Cited by 24Sarcoma Diagnosis and TreatmentGenetic Associations and EpidemiologyBone Tumor Diagnosis and Treatments

Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population

He, Jinshan, Wang, Jingcheng, Wang, Daxin, Dai, Shanhe, Yv, Tangyun, Chen, Pengtao, Ma, Renshi, Diao, Chunyv +1 more·2014·Endocrine

Abstract

Osteosarcoma (OS) is the most common malignant primary bone tumor in the world. The cytotoxic T-lymphocyte antigen-4 gene (CTLA-4) is an important candidate gene for influencing the development of OS. This study aimed to investigate the potential association of CTLA-4 genetic polymorphisms with OS risk in Chinese Han population. A total of 415 OS patients and 431 healthy controls were enrolled in this study. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were used to detect the genotyping of CTLA-4 c.75G[C and c.326G[A genetic polymorphisms. We observed that the genotypes/alleles of c.75G[C and c.326G[A genetic polymorphisms were statistically associated with the increased risk of OS (for c.75G[C, CC versus (vs.) GG: OR 1.72, 95% CI 1.09–2.74; C vs. G: OR 1.30, 95% CI 1.06–1.60; for c.326G[A, AA vs. GG: OR 2.12, 95% CI 1.31–3.42; A vs. G: OR 1.31, 95% CI 1.07–1.61). The allele-C/genotype-CC of c.75G[C and allele-A/genotype-AA of c.326G[A may contribute to OS susceptibility. These data indicate that CTLA-4 genetic polymorphisms are potentially related to OS risk in Chinese Han population, and might be used as molecular markers for evaluating the risk of OS.

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Crossref · 10.1007/s12020-013-0050-8

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  • CTLA-4 genetic polymorphisms are potentially associated with osteosarcoma risk.

    “The study suggested that CTLA-4 genetic polymorphisms also potentially associated with osteosarcoma risk [92, 93].”

    From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [92]

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Authors
He, J., Wang, J., Wang, D., Dai, S., Yv, T., Chen, P., Ma, R., Diao, C., & Lv, G.
Affiliations
  • Central South University (CN)
  • Yangzhou University (CN)
Corresponding author
Lv, Guohua
Venue
Endocrine
Published
2013-09-28
Volume
45
Issue
2
Pages
325-330
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
OpenAlex
W2015400795
Cited by
24
References
30
Citations by year
2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 4
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
Keywords
osteosarcoma, CTLA-4, genetic polymorphism, cancer susceptibility, genetic association, Han Chinese, risk indicators
MeSH terms
Adolescent, Adult, Aged, Alleles, Bone Neoplasms, Child, China, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Osteosarcoma, Case-Control Studies, Genetic Predisposition to Disease, Asian People, Young Adult, CTLA-4 Antigen

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