CoChat
Sign Up
Cited by 49Growth Hormone and Insulin-like Growth FactorsHormonal and reproductive studiesCardiovascular Health and Disease Prevention

Intima-media thickness in cardiovascularly asymptomatic hypopituitary adults with growth hormone deficiency: relation to body mass index, gender, and other cardiovascular risk factors

Leonsson, Maria, Hulthe, Johannes, Oscarsson, Jan, Johannsson, Gudmundur, Wendelhag, Inger, Wikstrand, John, Bengtsson, Bengt‐Åke·2002·Clinical Endocrinology
DOI 10.1046/j.1365-2265.2002.01663.x
Open this paper in CoChat — free account

Abstract

OBJECTIVE: Increased cardiovascular mortality and carotid atherosclerosis have been observed in hypopituitary patients with untreated GH deficiency (GHD), but results are contradictory and relations to cardiovascular risk factors are not clear. The aim of this study was to investigate intima-media thickness (IMT) in relation to cardiovascular risk factors in adults with GHD. DESIGN: Cross-sectional observational study of 21 men and 13 women with GHD, but without cardiovascular disease, compared to two healthy control groups matched for age, sex and smoking habits. One control group was matched for body mass index (BMI) and the other group was nonobese. MEASUREMENTS: IMT of the carotid and femoral arteries, blood pressure, blood samples and anthropometric data. RESULTS: Patients had 12% thicker composite carotid IMT [(IMT of common carotid artery + IMT of bulb)/2] compared to nonobese controls (P = 0.022), but IMT was not different compared to BMI-matched controls. Femoral IMT did not differ between patients and controls. Patients had higher waist : hip ratio (WHR), heart rate, serum triglycerides and fasting insulin concentrations in combination with lower high-density lipoprotein (HDL) cholesterol and smaller low-density lipoprotein (LDL) peak particle size compared to both nonobese and to BMI-matched controls. This cardiovascular risk pattern was more pronounced in female patients than in male patients compared to their gender controls. Carotid IMT was related to age, serum cholesterol, LDL cholesterol and smoking in the patient group. Only age was independently related to carotid IMT in multivariate analysis. CONCLUSIONS: These results indicate that high BMI in GH-deficient patients contribute to their increased intima-media thickness. However, several cardiovascular risk factors are present in this patient group independent of their increased BMI, especially in women.

Integrity signals

Registry

Crossref · 10.1046/j.1365-2265.2002.01663.x

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Altered body composition, insulin resistance, hypertension, unfavorable lipid profile, endothelial dysfunction and atherosclerosis have been found in several studies on patients with long-term GHD.

    “Altered body composition, insulin resistance, hypertension, unfavorable lipid profile, endothelial dysfunction and atherosclerosis have been found in several studies on patients with long-term GHD (74,76,77,(82)(83)(84)(85)(86)(87).”

    From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [83]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Leonsson, M., Hulthe, J., Oscarsson, J., Johannsson, G., Wendelhag, I., Wikstrand, J., & Bengtsson, B.
Affiliations
  • Sahlgrenska University Hospital (SE)
  • University of Gothenburg (SE)
Corresponding author
Hulthe, Johannes
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2002-12
Volume
57
Issue
6
Pages
751-759
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1046/j.1365-2265.2002.01663.x
OpenAlex
W2167403780
Cited by
49
References
47
Citations by year
2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 3
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hjärt-Lungfonden
  • Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
growth hormone deficiency, hypopituitarism, intima-media thickness, carotid atherosclerosis, cardiovascular risk factors, body mass index, obesity, sex differences, LDL particle size, HDL cholesterol, triglycerides, insulin, waist-to-hip ratio, femoral artery
MeSH terms
Adult, Age Factors, Cardiovascular Diseases, Cholesterol, Cross-Sectional Studies, Female, Femoral Artery, Humans, Hypopituitarism, Cholesterol, LDL, Male, Middle Aged, Obesity, Risk Factors, Sex, Sex Factors, Smoking, Growth Hormone, Ultrasonography, Body Mass Index, Multivariate Analysis, Case-Control Studies, Carotid Artery, Common, Tunica Intima, Statistics, Nonparametric

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review