Microparticles as a source of extracellular DNA
Open accessAbstract
Microparticles are small membrane-bound vesicles that display pro-inflammatory and pro-thrombotic activities important in the pathogenesis of a wide variety of diseases. These particles are released from activated and dying cells and incorporate nuclear and cytoplasmic molecules for extracellular export. Of these molecules, DNA is a central autoantigen in systemic lupus erythematosus (SLE). As studies in our laboratory show, DNA occurs prominently in microparticles, translocating into these structures during apoptotic cell death. This DNA is antigenically active and can bind to lupus anti-DNA autoantibodies. These findings suggest that microparticles are an important source of extracellular DNA to serve as an autoantigen and autoadjuvant in SLE.
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Detection of mitochondrial motives by innate and adaptive immunity might elicit potent pro-inflammatory responses.
“Given the bacterial features of mitochondria, the detection of mitochondrial motives by cells of the innate and adaptive immunity might elicit potent pro-inflammatory responses147,276,277.”
From The role of mitochondria in rheumatic diseases (2022) · cites this paper as [276]
The Introduction discusses immune responses to bacterial CpG motifs and to DNA-containing immune complexes, but it does not address mitochondrial motifs or their detection by innate and adaptive immune cells. Searches for mitochondrial DNA, mitochondria, and mitochondrial motifs found no passage supporting the attributed claim. The available passages have no page numbers. (LLM, conf=0.75)
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The Role of Microparticles as Biomarkers in the Development of Therapy for Autoimmune Disease
Pisetsky, D. S. (2017) · Springer eBooks · doi:10.1007/978-3-319-42252-7_3
Self-citationDemicheli, R. (2017) · Springer eBooks · doi:10.1007/978-3-319-57943-6_10
Yasasever, C. T., Duranyıldız, D., Bademler, S., & Oğuz, H. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb47010019
Lupus nephritis : the role of renal DNase I in the progression of the disease
Seredkina, N. (2011)
Lei, Z. (2026) · Cytometry Part B Clinical Cytometry · doi:10.1002/cytob.70011
DNASE1L3 maintains homeostatic levels of mitochondrial DNA on the mammalian cell surface
Porat, J., Sun, Y., Poli, V., Petkov, S., Almahayni, K., Crompton, A., George, B. M., Vitorino, F. N. D. L., Yi, L., Costa, C. B., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.09.012 · Cited by 1 · see citing works
- Authors
- Pisetsky, D. S., Gauley, J., & Ullal, A. J.
- Affiliations
- Durham VA Medical Center (US)
- Duke Medical Center (US)
- Corresponding author
- Pisetsky, David S.
- Venue
- Immunologic Research
- Published
- 2010-12-04
- Volume
- 49
- Issue
- 1-3
- Pages
- 227-234
- ISSN
- 0257-277X (ISSN-L)
- 1559-0755
- PMC
- PMC3724471
- OpenAlex
- W2037870966
- Cited by
- 80
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 5 · 2013: 8 · 2012: 8
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Immunologic Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI083923, R21AI082402, R21AI083923, AI082402)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- microparticles, extracellular DNA, systemic lupus erythematosus, autoantigens, apoptosis, membrane vesicles, autoimmunity
- MeSH terms
- Antibodies, Antinuclear, Autoantibodies, Autoantigens, Cell Line, DNA, Extracellular Space, Humans, Lupus Erythematosus, Systemic, Cytokines, Apoptosis, Toll-Like Receptors, Cell-Derived Microparticles
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