The DOI matches its Crossref record; 120 of the 122 references it cites were found in a registry or an index.
Psychosocial Stress and Cardiovascular Disease
Open accessAbstract
Purpose of review This manuscript reviews the epidemiological data linking psychosocial stress to cardiovascular disease (CVD), describes recent advances in understanding the biological pathway between them, discusses potential therapies against stress-related CVD, and identifies future research directions.Recent findings Metabolic activity of the amygdala (a neural center that is critically involved in the response to stress) can be measured on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) yielding a neurobiological signal that independently predicts subsequent CVD events. Furthermore, a serial pathway from ↑amygdalar activity → ↑hematopoietic tissue activity → ↑arterial inflammation → ↑CVD events has been elucidated, providing new insights into the mechanism linking stress to CVD. Psychosocial stress and stress conditions are independently associated with CVD in a manner that depends on the degree and duration of stress as well as the individual response to a stressor. Nevertheless, the fundamental biology remains incompletely defined, and stress is often confounded by adverse health behaviors. Thus, most clinical guidelines do not yet recognize psychosocial stress as an independent CVD risk factor or advocate for its treatment in CVD prevention. Clarification of this neurobiological pathway provides a better understanding of the underlying pathophysiology and suggests opportunities to develop novel preventive strategies and therapies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Therefore, such intersubjective dyadic practices and specific socio-emotional ones may be particularly efficient in reducing social stress, one of the most prominent causes of stress-related diseases (68–70).”
From Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training (2024) · cites this paper as [69]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Moreover, psychological stress has been shown to influence the onset of several cardiovascular diseases (Dar et al., 2019; Esler, 2017; Leo et al., 2023).”
From Remembering what did not happen: the role of hypnosis in memory recall and false memories formation (2025) · cites this paper as Dar et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Cholesterol Treatment Trialists' (CTT) Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)61350-5 · Cited by 6,550
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,865
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
Rozanski, A., Blumenthal, J. A., & Kaplan, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2192 · Cited by 2,846
Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., Franklin, B. A., Goldstein, L. B., Greenland, P., Grundy, S. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020190.45892.75 · Cited by 1,837
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Nicholson, A., Kuper, H., & Hemingway, H. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl338 · Cited by 1,353
Hemingway, H., & Marmot, M. G. (1999) · BMJ · doi:10.1136/bmj.318.7196.1460 · Cited by 1,342
Stress and cardiovascular disease
Steptoe, A., & Kivimäki, M. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.45 · Cited by 1,321
Anderson, T. J., Grégoire, J., Pearson, G. J., Barry, A. R., Couture, P., Dawes, M., Francis, G. A., Genest, J., Grover, S., Gupta, M., et al. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.07.510 · Cited by 1,173
Depression as a predictor for coronary heart disease
Rugulies, R. (2002) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(02)00439-7 · Cited by 1,110
Myocardial infarction accelerates atherosclerosis
Dutta, P., Courties, G., Wei, Y., Leuschner, F., Gorbatov, R., Robbins, C. S., Iwamoto, Y., Thompson, B. D., Carlson, A. L., Heidt, T., et al. (2012) · Nature · doi:10.1038/nature11260 · Cited by 1,109
Jiang, W., Alexander, J., Christopher, E., Kuchibhatla, M., Gaulden, L. H., Cuffe, M. S., Blazing, M. A., Davenport, C., Califf, R. M., Krishnan, R. R., et al. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1849 · Cited by 934
A Syndrome Produced by Diverse Nocuous Agents
Selye, H. (1998) · Journal of Neuropsychiatry · doi:10.1176/jnp.10.2.230a · Cited by 925
Anxiety and Risk of Incident Coronary Heart Disease
Roest, A. M., Martens, E. J., de Jonge, P., & Denollet, J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.034 · Cited by 865
Depression and Risk of Stroke Morbidity and Mortality: A Meta-analysis and Systematic Review
Pan, A., Sun, Q., Okereke, O. I., Rexrode, K. M., & Hu, F. B. (2011) · JAMA · doi:10.1001/jama.2011.1282 · Cited by 819
Sudden Cardiac Death Triggered by an Earthquake
Leor, J., Poole, W. K., & Kloner, R. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602153340701 · Cited by 819
Chronic variable stress activates hematopoietic stem cells
Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von zur Muhlen, C., Bode, C., Fricchione, G. L., Denninger, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3589 · Cited by 803
Depressive Symptoms and Health-Related Quality of Life
Ruo, B., Rumsfeld, J. S., Hlatky, M. A., Liu, H., Browner, W. S., & Whooley, M. A. (2003) · JAMA · doi:10.1001/jama.290.2.215 · Cited by 753
The cardiovascular toll of stress
Brotman, D. J., Golden, S. H., & Wittstein, I. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61305-1 · Cited by 713
Triggering of Acute Myocardial Infarction Onset by Episodes of Anger
Mittleman, M. A., Maclure, M., Sherwood, J. B., Mulry, R. P., Tofler, G. H., Jacobs, S. C., Friedman, R. B., Benson, H., & Muller, J. E. (1995) · Circulation · doi:10.1161/01.cir.92.7.1720 · Cited by 707
Tawakol, A., Ishai, A., Takx, R. A., Figueroa, A. L., Ali, A., Kaiser, Y., Truong, Q. A., Solomon, C. J., Calcagno, C., Mani, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31714-7 · Cited by 636
Self-citationStress reduction correlates with structural changes in the amygdala
Hölzel, B. K., Carmody, J., Evans, K. C., Hoge, E. A., Dusek, J. A., Morgan, L., Pitman, R. K., & Lazar, S. W. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp034 · Cited by 603
Self-citationCaregiving and risk of coronary heart disease in U.S. women
Lee, S., Colditz, G. A., Berkman, L. F., & Kawachi, I. (2003) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(02)00582-2 · Cited by 596
Epidemiology of comorbid coronary artery disease and depression
Rudisch, B. E., & Nemeroff, C. B. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00587-0 · Cited by 556
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00687-6 · Cited by 457
Cardiovascular Events during World Cup Soccer
Wilbert-Lampen, U., Leistner, D. M., Greven, S., Pohl, T., Sper, S., Völker, C., Güthlin, D., Plasse, A., Knez, A., Küchenhoff, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707427 · Cited by 426
Intensification of Statin Therapy Results in a Rapid Reduction in Atherosclerotic Inflammation
Tawakol, A. A., Fayad, Z. A., Mogg, R., Alon, A., Klimas, M. T., Dansky, H. M., Subramanian, S. S., Abdelbaky, A., Rudd, J. H. F., Farkouh, M. E., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.066 · Cited by 420
Self-citationSILENT MYOCARDIAL ISCHAEMIA DUE TO MENTAL STRESS
Deanfield, J. E., Kensett, M. J., Wilson, R., Shea, M. J., Horlock, P. L., de Landsheere, C., & Selwyn, A. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91106-1 · Cited by 413
The Role of the Central Nucleus of the Amygdala in Mediating Fear and Anxiety in the Primate
Kalin, N. H., Shelton, S. E., & Davidson, R. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0292-04.2004 · Cited by 406
Meena Kumari, B., Head, J. A., & Marmot, M. G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.17.1873 · Cited by 387
Depression, mortality, and medical morbidity in patients with coronary heart disease
Carney, R. M., & Freedland, K. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00111-2 · Cited by 378
BREMNER, J. D., VERMETTEN, E., SCHMAHL, C., VACCARINO, V., VYTHILINGAM, M., AFZAL, N., GRILLON, C., & CHARNEY, D. S. (2005) · Psychological Medicine · doi:10.1017/s0033291704003290 · Cited by 370
PORTER, K. A., CALNE, R. Y., & ZUKOSKI, C. F. (1964) · The Lancet · doi:10.1016/s0140-6736(64)90940-7 · Cited by 369
Mental Stress—Induced Myocardial Ischemia and Cardiac Events
Jiang, W. (1996) · JAMA · doi:10.1001/jama.275.21.1651 · Cited by 358
Analysis of possible triggers of acute myocardial infarction (the MILIS study)
Tofler, G. H., Stone, P. H., Maclure, M., Edelman, E., Davis, V. G., Robertson, T., Antman, E. M., & Muller, J. E. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90729-k · Cited by 356
Rumsfeld, J. S., Havranek, E. P., Masoudi, F. A., Peterson, E. D., Jones, P. G., Tooley, J. F., Krumholz, H. M., & Spertus, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.013 · Cited by 352
Brondolo, E. N., Rieppi, R., Kelly, K. P., & Gerin, W. (2003) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2501_08 · Cited by 347
Phobic Anxiety and Risk of Coronary Heart Disease and Sudden Cardiac Death Among Women
Albert, C. M., Chae, C. U., Rexrode, K. M., Manson, J. E., & Kawachi, I. I. (2005) · Circulation · doi:10.1161/01.cir.0000153813.64165.5d · Cited by 331
Levine, G. N., Lange, R. A., Bairey‐Merz, C. N., Davidson, R. J., Jamerson, K., Mehta, P. K., Michos, E. D., Norris, K., Ray, I. B., Saban, K. L., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.002218 · Cited by 330
Hamer, M., Molloy, G., & Stamatakis, E. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.057 · Cited by 324
Social status alters immune regulation and response to infection in macaques
Snyder-Mackler, N., Sanz, J., Kohn, J. N., Brinkworth, J. F., Morrow, S., Shaver, A. O., Grenier, J.-C., Pique-Regi, R., Johnson, Z. P., Wilson, M. E., et al. (2016) · Science · doi:10.1126/science.aah3580 · Cited by 318
Lagraauw, H. M., Kuiper, J., & Bot, I. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.007 · Cited by 289
Kubzansky, L. D., Kawachi, I. I., Weiss, S. T., & Sparrow, D. (1998) · Annals of Behavioral Medicine · doi:10.1007/bf02884448 · Cited by 285
Psychological distress as a risk factor for coronary heart disease in the Whitehall II Study
Stansfeld, S. A., Fuhrer, R., Shipley, M. J., & Marmot, M. G. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.248 · Cited by 272
Early-Onset Depression, Anxiety, and Risk of Subsequent Coronary Heart Disease
Janszky, I., Ahnve, S., Lundberg, I., & Hemmingsson, T. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.033 · Cited by 260
Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis
Booth, J., Connelly, L., Lawrence, M., Chalmers, C., Joice, S., Becker, C., & Dougall, N. J. (2015) · BMC Neurology · doi:10.1186/s12883-015-0456-4 · Cited by 260
Blumenthal, J. A., Sherwood, A., Smith, P. J., Watkins, L., Mabe, S., Kraus, W. E., Ingle, K., Miller, P., & Hinderliter, A. (2016) · Circulation · doi:10.1161/circulationaha.115.018926 · Cited by 257
Muscatell, K. A., Dedovic, K., Slavich, G. M., Jarcho, M. R., Breen, E. C., Bower, J. E., Irwin, M. R., & Eisenberger, N. I. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.06.201 · Cited by 240
Mental Stress–Induced Ischemia and All-Cause Mortality in Patients With Coronary Artery Disease
Sheps, D. S., McMahon, R. P., Becker, L. C., Carney, R. M., Freedland, K. E., Cohen, J. D., Sheffield, D., Goldberg, A. D., Ketterer, M. W., Pepine, C. J., et al. (2002) · Circulation · doi:10.1161/01.cir.0000014491.90666.06 · Cited by 239
The Amygdala: Corticotropin-Releasing Factor, Steroids, and Stress
Gray, T. S., & Bingaman, E. W. (1996) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v10.i2.10 · Cited by 230
Meijer, A., Conradi, H. J., Bos, E. H., Anselmino, M., Carney, R. M., Denollet, J., Doyle, F., Freedland, K. E., Grace, S. L., Hosseini, S. H., et al. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.111195 · Cited by 219
Steinberg, J. S., Arshad, A., Kowalski, M., Kukar, A., Suma, V. S., Vloka, M. E., EHLERT, F. A., Herweg, B., Donnelly, J., Philip, J., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.032 · Cited by 205
A prospective study of posttraumatic stress disorder symptoms and coronary heart disease in women.
Kubzansky, L. D., Koenen, K. C., Jones, C. C., & Eaton, W. W. (2009) · Health Psychology · doi:10.1037/0278-6133.28.1.125 · Cited by 203
Short-Term Catecholamine Response to Psychological Stress1
Dimsdale, J. E., & Moss, J. (1980) · Psychosomatic Medicine · doi:10.1097/00006842-198009000-00003 · Cited by 195
Does altered glucocorticoid homeostasis increase cardiovascular risk?
GIROD, J., & BROTMAN, D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.07.006 · Cited by 193
Lallukka, T. M., Lahelma, E. T., Rahkonen, O., Roos, E., Laaksonen, E., Martikainen, P., Head, J. A., Brunner, E. J., Mosdøl, A., Marmot, M. G., et al. (2008) · Social Science & Medicine · doi:10.1016/j.socscimed.2007.12.027 · Cited by 191
Goebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00019 · Cited by 189
Impact of Earthquakes on Takotsubo Cardiomyopathy
Watanabe, H., Kodama, M., Okura, Y., Aizawa, Y., Tanabe, N., Chinushi, M., Nakamura, Y., Nagai, T., Sato, M., & Okabe, M. (2005) · JAMA · doi:10.1001/jama.294.3.305 · Cited by 187
Kario, K., Matsuo, T., Kobayashi, H., Yamamoto, K., & Shimada, K. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00002-8 · Cited by 184
Burg, M. M., Jain, D., Soufer, R., Kerns, R. D., & Zaret, B. L. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90048-6 · Cited by 180
Mooy, J. M., de Vries, H., Grootenhuis, P. A., Bouter, L. M., & Heine, R. J. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.197 · Cited by 177
Kloner, R. A., Leor, J., Poole, W. K., & Perritt, R. L. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00281-7 · Cited by 169
Nabi, H., Mika Kivimaki, B., Batty, G. D., Shipley, M. J., Britton, A. R., Brunner, E. J., Vahtera, J., Lemogne, C., Elbaz, A., & Singh‐Manoux, A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht216 · Cited by 164
Effects of Job Strain on Blood Pressure: A Prospective Study of Male and Female White-Collar Workers
Guímont, C., Brisson, C., Dagenais, G. R., Milot, A., Vézina, M., Mâsse, B. R., Moisan, J., Laflamme, N., & Blanchette, C. (2006) · American Journal of Public Health · doi:10.2105/ajph.2004.057679 · Cited by 157
Psychosocial stress is associated with obesity and diet quality in Hispanic/Latino adults
Isasi, C. R., Parrinello, C. M., Jung, M., Carnethon, M. R., Birnbaum‐Weitzman, O., Espinoza, R. A., Penedo, F. J., Perreira, K. M., Schneiderman, N., Sotres‐Alvarez, D., et al. (2014) · Annals of Epidemiology · doi:10.1016/j.annepidem.2014.11.002 · Cited by 154
Cortisol Exerts bi-phasic Regulation of Inflammation in Humans
Yeager, M. P., Pioli, P. A., & Guyre, P. M. (2010) · Dose-Response · doi:10.2203/dose-response.10-013.yeager · Cited by 145
Kibler, J. L., Joshi, K., & Ma, M. (2008) · Behavioral Medicine · doi:10.3200/bmed.34.4.125-132 · Cited by 143
Aschbacher, K., Kornfeld, S., Picard, M. A., Puterman, E. M., Havel, P. J., Stanhope, K. L., Lustig, R. H., & Epel, E. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.003 · Cited by 143
Kang, H. K., Bullman, T. A., & Taylor, J. W. (2005) · Annals of Epidemiology · doi:10.1016/j.annepidem.2005.03.004 · Cited by 141
Increases in job strain are associated with incident hypertension in the CARDIA study
Markovitz, J. H., Matthews, K. A., Whooley, M. A., Lewis, C. E., & Greenlund, K. J. (2004) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2801_2 · Cited by 136
Gottlieb, S. S., Kop, W. J., Ellis, S. J., Binkley, P., Howlett, J., O'Connor, C., Blumenthal, J. A., Fletcher, G., Swank, A. M., & Cooper, L. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.025 · Cited by 133
Strike, P. C., Perkins-Porras, L., Whitehead, D. L., McEwan, J. R., & Steptoe, A. (2006) · Heart · doi:10.1136/hrt.2005.077362 · Cited by 130
Lifestyle Effects on Hematopoiesis and Atherosclerosis
Nahrendorf, M., & Świrski, F. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303550 · Cited by 124
Myocardial blood-flow response during mental stress in patients with coronary artery disease
Arrighi, J. A., Burg, M. M., Cohen, I. S., Kao, A. H., Pfau, S. E., Caulin‐Glaser, T., Zaret, B. L., & Soufer, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02510-1 · Cited by 123
Nabi, H., Hall, M. H., Koskenvuo, M. J., Singh‐Manoux, A., Oksanen, T., Suominen, S., Mika Kivimaki, B., & Vahtera, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.040 · Cited by 121
Social stress shortens lifespan in mice
Razzoli, M., Nyuyki, K. D., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., et al. (2018) · Aging Cell · doi:10.1111/acel.12778 · Cited by 119
Cortisol inhibits cholinergic vasodilatation in the human forearm
Mangos, G., Walker, B. R., Kelly, J. J., Lawson, J. A., Webb, D. J., & Whitworth, J. A. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01201-2 · Cited by 118
Long working hours as a risk factor for atrial fibrillation: a multi-cohort study
Mika Kivimaki, B., Nyberg, S. T., Batty, G. D., Kawachi, I. I., Jokela, M. M., Alfredsson, L. S., Bjørner, J. B., Borritz, M., Burr, H., Dragano, N., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx324 · Cited by 114
Role of Exertion or Emotion as Inciting Events for Acute Aortic Dissection
Hatzaras, I. S., Bible, J. E., Koullias, G. J., Tranquilli, M., Singh, M., & Elefteriades, J. A. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.06.039 · Cited by 110
Carroll, D., Ginty, A. T., Painter, R. C., Roseboom, T. J., Phillips, A. C., & de Rooij, S. R. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2012.04.001 · Cited by 93
Salmon, É., Collette, F., Degueldre, C., Lemaire, C. F., & Franck, G. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200005)10:1 · Cited by 91
Post-Traumatic Stress Disorder and Cardiovascular Diseases
Remch, M., Laskaris, Z., Flory, J. D., Mora‐McLaughlin, C., & Morabia, A. (2018) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.117.004572 · Cited by 89
Stewart-Knox, B. J., Duffy, M. E., Bunting, B. P., Parr, H. J., de Almeida, M. D. V., & Gibney, M. J. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-424 · Cited by 87
Impact of earthquakes on risk for pulmonary embolism
Watanabe, H., Kodama, M., Tanabe, N., Nakamura, Y., Nagai, T., Sato, M., Okabe, M., & Aizawa, Y. (2007) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.06.039 · Cited by 85
Persistent psychological distress and mortality in patients with stable coronary artery disease
Stewart, R., Colquhoun, D. M., Marschner, S. L., Kirby, A. C., Simes, J. R., Nestel, P. J., Glozier, N., O'Neil, A. E., Oldenburg, B. F., White, H. D., et al. (2017) · Heart · doi:10.1136/heartjnl-2016-311097 · Cited by 83
Goyal, A., Dey, A. K., Chaturvedi, A., Elnabawi, Y. A., Aberra, T. M., Chung, J. H. N., Belur, A. D., Groenendyk, J., Lerman, J. B., Rivers, J. P., et al. (2018) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.08.038 · Cited by 76
Self-citationWang, S.-S., Xue-bo, Y., Hofman, M. A., Swaab, D. F., & Zhou, J. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0329-1 · Cited by 72
Effects of chronic sympathectomy on vascular function in the human forearm
Eisenach, J. H., Clark, E. S., Charkoudian, N., Dinenno, F. A., Atkinson, J. L. D., Fealey, R. D., Dietz, N. M., & Joyner, M. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01025.2001 · Cited by 67
Chu, P., Pandya, A., Salomon, J. A., Goldie, S. J., & Hunink, M. G. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002737 · Cited by 59
Fransson, E. I., Nordin, M., Hanson, L. L. M., & Westerlund, H. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318777387 · Cited by 59
Coronary Plaque Morphology and the Anti-Inflammatory Impact of Atorvastatin
Singh, P., Emami, H., Subramanian, S. S., Maurovich‐Horvat, P., Marincheva-Savcheva, G., Medina, H. M., Abdelbaky, A., Alon, A., Shankar, S. S., Rudd, J. H. F., et al. (2016) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.115.004195 · Cited by 58
Self-citationFox, A. S., Oler, J. A., Shelton, S. E., Nanda, S. A., Davidson, R. J., Roseboom, P. H., & Kalin, N. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206723109 · Cited by 57
McCanlies, E. C., Araia, S. K., Joseph, P. N., Mnatsakanova, A., Andrew, M. E., Burchfiel, C. M., & Violanti, J. M. (2011) · Cytokine · doi:10.1016/j.cyto.2011.03.025 · Cited by 56
The stress of life: a modern complaint?
Jackson, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60093-3 · Cited by 55
Cumulative stress and autonomic dysregulation in a community sample
Lampert, R., Tuit, K., Hong, K.-I., Donovan, T., Lee, F., & Sinha, R. (2016) · Stress · doi:10.1080/10253890.2016.1174847 · Cited by 51
Batty, G. D., Russ, T. C., Stamatakis, E. A., & Mika Kivimaki, B. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.06.025 · Cited by 49
Central noradrenergic system modulates plasma interleukin-6 production by peripheral interleukin-1
Huang, Q., Takaki, A., & Arimura, A. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.2.r731 · Cited by 48
Adelborg, K., Schmidt, M., Sundbøll, J., Pedersen, L. H., Videbech, P., Bøtker, H. E., Egstrup, K., & Sørensen, H. T. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.004137 · Cited by 47
Ogilvie, R. P., Everson-Rose, S., Longstreth, W., Rodriguez, C., Diez-Roux, A., & Lutsey, P. (2015) · Circulation: Heart Failure · doi:10.1161/circheartfailure.115.002243 · Cited by 47
Amygdalar activity predicts future incident diabetes independently of adiposity
Osborne, M. T., Ishai, A., Hammad, B., Tung, B., Wang, Y., Baruch, A., Fayad, Z. A., Giles, J. T., Lo, J., Shin, L. M., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.024 · Cited by 42
Self-citationSelective serotonin reuptake inhibitors and cardiovascular events: A systematic review
Nezafati, M. H., Eshraghi, A., Vojdanparast, M., Abtahi, S., & Nezafati, P. (2016) · Journal of Research in Medical Sciences · doi:10.4103/1735-1995.189647 · Cited by 40
Sudden changes in heart rate variability during the 1999 Taiwan earthquake
Huang, J., Chiou, C.-W., Ting, C.-T., Chen, Y., & Chen, S. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01331-x · Cited by 38
Hemostatic activation and cardiac events after the 1995 Hanshin-Awaji earthquake.
Matsuo (1998) · International Journal of Hematology · doi:10.1016/s0925-5710(97)00118-7 · Cited by 37
Clinical Indicators and Psychosocial Aspects in Peripheral Arterial Disease
Aquarius, A. E. (2006) · Archives of Surgery · doi:10.1001/archsurg.141.2.161 · Cited by 36
Risk of Severe Cardiac Arrhythmia in Male Utility Workers: A Nationwide Danish Cohort Study
Johansen, C. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf137 · Cited by 31
Psychological interventions in cardiovascular disease
Tan, M. P., & Morgan, K. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000181 · Cited by 31
PET Mapping of Neurofunctional Changes in a Posttraumatic Stress Disorder Model
Zhu, Y., Du, R., Zhu, Y., Shen, Y., Zhang, K., Chen, Y., Song, F., Wu, S., Zhang, H., & Tian, M. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.173443 · Cited by 31
Psychological stress and short-term hospitalisations or death in patients with heart failure
Endrighi, R., Waters, A. J., Gottlieb, S. S., Harris, K. M., Wawrzyniak, A. J., Bekkouche, N. S., Li, Y., Kop, W. J., & Krantz, D. S. (2016) · Heart · doi:10.1136/heartjnl-2015-309154 · Cited by 30
Yamabe, H., Hanaoka, J., Funakoshi, T., Iwahashi, M., Takeuchi, M., Saito, K., Kawashima, S., & Yokoyama, M. (1996) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)41699-4 · Cited by 27
Bhasin, M., Denninger, J. W., Huffman, J. C., Joseph, M. G., Niles, H. F., Chad‐Friedman, E., Goldman, R. E., Buczynski, B., Mahoney, B. A., Fricchione, G. L., et al. (2018) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2017.0053 · Cited by 26
The effect of selective serotonin reuptake inhibitors on major adverse cardiovascular events
Kim, Y., Lee, Y. S., Kim, M. G., Song, Y.-K., Kim, Y., Jang, H.-Y., Kim, J. H., Han, N., Ji, E., Kim, I., et al. (2018) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000238 · Cited by 19
Depressive Symptoms and Risk for Sudden Cardiac Death in Stable Coronary Artery Disease
Lahtinen, M., Kiviniemi, A. M., Junttila, J. M., Kääriäinen, M., Huikuri, H. V., & Tulppo, M. P. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.05.006 · Cited by 15
Orth-Gomér, K., Wamala, S. P., Horsten, M., Schenck-Gustafsson, K., Schneiderman, N., & Mittleman, M. A. (2000) · JAMA · doi:10.1001/jama.284.23.3008 · Cited by 6
Thomas, M. B., Buchanan, D. M., Patel, K., GOSCH, K. L., & Smolderen, K. G. E. (2018) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(18)32581-6 · Cited by 2
Cited by
Sorted by citations
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485
Social Determinants of Cardiovascular Disease
Powell‐Wiley, T. M., Baumer, Y., Baah, F. O., Baez, A. S., Farmer, N., Mahlobo, C. T., Pita, M. A., Potharaju, K. A., Tamura, K., & Wallen, G. R. (2022) · Circulation Research · doi:10.1161/circresaha.121.319811 · Cited by 934
NAFLD and cardiovascular diseases: a clinical review
Kasper, P., Martin, A., Lang, S., Kütting, F., Goeser, T., Demir, M., & Steffen, H. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01709-7 · Cited by 691
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 586
Disentangling the Links Between Psychosocial Stress and Cardiovascular Disease
Osborne, M. T., Shin, L. M., Mehta, N. N., Pitman, R. K., Fayad, Z. A., & Tawakol, A. A. (2020) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.120.010931 · Cited by 339
Self-citation
Metadata
- Authors
- Dar, T., Radfar, A., Abohashem, S., Pitman, R. K., Tawakol, A., & Osborne, M. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Osborne, Michael T.
- Venue
- Current Treatment Options in Cardiovascular Medicine
- Published
- 2019-04-26
- Volume
- 21
- Issue
- 5
- Pages
- 23-23
- ISSN
- 1092-8464 (ISSN-L)
- 1534-3189
- PMC
- PMC6568256
- OpenAlex
- W2940673845
- Cited by
- 248
- References
- 122
- Citations by year
- 2026: 23 · 2025: 56 · 2024: 42 · 2023: 42 · 2022: 41 · 2021: 24 · 2020: 16 · 2019: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Treatment Options in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (18CDA34110366)
- National Institutes of Health (KL2TR002542)
- National Heart, Lung, and Blood Institute (P01HL131478)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- psychosocial stress, cardiovascular disease, amygdala, arterial inflammation, hematopoietic tissue, stress response, cardiovascular risk factors, stress biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
