The DOI matches its Crossref record; 120 of the 122 references it cites were found in a registry or an index.
Psychosocial Stress and Cardiovascular Disease
Open accessAbstract
Purpose of review This manuscript reviews the epidemiological data linking psychosocial stress to cardiovascular disease (CVD), describes recent advances in understanding the biological pathway between them, discusses potential therapies against stress-related CVD, and identifies future research directions.Recent findings Metabolic activity of the amygdala (a neural center that is critically involved in the response to stress) can be measured on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) yielding a neurobiological signal that independently predicts subsequent CVD events. Furthermore, a serial pathway from ↑amygdalar activity → ↑hematopoietic tissue activity → ↑arterial inflammation → ↑CVD events has been elucidated, providing new insights into the mechanism linking stress to CVD. Psychosocial stress and stress conditions are independently associated with CVD in a manner that depends on the degree and duration of stress as well as the individual response to a stressor. Nevertheless, the fundamental biology remains incompletely defined, and stress is often confounded by adverse health behaviors. Thus, most clinical guidelines do not yet recognize psychosocial stress as an independent CVD risk factor or advocate for its treatment in CVD prevention. Clarification of this neurobiological pathway provides a better understanding of the underlying pathophysiology and suggests opportunities to develop novel preventive strategies and therapies.
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“Therefore, such intersubjective dyadic practices and specific socio-emotional ones may be particularly efficient in reducing social stress, one of the most prominent causes of stress-related diseases (68–70).”
From Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training (2024) · cites this paper as [69]
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“Moreover, psychological stress has been shown to influence the onset of several cardiovascular diseases (Dar et al., 2019; Esler, 2017; Leo et al., 2023).”
From Remembering what did not happen: the role of hypnosis in memory recall and false memories formation (2025) · cites this paper as Dar et al., 2019
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2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485
Social Determinants of Cardiovascular Disease
Powell‐Wiley, T. M., Baumer, Y., Baah, F. O., Baez, A. S., Farmer, N., Mahlobo, C. T., Pita, M. A., Potharaju, K. A., Tamura, K., & Wallen, G. R. (2022) · Circulation Research · doi:10.1161/circresaha.121.319811 · Cited by 934
NAFLD and cardiovascular diseases: a clinical review
Kasper, P., Martin, A., Lang, S., Kütting, F., Goeser, T., Demir, M., & Steffen, H. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01709-7 · Cited by 691
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 586
Disentangling the Links Between Psychosocial Stress and Cardiovascular Disease
Osborne, M. T., Shin, L. M., Mehta, N. N., Pitman, R. K., Fayad, Z. A., & Tawakol, A. A. (2020) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.120.010931 · Cited by 339
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Metadata
- Authors
- Dar, T., Radfar, A., Abohashem, S., Pitman, R. K., Tawakol, A., & Osborne, M. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Osborne, Michael T.
- Venue
- Current Treatment Options in Cardiovascular Medicine
- Published
- 2019-04-26
- Volume
- 21
- Issue
- 5
- Pages
- 23-23
- ISSN
- 1092-8464 (ISSN-L)
- 1534-3189
- PMC
- PMC6568256
- OpenAlex
- W2940673845
- Cited by
- 248
- References
- 122
- Citations by year
- 2026: 23 · 2025: 56 · 2024: 42 · 2023: 42 · 2022: 41 · 2021: 24 · 2020: 16 · 2019: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Treatment Options in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (18CDA34110366)
- National Institutes of Health (KL2TR002542)
- National Heart, Lung, and Blood Institute (P01HL131478)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- psychosocial stress, cardiovascular disease, amygdala, arterial inflammation, hematopoietic tissue, stress response, cardiovascular risk factors, stress biomarkers
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