Cited by 78Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionbiodegradable polymer synthesis and properties

Recent advances in lactic acid production by lactic acid bacteria

Tian, Xuejiao, Chen, Hao, Liu, Hao, Chen, Jihong·2021·Applied Biochemistry and Biotechnology

Abstract

Lactic acid can synthesize high value-added chemicals such as poly lactic acid. In order to further minimize the cost of lactic acid production, some effective strategies (e.g., effective mutagenesis and metabolic engineering) have been applied to increase productive capacity of lactic acid bacteria. In addition, low-cost cheap raw materials (e.g., cheap carbon source and cheap nitrogen source) are also used to reduce the cost of lactic acid production. In this review, we summarized the recent developments in lactic acid production, including efficient strain modification technology (high-efficiency mutagenesis means, adaptive laboratory evolution, and metabolic engineering), the use of low-cost cheap raw materials, and also discussed the future prospects of this field, which could promote the development of lactic acid industry.

Integrity signals

Registry

Crossref · 10.1007/s12010-021-03672-z

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128 of 128 references verified0 citation errors · 0 not checkable

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  • The presence of both hexose and pentose sugars in agricultural residues can be effectively utilized by genetically modified microorganisms, enhancing the overall efficiency of lactic acid production.

    “The presence of both hexose and pentose sugars in these residues can be effectively utilized by genetically modified microorganisms, enhancing the overall efficiency of lactic acid production [63,64].”

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Authors
Tian, X., Chen, H., Liu, H., & Chen, J.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Gansu Agricultural University (CN)
Corresponding author
Chen, Jihong
Venue
Applied Biochemistry and Biotechnology
Published
2021-09-14
Volume
193
Issue
12
Pages
4151-4171
ISSN
  • 0273-2289 (ISSN-L)
  • 1559-0291
OpenAlex
W3198928098
Cited by
78
References
129
Citations by year
2026: 15 · 2025: 23 · 2024: 20 · 2023: 11 · 2022: 9
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Applied Biochemistry and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Inner Mongolia Autonomous Region (2019ZD021)
  • National Natural Science Foundation of China (U1932141, U2032210)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
lactic acid production, lactic acid bacteria, polylactic acid, metabolic engineering, mutagenesis, adaptive laboratory evolution, low-cost carbon source, strain improvement, bioprocess cost reduction
MeSH terms
Industrial Microbiology, Lactic Acid, Lactobacillales, Metabolic Engineering

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