Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population
Abstract
Osteosarcoma (OS) is the most common malignant primary bone tumor in the world. The cytotoxic T-lymphocyte antigen-4 gene (CTLA-4) is an important candidate gene for influencing the development of OS. This study aimed to investigate the potential association of CTLA-4 genetic polymorphisms with OS risk in Chinese Han population. A total of 415 OS patients and 431 healthy controls were enrolled in this study. The created restriction site-polymerase chain reaction (CRS-PCR) and DNA sequencing methods were used to detect the genotyping of CTLA-4 c.75G[C and c.326G[A genetic polymorphisms. We observed that the genotypes/alleles of c.75G[C and c.326G[A genetic polymorphisms were statistically associated with the increased risk of OS (for c.75G[C, CC versus (vs.) GG: OR 1.72, 95% CI 1.09–2.74; C vs. G: OR 1.30, 95% CI 1.06–1.60; for c.326G[A, AA vs. GG: OR 2.12, 95% CI 1.31–3.42; A vs. G: OR 1.31, 95% CI 1.07–1.61). The allele-C/genotype-CC of c.75G[C and allele-A/genotype-AA of c.326G[A may contribute to OS susceptibility. These data indicate that CTLA-4 genetic polymorphisms are potentially related to OS risk in Chinese Han population, and might be used as molecular markers for evaluating the risk of OS.
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CTLA-4 genetic polymorphisms are potentially associated with osteosarcoma risk.
“The study suggested that CTLA-4 genetic polymorphisms also potentially associated with osteosarcoma risk [92, 93].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [92]
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- Authors
- He, J., Wang, J., Wang, D., Dai, S., Yv, T., Chen, P., Ma, R., Diao, C., & Lv, G.
- Affiliations
- Central South University (CN)
- Yangzhou University (CN)
- Corresponding author
- Lv, Guohua
- Venue
- Endocrine
- Published
- 2013-09-28
- Volume
- 45
- Issue
- 2
- Pages
- 325-330
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2015400795
- Cited by
- 24
- References
- 30
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 4
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Keywords
- osteosarcoma, CTLA-4, genetic polymorphism, cancer susceptibility, genetic association, Han Chinese, risk indicators
- MeSH terms
- Adolescent, Adult, Aged, Alleles, Bone Neoplasms, Child, China, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Osteosarcoma, Case-Control Studies, Genetic Predisposition to Disease, Asian People, Young Adult, CTLA-4 Antigen
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