Cited by 54Respiratory viral infections researchSARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Establishing Correlates of Protection for Vaccine Development: Considerations for the Respiratory Syncytial Virus Vaccine Field

Open access
Kulkarni, Prasad S., Hurwitz, Julia L., Simões, Eric A.F., Piedra, Pedro A.·2018·Viral Immunology

Abstract

Correlates of protection (CoPs) can play a significant role in vaccine development by assisting the selection of vaccine candidates for clinical trials, supporting clinical trial design and implementation, and simplifying tests of vaccine modifications. Because of this important role in vaccine development, it is essential that CoPs be defined by well-designed immunogenicity and efficacy studies, with attention paid to benefits and limitations. The respiratory syncytial virus (RSV) field is unique in that a great deal of information about the humoral response is available from basic research and clinical studies. Polyclonal and monoclonal antibodies have been used routinely in the clinic to protect vulnerable infants from infection, providing a wealth of information about correlations between neutralizing antibodies and disease prevention. Considerations for the establishment of future CoPs to support RSV vaccine development in different populations are therefore discussed.

Integrity signals

Registry

Crossref · 10.1089/vim.2017.0147

Cites

120 of 120 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Measurement of serum neutralizing activity has been shown to be a mechanistic correlate of protection for other respiratory viruses, such as influenza and respiratory syncytial virus, and is generally accepted as a functional biomarker of the in vivo humoral response.

    “Though correlates of protection from SARS-CoV-2 infection have not yet been determined, measurement of serum neutralizing activity has been shown to be a mechanistic correlate of protection for other respiratory viruses, such as influenza14 and respiratory syncytial virus,15 and is generally accepted as a functional biomarker of the in vivo humoral response.16”

    From An mRNA Vaccine against SARS-CoV-2 — Preliminary Report (2020) · cites this paper as [15]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kulkarni, P. S., Hurwitz, J. L., Simões, E. A. F., & Piedra, P. A.
Affiliations
  • Serum Institute of India (India) (IN)
  • St. Jude Children's Research Hospital (US)
  • Colorado School of Public Health (US)
  • Baylor College of Medicine (US)
Venue
Viral Immunology
Published
2018-03
Volume
31
Issue
2
Pages
195-203
ISSN
  • 0882-8245 (ISSN-L)
  • 1557-8976
OpenAlex
W2783725776
Cited by
53
References
120
Citations by year
2025: 6 · 2024: 11 · 2023: 9 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 7
FWCI
0.79
Type
journal article
Language
en
Open access
Locations
  • Viral Immunology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Lebanese Syrian Associated Charities (CA 21765)
  • National Institutes of Health (NCI P30-CA21765, CA21765))
  • National Cancer Institute (CA21765, P 30CA 21765, P30CA021765)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
correlates of protection, RSV vaccine, vaccine development, neutralizing antibodies, humoral immune response, monoclonal antibodies, polyclonal antibodies, vaccine efficacy, immunogenicity, infants, vaccine candidate selection, clinical trial design
MeSH terms
Drug Evaluation, Preclinical, Humans, Biomarkers, Respiratory Syncytial Virus, Human, Respiratory Syncytial Virus Infections, Respiratory Syncytial Virus Vaccines, Drug Discovery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review