The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.
Accuracy of recommended sampling and assay methods for the determination of plasma-free and urinary fractionated metanephrines in the diagnosis of pheochromocytoma and paraganglioma: a systematic review
Open accessAbstract
Purpose To determine the accuracy of biochemical tests for the diagnosis of pheochromocytoma and paraganglioma.Methods A search of the PubMed database was conducted for English-language articles published between October 1958 and December 2016 on the biochemical diagnosis of pheochromocytoma and paraganglioma using immunoassay methods or high-performance liquid chromatography with coulometric/electrochemical or tandem mass spectrometric detection for measurement of fractionated metanephrines in 24-h urine collections or plasma-free metanephrines obtained under seated or supine blood sampling conditions.Results Application of the Standards for Reporting of Diagnostic Studies Accuracy Group criteria yielded 23 suitable articles. Summary receiver operating characteristic analysis revealed sensitivities/specificities of 94/93% and 91/93% for measurement of plasma-free metanephrines and urinary fractionated metanephrines using high-performance liquid chromatography or immunoassay methods, respectively. Partial areas under the curve were 0.947 vs. 0.911. Irrespective of the analytical method, sensitivity was significantly higher for supine compared with seated sampling, 95 vs. 89% (p < 0.02), while specificity was significantly higher for supine sampling compared with 24-h urine, 95 vs. 90% (p < 0.03). Partial areas under the curve were 0.942, 0.913, and 0.932 for supine sampling, seated sampling, and urine. Test accuracy increased linearly from 90 to 93% for 24-h urine at prevalence rates of 0.0-1.0, decreased linearly from 94 to 89% for seated sampling and was constant at 95% for supine conditions.Conclusions Current tests for the biochemical diagnosis of pheochromocytoma and paraganglioma show excellent diagnostic accuracy. Supine sampling conditions and measurement of plasma-free metanephrines using high-performance liquid chromatography with coulometric/electrochemical or tandem mass spectrometric detection provides the highest accuracy at all prevalence rates.
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“Plasma free or 24-hour urine fractionated metanephrines are recommended as the screening test of choice for pheochromocytoma with a sensitivity of 90% to 95% (202, 203).”
From Adrenal incidentaloma (2020) · cites this paper as [202]
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Cites
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
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Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
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Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline
Lenders, J. W. M., Duh, Q.-Y., Eisenhofer, G., Gimenez-Roqueplo, A.-P., Grebe, S. K. G., Murad, M. H., Naruse, M., Pacak, K., & Young, W. F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1498 · Cited by 2,827
The Threshold Approach to Clinical Decision Making
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Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?
Lenders, J. W. M., Pacak, K., Walther, M. M., Linehan, W. M., Mannelli, M., Friberg, P., Keiser, H. R., Goldstein, D. S., & Eisenhofer, G. (2002) · JAMA · doi:10.1001/jama.287.11.1427 · Cited by 1,134
The STARD Statement for Reporting Studies of Diagnostic Accuracy: Explanation and Elaboration
Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., Moher, D., Rennie, D., de Vet, H. C. W., & Lijmer, J. G. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-1-200301070-00012-w1 · Cited by 1,124
A Survey on Adrenal Incidentaloma in Italy
Mantero, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.637 · Cited by 907
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Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781
OMURA, M., SAITO, J., YAMAGUCHI, K., KAKUTA, Y., & NISHIKAWA, T. (2004) · Hypertension Research · doi:10.1291/hypres.27.193 · Cited by 562
Research works printed but not linked: 2
- W.M. Manger, R.W. Gifford, Clinical and Experimental Pheochromocytoma, 2nd ed. (Blackwell Science, Cambridge, MA, 1996)
- P.M. Bossuyt, J.B. Reitsma, D.E. Bruns, C.A. Gatsonis, P.P. Glasziou, L.M. Irwig, D. Moher, D. Rennie, H.C. de Vet, J.G. Lijmer; Standards for Reporting of Diagnostic, A., The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin. Chem. 49(1), 7–18 (2003) · DOI · Paper page
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Lenders, J. W. M., Kerstens, M. N., Amar, L., Prejbisz, A., Robledo, M., Taïeb, D., Pacák, K., Crona, J., Zelinka, T., Mannelli, M., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002438 · Cited by 415
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347
“For 24-hour urine estimation, the use of acidified containers (to achieve urine pH <4) and storage in a cold place is recommended; measurement of creatinine is often used to ensure adequate collection (108,202,211).”
BackgroundMethodApproach to the Patient With Adrenal Incidentaloma
Bancos, I., & Prete, A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab512 · Cited by 201
Eisenhofer, G., Prejbisz, A., Peitzsch, M., Pamporaki, C., Masjkur, J., Rogowski-Lehmann, N., Langton, K., Tsourdi, E., Pęczkowska, M., Fliedner, S., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.291369 · Cited by 181
Self-citationGarcía‐Carbonero, R., Teresa, F. M., Mercader-Cidoncha, E., Mitjavila, M., Robledo, M., Tena, I., Álvarez-Escolá, C., Arístegui, M., Bella-Cueto, M. R., Albiach, C. F., et al. (2021) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02622-9 · Cited by 188
Metadata
- Authors
- Därr, R., Kuhn, M., Bode, C., Bornstein, S. R., Pacak, K., Lenders, J. W. M., & Eisenhofer, G.
- Affiliations
- University of Freiburg (DE)
- University Hospital Carl Gustav Carus (DE)
- Radboud University Medical Center (NL)
- Corresponding author
- Därr, Roland
- Venue
- Endocrine
- Published
- 2017-04-12
- Volume
- 56
- Issue
- 3
- Pages
- 495-503
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- PMC
- PMC6297899
- OpenAlex
- W2607207406
- Cited by
- 105
- References
- 60
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 2
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (DE) (DA 1630/2-1)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Oncology › Neuroblastoma Research and Treatments
- Keywords
- pheochromocytoma, paraganglioma, metanephrine, plasma free metanephrines, 24-hour urine collection, diagnostic accuracy, immunoassay, HPLC, tandem mass spectrometry, biochemical diagnosis
- MeSH terms
- Adrenal Gland Neoplasms, Chromatography, High Pressure Liquid, Humans, Metanephrine, Paraganglioma, Pheochromocytoma, Sensitivity and Specificity, Specimen Handling, Tandem Mass Spectrometry
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