Asiatic Acid Ameliorates Doxorubicin-Induced Cardiac and Hepato-Renal Toxicities with Nrf2 Transcriptional Factor Activation in Rats

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works

Tissue sulfhydryl groups

Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824 · see citing works

The American Journal of Physiology

(1899) · The American Naturalist · doi:10.1086/277182 · Cited by 5,680 · see citing works

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

Tacar, O., Sriamornsak, P., & Dass, C. R. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01567.x · Cited by 2,469 · see citing works

Oxidative Medicine and Cellular Longevity

Zheng, T., Bian, F., Li, J., & Danesi, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2572 · Cited by 2,393 · see citing works

Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase

Kono, Y. (1978) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(78)90479-4 · Cited by 1,787 · see citing works

Adriamycin

Blum, R. H., & CARTER, S. K. (1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-2-249 · Cited by 1,059 · see citing works

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986 · see citing works

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Dinkova‐Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C. R., Risingsong, R., Honda, T., Gribble, G. W., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500815102 · Cited by 575 · see citing works

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

Hayes, J. D., McMahon, M. J., Chowdhry, S., & Dinkova‐Kostova, A. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3221 · Cited by 540 · see citing works

Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

Keizer, H. G., Pinedo, H. M., Schuurhuis, G. J., & Joenje, H. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90088-j · Cited by 517 · see citing works

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

Bachur, N. R., Gordon, S., Gee, M. V., & Kon, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.2.954 · Cited by 490 · see citing works

Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate Cardiocyte and Hepatocarcinoma Survival by Oxidative Stress

Monda, M., Messina, G., Scognamiglio, I., Lombardi, A., Martin, G., Sperlongano, P., Porcelli, M., Caraglia, M., & Stiuso, P. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/131024 · Cited by 411 · see citing works

Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

Cherrier, M., Borghesani, P., Shelton, A., & Higano, C. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-1 · Cited by 337 · see citing works

Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats

Ateşşahín, A., Yılmaz, S., Karahan, İ., et al. (2005) · Toxicology · doi:10.1016/j.tox.2005.04.016 · Cited by 308 · see citing works

International Journal of Drug Development and Research

(2019) · International Journal of Drug Development and Research · doi:10.21767/0975-9344 · Cited by 278 · see citing works

The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats

Saad, S. Y., Najjar, T. A. O., & Al‐Rikabi, A. C. (2001) · Pharmacological Research · doi:10.1006/phrs.2000.0769 · Cited by 265 · see citing works

Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

Yun, K., Kim, J., Kim, J., Lee, K., Jeong, S., Park, H.-J., Jung, H.-J., Cho, Y.-W., Yun, K., & Kyung-Tae, L. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.11.003 · Cited by 256 · see citing works

Mechanism of the Nrf2/Keap1/ARE signaling system

Tkachev, V., Брониславовна, М. Е., & Зенков, Н. К. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911040031 · Cited by 228 · see citing works

Cytotoxic and anti-tumour properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban

Babu, T. D., Kuttan, G., & Padikkala, J. (1995) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01284-k · Cited by 217 · see citing works

Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

Li, S., Wang, W., Niu, T., Wang, H., Li, B., Shao, L., Lai, Y., Li, H., Janicki, J. S., Wang, X. L., et al. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/748524 · Cited by 184 · see citing works

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain

Aluise, C. D., Miriyala, S., Noel, T. J., Rukhsana Sultana, A., Jungsuwadee, P., Taylor, T. J., Cai, J., Pierce, W. M. J., Vore, M. E., Moscow, J. A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.009 · Cited by 161 · see citing works

Asiatic acid, a pentacyclic triterpene from <i>Centella asiatica</i>, is neuroprotective in a mouse model of focal cerebral ischemia

Krishnamurthy, R. G., Senut, M., Zemke, D., Min, J., Frenkel, M. B., Greenberg, E. J., Yu, S., Ahn, N., Goudreau, J., Kassab, M., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22071 · Cited by 155 · see citing works

Medicinal Foodstuffs. XXVII. Saponin Constituents of Gotu Kola (2): Structures of New Ursane- and Oleanane-Type Triterpene Oligoglycosides, Centellasaponins B, C, and D, from Centella asiatica Cultivated in Sri Lanka.

Matsuda, H., Morikawa, T., Ueda, H. R., & Yoshikawa, M. (2001) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.49.1368 · Cited by 133 · see citing works

Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats

Mohan, M., Kamble, S. M., Gadhi, P., & Kasture, S. B. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.10.042 · Cited by 126 · see citing works

Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals

Lee, V., Randhawa, A. K., & Singal, P. K. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.4.h989 · Cited by 112 · see citing works

Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice

Resende, F. A., Barcala, C. A. M. D. A., Faria, M. C. D. S., Kato, F. H., Cunha, W. R., & Tavares, D. C. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.038 · Cited by 103 · see citing works

Response of Doxorubicin-induced Cardiomyopathy to the Current Management Strategy of Heart Failure

Tallaj, J. A., Franco, V., Rayburn, B. K., Pinderski, L. J., Benza, R. L., Pamboukian, S. V., Foley, B. A., & Bourge, R. C. (2005) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2004.12.108 · Cited by 99 · see citing works

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

Smirnova, N. A., Haskew-Layton, R. E., Basso, M., Hushpulian, D. M., Payappilly, J. B., Speer, R. E., Ahn, Y., Rakhman, I., Cole, P. A., Pinto, J. T., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.03.013 · Cited by 96 · see citing works

Acute Doxorubicin Toxicity Differentially Alters Cytochrome P450 Expression and Arachidonic Acid Metabolism in Rat Kidney and Liver

Zordoky, B. N. M., Anwar‐Mohamed, A., Aboutabl, M. E., & El‐Kadi, A. O. S. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.039123 · Cited by 85 · see citing works

Chemopreventive effects of diverse dietary phytochemicals against DMBA-induced hamster buccal pouch carcinogenesis via the induction of Nrf2-mediated cytoprotective antioxidant, detoxification, and DNA repair enzymes

Kavitha, K., Thiyagarajan, P., Nandhini, J. R., Mishra, R., & Nagini, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.05.004 · Cited by 74 · see citing works

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

Ryu, K., Susa, M., Choy, E., Cao, Y., Hornicek, F. J., Mankin, H. J., & Duan, Z. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-187 · Cited by 61 · see citing works

Dual activity of triterpenoids: apoptotic versus antidifferentiation effects

Čipák, L., Grausová, Ľ., Miadoková, E., Novotný, L., & Rauko, P. (2006) · Archives of Toxicology · doi:10.1007/s00204-006-0072-6 · Cited by 59 · see citing works

Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review

Kamble, S. M., Goyal, S. N., & Patil, C. R. (2014) · RSC Advances · doi:10.1039/c4ra02784a · Cited by 55 · see citing works

Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice

Pan, L., Xu, L., Zhao, X., et al. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.2.0010 · Cited by 53 · see citing works

Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway

Ma, K., Zhang, Y., Zhu, D., & Lou, Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.11.054 · Cited by 53 · see citing works

Protective effects of silymarin against doxorubicin-induced toxicity.

Cecen, E., Dost, T., Çulhacı, N., et al. (2011) · PubMed · Cited by 49 · see citing works

Asiatic acid prevents lipid peroxidation and improves antioxidant status in rats with streptozotocin-induced diabetes

Vinayagam, R., & Saravanan, R. (2013) · Journal of Functional Foods · doi:10.1016/j.jff.2013.03.003 · Cited by 46 · see citing works

Measurement of the SαT segment as the most reliable electrocardiogram parameter for the assessment of adriamycin-induced cardiotoxicity in the rat

Danesi, R., Tacca, M. D., & Soldani, G. (1986) · Journal of Pharmacological Methods · doi:10.1016/0160-5402(86)90046-x · Cited by 46 · see citing works

The Synthetic Triterpenoid CDDO-Methyl Ester Delays Estrogen Receptor–Negative Mammary Carcinogenesis in Polyoma Middle T Mice

Tran, K., Risingsong, R., Royce, D. B., Williams, C. R., Sporn, M. B., & Liby, K. T. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0404 · Cited by 46 · see citing works

Potential use of antioxidative mungbean protein hydrolysate as an anticancer asiatic acid carrier

Wongekalak, L., Sakulsom, P., Jirasripongpun, K., et al. (2011) · Food Research International · doi:10.1016/j.foodres.2011.01.043 · Cited by 34 · see citing works

Asiatic Acid Derivatives Protect Primary Cultures of Rat Hepatocytes against Carbon Tetrachloride-Induced Injury via the Cellular Antioxidant System

Lee, M. K., Kim, S., Yang, H., et al. (2009) · Natural Product Communications · doi:10.1177/1934578x0900400605 · Cited by 16 · see citing works

Protective effect of Solanum torvum on Doxorubicin- induced hepatotoxicity in rats

Mohan, M., Kamble, S. M., J.Satyanarayana, et al. (2011) · International Journal of Drug Development and Research · Cited by 13 · see citing works

Distinct roles of Smads and microRNAs in TGF-β signaling during kidney diseases

Li, R., Lan, H. Y., & Chung, A. C. K. (2013) · Hong Kong Journal of Nephrology · doi:10.1016/j.hkjn.2013.03.003 · Cited by 5 · see citing works

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568032 · Cited by 353 · see citing works

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice

Matthews, D. G., Caruso, M., Murchison, C. F., Zhu, J. Y., Wright, K. M., Harris, C. J., Gray, N. E., Quinn, J. F., & Soumyanath, A. (2019) · Antioxidants · doi:10.3390/antiox8120630 · Cited by 86 · see citing works

Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review

Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works

Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model

Welbat, J. U., Chaisawang, P., Pannangrong, W., & Wigmore, P. (2018) · Nutrients · doi:10.3390/nu10081053 · Cited by 42 · see citing works

Cardioprotective Effects of Lignanoid against Doxorubicin-Induced Oxidative Stress in Rat

Wang, Y. C., Ren, K., Lin, M., et al. (2013) · Applied Mechanics and Materials · doi:10.4028/www.scientific.net/amm.423-426.382

Repeated Remote Ischemic Conditioning Reduces Doxorubicin-Induced Cardiotoxicity

He, Q., Wang, F., Ryan, T. D., et al. (2020) · JACC CardioOncology · doi:10.1016/j.jaccao.2020.01.005 · Cited by 20 · see citing works

The Essential Strategies to Mitigate Cardiotoxicity Caused by Doxorubicin

Chaulin, A. M. (2023) · Life · doi:10.3390/life13112148 · Cited by 21 · see citing works

Research progress on the protective effects of polyphenols against doxorubicin-induced cardiotoxicity

Lin, H., Zhang, J., Meng, L., et al. (2018) · doi:10.3760/cma.j.issn.1008-1372.2018.03.049

The beneficial role of exercise in preventing doxorubicin-induced cardiotoxicity

Gaytan, S. L., Lawan, A., Chang, J., Nurunnabi, M., Bajpeyi, S., Boyle, J. B., Han, S. M., & Min, K. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1133423 · Cited by 26 · see citing works