Recent advances in lactic acid production by lactic acid bacteria
Abstract
Lactic acid can synthesize high value-added chemicals such as poly lactic acid. In order to further minimize the cost of lactic acid production, some effective strategies (e.g., effective mutagenesis and metabolic engineering) have been applied to increase productive capacity of lactic acid bacteria. In addition, low-cost cheap raw materials (e.g., cheap carbon source and cheap nitrogen source) are also used to reduce the cost of lactic acid production. In this review, we summarized the recent developments in lactic acid production, including efficient strain modification technology (high-efficiency mutagenesis means, adaptive laboratory evolution, and metabolic engineering), the use of low-cost cheap raw materials, and also discussed the future prospects of this field, which could promote the development of lactic acid industry.
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The presence of both hexose and pentose sugars in agricultural residues can be effectively utilized by genetically modified microorganisms, enhancing the overall efficiency of lactic acid production.
“The presence of both hexose and pentose sugars in these residues can be effectively utilized by genetically modified microorganisms, enhancing the overall efficiency of lactic acid production [63,64].”
From Potential Valorization of Banana Production Waste in Developing Countries: Bio-Engineering Aspects (2024) · cites this paper as [64]
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- Authors
- Tian, X., Chen, H., Liu, H., & Chen, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Gansu Agricultural University (CN)
- Corresponding author
- Chen, Jihong
- Venue
- Applied Biochemistry and Biotechnology
- Published
- 2021-09-14
- Volume
- 193
- Issue
- 12
- Pages
- 4151-4171
- ISSN
- 0273-2289 (ISSN-L)
- 1559-0291
- OpenAlex
- W3198928098
- Cited by
- 78
- References
- 129
- Citations by year
- 2026: 15 · 2025: 23 · 2024: 20 · 2023: 11 · 2022: 9
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Applied Biochemistry and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Inner Mongolia Autonomous Region (2019ZD021)
- National Natural Science Foundation of China (U1932141, U2032210)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- lactic acid production, lactic acid bacteria, polylactic acid, metabolic engineering, mutagenesis, adaptive laboratory evolution, low-cost carbon source, strain improvement, bioprocess cost reduction
- MeSH terms
- Industrial Microbiology, Lactic Acid, Lactobacillales, Metabolic Engineering
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