girls, present with persistent widespread pain and cardinal symptoms observed in adult FM. A majority of youth with JFM continue to experience symptoms into adulthood, which highlights the importance of early recognition and intervention. Some differences are observed between adult and juvenile-onset FM syndrome with regard to comorbidities (e.g., joint hypermobility is common in JFM). Psychological comorbidities are common but less severe in JFM. Compared to adult FM, approved pharmacological treatments for JFM are lacking, but non-pharmacologic approaches (e.g., cognitive-behavioral therapy and exercise) show promise. A number of conceptual issues still remain including (1) directly comparing similarities and differences in symptoms and (2) identifying shared and unique mechanisms underlying FM in adults and youths.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Symptom severity for several pain conditions including irritable bowel syndrome, temporomandibular disorders, headache, and fibromyalgia varies across the menstrual cycle.
“the severity of symptoms for several pain conditions including irritable bowel syndrome, temporomandibular disorders, headache, and fibromyalgia varies across the menstrual cycle 185–191.”
From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [188]
Cites
Wolfe, F., Clauw, D. J., Fitzcharles, M., Goldenberg, D. L., Katz, R. S., Mease, P., Russell, A. S., Russell, I. J., Winfield, J. B., & Yunus, M. B. (2010) · Arthritis Care & Research · doi:10.1002/acr.20140 · Cited by 3,952 · see citing works
Varni, J. W., Limbers, C. A., & Burwinkle, T. M. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-43 · Cited by 892 · see citing works
Exercise for treating fibromyalgia syndrome
Busch, A. J., Barber, K. A. R., Overend, T. J., Peloso, P. M. J., & Schachter, C. L. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003786.pub2 · Cited by 609 · see citing works
Arnold, L. M., Hudson, J. I., Hess, E. V., Ware, A. E., Fritz, D. A., Auchenbach, M. B., Starck, L. O., & Keck, P. E. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20042 · Cited by 454 · see citing works
Self-citationWolfe, F., Brähler, E., Hinz, A., & Häuser, W. (2013) · Arthritis Care & Research · doi:10.1002/acr.21931 · Cited by 443 · see citing works
Giesecke, T., Williams, D. A., Harris, R. E., Cupps, T. R., Tian, X., Tian, T. X., Gracely, R. H., & Clauw, D. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11272 · Cited by 424 · see citing works
Psychiatric disorders in patients with fibromyalgia. A multicenter investigation.
Epstein, S., Kay, G., Clauw, D., Heaton, R., Klein, D., Krupp, L., Kuck, J., Leslie, V. M., Masur, D., Wagner, M., et al. (1999) · Psychosomatics · doi:10.1016/s0033-3182(99)71272-7 · Cited by 417 · see citing works
Mansfield, K. E., Sim, J., Jordan, J. L., & Jordan, K. P. (2016) · Pain · doi:10.1097/j.pain.0000000000000314 · Cited by 402 · see citing works
Comorbidity of Fibromyalgia and Psychiatric Disorders
Arnold, L. M., Hudson, J. I., Keck, P. E., Auchenbach, M. B., Javaras, K. N., & Hess, E. V. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0807 · Cited by 382 · see citing works
Self-citationPsychological treatments for fibromyalgia: A meta-analysis
Glombiewski, J. A., Sawyer, A. T., Gutermann, J., Koenig, K., Rief, W., & Hofmann, S. G. (2010) · Pain · doi:10.1016/j.pain.2010.06.011 · Cited by 341 · see citing works
Non-specific musculoskeletal pain in preadolescents. Prevalence and 1-year persistence
Mikkelsson, M., Salminen, J. J., & Kautiainen, H. (1997) · Pain · doi:10.1016/s0304-3959(97)00073-0 · Cited by 310 · see citing works
Nijs, J. (2012) · Pain Physician · doi:10.36076/ppj.2012/15/es205 · Cited by 307 · see citing works
Yunus, M. B., & Masi, A. T. (1985) · Arthritis & Rheumatism · doi:10.1002/art.1780280205 · Cited by 301 · see citing works
The Prevalence and Characteristics of Fibromyalgia in the 2012 National Health Interview Survey
Walitt, B., Nahin, R., Katz, R., Bergman, M., & Wolfe, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138024 · Cited by 274 · see citing works
Staud, R. M., Robinson, M. E., & Price, D. D. (2005) · Pain · doi:10.1016/j.pain.2005.08.007 · Cited by 266 · see citing works
BERNARDY, K., FÜBER, N., KÖLLNER, V., & HÄUSER, W. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100104 · Cited by 266 · see citing works
Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome
Rowe, P. C., Barron, D. F., Calkins, H., Maumenee, I. H., Tong, P. Y., & Geraghty, M. T. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70173-3 · Cited by 230 · see citing works
Joint hypermobility and fibromyalgia in schoolchildren.
Gedalia, A., Press, J., Klein, M., & Buskila, D. (1993) · Annals of the Rheumatic Diseases · doi:10.1136/ard.52.7.494 · Cited by 189 · see citing works
Kashikar‐Zuck, S., Ting, T. V., Arnold, L. M., Bean, J. A., Powers, S. W., Graham, T. B., Passo, M. H., Schikler, K. N., Hashkes, P. J., Spalding, S. J., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30644 · Cited by 186 · see citing works
Self-citationEvidence for Shared Pain Mechanisms in Osteoarthritis, Low Back Pain, and Fibromyalgia
Staud, R. M. (2011) · Current Rheumatology Reports · doi:10.1007/s11926-011-0206-6 · Cited by 174 · see citing works
Assessment of nonarticular tenderness and prevalence of fibromyalgia in children.
Buskila, D., Press, J., Gedalia, A., Klein, M., Neumann, L., Boehm, R., & SUKENIK, S. (1993) · PubMed · Cited by 173 · see citing works
Reid, G. J., Lang, B. A., & McGrath, P. J. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400423 · Cited by 170 · see citing works
Depression, coping, and functional disability in juvenile primary fibromyalgia syndrome
Kashikar-Zuck, S., Vaught, M. H., Goldschneider, K. R., Graham, T. B., & Miller, J. C. (2002) · The Journal of Pain · doi:10.1054/jpai.2002.126786 · Cited by 164 · see citing works
Psychiatric comorbidities in a community sample of women with fibromyalgia
Raphael, K. G., Janal, M. N., Nayak, S., Schwartz, J. E., & Gallagher, R. M. (2006) · Pain · doi:10.1016/j.pain.2006.04.004 · Cited by 153 · see citing works
Bennett, R. M., Friend, R. M., Marcus, D. A., Bernstein, C., Han, B. K., Yachoui, R., Deodhar, A. A., Kaell, A. T., Bonafede, P., Chino, A. F., et al. (2014) · Arthritis Care & Research · doi:10.1002/acr.22301 · Cited by 144 · see citing works
Family factors, emotional functioning, and functional impairment in juvenile fibromyalgia syndrome
Kashikar‐Zuck, S., Lynch, A. M., Slater, S. K., Graham, T. B., Swain, N. F., & Noll, R. B. (2008) · Arthritis Care & Research · doi:10.1002/art.24099 · Cited by 141 · see citing works
Self-citationSocial functioning and peer relationships of adolescents with juvenile fibromyalgia syndrome
Kashikar‐Zuck, S., Lynch, A. M., Graham, T. B., Swain, N. F., Mullen, S., & Noll, R. B. (2007) · Arthritis Care & Research · doi:10.1002/art.22615 · Cited by 135 · see citing works
Self-citationLong-Term Outcomes of Adolescents With Juvenile-Onset Fibromyalgia in Early Adulthood
Kashikar-Zuck, S., Cunningham, N., Sil, S., Bromberg, M. H., Lynch-Jordan, A. M., Strotman, D., Peugh, J., Noll, J., Ting, T. V., Powers, S. W., et al. (2014) · Pediatrics · doi:10.1542/peds.2013-2220 · Cited by 135 · see citing works
Self-citationSiegel, D. M., Janeway, D., & Baum, J. (1998) · PEDIATRICS · doi:10.1542/peds.101.3.377 · Cited by 133 · see citing works
Nijs, J., Kosek, E., Oosterwijck, J. V., & Meeus, M. (2012) · PubMed · Cited by 129 · see citing works
(2005) · PubMed · Cited by 126 · see citing works
Stephens, S., Feldman, B. M., Bradley, N. S., Schneiderman, J. E., Wright, F. V., Singh‐Grewal, D., Lefebvre, A., Benseler, S. M., Cameron, B., Laxer, R. M., et al. (2008) · Arthritis Care & Research · doi:10.1002/art.24115 · Cited by 125 · see citing works
Staud, R. M., Vierck, C. J., Robinson, M. E., & Price, D. D. (2005) · Journal of Pain · doi:10.1016/j.jpain.2005.01.357 · Cited by 125 · see citing works
Anxiety, Mood, and Behavioral Disorders Among Pediatric Patients With Juvenile Fibromyalgia Syndrome
Kashikar‐Zuck, S., Parkins, I., Graham, T. B., Lynch, A. M., Passo, M. H., Johnston, M., Schikler, K. N., Hashkes, P. J., Banez, G. A., & Richards, M. M. (2008) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31816d7d23 · Cited by 122 · see citing works
Self-citationFibromyalgia syndrome in children--an outcome study.
Buskila, D., Neumann, L., Hershman, E. B., Gedalia, A., Press, J., & SUKENIK, S. (1995) · PubMed · Cited by 114 · see citing works
Kashikar‐Zuck, S., Johnston, M., Ting, T. V., Graham, B., Lynch-Jordan, A. M., Verkamp, E., Passo, M. H., Schikler, K. N., Hashkes, P., Spalding, S., et al. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsq020 · Cited by 113 · see citing works
Self-citationVarni, J. W., Burwinkle, T. M., Limbers, C. A., & Szer, I. S. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-9 · Cited by 100 · see citing works
Prevalence of fibromyalgia in children: a clinical study of Mexican children.
Clark, P., Burgos‐Vargas, R., Medina-Palma, C., Lavielle, P., & Ff, M. (1998) · PubMed · Cited by 97 · see citing works
Ting, T. V., Barnett, K., Lynch-Jordan, A., Whitacre, C., Henrickson, M., & Kashikar-Zuck, S. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.10.011 · Cited by 88 · see citing works
Self-citationKashikar‐Zuck, S., Flowers, S. R., Verkamp, E., Ting, T. V., Lynch-Jordan, A. M., Graham, T. B., Passo, M. H., Schikler, K. N., Hashkes, P. J., Spalding, S. J., et al. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.12.009 · Cited by 84 · see citing works
Self-citationFibromyalgia syndrome: experience in a pediatric rheumatology clinic.
Gedalia, A., García, C., Molina, J. F., Bradford, N. J., & Espinoza, L. R. (2000) · PubMed · Cited by 83 · see citing works
Effectiveness of exercise in management of fibromyalgia
Gowans, S. E., & deHueck, A. (2004) · Current Opinion in Rheumatology · doi:10.1097/00002281-200403000-00012 · Cited by 80 · see citing works
Quality of Life and Emotional Functioning in Youth With Chronic Migraine and Juvenile Fibromyalgia
Kashikar-Zuck, S., Zafar, M., Barnett, K. A., Aylward, B. S., Strotman, D., Slater, S. K., Allen, J. R., LeCates, S. L., Kabbouche, M. A., Ting, T. V., et al. (2013) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182850544 · Cited by 77 · see citing works
Self-citationBidirectional Associations Between Pain and Physical Activity in Adolescents
Rabbitts, J. A., Holley, A. L., Karlson, C., & Palermo, T. M. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31829550c6 · Cited by 71 · see citing works
Abnormal Pain Modulation in Patients with Spatially Distributed Chronic Pain: Fibromyalgia
Staud, R. M. (2009) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2009.05.006 · Cited by 70 · see citing works
Kashikar-Zuck, S., Parkins, I. S., Ting, T. V., Verkamp, E., Lynch-Jordan, A., Passo, M., & Graham, T. B. (2010) · Rheumatology · doi:10.1093/rheumatology/keq254 · Cited by 69 · see citing works
Self-citationCastro-Sánchez, A. M., Matarán-Peñarrocha, G. A., López-Rodríguez, M. M., Lara-Palomo, I. C., Arendt-Nielsen, L., & Fernández-de-las-Peñas, C. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01523.x · Cited by 69 · see citing works
One year outcome of preadolescents with fibromyalgia.
Mikkelsson, M. (1999) · PubMed · Cited by 68 · see citing works
Brain imaging in fibromyalgia syndrome.
Staud, R. M. (2012) · PubMed · Cited by 66 · see citing works
The Treatment of Juvenile Fibromyalgia with an Intensive Physical and Psychosocial Program
Sherry, D. D., Brake, L., Tress, J. L., Sherker, J. L., Fash, K., Ferry, K., & Weiss, P. F. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.06.036 · Cited by 59 · see citing works
Kashikar-Zuck, S., Tran, S. T., Barnett, K., Bromberg, M. H., Strotman, D., Sil, S., Thomas, S. M., Joffe, N., Ting, T. V., Williams, S. E., et al. (2016) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000221 · Cited by 55 · see citing works
Self-citationKashikar‐Zuck, S., Flowers, S. R., Strotman, D., Sil, S., Ting, T. V., & Schikler, K. N. (2012) · Arthritis Care & Research · doi:10.1002/acr.21849 · Cited by 51 · see citing works
Self-citationPreliminary Evidence of Altered Biomechanics in Adolescents With Juvenile Fibromyalgia
Sil, S., Thomas, S., DiCesare, C., Strotman, D., Ting, T. V., Myer, G., & Kashikar‐Zuck, S. (2015) · Arthritis Care & Research · doi:10.1002/acr.22450 · Cited by 48 · see citing works
Self-citationTing, T. V., Hashkes, P. J., Schikler, K. N., Desai, A. M., Spalding, S. J., & Kashikar‐Zuck, S. (2012) · Pediatric Rheumatology · doi:10.1186/1546-0096-10-16 · Cited by 47 · see citing works
Self-citationArnold, L. M., Sarzi‐Puttini, P., Arsenault, P., Khan, T. M., Brown, P. B., Clair, A. G., Scavone, J. M., Driscoll, J., Landen, J. W., & Pauer, L. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141196 · Cited by 46 · see citing works
Self-citationPsychiatric Disorders in Young Adults Diagnosed with Juvenile Fibromyalgia in Adolescence
Cunningham, N. R., Tran, S. T., Lynch-Jordan, A. M., Ting, T. V., Sil, S., Strotman, D., Noll, J. G., Powers, S. W., Arnold, L. M., & Kashikar‐Zuck, S. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141369 · Cited by 37 · see citing works
Self-citationAblin, J. N., Buskila, D., & Clauw, D. J. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0056-3 · Cited by 29 · see citing works
Arnold, L. M., Bateman, L., Palmer, R. H., & Lin, Y. (2015) · Pediatric Rheumatology · doi:10.1186/s12969-015-0025-9 · Cited by 27 · see citing works
Self-citationAn Exploratory, Open Trial of Fluoxetine Treatment of Juvenile Fibromyalgia
Mariutto, E., Stanford, S. B., Kashikar‐Zuck, S., Welge, J. A., & Arnold, L. M. (2012) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31824858dc · Cited by 17 · see citing works
Self-citationCan Modified Neuromuscular Training Support the Treatment of Chronic Pain in Adolescents?
Thomas, S. M., Sil, S., Kashikar‐Zuck, S., & Myer, G. D. (2013) · Strength and conditioning journal · doi:10.1519/ssc.0b013e31829206c1 · Cited by 14 · see citing works
Self-citationDefective removal of ribonucleotides from DNA promotes systemic lupus erythematosus
Günther, C., Kind, B., Reijns, M. A. M., et al. (2015) · Pediatric Rheumatology · doi:10.1186/1546-0096-13-s1-o86 · Cited by 6 · see citing works
(159) Fear of movement and physical deconditioning in adolescents with Juvenile Fibromyalgia
Sil, S., Thomas, S. M., DiCesare, C. A., et al. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.01.065 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Evaluating psychosocial contributions to chronic pain outcomes
Meints, S. M., & Edwards, R. R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.017 · Cited by 719 · see citing works
Sharp, H. E. C., Critchley, H. D., & Eccles, J. A. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.805 · Cited by 32 · see citing works
- Authors
- Kashikar-Zuck, S., King, C., Ting, T. V., & Arnold, L. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati (US)
- Venue
- Current Rheumatology Reports
- Published
- 2016-03-17
- Volume
- 18
- Issue
- 4
- Pages
- 19-19
- ISSN
- 1523-3774 (ISSN-L)
- 1534-6307
- OpenAlex
- W2301285628
- Cited by
- 50
- References
- 62
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 4
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Rheumatology Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R00 Grant (King, PI))
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K24AR056687)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- juvenile fibromyalgia, fibromyalgia, chronic widespread pain, adolescents, joint hypermobility, psychological comorbidity, pharmacotherapy, non-pharmacological treatment, cognitive behavioral therapy, physical activity, early recognition
- MeSH terms
- Age Factors, Fibromyalgia, Humans, Prognosis, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review