The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Fucoidans from Brown Seaweeds Sargassum hornery, Eclonia cava, Costaria costata: Structural Characteristics and Anticancer Activity
Abstract
Fucoidans were isolated by water extraction and ion-exchange chromatography from brown algae Eclonia cava, Sargassum hornery, and Costaria costata collected near of Korean coasts. The structures of fucoidans were investigated. Fucoidan from E. cava was mixture of sulfated rhamnogalactofucan and galactofucan. Fucoidan from C. costata was a sulfated galactofucan. Fucoidan isolated from S. hornery was separated into three fractions: a homofucan sulfate, a homofucan but without sulfate groups, and a sulfated rhamnofucan. The results clearly showed that fucoidans play an inhibitory role in colony formation in human melanoma and colon cancer cells and may be effective antitumor agents.
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“Nevertheless, it appears that the anti-cancer activity of fucoidans is not a function of a single specific structural trait but a combination of many factors such as the amount of sulfate groups, the monosaccharide composition, and the types of linkages of the sugar residues.1,30”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [30]
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Yu, Y., Shen, M., Song, Q., & Xie, J. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.12.009 · Cited by 1,447
Marine Polysaccharides from Algae with Potential Biomedical Applications
Raposo, M. F. D. J., Morais, A. M. M. B., & Morais, R. M. S. C. (2015) · Marine Drugs · doi:10.3390/md13052967 · Cited by 712
Anticancer polysaccharides from natural resources: A review of recent research
Zong, A., Cao, H., & Wang, F. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.07.026 · Cited by 667
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Metadata
- Authors
- Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T.
- Affiliations
- Pacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences (RU)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Ermakova, Svetlana
- Venue
- Applied Biochemistry and Biotechnology
- Published
- 2011-02-08
- Volume
- 164
- Issue
- 6
- Pages
- 841-850
- ISSN
- 0273-2289 (ISSN-L)
- 1559-0291
- OpenAlex
- W2055508057
- Cited by
- 229
- References
- 18
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 21 · 2023: 19 · 2022: 15 · 2021: 24 · 2020: 23 · 2019: 16 · 2018: 17 · 2017: 13 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 14 · 2012: 10
- FWCI
- 18.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Biochemistry and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, brown algae, Costaria costata, anticancer activity, melanoma, colon cancer, colony formation inhibition, seaweed polysaccharides
- MeSH terms
- Phaeophyceae, Antineoplastic Agents, Humans, Neoplasms, Polysaccharides, Seaweed, Cell Line, Tumor, Cell Proliferation
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