Follistatin like 1 regulates hypertrophy in heart failure with preserved ejection fraction
Open accessAbstract
Heart failure with preserved ejection fraction (HFpEF) accounts for ∼50% of all clinical presentations of heart failure, (HF) and its prevalence is expected to increase. However, there are no evidence-based therapies for HFpEF; thus, HFpEF represents a major unmet need. Although hypertension is the single most important risk factor for HFpEF, with a prevalence of 60% to 89% from clinical trials and human HF registries, blood pressure therapy alone is insufficient to prevent and treat HFpEF. Follistatin-like 1 (Fstl1), a divergent member of the follistatin family of extracellular glycoproteins, has previously been shown to be elevated in HF with reduced ejection fraction and associated with increased left ventricular mass. In this study, blood levels of Fstl1 were increased in humans with HFpEF. This increase was also evident in mice with hypertension-induced HFpEF and adult rat ventricular myocytes stimulated with aldosterone. Treatment with recombinant Fstl1 abrogated aldosterone-induced cardiac myocyte hypertrophy, suggesting a role for Fstl1 in the regulation of hypertrophy in HFpEF. There was also a reduction in the E/A ratio, a measure of diastolic dysfunction. Furthermore, HFpEF induced in a mouse model that specifically ablates Fstl1 in cardiac myocytes (cardiac myocyte-specific Fstl1 knockout [cFstl1-KO]) showed exacerbation of HFpEF with worsened diastolic dysfunction. In addition, cFstl1-KO-HFpEF mice demonstrated more marked cardiac myocyte hypertrophy with increased molecular markers of atrial natriuretic peptide and brain natriuretic peptide expression. These findings indicate that Fstl1 exerts therapeutic effects by modulating cardiac hypertrophy in HFpEF.
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High concentrations of FSTL1 are seen in patients with systolic and diastolic heart failure.
“high concentrations of FSTL1 are seen in patients with systolic and diastolic heart failure (196, 197)”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [197]
Circulating levels of FSTL1 may work as a biomarker.
“Circulating levels of FSTL1 may work as a biomarker as high concentrations of FSTL1 are seen in patients with systolic and diastolic heart failure (196, 197), and as FSTL1 levels exhibit prognostic significance in the acute coronary syndrome (198).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [197]
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1 retracted
Aldosterone Directly Induces Myocyte Apoptosis Through Calcineurin-Dependent Pathways
Mano, A., Tatsumi, T., Shiraishi, J., Keira, N., Nomura, T., Takeda, M., Nishikawa, S., Yamanaka, S., Matoba, S., Kobara, M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000135599.33787.ca · Cited by 93 · see citing works
Retracted2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536 · see citing works
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110 · see citing works
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879 · see citing works
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226 · see citing works
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works
Regulation of cardiac hypertrophy by intracellular signalling pathways
Heineke, J., & Molkentin, J. D. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1983 · Cited by 1,856 · see citing works
Mohammed, S. F., Hussain, S., Mirzoyev, S. A., Edwards, W. D., Maleszewski, J. J., & Redfield, M. M. (2015) · Circulation · doi:10.1161/circulationaha.114.009625 · Cited by 874 · see citing works
Frey, N., Katus, H. A., Olson, E. N., & Hill, J. A. (2004) · Circulation · doi:10.1161/01.cir.0000120390.68287.bb · Cited by 845 · see citing works
The Progression of Hypertensive Heart Disease
Drazner, M. H. (2011) · Circulation · doi:10.1161/circulationaha.108.845792 · Cited by 844 · see citing works
Trends in Patients Hospitalized With Heart Failure and Preserved Left Ventricular Ejection Fraction
Steinberg, B. A., Zhao, X., Heidenreich, P. A., Peterson, E. D., Bhatt, D. L., Cannon, C. P., Hernandez, A. F., & Fonarow, G. C. (2012) · Circulation · doi:10.1161/circulationaha.111.080770 · Cited by 776 · see citing works
Pathological Ventricular Remodeling
Burchfield, J. S., Xie, M., & Hill, J. A. (2013) · Circulation · doi:10.1161/circulationaha.113.001878 · Cited by 769 · see citing works
Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure
van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J. (2006) · Circulation · doi:10.1161/circulationaha.105.587519 · Cited by 655 · see citing works
Westermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931451 · Cited by 644 · see citing works
Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
Mentz, R. J., Kelly, J. P., von Lueder, T. G., Voors, A. A., Lam, C. S. P., Cowie, M. R., Kjeldsen, K., Jankowska, E. A., Atar, D., Butler, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.036 · Cited by 546 · see citing works
Zile, M. R., Gottdiener, J. S., Hetzel, S. J., McMurray, J. J., Komajda, M., McKelvie, R., Baicu, C. F., Massie, B. M., & Carson, P. E. (2011) · Circulation · doi:10.1161/circulationaha.110.011031 · Cited by 517 · see citing works
Myocardial Production of Aldosterone and Corticosterone in the Rat
Silvestre, J., Robert, V., Heymes, C., Aupetit, B., Mouas, C., Moalic, J., Bernard Swynghedauw, A., & Delcayre, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.4883 · Cited by 446 · see citing works
Tackling heart failure in the twenty-first century
Mudd, J. O., & Kass, D. A. (2008) · Nature · doi:10.1038/nature06798 · Cited by 404 · see citing works
Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338 · see citing works
Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart
Oshima, Y., Ouchi, N., Sato, K., Izumiya, Y., Pimentel, D. R., & Walsh, K. (2008) · Circulation · doi:10.1161/circulationaha.108.767673 · Cited by 275 · see citing works
CMR-Verified Diffuse Myocardial Fibrosis Is Associated With Diastolic Dysfunction in HFpEF
Su, M.-Y. M., Lin, L., Tseng, Y., Chang, C., Wu, C., Lin, J.-L., & Tseng, W. I. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.04.022 · Cited by 230 · see citing works
Zile, M. R., DeSantis, S. M., Baicu, C. F., Stroud, R. E., Thompson, S. B., McClure, C. D., Mehurg, S. M., & Spinale, F. G. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958199 · Cited by 216 · see citing works
Beneficial neurohormonal profile of spironolactone in severe congestive heart failure
Rousseau, M. F., Gurné, O., Duprez, D. A., Mieghem, W. V., Robert, A. R., Ahn, S. A., Galanti, L. M., & Ketelslegers, J.-M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02382-3 · Cited by 202 · see citing works
Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models
Ogura, Y., Ouchi, N., Ohashi, K., Shibata, R., Kataoka, Y., Kambara, T., Kito, T., Maruyama, S., Yuasa, D., Matsuo, K., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.115089 · Cited by 183 · see citing works
Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice
Dong, Y., Geng, Y., Li, L., Li, X., Yan, X., Fang, Y., Li, X., Dong, S., Liu, X., Li, X., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20121878 · Cited by 158 · see citing works
Myocardial hypertrophy and its role in heart failure with preserved ejection fraction
Heinzel, F. R., Hohendanner, F., Jin, G., Sedej, S., & Edelmann, F. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00374.2015 · Cited by 153 · see citing works
Rude, M. K., Duhaney, T.-A. S., Kuster, G. M., Judge, S., Heo, J., Colucci, W. S., Siwik, D. A., & Sam, F. (2005) · Hypertension · doi:10.1161/01.hyp.0000176236.55322.18 · Cited by 147 · see citing works
Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload
Shimano, M., Ouchi, N., Nakamura, K., van Wijk, B., Ohashi, K., Asaumi, Y., Higuchi, A., Pimentel, D. R., Sam, F., Murohara, T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108559108 · Cited by 133 · see citing works
Follistatin-Like Protein-1 Is a Novel Proinflammatory Molecule
Miyamae, T., Marinov, A. D., Sowders, D. P., Wilson, D. C., Devlin, J. E., Boudreau, R. M., Robbins, P. D., & Hirsch, R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4758 · Cited by 132 · see citing works
Follistatin-like protein 1 and its role in inflammation and inflammatory diseases
Chaly, Y., Hostager, B. S., Smith, S. M., & Hirsch, R. (2014) · Immunologic Research · doi:10.1007/s12026-014-8526-z · Cited by 113 · see citing works
Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling
Essick, E. E., Ouchi, N., Wilson, R. M., Ohashi, K., Ghobrial, J. M., Shibata, R., Pimentel, D. R., & Sam, F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00428.2011 · Cited by 110 · see citing works
Developmental changes in left and right ventricular diastolic filling patterns in mice
Zhou, Y., Foster, F. S., Parkes, R., & Adamson, S. L. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00384.2003 · Cited by 105 · see citing works
Signalling Pathways for Cardiac Hypertrophy
Yamazaki, T., Komuro, I., & Yazaki, Y. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00036-9 · Cited by 96 · see citing works
Kawabata, D., Tanaka, M., Fujii, T., Umehara, H., Fujita, Y., Yoshifuji, H., Mimori, T., & Ozaki, S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20023 · Cited by 95 · see citing works
Shibata, R., Sato, K., Kumada, M., Izumiya, Y., Sonoda, M., Kihara, S., Ouchi, N., & Walsh, K. X. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.010 · Cited by 92 · see citing works
Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure
Sam, F., Duhaney, T.-A. S., Sato, K., Wilson, R. M., Ohashi, K., Sono-Romanelli, S., Higuchi, A., Silva, D. S. D., Qin, F., Walsh, K., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0806 · Cited by 90 · see citing works
Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury
Miyabe, M., Ohashi, K., Shibata, R., Uemura, Y., Ogura, Y., Yuasa, D., Kambara, T., Kataoka, Y., Yamamoto, T., Matsuo, K., et al. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu105 · Cited by 86 · see citing works
Adiponectin Modulates Oxidative Stress-Induced Autophagy in Cardiomyocytes
Essick, E. E., Wilson, R. M., Pimentel, D. R., Shimano, M., Baid, S., Ouchi, N., & Sam, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068697 · Cited by 84 · see citing works
Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity
Fan, N., Sun, H., Wang, Y., Wang, Y., Zhang, L., Xia, Z., Peng, L., Hou, Y., Shen, W., Liu, R., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/752519 · Cited by 79 · see citing works
Widera, C., Horn-Wichmann, R., Kempf, T., Bethmann, K., Fiedler, B., Sharma, S. K., Lichtinghagen, R., Leitolf, H., Ivandic, B., Katus, H. A., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.129411 · Cited by 77 · see citing works
Follistatin-Like 1 in Chronic Systolic Heart Failure: A Marker of Left Ventricular Remodeling
El-Armouche, A., Ouchi, N., Tanaka, K., Doros, G., Wittköpper, K., Schulze, T., Eschenhagen, T., Walsh, K., & Sam, F. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.960625 · Cited by 76 · see citing works
Sumitomo, K., Kurisaki, A., Yamakawa, N., Tsuchida, K., Shimizu, E., Sone, S., & Sugino, H. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00407-9 · Cited by 74 · see citing works
Zile, M. R., & Baicu, C. F. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9472-1 · Cited by 71 · see citing works
Takemura, G., Fujiwara, H., Mukoyama, M., Saito, Y., Nakao, K., Kawamura, A., Ishida, M., Kida, M., Uegaito, T., & Tanaka, M. (1991) · Circulation · doi:10.1161/01.cir.83.1.181 · Cited by 71 · see citing works
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure
Garcia, A. G., Wilson, R. M., Heo, J., Murthy, N. R., Baid, S., Ouchi, N., & Sam, F. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00298.2012 · Cited by 70 · see citing works
Characterization of a Rat C6 Glioma‐Secreted Follistatin‐Related Protein (FRP)
Zwijsen, A., Blockx, H., Arnhem, W. V., Willems, J., Fransen, L., Devos, K., Raymackers, J., VOORDE, A. V. D., & Slegers, H. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.0937b.x · Cited by 68 · see citing works
Tanaka, K., Wilson, R. M., Essick, E. E., Duffen, J., Scherer, P. E., Ouchi, N., & Sam, F. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001279 · Cited by 67 · see citing works
Inflammation in HFpEF: Key or circumstantial?
van Empel, V. P. M., & Rocca, H. B. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.110 · Cited by 62 · see citing works
Heart Failure with Preserved Ejection Fraction: Current Understandings and Challenges
Andersen, M. J., & Borlaug, B. A. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0501-8 · Cited by 59 · see citing works
Cardiac Myocyte-Derived Follistatin-Like 1 Prevents Renal Injury in a Subtotal Nephrectomy Model
Hayakawa, S., Ohashi, K., Shibata, R., Kataoka, Y., Miyabe, M., Enomoto, T., Joki, Y., Shimizu, Y., Kambara, T., Uemura, Y., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014020210 · Cited by 54 · see citing works
Phan, T. T., Shivu, G. N., Abozguia, K., Sanderson, J. E., & Frenneaux, M. P. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.06.113 · Cited by 50 · see citing works
Wilson, R. M., Silva, D. S. D., Sato, K., Izumiya, Y., & Sam, F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134932 · Cited by 45 · see citing works
Kiatchoosakun, S., Restivo, J., Kirkpatrick, D. L., & Hoit, B. D. (2002) · Echocardiography · doi:10.1046/j.1540-8175.2002.00199.x · Cited by 37 · see citing works
Silva, D. S. D., Wilson, R. M., Hutchinson, C. T., Ip, P. C., Garcia, A. G., Lancel, S., Ito, M., Pimentel, D. R., & Sam, F. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00002.2009 · Cited by 35 · see citing works
Barron, A., Hughes, A. D., Sharp, A. S. P., Baksi, A. J., Surendran, P., Jabbour, R. J., Stanton, A. V., Poulter, N. R., Fitzgerald, D., Sever, P., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01360 · Cited by 32 · see citing works
Pentraxin 3—a marker of diastolic dysfunction and HF?
Kaess, B. M., & Vasan, R. S. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.50 · Cited by 23 · see citing works
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Muscle–Organ Crosstalk: The Emerging Roles of Myokines
Severinsen, M. C. K., & Pedersen, B. K. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa016 · Cited by 1,226 · see citing works
“Circulating levels of FSTL1 may work as a biomarker as high concentrations of FSTL1 are seen in patients with systolic and diastolic heart failure (196, 197), and as FSTL1 levels exhibit prognostic significance in the acute coronary syndrome (198).”
BackgroundRecinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261 · see citing works
Silva, A. C., Pereira, C., Fonseca, A. C. R. G., Pinto‐do‐Ó, P., & Nascimento, D. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.621644 · Cited by 220 · see citing works
Murine Models of Heart Failure With Preserved Ejection Fraction
Valero‐Muñoz, M., Backman, W., & Sam, F. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.013 · Cited by 207 · see citing works
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Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 190 · see citing works
Follistatin-like 1 in development and human diseases
Mattiotti, A., Prakash, S., Barnett, P., & van den Hoff, M. J. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2805-0 · Cited by 174 · see citing works
Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO
Segers, V. F. M., Brutsaert, D. L., & Keulenaer, G. W. D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00382 · Cited by 154 · see citing works
Withaar, C., Lam, C. S. P., Schiattarella, G. G., de Boer, R. A., & Meems, L. M. G. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab389 · Cited by 150 · see citing works
Decoding the Liver-Heart Axis in Cardiometabolic Diseases
Capone, F., Vacca, A., Bidault, G., Sarver, D. C., Kamińska, D., Strocchi, S., Vidal‐Puig, A., Greco, C. M., Lusis, A. J., & Schiattarella, G. G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325492 · Cited by 72 · see citing works
Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions
Senesi, P., Luzi, L., & Terruzzi, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218372 · Cited by 62 · see citing works
Seki, M., Powers, J. C., Maruyama, S., Zuriaga, M. A., Wu, C.-L., Kurishima, C., Kim, L., Johnson, J., Poidomani, A., Wang, T., et al. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004486 · Cited by 59 · see citing works
Guo, S., Feng, Y., Zhu, X., Zhang, X., Wang, H., Wang, R., Zhang, Q., Li, Y., Ren, Y., Gao, X., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41832-3 · Cited by 51 · see citing works
Koentges, C., Pepin, M. E., Muesse, C., Pfeil, K., Alvarez, S. V. V., Hoppe, N., Hoffmann, M. M., Odening, K. E., Sossalla, S. T., Zirlik, A., et al. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0666-6 · Cited by 44 · see citing works
The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?
Wu, Y., Zhu, B., Luo, A., Yang, L., & Yang, C. (2018) · BioMed Research International · doi:10.1155/2018/8207058 · Cited by 40 · see citing works
Follistatin-Like Proteins: Structure, Functions and Biomedical Importance
Parfenova, O. K., Kukes, V. G., & Grishin, D. V. (2021) · Biomedicines · doi:10.3390/biomedicines9080999 · Cited by 40 · see citing works
Smith, A., Altara, R., Amin, G., Habeichi, N. J., Thomas, D. G., Jun, S., Kaplan, A., Booz, G. W., & Zouein, F. A. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026071 · Cited by 37 · see citing works
Yang, H., Kong, B., Shuai, W., Zhang, J., & Huang, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15579 · Cited by 35 · see citing works
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Prakash, S., Jiménez‐Borreguero, L. J., Sylva, M., Ruiz, L. F., Rezai, F., Gunst, Q. D., de la Pompa, J. L., Ruijter, J. M., & van den Hoff, M. J. B. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309089 · Cited by 31 · see citing works
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Follistatin-like 1 in Cardiovascular Disease and Inflammation
Peters, M. M. C., Meijs, T. A., Gathier, W., Doevendans, P. A., Sluijter, J. P. G., Chamuleau, S. A. J., & Neef, K. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190312161551 · Cited by 26 · see citing works
Salman, O., Zamani, P. L., Zhao, L., Dib, M., Gan, S., Azzo, J. D., Pourmussa, B., Richards, M., Javaheri, A., Mann, D. L., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033675 · Cited by 24 · see citing works
Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2
Zhao, Y., Sun, J., Zhang, W., Peng, M., Chen, J., Zheng, L., Zhang, X., Yang, H., & Liu, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3598715 · Cited by 24 · see citing works
Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
Valero‐Muñoz, M., Saw, E. L., Hekman, R. M., Blum, B. C., Hourani, Z., Granzier, H. L. M., Emili, A., & Sam, F. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.966968 · Cited by 24 · see citing works
Yang, Y., Mu, T., Li, T., Xie, S., Zhou, J., Liu, M., & Li, D. (2017) · Thoracic Cancer · doi:10.1111/1759-7714.12491 · Cited by 23 · see citing works
Fleischer, S., Nash, T. R., Tamargo, M. A., Lock, R. I., Venturini, G., Morsink, M. A. J., Graney, P. L., Li, V., Lamberti, M. J., Liberman, M., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00525-w · Cited by 17 · see citing works
Shuai, W., Kong, B., Yang, H., Fu, H. Q., & Huang, H. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12620 · Cited by 16 · see citing works
Abubakar, M., Irfan, U., Abdelkhalek, A., Javed, I., Khokhar, M. I., Shakil, F., Raza, S., Salim, S. S., Altaf, M. M., Habib, R., et al. (2024) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10540-8 · Cited by 15 · see citing works
Nawrocka‐Millward, S., Biegus, J., Hurkacz, M., Guzik, M., Rosiek‐Biegus, M., Jankowska, E. A., Ponikowski, P. P., & Zymliński, R. (2021) · Biomolecules · doi:10.3390/biom11111701 · Cited by 15 · see citing works
Hindmarch, C. C. T., Tian, L., Xiong, P. Y., Potus, F., Bentley, R. E. T., Al‐Qazazi, R., Prins, K. W., & Archer, S. L. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.966454 · Cited by 13 · see citing works
Circulating Myokines as Novel Biomarkers for Cardiovascular Diseases
Lyu, J.-X., Guo, D., Song, Y.-C., Zhang, M.-R., Ge, F.-Q., Zhao, J., Zhu, H., & Hang, P. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2502056 · Cited by 13 · see citing works
From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk
Romero-Becerra, R., Santamans, A. M., Arcones, A. C., & Sabio, G. (2023) · Physiology · doi:10.1152/physiol.00018.2023 · Cited by 12 · see citing works
The role of urine chloride in acute heart failure
Nawrocka‐Millward, S., Biegus, J., Fudim, M., Guzik, M., Iwanek, G., Ponikowski, P. P., & Zymliński, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-64747-5 · Cited by 11 · see citing works
Fusco‐Allison, G., Li, D. K., Hunter, B., Jackson, D., Bannon, P. G., Lal, S., & O’Sullivan, J. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13504 · Cited by 11 · see citing works
Role of follistatin-like protein 1 in liver diseases
Gu, C., Xue, H., Yang, X., Nie, Y., & Qian, X. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221142604 · Cited by 11 · see citing works
Uematsu, M., Nakamura, K., Nakamura, T., Watanabe, Y., Yoshizaki, T., Deyama, J., Kobayashi, T., Fujioka, D., Saitō, Y., Kawabata, K., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.05.015 · Cited by 11 · see citing works
Xi, Y., Hao, M., & Tian, Z. (2019) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-019-0009-4 · Cited by 10 · see citing works
The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction—Victim of Its Environment?
Rocca, A., van Heeswijk, R. B., Richiardi, J., Meyer, P., & Hullin, R. (2022) · Cells · doi:10.3390/cells11050867 · Cited by 10 · see citing works
A network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Lanzer, J. D., Valdeolivas, A., Pepin, M. E., Hund, H., Backs, J., Frey, N., Friederich, H., Schultz, J., Sáez-Rodríguez, J., & Levinson, R. T. (2023) · BMC Medicine · doi:10.1186/s12916-023-02922-7 · Cited by 11 · see citing works
FSTL-1 as a Novel Cardiokine of Cardiac Angiogenesis: A Systematic Review
Karisa, P., Sylviana, N., Fitria, N., & Setiawan, I. (2025) · Vascular Health and Risk Management · doi:10.2147/vhrm.s509482 · Cited by 11 · see citing works
Epicardium as a new target for regenerative technologies in cardiology
Дергилев, К. В., Комова, А. В., Цоколаева, З. И., Beloglazova, I. B., & Parfyonova, Y. V. (2020) · Genes and Cells · doi:10.23868/202004016 · Cited by 9 · see citing works
Ponce-Ruiz, N., Herrera‐Moreno, J. F., Rojas‐García, A. E., Barrón-Vivanco, B. S., González-Arias, C. A., Bernal-Hernández, Y. Y., Ortega-Cervantes, L., Ponce-Gallegos, J., Hernández-Nolasco, J. A., & Medina‐Díaz, I. M. (2024) · Heart and Vessels · doi:10.1007/s00380-024-02364-y · Cited by 7 · see citing works
Prakash, S., Mattiotti, A., Sylva, M., Mulder, B. J. M., Postma, A. V., & van den Hoff, M. J. B. (2019) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.567 · Cited by 7 · see citing works
Skeletal Muscle as Endocrine Organ
Ma, M., Zhang, Z., Hai, B., & Zhang, Y. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_22 · Cited by 6 · see citing works
Role of follistatin-like 1 levels and functions in calcific aortic stenosis
Zhang, Q., Ye, J., Yang, G., Yang, L., Chen, Z., Yang, K., Sun, J. T., & Liu, Y. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1050310 · Cited by 5 · see citing works
Wollert, K. C. (2016) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2016.05.001 · Cited by 3 · see citing works
Novelties in the treatment of heart failure
Souček, F., & Novák, J. (2017) · Vnitřní lékařství · doi:10.36290/vnl.2017.053 · Cited by 2 · see citing works
Specific FSTL1 polymorphism may determine the risk of cardiomyopathy in patients with acromegaly
Şendur, S. N., Hazırolan, T., Aydin, B., Lay, İ., Alikaşifoğlu, M., & Erbas, T. A. (2021) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2021.1948206 · Cited by 2 · see citing works
Ahmadzadeh, A. M., Khodashahi, R., Shabestari, M. M., Aliakbarian, M., Sahebkar, A., & Arjmand, M. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x304195240715103930 · Cited by 1 · see citing works
Modeling heart failure with preserved ejection fraction in rodents: Where do we stand?
Chou, C., & Chin, M. T. (2022) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2022.948407 · Cited by 1 · see citing works
Valero‐Muñoz, M., & Sam, F. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.01.006
Muskulatur: „peripheres mechanisch- und Signalstoff-gestütztes Zentrum der Gesundheit“
Laube, W. (2023) · Springer eBooks · doi:10.1007/978-3-662-67753-7_8
Bolanle, I. O., & Beaufort, G. C. D. L. (2025) · Vascular Pharmacology · doi:10.1016/j.vph.2025.107549
Kobak, K. A., Kasztura, M., Josiak, K., Zymliński, R., Świątoniowska-Lonc, N., Banasiak, W., & Węgrzynowska‐Teodorczyk, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114850
Follistatin-Like Protein 1 and Cardiovascular Diseases
Alieva, A. M., Baykova, I. E., Булатовна, С. А., & Nikitin, I. G. (2026) · Innovative medicine of Kuban · doi:10.35401/2541-9897-2026-11-2-132-139
Assessing left atrial systolic contribution via pressure-volume loops in murine HFpEF
Baker, H. E., Belle-Oladeji, T., Andreasson, M., Christie, R., Hyatt, K., Wang, X., Borlaug, B. A., & Sam, F. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1919465
Jia, X., Liu, J. H., Wang, R., Wu, X., Che, Y., Wu, M., Shang, H.-W., Lu, X., Lu, T., Wang, L., et al. (2026) · Advanced Science · doi:10.1002/advs.77433
- Authors
- Tanaka, K., Valero-Muñoz, M., Wilson, R. M., Essick, E. E., Fowler, C. T., Nakamura, K., van den Hoff, M., Ouchi, N., & Sam, F.
- Affiliations
- Boston University (US)
- Nagoya University (JP)
- Corresponding author
- Sam, Flora
- Venue
- JACC Basic to Translational Science
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 1
- Issue
- 4
- Pages
- 207-221
- ISSN
- 2452-302X (ISSN-L)
- PMC
- PMC4944656
- OpenAlex
- W2473248170
- Cited by
- 59
- References
- 57
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 1
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- JACC Basic to Translational Science (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL117153)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- FSTL1, heart failure with preserved ejection fraction, cardiac hypertrophy, diastolic dysfunction, aldosterone, hypertension, cardiomyocytes, atrial natriuretic peptide, brain natriuretic peptide
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