Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Open accessAbstract
Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The paracrine role of MSCs in tissue regeneration is attracting particular attention. We investigate the role of MSC exosomes in skeletal muscle regeneration. MSC exosomes promote myogenesis and angiogenesis in vitro, and muscle regeneration in an in vivo model of muscle injury. Although MSC exosomes had low concentrations of muscle‐repair‐related cytokines, a number of repair‐related miRNAs were identified. This study suggests that the MSC‐derived exosomes promote muscle regeneration by enhancing myogenesis and angiogenesis, which is at least in part mediated by miRNAs such as miR‐494.
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Administration of MSC-derived exosomes is efficacious in promoting skeletal muscle regeneration, cartilage repair, bone fracture healing, and cutaneous wound healing.
“Administration of MSCs derived exosomes has been reported to be efficacious in promoting skeletal muscle regeneration [12], cartilage repair [13], and bone fracture healing [14], and cutaneous wound healing [15].”
From A tailored bioactive 3D porous poly(lactic-acid)-exosome scaffold with osteo-immunomodulatory and osteogenic differentiation properties (2022) · cites this paper as [12]
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- Authors
- Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M.
- Affiliations
- Hiroshima University (JP)
- Hiroshima University Hospital (JP)
- Center for Disease Biology and Integrative Medicine, The University of Tokyo (JP)
- ORCID
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2015-04-08
- Volume
- 589
- Issue
- 11
- Pages
- 1257-1265
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1979493465
- Cited by
- 511
- References
- 30
- Citations by year
- 2026: 23 · 2025: 31 · 2024: 31 · 2023: 48 · 2022: 60 · 2021: 65 · 2020: 76 · 2019: 54 · 2018: 48 · 2017: 44 · 2016: 25 · 2015: 5
- FWCI
- 17.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MEXT/JSPS KAKENHI (25253089, 24689057)
- Mochida Memorial Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- mesenchymal stem cells, exosomes, skeletal muscle regeneration, muscle damage, myogenesis, angiogenesis, microRNA, miR-494, paracrine signaling, cytokines
- MeSH terms
- Animals, Cell Line, Humans, Regeneration, Muscle, Skeletal, Muscle Development, Myoblasts, Skeletal, MicroRNAs, Mice, Exosomes, Mesenchymal Stem Cells
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