The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Endurance training enhances skeletal muscle interleukin-15 in human male subjects
Abstract
Regular endurance exercise promotes metabolic and oxidative changes in skeletal muscle. Overexpression of interleukin-15 (IL-15) in mice exerts similar metabolic changes in muscle as seen with endurance exercise. Muscular IL-15 production has been shown to increase in mice after weeks of regular endurance running. With the present study we aimed to determine if muscular IL-15 production would increase in human male subjects following 12 weeks of endurance training. In two different studies we obtained plasma and muscle biopsies from young healthy subjects performing: (1) 12 weeks of ergometer cycling exercise five times per week with plasma and biopsies before and after the intervention, and (2) 3 h of ergometer cycling exercise with plasma and biopsies before and after the exercise bout and well into recovery. We measured changes in plasma IL-15, muscle IL-15 mRNA and IL-15 protein. Twelve weeks of regular endurance training induced a 40% increase in basal skeletal muscle IL-15 protein content (p < 0.01), but with no changes in either muscle IL-15 mRNA or plasma IL-15 levels. However, an acute bout of 3-h exercise did not show significant changes in muscle IL-15 or plasma IL-15 levels. The induction of muscle IL-15 protein in humans following a regular training period supports previous findings in mice and emphasizes the hypothesis of IL-15 taking part in skeletal muscle adaptation during training.
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“IL-15 concentrations in SkM biopsies are markedly increased despite no apparent increase in the circulation following exercise [85].”
Citations
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Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
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Searching for the exercise factor: is IL-6 a candidate?
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Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
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Items 101–101 of 101
Skorkina, M., Bobylev, A. G., Belova, D., Bravyy, Y. R., Mutig, K., & Lebedeva, S. A. (2026) · Biomolecules · doi:10.3390/biom16101536
“Individual studies have reported increases, decreases, or no significant changes in circulating IL-15 after exercise [136,140].”
Metadata
- Authors
- Rinnov, A., Yfanti, C., Nielsen, S., Åkerström, T. C. A., Peijs, L., Zankari, A., Fischer, C. P., & Pedersen, B. K.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Rinnov, Anders
- Venue
- Endocrine
- Published
- 2013-05-07
- Volume
- 45
- Issue
- 2
- Pages
- 271-278
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2020374367
- Cited by
- 103
- References
- 32
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 10 · 2023: 5 · 2022: 14 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 4 · 2016: 9 · 2015: 8 · 2014: 6
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- IL-15, endurance training, skeletal muscle, muscle adaptation, acute exercise, cycle ergometry, plasma cytokines, exercise training
- MeSH terms
- Adaptation, Physiological, Adult, Biopsy, Exercise Test, Humans, Male, Physical Endurance, RNA, Messenger, Time Factors, Exercise, Up-Regulation, Muscle, Skeletal, Interleukin-15
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