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Follistatin-like protein 1 and its role in inflammation and inflammatory diseases.

Chaly, Yury, Hostager, Bruce, Smith, Sonja, Hirsch, Raphael·2014·Immunologic Research
DOI 10.1007/s12026-014-8526-z
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Abstract

Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein produced mainly by cells of mesenchymal origin. FSTL1 has been shown to play an important role during embryogenesis; FSTL1-deficient mice die at birth from multiple developmental abnormalities. In the last decade, FSTL1 has been identified as a novel inflammatory protein, enhancing synthesis of proinflammatory cytokines and chemokines by immune cells in vitro and in vivo. FSTL1 mediates proinflammatory events in animal models of inflammatory diseases, particularly in collagen-induced arthritis in mice. FSTL1 is elevated in various inflammatory conditions and decreased during the course of treatment. FSTL1 may therefore be a valuable biomarker for such diseases. Moreover, a variety of experiments suggest that targeting of FSTL1 may be useful in the treatment of diseases in which inflammation plays a central role.

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Metadata

Authors
Chaly, Y., Hostager, B., Smith, S., & Hirsch, R.
Venue
Immunologic Research
Publisher
Springer Science and Business Media LLC
Published
2014-05-17
Volume
59
Issue
1-3
Pages
266-272
ISSN
  • 0257-277X
  • 1559-0755
DOI
10.1007/s12026-014-8526-z
Cited by
105
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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