Biochemical diagnosis of chromaffin cell tumors in patients at high and low risk of disease: plasma versus urinary free or deconjugated O-methylated catecholamine metabolites

Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline

Lenders, J. W. M., Duh, Q.-Y., Eisenhofer, G., Gimenez-Roqueplo, A.-P., Grebe, S. K. G., Murad, M. H., Naruse, M., Pacak, K., & Young, W. F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1498 · Cited by 2,827 · see citing works

Management of adrenal incidentalomas: European society of endocrinology clinical practice guideline in collaboration with the European network for the study of adrenal tumors

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Phaeochromocytoma

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Biochemical Diagnosis of Pheochromocytoma: Which Test Is Best?

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European Society of Endocrinology Clinical Practice Guideline for long-term follow-up of patients operated on for a phaeochromocytoma or a paraganglioma

Plouin, P., Amar, L., Dekkers, O. M., Faßnacht, M., Gimenez‐Roqueplo, A., Lenders, J. W. M., Lussey‐Lepoutre, C., Steichen, O., & _, _. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0033 · Cited by 475 · see citing works

Substantial Production of Dopamine in the Human Gastrointestinal Tract

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Plasma methoxytyramine: A novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status

Eisenhofer, G., Lenders, J. W. M., Siegert, G., Bornstein, S. R., Friberg, P., Milosevic, D., Mannelli, M., Linehan, W. M., Adams, K. T., Timmers, H. J. L. M., et al. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.07.016 · Cited by 375 · see citing works

Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma

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Laboratory Evaluation of Pheochromocytoma and Paraganglioma

Eisenhofer, G., & Peitzsch, M. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.224832 · Cited by 187 · see citing works

Understanding Catecholamine Metabolism as a Guide to the Biochemical Diagnosis of Pheochromocytoma

Eisenhofer, G., Huynh, T., Hiroi, M., & Pacák, K. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011572617314 · Cited by 182 · see citing works

Dietary Influences on Plasma and Urinary Metanephrines: Implications for Diagnosis of Catecholamine-Producing Tumors

de Jong, W. H. A., Eisenhofer, G., Post, W. J., Muskiet, F. A. J., de Vries, E. G. E., & Kema, I. P. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0303 · Cited by 150 · see citing works

Measurement of Plasma Free Metanephrine and Normetanephrine by Liquid Chromatography–Tandem Mass Spectrometry for Diagnosis of Pheochromocytoma

Lagerstedt, S. A., O’Kane, D. J., & Singh, R. J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.024703 · Cited by 127 · see citing works

Biochemical diagnosis of phaeochromocytoma using plasma‐free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions

Därr, R., Pamporaki, C., Peitzsch, M., Miehle, K., Prejbisz, A., Pęczkowska, M., Weismann, D., Beuschlein, F., Sinnott, R., Bornstein, S. R., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12327 · Cited by 122 · see citing works

Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatographytandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma

Peitzsch, M., Prejbisz, A., Kroiß, M., Beuschlein, F., Arlt, W., Januszewicz, A., Siegert, G., & Eisenhofer, G. (2013) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2012.012112 · Cited by 120 · see citing works

Comparison of Diagnostic Accuracy of Urinary Free Metanephrines, Vanillyl Mandelic Acid, and Catecholamines and Plasma Catecholamines for Diagnosis of Pheochromocytoma

Boyle, J. G., Davidson, D. F., Perry, C. G., & Connell, J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2668 · Cited by 120 · see citing works

Is Supine Rest Necessary before Blood Sampling for Plasma Metanephrines?

Lenders, J. W. M., Willemsen, J. J., Eisenhofer, G., Ross, H. A., Pacák, K., Timmers, H. J. L. M., & Sweep, F. C. G. J. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.076489 · Cited by 120 · see citing works

Plasma free metanephrines are superior to urine and plasma catecholamines and urine catecholamine metabolites for the investigation of phaeochromocytoma

Hickman, P. E., Leong, M., Chang, J., Wilson, S. R., & McWhinney, B. C. (2009) · Pathology · doi:10.1080/00313020802579284 · Cited by 109 · see citing works

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A systematic review of the literature examining the diagnostic efficacy of measurement of fractionated plasma free metanephrines in the biochemical diagnosis of pheochromocytoma

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Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma

Rao, D., Peitzsch, M., Prejbisz, A., Hanuš, K., Faßnacht, M., Beuschlein, F., Brugger, C., Fliedner, S. M. J., Langton, K., Pamporaki, C., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0077 · Cited by 104 · see citing works

Adrenal causes of hypertension: Pheochromocytoma and primary aldosteronism

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Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites

Peitzsch, M., Pelzel, D., Glöckner, S., Prejbisz, A., Faßnacht, M., Beuschlein, F., Januszewicz, A., Siegert, G., & Eisenhofer, G. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.12.031 · Cited by 99 · see citing works

Metabologenomics of Phaeochromocytoma and Paraganglioma: An Integrated Approach for Personalised Biochemical and Genetic Testing.

Eisenhofer, G., Klink, B., Richter, S., Lenders, J. W. M., & Robledo, M. (2017) · Europe PMC (PubMed Central) · Cited by 84 · see citing works

Simultaneous measurement of urinary metanephrines and catecholamines by liquid chromatography with tandem mass spectrometric detection

Whiting, M. J. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008180 · Cited by 76 · see citing works

Precision Medicine: An Update on Genotype/Biochemical Phenotype Relationships in Pheochromocytoma/Paraganglioma Patients

Gupta, G., & Pacák, K. (2017) · Endocrine Practice · doi:10.4158/ep161718.ra · Cited by 76 · see citing works

Measurements of plasma metanephrines by immunoassay vs liquid chromatography with tandem mass spectrometry for diagnosis of pheochromocytoma

Weismann, D., Peitzsch, M., Raida, A., Prejbisz, A., Gosk-Przybyłek, M., Riester, A., Willenberg, H. S., Klemm, R., Manz, G., Deutschbein, T., et al. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0730 · Cited by 64 · see citing works

An analysis of the biochemical diagnosis of 66 pheochromocytomas

d’Herbomez, M., Forzy, G., Bauters, C. C., Tierny-Fontalirand, C., Pigny, P., Carnaille, B. M. L., Pattou, F. N., Wémeau, J.-L., & Rouaix, N. (2007) · European Journal of Endocrinology · doi:10.1530/eje-06-0640 · Cited by 39 · see citing works

Pilot quality assurance programme for plasma metanephrines

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Diagnostic accuracy of plasma free metanephrines in a seated position compared with 24-hour urinary metanephrines in the investigation of pheochromocytoma

Kim, H. J., Lee, J. I., Cho, Y. Y., Lee, S., Kim, H. J., Jung, B. C., Kim, S. W., Chung, J. H., Min, Y., Lee, M., et al. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0384 · Cited by 34 · see citing works

Plasma‐free vs deconjugated metanephrines for diagnosis of phaeochromocytoma

Pamporaki, C., Därr, R., Bursztyn, M., Glöckner, S., Bornstein, S. R., Lenders, J. W. M., Pacák, K., Krinner, A., & Eisenhofer, G. (2013) · Clinical Endocrinology · doi:10.1111/cen.12191 · Cited by 19 · see citing works

An audit of management of patients with borderline increased plasma-free metanephrines

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Low specificity of urinary 3-methoxytyramine in screening of dopamine-secreting pheochromocytomas and paragangliomas

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The importance of standardisation of measurement and reference intervals for detection of phaeochromocytoma and paraganglioma (PPGL)

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The challenge of improving the diagnostic yield from metanephrine testing in suspected phaeochromocytoma and paraganglioma

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Urinary free metanephrines and suitability of available quality control material

Davison, A. S. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.018 · Cited by 4 · see citing works

Personalized Management of Pheochromocytoma and Paraganglioma

Nölting, S., Bechmann, N., Taïeb, D., Beuschlein, F., Faßnacht, M., Kroiß, M., Eisenhofer, G., Grossman, A. B., & Pacák, K. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab019 · Cited by 441 · see citing works

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Lenders, J. W. M., Kerstens, M. N., Amar, L., Prejbisz, A., Robledo, M., Taïeb, D., Pacák, K., Crona, J., Zelinka, T., Mannelli, M., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002438 · Cited by 415 · see citing works

Adrenal incidentaloma

Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works

Approach to the Patient With Adrenal Incidentaloma

Bancos, I., & Prete, A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab512 · Cited by 201 · see citing works

Current Management of Pheochromocytoma/Paraganglioma: A Guide for the Practicing Clinician in the Era of Precision Medicine

Nölting, S., Ullrich, M., Pietzsch, J., Ziegler, C. G., Eisenhofer, G., Grossman, A. B., & Pacák, K. (2019) · Cancers · doi:10.3390/cancers11101505 · Cited by 173 · see citing works

International consensus on initial screening and follow-up of asymptomatic SDHx mutation carriers

Amar, L., Pacák, K., Steichen, O., Akker, S. A., Aylwin, S. J. B., Baudin, É., Buffet, A., Burnichon, N., Clifton-Bligh, R. J., Dahia, P. L. M., et al. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00492-3 · Cited by 172 · see citing works

Pheochromocytoma

Farrugia, F., & Charalampopoulos, A. A. (2019) · Endocrine Regulations · doi:10.2478/enr-2019-0020 · Cited by 123 · see citing works

Pheochromocytoma and paraganglioma: clinical feature-based disease probability in relation to catecholamine biochemistry and reason for disease suspicion

Geroula, A., Deutschbein, T., Langton, K., Masjkur, J. R., Pamporaki, C., Peitzsch, M., Fliedner, S. M. J., Timmers, H. J. L. M., Bornstein, S. R., Beuschlein, F., et al. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0159 · Cited by 113 · see citing works

Biochemical Assessment of Pheochromocytoma and Paraganglioma

Eisenhofer, G., Pamporaki, C., & Lenders, J. W. M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad011 · Cited by 118 · see citing works

Management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants: an international expert Consensus statement

Taïeb, D., Nölting, S., Perrier, N. D., Faßnacht, M., Carrasquillo, J. A., Grossman, A. B., Clifton-Bligh, R. J., Wanna, G. B., Schwam, Z. G., Amar, L., et al. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00926-0 · Cited by 112 · see citing works

Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants

Taïeb, D., Wanna, G. B., Ahmad, M. F., Lussey‐Lepoutre, C., Perrier, N. D., Nölting, S., Amar, L., Timmers, H. J. L. M., Schwam, Z. G., Estrera, A. L., et al. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00038-4 · Cited by 96 · see citing works

Imaging of Pheochromocytomas and Paragangliomas

Timmers, H., Taïeb, D., Pacak, K., & Lenders, J. (2024) · Endocrine reviews · doi:10.1210/endrev/bnae001 · Cited by 67 · see citing works

Pheochromocytoma: An approach to diagnosis

Sbardella, E., & Grossman, A. B. (2019) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2019.101346 · Cited by 103 · see citing works

Reference intervals for LC-MS/MS measurements of plasma free, urinary free and urinary acid-hydrolyzed deconjugated normetanephrine, metanephrine and methoxytyramine

Eisenhofer, G., Peitzsch, M., Kaden, D., Langton, K., Mangelis, A., Pamporaki, C., Masjkur, J. R., Geroula, A., Kurlbaum, M., Deutschbein, T., et al. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.12.019 · Cited by 75 · see citing works

Silent pheochromocytoma and paraganglioma: Systematic review and proposed definitions for standardized terminology

Constantinescu, G. A., Preda, C., Constantinescu, V., Siepmann, T., Bornstein, S. R., Lenders, J. W. M., Eisenhofer, G., & Pamporaki, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1021420 · Cited by 77 · see citing works

Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma

Berends, A. M. A., Eisenhofer, G., Fishbein, L. M., van der Horst‐Schrivers, A. N. A., Kema, I. P., Links, T. P., Lenders, J. W. M., & Kerstens, M. N. (2019) · Cancers · doi:10.3390/cancers11081121 · Cited by 63 · see citing works

Pheochromocytoma/paraganglioma: recent updates in genetics, biochemistry, immunohistochemistry, metabolomics, imaging and therapeutic options

Antonio, K. L., Valdez, M. M. N., MERCADO-ASIS, L. B., Taïeb, D., & Pacák, K. (2020) · Gland Surgery · doi:10.21037/gs.2019.10.25 · Cited by 65 · see citing works

HIF2α supports pro-metastatic behavior in pheochromocytomas/paragangliomas

Bechmann, N., Moskopp, M. L., Ullrich, M., Calsina, B., Wallace, P. W., Richter, S., Friedemann, M., Langton, K., Fliedner, S. M. J., Timmers, H. J. L. M., et al. (2020) · Endocrine Related Cancer · doi:10.1530/erc-20-0205 · Cited by 61 · see citing works

Pheochromocytoma and Pregnancy

Lenders, J. W. M., Langton, K., Langenhuijsen, J. F., & Eisenhofer, G. (2019) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2019.05.006 · Cited by 60 · see citing works

Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma

Eisenhofer, G., Deutschbein, T., Constantinescu, G. A., Langton, K., Pamporaki, C., Calsina, B., Monteagudo, M., Peitzsch, M., Fliedner, S. M. J., Timmers, H. J. L. M., et al. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0904 · Cited by 59 · see citing works

Catecholamine-induced hypertensive crises: current insights and management

Nazari, M. A., HASAN, M. R., Haigney, M. C., Maghsoudi, A., Lenders, J. W. M., Carey, R. M., & Pacák, K. (2023) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(23)00256-5 · Cited by 55 · see citing works

Guidelines for surveillance of patients with von Hippel‐Lindau disease: Consensus statement of the International VHL Surveillance Guidelines Consortium and VHL Alliance

Daniels, A. B., Tirosh, A., Huntoon, K. M., Mehta, G. U., Spiess, P. E., Friedman, D. L., Waguespack, S. G., Kilkelly, J. E., Rednam, S. P., Pruthi, S., et al. (2023) · Cancer · doi:10.1002/cncr.34896 · Cited by 52 · see citing works

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

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Plasma Steroid Profiling in Patients With Adrenal Incidentaloma

Berke, K., Constantinescu, G. A., Masjkur, J. R., Kimpel, O., Dischinger, U., Peitzsch, M., Kwapiszewska, A., Dobrowolski, P., Nölting, S., Reincke, M., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab751 · Cited by 52 · see citing works

Perioperative Management of Pheochromocytomas and Sympathetic Paragangliomas

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Determinants of disease-specific survival in patients with and without metastatic pheochromocytoma and paraganglioma

Pamporaki, C., Prodanov, T., Meuter, L., Berends, A. M. A., Bechmann, N., Constantinescu, G. A., Beuschlein, F., Remde, H., Januszewicz, A., Kerstens, M. N., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.03.032 · Cited by 47 · see citing works

Diagnosis and Management of Pheochromocytomas and Paragangliomas: A Guide for the Clinician

Sharma, S., & Fishbein, L. M. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.07.027 · Cited by 47 · see citing works

Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine

Richter, S., Qiu, B., Ghering, M., Kunath, C., Constantinescu, G. A., Luths, C., Pamporaki, C., Bechmann, N., Meuter, L., Kwapiszewska, A., et al. (2022) · Endocrine Related Cancer · doi:10.1530/erc-21-0359 · Cited by 44 · see citing works

Biochemical Diagnosis of Catecholamine-Producing Tumors of Childhood: Neuroblastoma, Pheochromocytoma and Paraganglioma

Eisenhofer, G., Peitzsch, M., Bechmann, N., & Huebner, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.901760 · Cited by 45 · see citing works

MEN2-related pheochromocytoma: current state of knowledge, specific characteristics in MEN2B, and perspectives

Amodru, V., Taïeb, D., Guérin, C., Romanet, P., Paladino, N. C., Brue, T. C., Cuny, T., Barlier, A., Sebag, F. A., & Castinetti, F. (2020) · Endocrine · doi:10.1007/s12020-020-02332-2 · Cited by 43 · see citing works

New Biology of Pheochromocytoma and Paraganglioma

Pacák, K. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.09.003 · Cited by 44 · see citing works

Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy

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Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine

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The Role of 68Ga-DOTA-Octreotate PET/CT in Follow-Up of SDH-Associated Pheochromocytoma and Paraganglioma

Kong, G., Schenberg, T., Yates, C. J., Trainer, A. H., Sachithanandan, N., Iravani, A., Kumar, A. S. R., Hofman, M. S., Akhurst, T. J., Michael, M., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00018 · Cited by 36 · see citing works

A high rate of modestly elevated plasma normetanephrine in a population referred for suspected PPGL when measured in a seated position

Boyd, J. M., Leung, A. A. C., Sadrzadeh, H. S. M., Pamporaki, C., Pacák, K., Deutschbein, T., Fliedner, S. M. J., & Kline, G. A. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0176 · Cited by 35 · see citing works

Diagnostic Accuracy of Computed Tomography to Exclude Pheochromocytoma: A Systematic Review, Meta-analysis, and Cost Analysis

Buitenwerf, E., Berends, A. M. A., van Asselt, A. D. I., Korteweg, T., Greuter, M. J. W., Veeger, N. J. G. M., Links, T. P., Dullaart, R. P. F., & Kerstens, M. N. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.03.030 · Cited by 34 · see citing works

Ganglioneuromas across age groups: Systematic review of individual patient data

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Harmonization of LC-MS/MS Measurements of Plasma Free Normetanephrine, Metanephrine, and 3-Methoxytyramine

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Screening in adrenal tumors

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