The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Implication of Vitamin D and Autoimmunity: a Comprehensive Review
Open accessAbstract
Historically, vitamin D has been associated with the regulation of bone metabolism. However, increasing evidence demonstrates a strong association between vitamin D signaling and many biological processes that regulate immune responses. The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases. In this review we, discuss five major areas in vitamin D biology of high immunological significance: (1) the metabolism of vitamin D; (2) the significance of vitamin D receptor polymorphisms in autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; (3) vitamin D receptor transcriptional regulation of immune cell lineages, including Th1, Th17, Th2, regulatory T, and natural killer T cells; (4) the prevalence of vitamin D insufficiency/deficiency in patients with multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; and finally, (5) the therapeutic effects of vitamin D supplementation on disease severity and progression.
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Citations
Cites
Vitamin D deficiency: a worldwide problem with health consequences
Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689
Cited by
Obesity in autoimmune diseases: Not a passive bystander
Versini, M., Jeandel, P.-Y., Rosenthal, E., & Shoenfeld, Y. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.07.001 · Cited by 694
Marques, A. H., O'Connor, T. G., Roth, C., Susser, E., & Bjørke-Monsen, A.-L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00120 · Cited by 226
Autism Spectrum Disorder and low vitamin D at birth: A sibling control study
Fernell, E., Bejerot, S., Westerlund, J., Miniscalco, C., Simila, H., Eyles, D., Gillberg, C., & Humble, M. B. (2015) · Molecular Autism · doi:10.1186/2040-2392-6-3 · Cited by 160
Current understandings of the pathogenesis of type 1 diabetes: genetics to environment
Giwa, A. M., Ahmed, R., Omidian, Z., Majety, N., Karakus, K. E., Omer, S. M., Donner, T., & Hamad, A. R. A. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i1.13 · Cited by 137
Environmental Basis of Autoimmunity
Floreani, A., Leung, P. S. C., & Gershwin, M. E. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8493-8 · Cited by 122
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Metadata
- Authors
- Yang, C.-Y., Leung, P. S. C., Adamopoulos, I. E., & Gershwin, M. E.
- Venue
- Clinical Reviews in Allergy & Immunology
- Published
- 2013-01-29
- Volume
- 45
- Issue
- 2
- Pages
- 217-226
- ISSN
- 1080-0549 (ISSN-L)
- 1559-0267
- OpenAlex
- W2098442452
- Cited by
- 299
- References
- 1
- FWCI
- 17.34
- Type
- journal article
- Language
- en
- Open access
- green
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