The fucoidans from brown algae of Far-Eastern seas: Anti-tumor activity and structure-function relationship
Abstract
The sulfated polysaccharides from brown algae - the fucoidans - are known to be a topic of numerous studies, due to their beneficial biological activities including anti-tumour activity. In this study the effect of fucoidans isolated from brown algae Saccharina cichorioides, Fucus evanescens, and Undaria pinnatifida on the proliferation, neoplastic transformation, and colony formation of mouse epidermal cells JB6 Cl41, human colon cancer DLD-1, breast cancer T-47D, and melanoma RPMI-7951 cell lines was investigated. The algal fucoidans specifically and markedly suppressed the proliferation of human cancer cells with less cytotoxic effects against normal mouse epidermal cells. The highly sulfated (1→3)-α-l-fucan from S. cichorioides was found to be vitally important in the inhibition of EGF-induced neoplastic transformation of JB6 Cl41 cells. In colony formation assay the fucoidans from different species of brown algae showed selective anti-tumour activity against different types of cancer, which depended on unique structures of the investigated polysaccharides. These results provide evidence for further exploring the use of the fucoidans from S. cichorioides, F. evanescens, and U. pinnatifida as novel chemotherapeutics against different types of cancer.
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Fucoidans have attracted attention as practically nontoxic natural products with antitumor, immunomodulatory, and other useful properties.
“This research is necessary for the solution of problems of standardization of preparations on the basis of fucoidans, which have attracted attention as practically nontoxic natural products [25,26,27] with antitumor, immunomodulatory, and other useful properties [24,28,29,30].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [29]
Inhibition of cell transformation provided evidence of anti-tumorigenic potential of fucoidans from A. nodosum, S. japonica, U. pinnatifida, Alaria sp., and F. evanescens.
“The inhibition of cell transformation provided evidence on the anti-tumorigenic potential of fucoidans from A. nodosum [57], S. japonica, U. pinnatifida, Alaria sp., and F. evanescens [29,45,58].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [29]
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Self-citation
- Authors
- Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Venue
- Food Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 141
- Issue
- 2
- Pages
- 1211-1217
- ISSN
- 0308-8146 (ISSN-L)
- OpenAlex
- W2066719859
- Cited by
- 117
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 14 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 18 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 5 · 2014: 8 · 2013: 1
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Physical Sciences › Earth and Planetary Sciences › Oceanography › Marine and coastal plant biology
- Keywords
- fucoidan, sulfated polysaccharides, brown algae, anticancer activity, structure-function relationship, Fucus evanescens, Undaria pinnatifida, colon cancer, breast cancer, melanoma, cell proliferation inhibition, colony formation, chemotherapeutics, Far Eastern seas
- MeSH terms
- Phaeophyceae, Animals, Antineoplastic Agents, Humans, Neoplasms, Polysaccharides, Structure-Activity Relationship, Cell Proliferation, Mice
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