MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

Cardo, Lucía F.; Coto, Eliecer; Ribacoba, René; Menéndez, Manuel; Moris, Germán; Suárez, Esther; Alvarez, Victoria

doi:10.1007/s12031-014-0428-y

Cited by 75Parkinson's Disease Mechanisms and TreatmentsMicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

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Cardo, Lucía F., Coto, Eliecer, Ribacoba, René, Menéndez, Manuel, Moris, Germán, Suárez, Esther, Alvarez, Victoria·2014·Journal of Molecular Neuroscience

DOI 10.1007/s12031-014-0428-y

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Abstract

The deregulation of several microRNAs (miRNAs) has been associated with neurodegenerative processes, including Parkinson's disease (PD). Our aim was to characterize the level of miRNAs in the substantia nigra (SN) of PD patients and healthy donors. This is an important issue to characterize new putative markers and therapeutic targets for PD. RNA was extracted from the SN of postmortem PD (n=8) and healthy (n=4) subjects, and the level of 733 human miRNAs was assayed with TaqMan low-density arrays (TLDAs). Overall, there was a miRNA downregulation in the SN of patients. The mean level of 11 miRNAs was significantly different (p<0.05) between patients and controls, with 10 downregulated among the patients. MiR-198, -135b, -485-5p, and -548d were the best candidates and were quantified with individual TaqMan assays in the 12 samples. MiR-135b showed the most significant difference between patients and healthy donors. The bioinformatic analysis suggested that this miRNA could bind to genes implicated in several neurodegenerative pathways.

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The circulating miRNA pattern in PD has not been well defined yet.
“Although the aberrant expression of miRNAs was reported frequently in PD‐diagnosed patients (Cardo et al., 2014; Filatova et al., 2012; Hoss et al., 2016), the circulating miRNA pattern in PD has not been well defined yet.”
From Identification of aberrant circulating mi<scp>RNA</scp>s in Parkinson's disease plasma samples (2018) · cites this paper as Cardo et al., 2014
miRNA expression profiles in PD-diagnosed patients have been analyzed and reported.
“miRNA expression profiles in PD‐diagnosed patients have been analyzed and reported (Cardo et al., 2014; Hoss, Labadorf, Beach, Latourelle, & Myers, 2016)”
From Identification of aberrant circulating mi<scp>RNA</scp>s in Parkinson's disease plasma samples (2018) · cites this paper as Cardo et al., 2014
miR-27a/b are expressed in SN of human midbrain.
“miR-27a/b are expressed in SN of human midbrain (Additional file 2a) [34–36]”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [36]
miR-27a/b are expressed in human midbrain.
“Several previous studies showed that miR-27a/b are expressed in human midbrain [34–36].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [36]

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Authors: Cardo, L. F., Coto, E., Ribacoba, R., Menéndez, M., Moris, G., Suárez, E., & Alvarez, V.
Affiliations: Hospital Universitario Central de Asturias (ES)
ORCID: Cardo, Lucía F.
Venue: Journal of Molecular Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-10-05
Volume: 54
Issue: 4
Pages: 830-836
ISSN: 0895-8696 (ISSN-L)
1559-1166
DOI: 10.1007/s12031-014-0428-y
OpenAlex: W2058143042
Cited by: 75
References: 37
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 5
FWCI: 4.78
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.springer.com/tdm (tdm)
Locations: Journal of Molecular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
Funders: Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
Topics: Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Parkinson's disease, microRNA, substantia nigra, microRNA downregulation, miR-135b, miR-198, miR-485-5p, biomarkers, neurodegeneration, postmortem brain
MeSH terms: Adult, Aged, Child, Female, Humans, Male, Middle Aged, Parkinson Disease, Substantia Nigra, Case-Control Studies, MicroRNAs, Gene Regulatory Networks

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MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects

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