The impact of glycemic variability on diabetic peripheral neuropathy
Abstract
Mean glucose values alone cannot explain the patterns of morbidity and mortality due to dysglycemia in diabetes. Development of continuous glucose monitoring systems has improved the analysis and interpretation of glycemic variability. The roles of glycemic components other than constant hyperglycemia in diabetic complications must be investigated because large clinical studies have indicated that risk factors besides the average glucose value of HbA1c are involved in chronic macrocomplications/microcomplications of diabetes. Among these complications, the pathogenesis of diabetic peripheral neuropathy is particularly complex, and several factors related to glucose and nonglucose pathways have been suggested as risk factors. There is little information regarding the effect of glycemic variability on diabetic peripheral neuropathy, unlike other microvascular complications of retinopathy and nephropathy, and whether glycemic variability causes harmful effects is still a matter of debate. In this review, we discuss the relationships between glycemic variability and diabetic peripheral neuropathy, focusing on somatosensory peripheral neuropathies rather than autonomic neuropathies.
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There is inconsistency in the relationship between glucose variability and diabetic peripheral neuropathy in the literature.
“There is inconsistency in the relationship between glucose variability and DPN in the literature, and some research indicates that for type 2 DM, glucose variability may be regarded as a marker of beta-cell function rather than direct cause of DPN.37–39”
From Glucose time in range and peripheral neuropathy in type 2 diabetes mellitus and chronic kidney disease (2020) · cites this paper as [39]
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- Authors
- Jin, H. Y., Lee, K. A., & Park, T. S.
- Affiliations
- Jeonbuk National University Hospital (KR)
- Corresponding author
- Park, Tae Sun
- Venue
- Endocrine
- Published
- 2016-07-06
- Volume
- 53
- Issue
- 3
- Pages
- 643-648
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2472726498
- Cited by
- 49
- References
- 41
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 7
- Type
- book review
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chonbuk National University Hospital
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- glycemic variability, diabetic peripheral neuropathy, continuous glucose monitoring, HbA1c, microvascular complications, macrovascular complications, hyperglycemia, risk factors, diabetes mellitus
- MeSH terms
- Blood Glucose, Diabetic Neuropathies, Humans, Peripheral Nervous System Diseases
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