Cited by 248Cardiac Health and Mental HealthHeart Rate Variability and Autonomic ControlStress Responses and Cortisol

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Psychosocial Stress and Cardiovascular Disease

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Dar, Tawseef, Radfar, Azar, Abohashem, Shady, Pitman, Roger K., Tawakol, Ahmed, Osborne, Michael T.·2019·Current Treatment Options in Cardiovascular Medicine

DOI 10.1007/s11936-019-0724-5PMC PMC6568256

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Abstract

Purpose of review This manuscript reviews the epidemiological data linking psychosocial stress to cardiovascular disease (CVD), describes recent advances in understanding the biological pathway between them, discusses potential therapies against stress-related CVD, and identifies future research directions.Recent findings Metabolic activity of the amygdala (a neural center that is critically involved in the response to stress) can be measured on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) yielding a neurobiological signal that independently predicts subsequent CVD events. Furthermore, a serial pathway from ↑amygdalar activity → ↑hematopoietic tissue activity → ↑arterial inflammation → ↑CVD events has been elucidated, providing new insights into the mechanism linking stress to CVD. Psychosocial stress and stress conditions are independently associated with CVD in a manner that depends on the degree and duration of stress as well as the individual response to a stressor. Nevertheless, the fundamental biology remains incompletely defined, and stress is often confounded by adverse health behaviors. Thus, most clinical guidelines do not yet recognize psychosocial stress as an independent CVD risk factor or advocate for its treatment in CVD prevention. Clarification of this neurobiological pathway provides a better understanding of the underlying pathophysiology and suggests opportunities to develop novel preventive strategies and therapies.

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Authors: Dar, T., Radfar, A., Abohashem, S., Pitman, R. K., Tawakol, A., & Osborne, M. T.
Affiliations: Harvard University (US)
Corresponding author: Osborne, Michael T.
ORCID: Dar, Tawseef
Radfar, Azar
Abohashem, Shady
Pitman, Roger K.
Tawakol, Ahmed
Osborne, Michael T.
Venue: Current Treatment Options in Cardiovascular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2019-04-26
Volume: 21
Issue: 5
Pages: 23-23
ISSN: 1092-8464 (ISSN-L)
1534-3189
DOI: 10.1007/s11936-019-0724-5
PMC: PMC6568256
OpenAlex: W2940673845
Cited by: 248
References: 122
Citations by year: 2026: 23 · 2025: 56 · 2024: 42 · 2023: 42 · 2022: 41 · 2021: 24 · 2020: 16 · 2019: 2
FWCI: 3.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Treatment Options in Cardiovascular Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association (18CDA34110366)
National Institutes of Health (KL2TR002542)
National Heart, Lung, and Blood Institute (P01HL131478)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: psychosocial stress, cardiovascular disease, amygdala, arterial inflammation, hematopoietic tissue, stress response, cardiovascular risk factors, stress biomarkers

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