The Immune Response to Respiratory Syncytial Virus Infection: Friend or Foe?

Welliver, Robert C.

doi:10.1007/s12016-007-8033-2

Cited by 46Respiratory viral infections researchImmune responses and vaccinationsAsthma and respiratory diseases

The Immune Response to Respiratory Syncytial Virus Infection: Friend or Foe?

Welliver, Robert C.·2008·Clinical Reviews in Allergy & Immunology

DOI 10.1007/s12016-007-8033-2

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Abstract

The immune response to respiratory syncytial virus (RSV) infection has fascinated and frustrated investigators for decades. After adverse responses to early attempts at vaccination, it became popularly held that disease following infection was related to overly aggressive immune responses. However, recent data illustrate that severe forms of disease are related to inadequate, rather than hyperresponsive, adaptive immune reactions. Thus, recovery from primary (and perhaps later) RSV infection is dependent on the quality of innate immune responses. These findings should have enormous significance to the development of vaccines and antiviral compounds.

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No cellular damage was observed in rhinovirus-infected nasal epithelial cells.
“no cellular damage was observed in rhinovirus-infected nasal epithelial cells (318).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [318]
Respiratory viruses are able to induce ciliary impairment, including disruption of ciliary beating and loss of ciliated cells, leading to mucostasis.
“Respiratory viruses are also able to induce ciliary impairment, including disruption of ciliary beating and loss of ciliated cells, leading to mucostasis (318, 332).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [318]

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The airway epithelium: soldier in the fight against respiratory viruses
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“…virus infections, including those caused by respiratory syncytial virus (RSV), are characterized by robust host inflammatory responses that, left unchecked, contribute significantly to illness severity (Mukherjee & Lukacs, 2013; Arruvito et al., 2015; Tabarani et al., 2013; Welliver, 2008).”
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Paramyxoviruses: Respiratory Syncytial Virus and Human Metapneumovirus
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Authors: Welliver, R. C.
Venue: Clinical Reviews in Allergy & Immunology
Publisher: Springer Science and Business Media LLC
Published: 2007-11-06
Volume: 34
Issue: 2
Pages: 163-173
ISSN: 1080-0549 (ISSN-L)
1559-0267
DOI: 10.1007/s12016-007-8033-2
OpenAlex: W2015448026
Cited by: 46
References: 105
Citations by year: 2025: 2 · 2023: 2 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 2
FWCI: 0.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Clinical Reviews in Allergy & Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords: respiratory syncytial virus, immune response, innate immunity, adaptive immunity, RSV vaccination, vaccine development, antiviral agents, primary infection, disease severity, hyperimmune response
MeSH terms: Antibodies, Viral, Humans, Immunity, Cellular, Immunity, Innate, Infant, Respiratory System, Respiratory Tract Infections, Cytokines, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Inflammation Mediators, Pulmonary Surfactant-Associated Proteins, Toll-Like Receptors

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The Immune Response to Respiratory Syncytial Virus Infection: Friend or Foe?

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