Effect of orlistat on weight loss, hormonal and metabolic profiles in women with polycystic ovarian syndrome: a randomized double-blind placebo-controlled trial
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No significant benefits were observed in other metabolic parameters with orlistat in PCOS.
“However, no significant benefits were observed in other metabolic parameters [170].”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [170]
In a randomized trial (n=86), orlistat 120 mg three times daily for three months plus lifestyle intervention was superior to placebo plus lifestyle in achieving greater percent weight loss (−6.37% vs −2.27%), greater reduction in waist-to-hip ratio (0.76 vs 0.86), and improvements in total testosterone and lipid profiles.
“The drug plus lifestyle intervention was superior to placebo plus lifestyle in achieving greater percent weight loss (− 6.37% vs. −2.27%), greater reduction in waist-to-hip ratio (0.76 vs. 0.86), and improvements in total testosterone and lipid profiles [170].”
From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [170]
Cites
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
Legro, R. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.165 · Cited by 1,743 · see citing works
Franks, S. (1997) · Archives of Disease in Childhood · doi:10.1136/adc.77.1.89 · Cited by 802 · see citing works
Garg, A., Bonanome, A., Grundy, S. M., Zhang, Z.-J., & Unger, R. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809293191304 · Cited by 394 · see citing works
Abdominal adiposity and the polycystic ovary syndrome
Escobar-Morreale, H. F., & Millán, J. L. S. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.07.003 · Cited by 386 · see citing works
Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome
Pasquali, R., Gambineri, A., & Pagotto, U. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00990.x · Cited by 359 · see citing works
Heymsfield, S. B., Segal, K. R., Hauptman, J., Lucas, C. P., Boldrin, M. N., Rissanen, A., Wilding, J. P. H., & Sjöström, L. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.9.1321 · Cited by 358 · see citing works
Obesity and PCOS: Implications for Diagnosis and Treatment
Legro, R. S. (2012) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1328878 · Cited by 280 · see citing works
Huber-Buchholz, M.-M. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1470 · Cited by 269 · see citing works
Parillo, M., Rivellese, A. A., Ciardullo, A. V., Capaldo, B., Giacco, A., Genovese, S., & Riccardi, G. (1992) · Metabolism · doi:10.1016/0026-0495(92)90111-m · Cited by 211 · see citing works
Role of Diet in the Treatment of Polycystic Ovary Syndrome
Douglas, C. C., Gower, B. A., Darnell, B. E., Ovalle, F., Oster, R. A., & Azziz, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.08.045 · Cited by 170 · see citing works
Mehrabani, H. H., Salehpour, S., Amiri, Z., Farahani, S. J., Meyer, B. J., & Tahbaz, F. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720017 · Cited by 141 · see citing works
Androgen circle of polycystic ovary syndrome
Homburg, R. (2009) · Human Reproduction · doi:10.1093/humrep/dep049 · Cited by 134 · see citing works
Orlistat Is as Beneficial as Metformin in the Treatment of Polycystic Ovarian Syndrome
Jayagopal, V., Kilpatrick, E. S., Holding, S., Jennings, P. E., & Atkin, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0176 · Cited by 134 · see citing works
The Role of Obesity in the Development of Polycystic Ovary Syndrome
Motta, A. B. (2012) · Current Pharmaceutical Design · doi:10.2174/13816128112092482 · Cited by 103 · see citing works
Johansson, K., Neovius, K., DeSantis, S. M., Rössner, S., & Neovius, M. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00581.x · Cited by 86 · see citing works
Cho, L., Kilpatrick, E. S., Keevil, B. G., Coady, A., & Atkin, S. L. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03309.x · Cited by 82 · see citing works
Jacob, S., Rabbia, M. A., Meier, M. K., & Hauptman, J. B. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00970.x · Cited by 72 · see citing works
Insulin resistance in patients with polycystic ovary syndrome
Schröder, A. K., Tauchert, S., Ortmann, O., Diedrich, K., & Weiss, J. M. (2004) · Annals of Medicine · doi:10.1080/07853890410035296 · Cited by 59 · see citing works
Smith, S. R., Stenlof, K. S., Greenway, F. L., McHutchison, J., Schwartz, S. M., Dev, V. B., Berk, E. S., & Kapikian, R. (2011) · Obesity · doi:10.1038/oby.2011.143 · Cited by 51 · see citing works
An RCT of metformin versus orlistat for the management of obese anovulatory women
Metwally, M., Amer, S. A. K. S., Li, T. C., & Ledger, W. J. (2008) · Human Reproduction · doi:10.1093/humrep/den454 · Cited by 46 · see citing works
Ghandi, S., D, A. A. M., Tabibnejad, N., & Moghaddam, M. H. S. (2011) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-011-9564-2 · Cited by 45 · see citing works
Panidis, D., Tziomalos, K., Papadakis, E., Chatzis, P., Kandaraki, E. A., Tsourdi, E. A., & Katsikis, I. (2014) · Clinical Endocrinology · doi:10.1111/cen.12305 · Cited by 43 · see citing works
Treatment of the Obese Patient in Primary Care: Targeting and Meeting Goals and Expectations
Bray, G. A., Look, M., & Ryan, D. H. (2013) · Postgraduate Medicine · doi:10.3810/pgm.2013.09.2692 · Cited by 33 · see citing works
Ravn, P., Haugen, A. G., & Glintborg, D. (2013) · PubMed · Cited by 29 · see citing works
Díaz, E. G., & Folgueras, T. M. (2011) · PubMed · doi:10.1590/s0212-16112011000300004 · Cited by 23 · see citing works
Şahi̇n, M., Tanaci, N., Yücel, M., Tütüncü, N. B., & Guvener, N. D. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02888.x · Cited by 17 · see citing works
Leptin levels and adipose tissue percentage in adolescents with polycystic ovary syndrome
Kedikova, S., Sirakov, M., & Boyadzhieva, M. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2012.752455 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wang, F., Wu, Y. T., Zhu, Y. ‐., Ding, T., Batterham, R. L., Qu, F., & Hardiman, P. J. (2018) · Obesity Reviews · doi:10.1111/obr.12720 · Cited by 92 · see citing works
Samarasinghe, S., Leca, B. M., Alabdulkader, S., Dimitriadis, G. K., Davasgaium, A., Thadani, P., Parry, K., Luli, M., O'Donnell, K., Johnson, B., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00538-5 · Cited by 84 · see citing works
Graff, S. K., Mario, F. M., Ziegelmann, P., & Spritzer, P. M. (2016) · International Journal of Clinical Practice · doi:10.1111/ijcp.12787 · Cited by 63 · see citing works
Goldberg, A., Graca, S., Liu, J., Rao, V., Witchel, S. F., Pena, A., Li, R., Mousa, A., Tay, C. T., Pattuwage, L., et al. (2024) · Obesity Reviews · doi:10.1111/obr.13704 · Cited by 59 · see citing works
Jing-hua, S., Ruan, X., Gu, M., Wang, L., Wang, H., & Mueck, A. O. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1407752 · Cited by 49 · see citing works
Feng, X., Lin, Y., Zhuo, S., Dong, Z., Shao, C., Ye, J., & Zhong, B. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.02.008 · Cited by 34 · see citing works
Tuccinardi, D., Masi, D., Watanabe, M., Zanghi Buffi, V., De Domenico, F., Berti, S., Cipriani, V., Manco, M., Manfrini, S., & Pagotto, U. (2025) · Journal of Endocrinological Investigation · doi:10.1007/s40618-025-02700-7 · Cited by 29 · see citing works
Scragg, J., Hobson, A., Willis, L., Taylor, K., Dixon, S., & Jebb, S. A. (2024) · Annals of Internal Medicine · doi:10.7326/m23-3179 · Cited by 24 · see citing works
Kujawska-Łuczak, M., Musialik, K., Szulińska, M., Swora-Cwynar, E., Kargulewicz, A., Grzymisławska, M., Pupek-Musialik, D., & Bogdański, P. (2017) · Archives of Medical Science · doi:10.5114/aoms.2016.62014 · Cited by 21 · see citing works
Strong inhibitory activities and action modes of lipopeptides on lipase
Chen, M., Liu, T.-T., Wang, J.-P., Chen, Y., Chen, Q.-X., Zhu, Y.-J., & Liu, B. (2020) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2020.1734798 · Cited by 20 · see citing works
Abdalla, M. A., Shah, N. Z., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2021) · Clinical Endocrinology · doi:10.1111/cen.14623 · Cited by 18 · see citing works
Samarasinghe, S., Oštarijaš, E., Long, M. J., Erridge, S., Purkayastha, S., Dimitriadis, G. K., & Miras, A. D. (2024) · Obesity Reviews · doi:10.1111/obr.13744 · Cited by 16 · see citing works
Abdel-Maboud, M., Menshawy, A., Hasabo, E. A., Abdelraoof, M. I., Alshandidy, M., Eid, M., Menshawy, E., Outani, O., & Menshawy, A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254412 · Cited by 16 · see citing works
RetractedBo, Y., Zhao, J., Liu, C., & Yu, T. (2025) · BMC Women s Health · doi:10.1186/s12905-025-03594-6 · Cited by 16 · see citing works
Ramirez, A. V. G., Filho, D. R., & Filho, I. J. Z. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666191113125247 · Cited by 12 · see citing works
Kumbhar, P., Chavan, R., Darekar, S., Kolekar, K. A., Sequeira, A., Vishwas, S., Gupta, G., Paudel, K. R., Singh, S. K., Dua, K., et al. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03578-7 · Cited by 9 · see citing works
The Efficacy of Various Weight Loss Strategies in Alleviating Polycystic Ovary Syndrome
Yang, S., Pan, X., Yang, R., Wang, Y., Zhang, Z., Chen, G., Li, Z., Qiu, G., Li, L., Jing, C., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00649-5 · Cited by 8 · see citing works
The Role of Antiobesity Agents in the Management of Polycystic Ovary Syndrome
Chatzis, P., Τζιόμαλος, Κ., Pratilas, G. C., Makris, V., Sotiriadis, A., & Dinas, K. D. (2018) · Folia Medica · doi:10.2478/folmed-2018-0036 · Cited by 7 · see citing works
Yang, J., Wang, E., Chen, W., Xu, B., Chen, C., Zhang, G., & Yao, J. (2023) · ACS Omega · doi:10.1021/acsomega.3c00578 · Cited by 7 · see citing works
Xie, P., Shao, T., Long, Y., Xie, W., Liu, Y., Yang, Y., Huang, Y., Wu, R., Deng, Q., & Tang, H. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02214-w · Cited by 7 · see citing works
QRLISTAT (THE LIPASE INHIBITOR) THERAPY IN OVERWEIGHT AND OBESE SUB-FERTILE WOMEN
Al-Qahwajy, M. A. A., Eissa, A. K. A., Taha, W. S., & Abdelmoaty, M. A. (2022) · Al-Azhar Medical Journal · doi:10.21608/amj.2022.230460 · Cited by 4 · see citing works
Abdalla, M. A., Shah, N. Z., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2021) · Clinical Endocrinology · doi:10.1111/cen.14663 · Cited by 4 · see citing works
Fernandes, A., Gordon, A., & Sweeting, A. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70116 · Cited by 3 · see citing works
Wan, K., Dai, Z.-H., Lei, E. F.-C., Wong, P.-S., Wang, Y.-Y., Yu, A. P., Lin, F., Huang, Y., Duncan, W. C., Chan, K. Y., et al. (2026) · The Lancet Obstetrics Gynaecology & Women s Health · doi:10.1016/s3050-5038(25)00219-5 · Cited by 2 · see citing works
Bacillus lipopeptides inhibit lipase activity and promote 3T3-L1 preadipocyte differentiation
Chen, M., Chen, D., Xiao, R., Zheng, X., Liu, B., & Wang, J. (2024) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2024.2417915 · Cited by 2 · see citing works
Advanced therapy of overweight or obese polycystic ovary syndrome: a prospective study
Min, M., Ruan, X., & Mueck, A. O. (2022) · Global Health Journal · doi:10.1016/j.glohj.2022.04.004 · Cited by 2 · see citing works
Salim, J., Tandy, S., & Puspitasari, G. (2024) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1177/1973798x241289779 · Cited by 1 · see citing works
Polycystic Ovary Disease and Obesity: Leptin, Weight-loss Medication, and Bariatric Surgery
Burgart, J. (2020) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000599 · Cited by 1 · see citing works
Andre, N., Aristyo, K., Zhafira, A. S., Hanjani, R., Susantono, D. P., Ethelind, R., & Mirtha, L. T. (2017) · IOSR Journal of Pharmacy (IOSRPHR) · doi:10.9790/3013-0701011520 · Cited by 1 · see citing works
Effect of orlistat on obese women with polycystic ovary syndrome
Jiang, Q., & Shi, Y. (2018) · Journal of Bio-X Research · doi:10.1097/jbr.0000000000000017 · Cited by 1 · see citing works
Medical interventions to improve outcomes in infertile obese women planning for pregnancy
Talaulikar, V. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817919-2.00016-4 · Cited by 1 · see citing works
Thylakoid membranes from green plants affect appetite and promote body weight loss
Montelius, C. (2015) · Lund University Publications (Lund University)
de Vasconcelos, I. H. A., Andrade, R. N., de Albuquerque, B. P., Cid, B. T., Souza, B. P., Mascarenhas, E. B., Mendes, F. P., Soares, I. T. D., Machado, L. P., & Queiroz, R. M. (2020) · Revista Científica Multidisciplinar Núcleo do Conhecimento · doi:10.32749/nucleodoconhecimento.com.br/saude/terapias-combinadas
Min, M., Xiangyan, R., & Mueck, A. O. (2021) · Global Health Journal · doi:10.1016/j.glohj.2021.05.004
RetractedXie, P., Shao, T., Long, Y., Xie, W., Liu, Y., Yang, Y., Huang, Y., Wu, R., Deng, Q., & Tang, H. (2024) · Figshare · doi:10.6084/m9.figshare.26367930
Obesity and female reproductive health in Asian population
Panyakhamlerd, K., Sophonsritsuk, A., Pantasri, T., Suwan, A., Panyawongudom, N., & Samakkarnthai, P. (2026) · Obesity Pillars · doi:10.1016/j.obpill.2026.100255
- Authors
- Moini, A., Kanani, M., Kashani, L., Hosseini, R., & Hosseini, L.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Hosseini, Reihaneh
- Venue
- Endocrine
- Published
- 2014-10-08
- Volume
- 49
- Issue
- 1
- Pages
- 286-289
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2043228530
- Cited by
- 37
- References
- 28
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- orlistat, polycystic ovary syndrome, weight loss, hormonal profile, metabolic profile, women, obesity
- MeSH terms
- Orlistat, Adult, Combined Modality Therapy, Double-Blind Method, Enzyme Inhibitors, Female, Humans, Lactones, Obesity, Polycystic Ovary Syndrome, Testosterone, Weight Loss, Body Mass Index, Treatment Outcome, Caloric Restriction, Overweight, Metabolome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
