Fucoidan: Structure and bioactivity
Open accessAbstract
Fucoidan refers to a type of polysaccharide which contains substantial percentages of L-fucose and sulfate ester groups, mainly derived from brown seaweed. For the past decade fucoidan has been extensively studied due to its numerous interesting biological activities. Recently the search for new drugs has raised interest in fucoidans. In the past few years, several fucoidans' structures have been solved, and many aspects of their biological activity have been elucidated. This review summarizes the research progress on the structure and bioactivity of fucoidan and the relationships between structure and bioactivity.
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Li et al. [26] described the structure of the fucoidan from F. vesiculosus, which is composed of α-(1,3)-linked fucose with sulfate groups substituted at the C-4 position on some of the fucose residues.
“Li et al. [26] described the structure of the fucoidan from F. vesiculosus, which is composed of α-(1,3)-linked fucose with sulfate groups substituted at the C-4 position on some of the fucose residues.”
From Antimicrobial and Antibiofilm Activities of Sulfated Polysaccharides from Marine Algae against Dental Plaque Bacteria (2018) · cites this paper as [26]
Fucoidans from different algal species differ in positions and level of sulfation, molecular mass, and sometimes in structures of main carbohydrate chains.
“As a rule, fucoidans from different algal species differ from each other and vary not only in positions and level of sulfation and molecular mass, but sometimes in the structures of the main carbohydrate chains [12,13].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [13]
The anticancer properties of fucoidans have been established many times by in vitro and in vivo experiments.
“The anticancer properties of fucoidans have been established many times by in vitro and in vivo experiments [9,12,13,31,32,33].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [13]
Distinct fucoidan structures can be isolated by different extraction conditions.
“Distinct structures can be isolated by different extraction conditions.2,5”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [2]
The bioactivities of fucoidans are related to their structural make-up, monosaccharide composition, sulfate content, position of sulfate ester groups, and molecular weight.
“The bioactivities of fucoidans are related to their structural make-up, monosaccharide composition, sulfate content, position of sulfate ester groups, and molecular weight.2”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [2]
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Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., et al. (2007) · Glycobiology · doi:10.1093/glycob/cwm014 · Cited by 1,026 · see citing works
Antioxidant activity of sulfated polysaccharide fractions extracted from Laminaria japonica
Wang, J., Zhang, Q., Zhang, Z., & Li, Z. (2007) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.003 · Cited by 745 · see citing works
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531 · see citing works
Antioxidant activities of sulfated polysaccharides from brown and red seaweeds
de Souza, M. C. R., Marques, C. T., Dore, C. M. P. G., da Silva, F. R. F., Rocha, H. A. O., & Leite, E. L. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9121-z · Cited by 525 · see citing works
Ponce, N. M. A., Pujol, C. A., Damonte, E. B., Flores, M. L., & Stortz, C. A. (2003) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00403-2 · Cited by 484 · see citing works
Structure of a fucoidan from the brown seaweed Fucus evanescens C.Ag.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00053-8 · Cited by 412 · see citing works
Structure and Anticoagulant Activity of Sulfated Fucans
Pereira, M. S., Mulloy, B., & Mourão, P. A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7656 · Cited by 377 · see citing works
Structure and Anticoagulant Activity of Sulfated Galactans
Farias, W. R. L., Valente, A. P., Pereira, M. S., & Mourão, P. A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002422200 · Cited by 369 · see citing works
Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity
Chevolot, L., Foucault, A., Chaubet, F., Kervarec, N., Sinquin, C., Fisher, A.-M., & Boisson-Vidal, C. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00127-5 · Cited by 330 · see citing works
A study of fucoidan from the brown seaweed Chorda filum
Chizhov, A. O., Dell, A., Morris, H. R., Haslam, S. M., McDowell, R. A., Shashkov, A. S., Nifant’ev, N. E., Khatuntseva, E. A., & Usov, A. I. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00148-2 · Cited by 326 · see citing works
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
Duarte, M. E. R., Cardoso, M. A., Noseda, M. D., & Cerezo, A. S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00149-5 · Cited by 319 · see citing works
Aisa, Y., Miyakawa, Y., Nakazato, T., Shibata, H., Saito, K., Ikeda, Y., & Kizaki, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20182 · Cited by 307 · see citing works
A disaccharide repeat unit is the major structure in fucoidans from two species of brown algae
Chevolot, L., Mulloy, B., Ratiskol, J., Foucault, A. P., & Colliec‐Jouault, S. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(00)00314-1 · Cited by 304 · see citing works
Novel Antiviral Fucoidan from Sporophyll of Undaria pinnatifida (Mekabu)
Lee, J., Hayashi, K., HASHIMOTO, M., Nakano, T., & Hayashi, T. (2004) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.52.1091 · Cited by 277 · see citing works
Structure of a fucoidan from the brown seaweed Fucus serratus L.
Bilan, M. I., Grachev, A. A., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2006) · Carbohydrate Research · doi:10.1016/j.carres.2005.11.009 · Cited by 263 · see citing works
Relationship between sulfate groups and biological activities of fucans
Haroun-Bouhedja, F., Ellouali, M., Sinquin, C., & Boisson-Vidal, C. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00338-8 · Cited by 256 · see citing works
A highly regular fraction of a fucoidan from the brown seaweed Fucus distichus L.
Bilan, M. I., Grachev, A. A., Ustuzhanina, N. E., Shashkov, A. S., Nifantiev, N. E., & Usov, A. I. (2004) · Carbohydrate Research · doi:10.1016/j.carres.2003.10.028 · Cited by 255 · see citing works
Hayashi, K., Nakano, T., Hashimoto, M., Kanekiyo, K., & Hayashi, T. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2007.10.017 · Cited by 247 · see citing works
Alekseyenko, T. V., Zhanayeva, S. Y., Venediktova, A. A., Zvyagintseva, T. N., Kuznetsova, T. A., Besednova, N. N., & Korolenko, T. A. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0226-4 · Cited by 244 · see citing works
Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum
Adhikari, U., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.05.024 · Cited by 213 · see citing works
Occurrence of a unique fucose-branched chondroitin sulfate in the body wall of a sea cucumber.
Vieira, R. P., & Mourão, P. A. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81341-8 · Cited by 205 · see citing works
Mandal, P., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2007) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020701800305 · Cited by 205 · see citing works
Sezer, A. D., Hatıpoğlu, F., Cevher, E., et al. (2007) · AAPS PharmSciTech · doi:10.1208/pt0802039 · Cited by 204 · see citing works
Chandía, N. P., & Matsuhiro, B. (2008) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2007.10.023 · Cited by 201 · see citing works
A new procedure for the separation of water-soluble polysaccharides from brown seaweeds
Zvyagintseva, T. N., Shevchenko, N. M., Popivnich, I. B., Isakov, V. V., Scobun, A. S., Sundukova, E. V., & Elyakova, L. A. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00206-2 · Cited by 198 · see citing works
Use of Sulfated Fucans as Anticoagulant and Antithrombotic Agents: Future Perspectives
Mourao, P. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452730 · Cited by 195 · see citing works
Treanor, R. E., Meade, J. B., Whinna, H. C., & Church, F. C. (2021) · PubMed · doi:10.17615/gvp1-c649 · Cited by 182 · see citing works
Mulloy, B., Ribeiro, A.-C., Alves, A.-P., Vieira, R. P., & Mourão, P. A. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31763-5 · Cited by 175 · see citing works
Pereira, M. S., Melo, F. R., & Mourao, P. A. S. (2002) · Glycobiology · doi:10.1093/glycob/cwf077 · Cited by 175 · see citing works
Hemmingson, J. A., Falshaw, R., Furneaux, R. H., & Thompson, K. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9096-9 · Cited by 171 · see citing works
Nardella, A., Chaubet, F., Boisson-Vidal, C., Blondin, C., Durand, P., & Jozefonvicz, J. (1996) · Carbohydrate Research · doi:10.1016/0008-6215(96)00110-3 · Cited by 166 · see citing works
Li, B., Wei, X.-J., Sun, J.-L., & Xu, S.-Y. (2006) · Carbohydrate Research · doi:10.1016/j.carres.2006.03.035 · Cited by 161 · see citing works
Self-citationAntithrombin-mediated Anticoagulant Activity of Sulfated Polysaccharides
Melo, F. R., Pereira, M. S., Foguel, D., & Mourão, P. A. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308688200 · Cited by 158 · see citing works
Immunomodulating Activity of Arabinogalactan and Fucoidan In Vitro
Choi, E., Kim, A.-J., Kim, Y.-O., & Hwang, J. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.446 · Cited by 158 · see citing works
Nishino, T., Nishioka, C., Ura, H., & Nagumo, T. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90980-7 · Cited by 157 · see citing works
Silva, T. M. A., Alves, L. G., Queiroz, K. C. S., Santos, M. G. L., Marques, C. T., Chavante, S. F., Rocha, H. A. O., & Leite, E. L. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000400005 · Cited by 157 · see citing works
Rocha, H. A. O., Moraes, F. A., Trindade, E. D. S., Franco, C. R. C., Torquato, R. J. S., Veiga, S. S., Valente, A. P., Mourão, P. A. S., Leite, E. L., Nader, H. B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501124200 · Cited by 156 · see citing works
A fucoidan fraction from Ascophyllum nodosum
Marais, M. F., & Joseleau, J. P. (2001) · Carbohydrate Research · doi:10.1016/s0008-6215(01)00257-9 · Cited by 155 · see citing works
Maruyama, H., Tamauchi, H., Iizuka, M., & Nakano, T. (2006) · Planta Medica · doi:10.1055/s-2006-951703 · Cited by 151 · see citing works
Luyt, C., Meddahi‐Pellé, A., Ho‐Tin‐Noé, B., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046144 · Cited by 139 · see citing works
Nishino, T., Yokoyama, G., Dobashi, K., Fujihara, M., & Nagumo, T. (1989) · Carbohydrate Research · doi:10.1016/0008-6215(89)84010-8 · Cited by 132 · see citing works
Haneji, K., Matsuda, T., Tomita, M., Kawakami, H., Ohshiro, K., Uchihara, J., Masuda, M., Takasu, N., Tanaka, Y., Ohta, T., et al. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5202_9 · Cited by 132 · see citing works
Nakamura, S., Nambu, M., Ishizuka, T., et al. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31563 · Cited by 131 · see citing works
Pomin, V. H., Pereira, M. S., Valente, A.-P., Tollefsen, D. M., Pavão, M. S. G., & Mourão, P. A. S. (2005) · Glycobiology · doi:10.1093/glycob/cwi021 · Cited by 129 · see citing works
Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells
Kim, M.-H., & Joo, H.-G. (2008) · Immunology Letters · doi:10.1016/j.imlet.2007.10.016 · Cited by 123 · see citing works
Anticoagulant and antithrombin activities of oversulfated fucans
Nishino, T., & Nagumo, T. (1992) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90581-0 · Cited by 122 · see citing works
A sulfated α-l-fucan from sea cucumber
Ribeiro, A.-C., Vieira, R. P., Mourão, P. A. S., & Mulloy, B. (1994) · Carbohydrate Research · doi:10.1016/s0008-6215(00)90981-9 · Cited by 122 · see citing works
Suppression of Th2 Immune Responses by Mekabu Fucoidan from Undaria pinnatifida Sporophylls
Maruyama, H., Tamauchi, H., HASHIMOTO, M., & Nakano, T. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000086422 · Cited by 118 · see citing works
Nishino, T., Nagumo, T., Kiyohara, H., & Yamada, H. (1991) · Carbohydrate Research · doi:10.1016/0008-6215(91)84147-7 · Cited by 116 · see citing works
Heterofucans from Dictyota menstrualis have anticoagulant activity
Albuquerque, I. R. L., Queiroz, K. C. S., Alves, L. G., dos Santos, E. A., Leite, E. L., & Rocha, H. A. O. (2004) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2004000200002 · Cited by 116 · see citing works
Ultrastructure of acidic polysaccharides from the cell walls of brown algae
de Andrade, L. R., Salgado, L. T., Farina, M., Pereira, M. S., Mourão, P. A. S., & Filho, G. M. A. (2003) · Journal of Structural Biology · doi:10.1016/j.jsb.2003.11.011 · Cited by 115 · see citing works
Effect of oversulfation on the chemical and biological properties of fucoidan
Qiu, X., Amarasekara, A. S., & DOCTOR, V. M. (2005) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2005.08.064 · Cited by 102 · see citing works
Bifunctional effects of fucoidan on the expression of inducible nitric oxide synthase
Yang, J. W., Yoon, S. Y., Oh, S. J., Kim, S. K., & Kang, K. W. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.135 · Cited by 101 · see citing works
O’Leary, R., Rerek, M. E., & Wood, E. J. (2004) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.27.266 · Cited by 95 · see citing works
Deux, J., Meddahi‐Pellé, A., Blanche, A. F. L., Feldman, L. J., Colliec‐Jouault, S., Brée, F., Boudghene, F. P., Michel, J., & Letourneur, D. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000032034.91020.0a · Cited by 95 · see citing works
Tissot, B., Salpin, J., Martinez, M., Gaigeot, M., & Daniel, R. (2006) · Carbohydrate Research · doi:10.1016/j.carres.2005.11.029 · Cited by 88 · see citing works
Inhibition of complement activation by natural sulfated polysaccharides (fucans) from brown seaweed
Blondin, C., Fischer, E., Boisson‐Vidal, C., Kazatchkine, M. D., & Jozefonvicz, J. (1994) · Molecular Immunology · doi:10.1016/0161-5890(94)90121-x · Cited by 87 · see citing works
Daniel, R., Berteau, O., Jozefonvicz, J., & Goasdoué, N. (1999) · Carbohydrate Research · doi:10.1016/s0008-6215(99)00223-2 · Cited by 84 · see citing works
Berteau, O., McCort‐Tranchepain, I., Goasdoué, N., Tissot, B., & Daniel, R. (2002) · Glycobiology · doi:10.1093/glycob/12.4.273 · Cited by 84 · see citing works
167. Fucoidin. Part II. The hydrolysis of a methylated fucoidin prepared from Fucus vesiculosus
Conchie, J., & Percival, E. G. V. (1950) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9500000827 · Cited by 83 · see citing works
Veena, C. K., Josephine, A., Preetha, S. P., & Varalakshmi, P. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.12.040 · Cited by 82 · see citing works
Zoysa, M. D., Nikapitiya, C., Jeon, Y., Jee, Y., & Lee, J. (2007) · Journal of Applied Phycology · doi:10.1007/s10811-007-9182-7 · Cited by 81 · see citing works
Fucoidan partly prevents CCl4-induced liver fibrosis
Hayashi, S., Itoh, A., Isoda, K., Kondoh, M., Kawase, M., & Yagi, K. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.015 · Cited by 81 · see citing works
Anticoagulant Activity of Fucoidan from Brown Algae Fucus evanescens of the Okhotsk Sea
Kuznetsova, T. A., Besednova, N. N., An, M., Momot, A. P., Шевченко, Н. М., & Николаевна, З. Т. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/b:bebm.0000017096.72246.1f · Cited by 77 · see citing works
A 2-sulfated, 3-linked α-l-galactan is an anticoagulant polysaccharide
Pereira, M. S., Vilela-Silva, A.-C. E. S., Valente, A.-P., & Mourão, P. A. S. (2002) · Carbohydrate Research · doi:10.1016/s0008-6215(02)00215-x · Cited by 77 · see citing works
Yoon, S.-J., Pyun, Y., Hwang, J., & Mourão, P. A. S. (2007) · Carbohydrate Research · doi:10.1016/j.carres.2007.06.019 · Cited by 75 · see citing works
Manufacture of algal chemicals. IV—Laboratory-scale isolation of fucoidin from brown marine algae
Black, W. A. P., Dewar, E. T., & Woodward, F. N. (1952) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740030305 · Cited by 75 · see citing works
Daniel, R., Chevolot, L., Carrascal, M., Tissot, B., Mourão, P. A. S., & Abián, J. (2007) · Carbohydrate Research · doi:10.1016/j.carres.2007.01.009 · Cited by 75 · see citing works
Dobashi, K., Nishino, T., Fujihara, M., & Nagumo, T. (1989) · Carbohydrate Research · doi:10.1016/0008-6215(89)85032-3 · Cited by 73 · see citing works
Properties of fucoidan from Cladosiphon okamuranus tokida in gastric mucosal protection
Shibata, H., Kimura‐Takagi, I., Nagaoka, M., Hashimoto, S., Aiyama, R., Iha, M., Ueyama, S., & Yokokura, T. (2000) · BioFactors · doi:10.1002/biof.5520110402 · Cited by 67 · see citing works
Glucuronoxylofucan, a cell-wall component of ascophyllum nodosum. Part I
Percival, E. E. (1968) · Carbohydrate Research · doi:10.1016/s0008-6215(00)81200-8 · Cited by 65 · see citing works
Usui, T., Asari, K., & Mizuno, T. (1980) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.44.1965 · Cited by 63 · see citing works
Inhibitory effect of fucoidan on the adhesion of adenocarcinoma cells to fibronectin.
Liu, J. M., Bignon, J. S., Haroun-Bouhedja, F., Bittoun, P., Vassy, J., Fermandjian, S., Wdzieczak-Bakala, J., & Boisson‐Vidal, C. (2005) · PubMed · Cited by 61 · see citing works
Renal peroxidative changes mediated by oxalate: The protective role of fucoidan
Veena, C. K., Josephine, A., Preetha, S. P., Varalakshmi, P., & Sundarapandiyan, R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.014 · Cited by 60 · see citing works
Shimizu, J., Wada-Funada, U., Mano, H., et al. (2005) · Eisei kagaku · doi:10.1248/jhs.51.394 · Cited by 60 · see citing works
Logeart‐Avramoglou, D., Prigent-Richard, S., Jozefonvicz, J., et al. (1997) · PubMed · Cited by 56 · see citing works
Mitochondrial dysfunction in an animal model of hyperoxaluria: A prophylactic approach with fucoidan
Veena, C. K., Josephine, A., Preetha, S. P., Ganesh, R. N., & Varalakshmi, P. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.044 · Cited by 52 · see citing works
Effects of Fucoidan from Mozuku on Human Stomach Cell Lines
KAWAMOTO, H., Miki, Y., Kimura, T., Tanaka, K., Nakagawa, T., Kawamukai, M., & Matsuda, H. (2006) · Food Science and Technology Research · doi:10.3136/fstr.12.218 · Cited by 52 · see citing works
Carbohydrates of the brown seaweeds himanthalia lorea and bifurcaria bifurcata
Mian, A. J., & Percival, E. (1973) · Carbohydrate Research · doi:10.1016/s0008-6215(00)85031-4 · Cited by 50 · see citing works
Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice
Saito, A., Yoneda, M., Yokohama, S., OKADA, M., Haneda, M., & Nakamura, K. (2006) · Hepatology Research · doi:10.1016/j.hepres.2006.03.012 · Cited by 49 · see citing works
A comparative study of specificity of fucoidanases from marine microorganisms and invertebrates
Игоревич, К. М., Chizhov, A. O., Grachev, A. A., Alekseeva, S. A., Bakunina, I. Y., Nedashkovskaya, O. I., Сова, В. В., & Николаевна, З. Т. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9042-x · Cited by 49 · see citing works
Usui, T., Asari, K., & Mizuno, T. (1980) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1980.10864249 · Cited by 48 · see citing works
Degradative Studies on Fucoidin<sup>1</sup>
O'Neill, A. N. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01649a018 · Cited by 43 · see citing works
Николаевна, З. Т., Шевченко, Н. М., Nazarova, I. V., Scobun, A. S., Lukyanov, P. A., & Elyakova, L. A. (2000) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(00)00114-6 · Cited by 41 · see citing works
Лапшина, Л. А., Реунов, А. В., Nagorskaya, V. P., Николаевна, З. Т., & Шевченко, Н. М. (2006) · Russian Journal of Plant Physiology · doi:10.1134/s1021443706020154 · Cited by 40 · see citing works
Fucoidan inhibits the development of proteinuria in active Heymann nephritis
Zhang, Q., Li, N., Zhao, T., Qi, H., Xu, Z., & Li, Z. (2005) · Phytotherapy Research · doi:10.1002/ptr.1623 · Cited by 39 · see citing works
A comparative study of specificity of fucoidanases from marine microorganisms and invertebrates
Игоревич, К. М., Chizhov, A. O., Grachev, A. A., Alekseeva, S. A., Bakunina, I. Y., Nedashkovskaya, O. I., Сова, В. В., & Николаевна, З. Т. (2008) · Springer eBooks · doi:10.1007/978-1-4020-5670-3_18 · Cited by 37 · see citing works
Structure of a unique sulfated α-l-galactofucan from the tunicate Clavelina
Pavão, M. S. G., Mourão, P. A. S., & Mulloy, B. (1990) · Carbohydrate Research · doi:10.1016/0008-6215(90)80095-k · Cited by 36 · see citing works
Antiviral polysaccharides isolated from Hong Kong brown seaweed Hydroclathrus clathratus
Wang, H., Ooi, E. V., & Ang, P. O. (2007) · Science in China Series C Life Sciences · doi:10.1007/s11427-007-0086-1 · Cited by 36 · see citing works
Tissot, B. (2003) · Glycobiology · doi:10.1093/glycob/cwg126 · Cited by 34 · see citing works
Prophylactic Effect of Dietary Seaweed Fucoidan against Enteral Prion Infection
Doh‐ura, K., Kuge, T., Uomoto, M., Nishizawa, K., Kawasaki, Y., & Iha, M. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00917-06 · Cited by 34 · see citing works
Veena, C. K., Josephine, A., Preetha, S., & Varalakshmi, P. (2007) · Human & Experimental Toxicology · doi:10.1177/0960327107087792 · Cited by 32 · see citing works
Low molecular weight fucan prevents transplant coronaropathy in rat cardiac allograft model
Alkhatib, B., Fréguin-Bouilland, C., Lallemand, F., Henry, J., Litzler, P., Henry, J., Richard, V. J., Thuillez, C., & Plissonnier, D. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.03.003 · Cited by 31 · see citing works
Low Molecular Weight Fucoidan Prevents Neointimal Hyperplasia After Aortic Allografting
Fréguin-Bouilland, C., Alkhatib, B., David, N., et al. (2007) · Transplantation · doi:10.1097/01.tp.0000261109.97928.9c · Cited by 28 · see citing works
NISHINO, T., & NAGUMO, T. (1987) · Journal of the agricultural chemical society of Japan · doi:10.1271/nogeikagaku1924.61.361 · Cited by 26 · see citing works
The study of antioxidant activities of fucoidan from {\sl Laminaria japonica}
Zhao, X., Xue, C., Yuepiao, C., et al. (2005) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Isolation of l-fucose 4-sulfate from fucoidan
Anno, K., Seno, N., & Ota, M. (1970) · Carbohydrate Research · doi:10.1016/s0008-6215(00)84905-8 · Cited by 25 · see citing works
Grachev, A. A., Gerbst, A. G., Ustyuzhanina, N. E., et al. (2006) · Journal of Carbohydrate Chemistry · doi:10.1080/07328300600770493 · Cited by 24 · see citing works
The study of antioxidant activities of fucoidan from Laminaria japonica
ZhaoXue, XUEChanghu, CaiYuepiao, et al. (2005) · 高技术通讯:英文版 · Cited by 22 · see citing works
Sulphated heteropolysaccharides from Padina pavonia
Hussein, M. M.-D., Abdel-Aziz, A., & Salem, H. M. (1980) · Phytochemistry · doi:10.1016/s0031-9422(00)82208-6 · Cited by 22 · see citing works
Some structural features of a new sulphated heteropolysaccharide from Padina pavonia
Hussein, M. M.-D., Abdel-Aziz, A., & Salem, H. M. (1980) · Phytochemistry · doi:10.1016/s0031-9422(00)82209-8 · Cited by 22 · see citing works
KAWANO, N., Egashira, Y., & Sanada, H. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.446 · Cited by 22 · see citing works
Induction of hepatocyte growth factor by fucoidan and fucoidan-derived oligosaccharides
Fukuta, K., & Nakamura, T. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.4.0013 · Cited by 21 · see citing works
Christopher, D., Adams, W. P., Lee, D. S., et al. (2007) · AAPS PharmSciTech · doi:10.1208/pt0801005 · Cited by 20 · see citing works
Isolation and Purification of Fucoidin from Brown SeaweedPelvetia wrightii
Anno, K., Terahata, H., Hayashi, Y., et al. (1966) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1966.10858624 · Cited by 18 · see citing works
A Comparative Study of the Specificity of Fucoidanases of Marine Microorganisms and Invertebrates
Кусайкин, М. И., Chizhov, A. O., Alekseeva, S. A., Bakunina, I. Y., Nedashkovskaya, O. I., Сова, В. В., Николаевна, З. Т., & Elyakov, G. B. (2004) · Doklady Biochemistry and Biophysics · doi:10.1023/b:dobi.0000033525.32259.15 · Cited by 18 · see citing works
Veena, C. K., Josephine, A., Preetha, S. P., & Varalakshmi, P. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.3.0012 · Cited by 15 · see citing works
EFFECTS OF FUCOIDAN EXTRACTED FROM BROWN SEA WEED ON LIPID PEROXIDATION IN MICE
Xiao-bao, S. (2002) · Acta Nutrimenta Sinica · Cited by 15 · see citing works
Study on anti-virus effect of fucoidan in vitro
Li, F., Tian, T., Shi, Y., et al. (1995) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Xue, C. (2006) · Acta Oceanologica Sinica · Cited by 11 · see citing works
Fu, X., Xue, C., Yan, N., et al. (2004) · Europe PMC (PubMed Central) · Cited by 10 · see citing works
Effect of fucoidan on splenic lymphocyte apoptosis induced by radiation
Xiaolan, H. (2003) · Cited by 10 · see citing works
Isolation and Purification of Fucoidin from Brown Seaweed Pelvetia wrightii
Anno, K., Terahata, H., Hayashi, Y., & Seno, N. (1966) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.30.495 · Cited by 10 · see citing works
KAWANO, N., Egashira, Y., & Sanada, H. (2007) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.53.315 · Cited by 9 · see citing works
Effect of fucoidan on splenic lymphocyte apoptosis induced by radiation
吴晓旻, 杨明亮, 黄晓兰, et al. (2003) · 中华放射医学与防护杂志 · doi:10.3760/cma.j.issn.0254-5098.2003.06.013 · Cited by 9 · see citing works
Li, Laihao, Xue, et al. (2006) · 海洋学报:英文版 · Cited by 8 · see citing works
Effect of Fucoidan on Renal Interstitial Fibrosis in Adenine-Induced Chronic Renal Failure in Rats
Liu, Y.-P. (2008) · Chinese Journal of Integrated Traditional and Western Nephrology · Cited by 6 · see citing works
Effect of laminaria japonica polysaccharides on radioprotection and splenic lymphocyte apoptosis
Wu, X., Mingliang, Y., Xiaolan, W., et al. (2004) · Wuhan Daxue xuebao. Yixue ban · Cited by 6 · see citing works
Pharmacological activity of fucoidan from Laminaria japonica
Shi, Z., Yazhen, G., & wang (2000) · Cited by 5 · see citing works
Determination of the Position of Sulphate Group in Sulphated Polysaccharides
Li, B., Xiao-hong, G., & Shi-ying, X. (2004) · Journal of Analytical Science · Cited by 4 · see citing works
Self-citationIsolation,purification and the anticoagulant activities of fucoidan
Wang, Y. (2002) · Journal Fo Molecular Science · Cited by 3 · see citing works
Shi-ying, X. (2007) · Tianran chanwu yanjiu yu kaifa · Cited by 2 · see citing works
Study on Anticoagulant Activities in vitro of Fucoidan and Fucoidan / Collagen Blends
Zong-ling, C. (2003) · Journal of Functional Polymers · Cited by 1 · see citing works
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Bioactive compounds in seaweed: functional food applications and legislation
Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works
Algae as nutritional and functional food sources: revisiting our understanding.
Wells, M. L., Potin, P., Craigie, J. S., Raven, J. A., Merchant, S. S., Helliwell, K. E., Smith, A. G., Camire, M. E., & Brawley, S. H. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0974-5 · Cited by 1,562 · see citing works
Chemical structures and bioactivities of sulfated polysaccharides from marine algae
Jiao, G., Yu, G., Zhang, J., & Ewart, H. S. (2011) · Marine Drugs · doi:10.3390/md9020196 · Cited by 1,054 · see citing works
Wijesekara, I., Pangestuti, R., & Kim, S.-K. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.10.062 · Cited by 992 · see citing works
Ale, M. T., Mikkelsen, J. D., & Meyer, A. S. (2011) · Marine Drugs · doi:10.3390/md9102106 · Cited by 779 · see citing works
Biological activities of sulfated polysaccharides from tropical seaweeds
Costa, L. S., Fidelis, G. P., Cordeiro, S. L., Oliveira, R. M., Sabry, D. A., Câmara, R. B. G., Nobre, L. T. D. B., Costa, M. S. S. P., Almeida-Lima, J., Farias, E. H. C., et al. (2010) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2009.03.005 · Cited by 659 · see citing works
Potentials of macroalgae as feedstocks for biorefinery
Jung, K. A., Lim, S.-R., Kim, Y., & Park, J. M. (2013) · Bioresource Technology · doi:10.1016/j.biortech.2012.10.025 · Cited by 487 · see citing works
Synytsya, A., Kim, W.-J., Kim, S.-M., Pohl, R., Synytsya, A., Kvasnička, F., Čopíková, J., & Il Park, Y. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.01.052 · Cited by 461 · see citing works
Wijesinghe, W. A. J. P., & Jeon, Y.-J. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.12.029 · Cited by 449 · see citing works
Risks and benefits of consuming edible seaweeds
Cherry, P., O’Hara, C., Magee, P. J., McSorley, E. M., & Allsopp, P. J. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy066 · Cited by 440 · see citing works
Prebiotics from marine macroalgae for human and animal health applications
O’Sullivan, L., Murphy, B., McLoughlin, P., Duggan, P., Lawlor, P. G., Hughes, H., & Gardiner, G. E. (2010) · Marine Drugs · doi:10.3390/md8072038 · Cited by 421 · see citing works
Ale, M. T., & Meyer, A. S. (2013) · RSC Adv. · doi:10.1039/c3ra23373a · Cited by 381 · see citing works
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Tanna, B., & Mishra, A. (2019) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12441 · Cited by 329 · see citing works
Macroalgae as a sustainable aquafeed ingredient
Wan, A. H. L., Davies, S. J., Soler‐Vila, A., Fitzgerald, R., & Johnson, M. P. (2019) · Reviews in Aquaculture · doi:10.1111/raq.12241 · Cited by 292 · see citing works
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Kim, E. J., Park, S. Y., Lee, J.-Y., & Park, J. H. Y. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-96 · Cited by 275 · see citing works
Vishchuk, O. S., Ermakova, S. P., & Zvyagintseva, T. N. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.09.034 · Cited by 267 · see citing works
Shang, Q., Song, G., Zhang, M., Shi, J., Xu, C., Hao, J., Li, G., & Yu, G. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.11.002 · Cited by 258 · see citing works
Ermakova, S., Sokolova, R., Kim, S.-M., Um, B.-H., Isakov, V., & Zvyagintseva, T. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9178-2 · Cited by 229 · see citing works
Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo
Xue, M., Ge, Y., Zhang, J., Wang, Q., Hou, L., Liu, Y., Sun, L., & Li, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043483 · Cited by 192 · see citing works
Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
Fedorov, S., Ermakova, S., Zvyagintseva, T., & Stonik, V. (2013) · Marine Drugs · doi:10.3390/md11124876 · Cited by 189 · see citing works
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Jun, J.-Y., Jung, M.-J., Jeong, I.-H., Yamazaki, K., Kawai, Y., & Kim, B.-M. (2018) · Marine Drugs · doi:10.3390/md16090301 · Cited by 160 · see citing works
Cong, Q., Chen, H., Liao, W., Xiao, F., Wang, P., Qin, Y., Dong, Q., & Ding, K. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.09.087 · Cited by 156 · see citing works
Fernando, I. P. S., Sanjeewa, K. K. A., Samarakoon, K. W., Lee, W. W., Kim, H.-S., Kang, N., Ranasinghe, P., Lee, H.-S., & Jeon, Y.-J. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.07.031 · Cited by 157 · see citing works
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Tsubaki, S., Oono, K., Hiraoka, M., Onda, A., & Mitani, T. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.04.121 · Cited by 150 · see citing works
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Chen, L., Xu, W., Chen, D., Chen, G., Liu, J., Zeng, X., Shao, R., & Zhu, H. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.01.183 · Cited by 140 · see citing works
Sanjeewa, K. K. A., Fernando, I. P. S., Kim, S.-Y., Kim, H.-S., Ahn, G., Jee, Y., & Jeon, Y.-J. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.09.050 · Cited by 116 · see citing works
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Magalhaes, K. D., Costa, L. S., Fidelis, G. P., Oliveira, R. M., Nobre, L. T. D. B., Dantas-Santos, N., Camara, R. B. G., Albuquerque, I. R. L., Cordeiro, S. L., Sabry, D. A., et al. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053352 · Cited by 97 · see citing works
Jayawardena, T. U., Fernando, I. P. S., Lee, W. W., Sanjeewa, K. K. A., Kim, H.-S., Lee, D.-S., & Jeon, Y.-J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.105 · Cited by 95 · see citing works
Wang, Y., Su, W., Zhang, C., Xue, C., Chang, Y., Wu, X., Tang, Q., & Wang, J. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.028 · Cited by 92 · see citing works
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Menshova, R. V., Shevchenko, N. M., Imbs, T. I., Zvyagintseva, T. N., Malyarenko, O. S., Zaporoshets, T. S., Besednova, N. N., & Ermakova, S. P. (2016) · Frontiers in Marine Science · doi:10.3389/fmars.2016.00129 · Cited by 85 · see citing works
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Jang, J.-Y., Moon, S.-Y., & Joo, H.-G. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.03.024 · Cited by 66 · see citing works
Duncan, C., Prashar, A., So, J., Tang, P., Low, D. E., Terebiznik, M., & Guyard, C. (2011) · Infection and Immunity · doi:10.1128/iai.01304-10 · Cited by 63 · see citing works
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Vishchuk, O. S., Tarbeeva, D. V., Ermakova, S. P., & Zvyagintseva, T. N. (2012) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100266 · Cited by 56 · see citing works
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Silva Costa, L., Silva Telles, C. B., Medeiros Oliveira, R., Duarte Barreto Nobre, L. T., Dantas-Santos, N., Barros Gomes Camara, R., Santana Santos Pereira Costa, M., Almeida-Lima, J., Melo-Silveira, R. F., Lopes Albuquerque, I. R., et al. (2011) · Marine Drugs · doi:10.3390/md9040603 · Cited by 51 · see citing works
AlKahtane, A. A., Abushouk, A. I., Mohammed, E. T., ALNasser, M., Alarifi, S., Ali, D., Alessia, M. S., Almeer, R. S., AlBasher, G., Alkahtani, S., et al. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06931-z · Cited by 48 · see citing works
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Lim, S. J., & Wan Aida, W. M. (2017) · Seaweed Polysaccharides · doi:10.1016/b978-0-12-809816-5.00003-7 · Cited by 51 · see citing works
Nagahawatta, D. P., Liyanage, N. M., Jayawardhana, H. H. A. C. K., Lee, H.-G., Jayawardena, T., & Jeon, Y.-J. (2022) · Marine Drugs · doi:10.3390/md20070413 · Cited by 43 · see citing works
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Hahn, T., Zayed, A., Kovacheva, M., Stadtmüller, R., Lang, S., Muffler, K., & Ulber, R. (2016) · Engineering in Life Sciences · doi:10.1002/elsc.201500044 · Cited by 40 · see citing works
Wang, L., Xu, R., Meng, L., Zhang, Q., Qian, Z., Chen, J., & Pan, C. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213960 · Cited by 32 · see citing works
Aparicio, E., Rodríguez-Jasso, R. M., Lara, A., Loredo-Treviño, A., Aguilar, C. N., Kostas, E. T., & Ruiz, H. A. (2020) · Sustainable Seaweed Technologies · doi:10.1016/b978-0-12-817943-7.00015-9 · Cited by 32 · see citing works
Charoensiddhi, S., Conlon, M. A., Methacanon, P., Franco, C. M. M., Su, P., & Zhang, W. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.08.040 · Cited by 30 · see citing works
Kale, V., Freysdottir, J., Paulsen, B. S., Friðjónsson, Ó. H., Óli Hreggviðsson, G., & Omarsdottir, S. (2013) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2013.09.009 · Cited by 29 · see citing works
Activation of NK cells in male cancer survivors by fucoidan extracted from Cladosiphon okamuranus
Nagamine, T., Kadena, K., Tomori, M., Nakajima, K., & Iha, M. (2019) · Molecular and Clinical Oncology · doi:10.3892/mco.2019.1943 · Cited by 27 · see citing works
Applications of Marine Nutraceuticals in Dairy Products
Vidanarachchi, J. K., Kurukulasuriya, M. S., Malshani Samaraweera, A., & Silva, K. F. S. T. (2012) · Advances in food and nutrition research · doi:10.1016/b978-0-12-416003-3.00030-5 · Cited by 24 · see citing works
- Authors
- Li, B., Lu, F., Wei, X., & Zhao, R.
- Affiliations
- Henan Institute of Science and Technology (CN)
- School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, Henan, P.R. China
- Corresponding author
- Li, Bo
- ORCID
- Li, Bo
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2008-08-12
- Volume
- 13
- Issue
- 8
- Pages
- 1671-1695
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6245444
- OpenAlex
- W2102139406
- Cited by
- 1,383
- References
- 124
- Citations by year
- 2026: 78 · 2025: 94 · 2024: 89 · 2023: 98 · 2022: 110 · 2021: 104 · 2020: 129 · 2019: 99 · 2018: 82 · 2017: 78 · 2016: 77 · 2015: 73 · 2014: 79 · 2013: 49 · 2012: 53
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, brown seaweed polysaccharides, L-fucose, sulfate esters, polysaccharide structure, structure-activity relationship, biological activity, drug discovery
- MeSH terms
- Anticoagulants, Blood Coagulation, Humans, Polysaccharides, Molecular Structure
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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