Cited by 63Exercise and Physiological ResponsesCardiovascular and exercise physiologyAngiogenesis and VEGF in Cancer

The role of exercise-induced myokines in promoting angiogenesis

Open access
Qi, Chao, Song, Xianjing, Wang, He, Yan, Youyou, Liu, Bin·2022·Frontiers in Physiology

Abstract

Ischemic diseases are a major cause of mortality or disability in the clinic. Surgical or medical treatment often has poor effect on patients with tissue and organ ischemia caused by diffuse stenoses. Promoting angiogenesis is undoubtedly an effective method to improve perfusion in ischemic tissues and organs. Although many animal or clinical studies tried to use stem cell transplantation, gene therapy, or cytokines to promote angiogenesis, these methods could not be widely applied in the clinic due to their inconsistent experimental results. However, exercise rehabilitation has been written into many authoritative guidelines in the treatment of ischemic diseases. The function of exercise in promoting angiogenesis relies on the regulation of blood glucose and lipids, as well as cytokines that secreted by skeletal muscle, which are termed as myokines, during exercise. Myokines, such as interleukin-6 (IL-6), chemokine ligand (CXCL) family proteins, irisin, follistatin-like protein 1 (FSTL1), and insulin-like growth factor-1 (IGF-1), have been found to be closely related to the expression and function of angiogenesis-related factors and angiogenesis in both animal and clinical experiments, suggesting that myokines may become a new molecular target to promote angiogenesis and treat ischemic diseases. The aim of this review is to show current research progress regarding the mechanism how exercise and exercise-induced myokines promote angiogenesis. In addition, the limitation and prospect of researches on the roles of exercise-induced myokines in angiogenesis are also discussed. We hope this review could provide theoretical basis for the future mechanism studies and the development of new strategies for treating ischemic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphys.2022.981577

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Under pathological conditions such as atherosclerosis, IL-6 trans-signaling mediated by soluble IL-6 receptors predominates, promoting vascular inflammation, monocyte recruitment, and plaque instability.

    “Under pathological conditions like atherosclerosis, the “trans-signaling” pathway mediated by soluble IL-6 receptors predominates, promoting vascular inflammation, monocyte recruitment, and plaque instability [14,36].”

    From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [36]

    Section 4.2 describes IL-6 as proinflammatory and discusses its roles in angiogenesis and metabolism, but does not address IL-6 trans-signaling in atherosclerosis. Searches for soluble IL-6 receptors, monocyte recruitment, and plaque instability found no passage supporting the specific pathway or its claimed effects. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Qi, C., Song, X., Wang, H., Yan, Y., & Liu, B.
Affiliations
Jilin University (CN)
Corresponding author
Liu, Bin
Venue
Frontiers in Physiology
Published
2022-08-26
Volume
13
Pages
981577-981577
ISSN
1664-042X (ISSN-L)
OpenAlex
W4293200098
Cited by
63
References
95
Citations by year
2026: 21 · 2025: 20 · 2024: 15 · 2023: 7
FWCI
1.25
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
People's Government of Jilin Province
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
angiogenesis, ischemic diseases, skeletal muscle, interleukin-6, CXCL chemokines, irisin, follistatin-like protein 1, insulin-like growth factor I, exercise rehabilitation, tissue perfusion, molecular targets

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review