Abdominal adiposity and the polycystic ovary syndrome

Escobar-Morreale, Héctor F.; Millán, José L. San

doi:10.1016/j.tem.2007.07.003

Cited by 386Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

Abdominal adiposity and the polycystic ovary syndrome

Escobar-Morreale, Héctor F., Millán, José L. San·2007·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2007.07.003

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Abstract

Abdominal adiposity, overweightness and obesity are frequently present in patients with polycystic ovary syndrome (PCOS). A large body of evidence suggests that abdominal adiposity and the resulting insulin resistance contribute to ovarian and, possibly, adrenal hyperandrogenism. However, androgen excess itself might also contribute to abdominal fat deposition in hyperandrogenic women. Recent genomic and proteomic analyses of visceral fat from PCOS patients have detected differences in gene expression and protein content compared with those of non-hyperandrogenic women. Here we review the existing evidence for a vicious circle whereby androgen excess favoring the abdominal deposition of fat further facilitates androgen secretion by the ovaries and adrenals in PCOS patients.

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Weight gain and central obesity, although not a diagnostic criterion, are common features of PCOS.
“Weight gain and central obesity, although not a diagnostic criterion, are common features of PCOS [22].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [22]

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Authors: Escobar-Morreale, H. F., & Millán, J. L. S.
Affiliations: Universidad de Alcalá (ES)
Corresponding author: Escobar-Morreale, Héctor F.
ORCID: Escobar-Morreale, Héctor F.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2007-09
Volume: 18
Issue: 7
Pages: 266-272
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2007.07.003
OpenAlex: W2001434052
Cited by: 386
References: 71
Citations by year: 2026: 6 · 2025: 14 · 2024: 26 · 2023: 24 · 2022: 28 · 2021: 36 · 2020: 21 · 2019: 26 · 2018: 17 · 2017: 24 · 2016: 19 · 2015: 22 · 2014: 20 · 2013: 29 · 2012: 17
FWCI: 2.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: polycystic ovary syndrome, abdominal fat, visceral fat, insulin resistance, hyperandrogenism, obesity, overweight, adrenal androgen secretion
MeSH terms: Female, Humans, Hyperinsulinism, Insulin Resistance, Models, Biological, Polycystic Ovary Syndrome, Hyperandrogenism, Leptin, Abdominal Fat, Adiposity

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Abdominal adiposity and the polycystic ovary syndrome

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