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Identifying Serum Metabolites and Gut Bacterial Species Associated with Nephrotoxicity Caused by Arsenic and Fluoride Exposure

Tian, Xiaolin, Yan, Xiaoyan, Chen, Xushen, Liu, Penghui, Sun, Zilong, Niu, Ruiyan·2023·Biological Trace Element Research
DOI 10.1007/s12011-023-03568-5
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Abstract

Co-contamination of arsenic (As) and fluoride (F) is widely distributed in groundwater, which are known risk factors for the nephrotoxicity. Emerging evidence has linked environmentally associated nephrotoxicity with the disturbance of gut microbiota and blood metabolites. In this study, we generated gut microbiota and blood metabolomic profile and identified multiple serum metabolites and gut bacteria species, which were associated with kidney injury on rat model exposed to As and F alone or combined. Combined As and F exposure significantly increased creatinine level. Abnormal autophagosomes and lysosome were observed, and the autophagic genes were enhanced in kidney tissue after single and combined As and F exposure. The metabolome data showed that single and combined As and F exposure remarkably altered the serum metabolites associated with the proximal tubule reabsorption function pathway, with glutamine and alpha-ketoglutarate level decreased in all exposed group. Furthermore, phosphatidylethanolamine (PE), the key contributor of autophagosomes, was decreased significantly in As and F + As exposed groups during the screen of autophagy-animal pathway. Multiple altered gut bacterial microbiota at phylum and species levels post As and F exposure were associated with targeted kidney injury, including p_Bacteroidetes, s_Chromohalobacter_unclassified, s_Halomonas_unclassified, s_Ignatzschineria_unclassified, s_Bacillus_subtilis, and s_Brevundimonas_sp._NA6. Meanwhile, our ana…

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Metadata

Authors
Tian, X., Yan, X., Chen, X., Liu, P., Sun, Z., & Niu, R.
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2023-01-24
Volume
201
Issue
10
Pages
4870-4881
ISSN
  • 0163-4984
  • 1559-0720
DOI
10.1007/s12011-023-03568-5
Cited by
9
References
2
Language
en
Licence
Funders
  • Shanxi Graduate Education Innovation Program (2020BY051)
  • National Natural Science Foundation of China (82173644)

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