MicroRNA Expression Aberration as Potential Peripheral Blood Biomarkers for Schizophrenia
Open accessAbstract
Since brain tissue is not readily accessible, a new focus in search of biomarkers for schizophrenia is blood-based expression profiling of non-protein coding genes such as microRNAs (miRNAs), which regulate gene expression by inhibiting the translation of messenger RNAs. This study aimed to identify potential miRNA signature for schizophrenia by comparing genome-wide miRNA expression profiles in patients with schizophrenia vs. healthy controls. A genome-wide miRNA expression profiling was performed using a Taqman array of 365 human miRNAs in the mononuclear leukocytes of a learning set of 30 cases and 30 controls. The discriminating performance of potential biomarkers was validated in an independent testing set of 60 cases and 30 controls. The expression levels of the miRNA signature were then evaluated for their correlation with the patients' clinical symptoms, neurocognitive performances, and neurophysiological functions. A seven-miRNA signature (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) was derived from a supervised classification with internal cross-validation, with an area under the curve (AUC) of receiver operating characteristics of 93%. The putative signature was then validated in the testing set, with an AUC of 85%. Among these miRNAs, miR-34a was differentially expressed between cases and controls in both the learning (P = 0.005) and the testing set (P = 0.002). These miRNAs were differentially correlated with patients' negative symptoms, neurocognitive performance scores, and event-related potentials. The results indicated that the mononuclear leukocyte-based miRNA profiling is a feasible way to identify biomarkers for schizophrenia, and the seven-miRNA signature warrants further investigation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
miR-34 dysregulation is related to schizophrenia, Alzheimer's disease, and MDD.
“miR-34 dysregulation is related to different psychiatric disorders, including schizophrenia236, Alzheimer’s disease,237 and MDD.238”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [236]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Gene selection for cancer classification using support vector machines
Guyon, I., Weston, J., Barnhill, S., & Vapnik, V. (2002) · Machine Learning · doi:10.1023/a:1012487302797 · Cited by 9,954 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Siegel, L. J., & Fletcher‐Janzen, E. (2008) · Wiley eBooks · doi:10.1002/9780470373699.speced0655 · Cited by 8,468 · see citing works
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603 · see citing works
Wisconsin Card Sorting Test Manual – Revised and Expanded
Heaton, R. K., Chelune, C., Talley, J., Kay, G., & Curtiss, G. (1981) · Medical Entomology and Zoology · Cited by 2,975 · see citing works
The microRNA.org resource: targets and expression
Betel, D., Wilson, M. T., Gabow, A. P., Marks, D. S., & Sander, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm995 · Cited by 2,490 · see citing works
Diagnostic Interview for Genetic Studies
Nürnberger, J. I. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950110009002 · Cited by 2,066 · see citing works
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
The environment and schizophrenia
van Os, J., Kenis, G., & Rutten, B. P. F. (2010) · Nature · doi:10.1038/nature09563 · Cited by 1,572 · see citing works
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,453 · see citing works
miRecords: an integrated resource for microRNA-target interactions
Xiao, F., Zuo, Z., Cai, G., Kang, S., Gao, X., & Li, T. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn851 · Cited by 1,439 · see citing works
Allen, N. C., Bagade, S., McQueen, M. B., Ioannidis, J. P. A., Kavvoura, F. K., Khoury, M. J., Tanzi, R. E., & Bertram, L. (2008) · Nature Genetics · doi:10.1038/ng.171 · Cited by 1,054 · see citing works
Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification
Simon, R., Radmacher, M. D., Dobbin, K. K., & McShane, L. M. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.1.14 · Cited by 1,009 · see citing works
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · see citing works
Self-citationA combined computational-experimental approach predicts human microRNA targetsPreprint
Kiriakidou, M., Nelson, P. T., Kouranov, A., Fitziev, P., Bouyioukos, C., Mourelatos, Z., & Hatzigeorgiou, A. G. (2004) · Genes & Development · doi:10.1101/gad.1184704 · Cited by 774 · see citing works
microRNA Modulation of Circadian-Clock Period and Entrainment
Cheng, H. M., Papp, J. W., Varlamova, O., Dziema, H., Russell, B. S., Curfman, J. P., Nakazawa, T., Shimizu, K., Okamura, H., Impey, S., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.017 · Cited by 589 · see citing works
Evaluating the comparability of gene expression in blood and brain
Sullivan, P. F., Fan, C., & Perou, C. M. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30272 · Cited by 581 · see citing works
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky, B. I., Calkins, M. E., Light, G. A., D, A. O. M., Radant, A. D., & Swerdlow, N. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl060 · Cited by 563 · see citing works
Sethupathy, P., Megraw, M. S., & Hatzigeorgiou, A. G. (2006) · Nature Methods · doi:10.1038/nmeth954 · Cited by 540 · see citing works
Real-time PCR quantification of precursor and mature microRNA
Schmittgen, T. D., Lee, E. J., Jiang, J., Sarkar, A., Yang, L., Elton, T. S., & Chen, C. (2008) · Methods · doi:10.1016/j.ymeth.2007.09.006 · Cited by 535 · see citing works
Self-citationPerkins, D. O., Jeffries, C. D., Jarskog, L. F., Thomson, J. M., Woods, K., Newman, M. A., Parker, J. S., Jin, J., & Hammond, S. M. (2007) · Genome Biology · doi:10.1186/gb-2007-8-2-r27 · Cited by 479 · see citing works
Schizophrenia is associated with an increase in cortical microRNA biogenesis
Beveridge, N. J., Gardiner, E. J., Carroll, A. P., Tooney, P. A., & Cairns, M. J. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.84 · Cited by 431 · see citing works
Mismatch Negativity Deficits Are Associated With Poor Functioning in Schizophrenia Patients
Light, G. A., & Braff, D. L. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.2.127 · Cited by 407 · see citing works
Lymphocytes as a neural probe: potential for studying psychiatric disorders
Gladkevich, A. V., Kauffman, H. F., & Korf, J. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.01.009 · Cited by 359 · see citing works
STRATIFICATION BY A MULTIVARIATE CONFOUNDER SCORE
Miettinen, O. S. (1976) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112339 · Cited by 351 · see citing works
Schizophrenia, “just the facts”: What we know in 2008Part 3: Neurobiology
Keshavan, M. S., TANDON, R., Boutros, N. N., & Nasrallah, H. A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.020 · Cited by 345 · see citing works
Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
Beveridge, N. J., Tooney, P. A., Carroll, A. P., Gardiner, E. J., Bowden, N. A., Scott, R. J., Tran, N., Dedova, I. V., & Cairns, M. J. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn005 · Cited by 328 · see citing works
Glatt, S. J., Everall, I., Kremen, W. S., Corbeil, J., Šášik, R., Khanlou, N., Han, M., Liew, C., & Tsuang, M. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507666102 · Cited by 322 · see citing works
Zhou, R., Yuan, P., Wang, Y., Hunsberger, J. G., Elkahloun, A. G., Wei, Y., Damschroder-Williams, P. J., Du, J., Chen, G., & Manji, H. K. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.131 · Cited by 313 · see citing works
Kim, A. H., Reimers, M., Maher, B., Williamson, V., McMichael, O., McClay, J. L., van den Oord, E. J. C. G., Riley, B. P., Kendler, K. S., & Vladimirov, V. I. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.002 · Cited by 298 · see citing works
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
Kocerha, J., Faghihi, M. A., López-Toledano, M. A., Huang, J., Ramsey, A. J., Caron, M. G., Salès, N., Willoughby, D., Elmén, J., Hansen, H. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805854106 · Cited by 292 · see citing works
miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes
Hsu, S., Chu, C.-H., Tsou, A.-P., Chen, S., Chen, H.-C., Hsu, P. W.-C., Wong, Y.-H., Chen, Y., Chen, G.-H., & Huang, H. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1012 · Cited by 290 · see citing works
Self-citationHeterogeneous dysregulation of microRNAs across the autism spectrum
Abu-Elneel, K., Liu, T., Gazzaniga, F. S., Nishimura, Y., Wall, D. P., Geschwind, D. H., Lao, K., & Kosik, K. S. (2008) · neurogenetics · doi:10.1007/s10048-008-0133-5 · Cited by 271 · see citing works
Phenotype of schizophrenia: a review and formulation
Tamminga, C. A., & Holcomb, H. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001563 · Cited by 261 · see citing works
Chen, W. J., Liu, S. K., Chang, C., Lien, Y.-J., Chang, Y., & Hwu, H. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.9.1214 · Cited by 260 · see citing works
Self-citationFreedman, R. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830120052009 · Cited by 246 · see citing works
MicroRNA Expression in Alzheimer Blood Mononuclear Cells
Schipper, H. M., Maes, O. C., Chertkow, H. M., & Wang, E. (2007) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s361 · Cited by 244 · see citing works
Tsuang, M. T., Nossova, N., Yager, T. D., Tsuang, M., Guo, S., Shyu, K. G., Glatt, S. J., & Liew, C. C. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30161 · Cited by 239 · see citing works
Wang, X. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl068 · Cited by 215 · see citing works
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis
Lizé, M., Pilarski, S. M., & Dobbelstein, M. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.188 · Cited by 206 · see citing works
Cognitive heterogeneity in schizophrenia
Joyce, E. M., & Roiser, J. P. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3280ba4975 · Cited by 198 · see citing works
Positive and negative syndromes in schizophrenia: Assessment and research.
Kay, S. R. (1991) · Medical Entomology and Zoology · Cited by 185 · see citing works
Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases
Cheung, Z. H., Fu, A. K. Y., & Ip, N. Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.024 · Cited by 182 · see citing works
MicroRNA dysregulation in psychiatric disease
Miller, B. H., & Wahlestedt, C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.035 · Cited by 181 · see citing works
Positive and negative syndromes in schizophrenia: Assessment and research
Barnes, T. R. E. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90042-7 · Cited by 160 · see citing works
Performance of the Continuous Performance Test Among Community Samples
Chen, W. J., Hsiao, C. K., Hsiao, L.-L., & Hwu, H. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033308 · Cited by 150 · see citing works
Self-citationBrain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 132 · see citing works
Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
Vawter, M. P. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00151-8 · Cited by 132 · see citing works
Shifting emphasis from pharmacogenomics to theragnostics
Özdemir, V., Williams–Jones, B., Glatt, S. J., Tsuang, M. T., Lohr, J. B., & Reist, C. (2006) · Nature Biotechnology · doi:10.1038/nbt0806-942 · Cited by 130 · see citing works
GAP: A graphical environment for matrix visualization and cluster analysis
Wu, H., Tien, Y.-J., & Chen, C. (2008) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2008.09.029 · Cited by 110 · see citing works
Self-citationIdentification of new central nervous system specific mouse microRNAs
Wheeler, G., Ntounia-Fousara, S., Granda, B., Rathjen, T. M., & Dalmay, T. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.03.019 · Cited by 107 · see citing works
Perkins, D. O., Jeffries, C. D., & Sullivan, P. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001577 · Cited by 103 · see citing works
Dwivedi, Y., Rizavi, H. S., Zhang, H., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990575 · Cited by 101 · see citing works
Jasinska, A. J., Service, S. K., Choi, O., DeYoung, J. A., Grujic, O., Kong, S.-Y., Jorgensen, M. J., Bailey, J. N., Breidenthal, S. E., Fairbanks, L. A., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp397 · Cited by 87 · see citing works
Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia
Kerns, D. C., Vong, G. S., Barley, K. M., Dracheva, S. M., Katsel, P., Casaccia, P., Haroutunian, V. H., & Byne, W. M. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.04.012 · Cited by 75 · see citing works
Lin, C. C. H., Chen, W. J., Yang, H., Hsiao, C. K., & Tien, A. Y. (2000) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/1380-3395(200002)22:1;1-8;ft069 · Cited by 69 · see citing works
Self-citationKuzman, M. R., Medved, V., Terzić, J., & Krainc, D. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.03.005 · Cited by 68 · see citing works
Chang, C.-J., Chen, W. J., Liu, S. K., Cheng, J. J., Ouyang, W., Chang, H.-J., Lane, H.-Y., Lin, S., Yang, T.-W., & Hwu, H. (2002) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006947 · Cited by 68 · see citing works
Self-citationSchwarz, E., & Bahn, S. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707658 · Cited by 59 · see citing works
Clinical symptom dimensions and deficits on the continuous performance test in schizophrenia
LIU, S., Hwu, H., & Chen, W. J. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00026-1 · Cited by 59 · see citing works
Self-citationLiu, L., Jia, F., Yuan, G., Chen, Z., Yao, J., Li, H., & Fang, C. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2008.10.024 · Cited by 57 · see citing works
Glatt, S. J., Faraone, S. V., Lasky-Su, J. A., Kanazawa, T., Hwu, H., & Tsuang, M. T. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.30 · Cited by 54 · see citing works
Self-citationMicroRNA expression profiling of the human uterine cervix after term labor and delivery
Hassan, S. S., Romero, R. J., Pineles, B. L., Tarca, A. L., Montenegro, D. A., Erez, O., Mittal, P., Kusanovic, J. P., Mazaki‐Tovi, S., Espinoza, J., et al. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.08.016 · Cited by 51 · see citing works
Shibata, H., Tani, A., Chikuhara, T., Kikuta, R., Sakai, M., Ninomiya, H., Tashiro, N., Iwata, N., Ozaki, N., & Fukumaki, Y. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2007.12.002 · Cited by 49 · see citing works
BCL2 Genotypes: Functional and Neurobehavioral Outcomes after Severe Traumatic Brain Injury
Hoh, N. Z., Wagner, A. K., Alexander, S. A., Clark, R. B., Beers, S. R., Okonkwo, D. O., Ren, D., & Conley, Y. P. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1256 · Cited by 48 · see citing works
van Heerden, J. H., Conesa, A., Stein, D. J., Montaner, D. A., Russell, V. A., & Illing, N. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-195 · Cited by 40 · see citing works
Yao, Y., Schröder, J., & Karlsson, H. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.07.011 · Cited by 39 · see citing works
MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia
Coyle, J. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813321106 · Cited by 28 · see citing works
Marazziti, D., Dell’Osso, M. C., Baroni, S., Másala, I., Dell’Osso, B. M., Consoli, G., Giannaccini, G., Betti, L., & Lucacchini, A. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.03.009 · Cited by 20 · see citing works
Richardson, J. C., Cogswell, J. P., Ward, J. M., Taylor, I. A., Waters, M., Shi, Y., Cannon, B. D., Kelnar, K., Kemppainen, J., Brown, D., et al. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.420 · Cited by 18 · see citing works
Self-citationStress Gene Deregulation in Alzheimer Peripheral Blood Mononuclear Cells
Maes, O. C., Chertkow, H. M., Wang, E., & Schipper, H. M. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-956-7_11 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
MicroRNA profiling: approaches and considerations
Pritchard, C. C., Cheng, H. H., & Tewari, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3198 · Cited by 1,765 · see citing works
Circulating miRNA Biomarkers for Alzheimer's Disease
Kumar, P., Dezső, Z., MacKenzie, C. J., Oestreicher, J., Agoulnik, S. I., Byrne, M., Bernier, F., Yanagimachi, M., Aoshima, K., & Oda, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069807 · Cited by 386 · see citing works
Miller, B. H., Zeier, Z., Xi, L., Lanz, T. A., Deng, S., Strathmann, J., Willoughby, D., Kenny, P. J., Elsworth, J. D., Lawrence, M. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113793109 · Cited by 309 · see citing works
Banigan, M. G., Kao, P. F., Kozubek, J. A., Winslow, A. R., Medina, J., Costa, J., Schmitt, A., Schneider, A., Cabral, H., Cagsal‐Getkin, O., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0048814 · Cited by 267 · see citing works
The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
Benetatos, L., Hatzimichael, E. C., Londin, E. R., Vartholomatos, G., Loher, P., Rigoutsos, I., & Briasoulis, E. C. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1080-8 · Cited by 263 · see citing works
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
van den Berg, M. M. J., Krauskopf, J., Ramaekers, J. G., Kleinjans, J. C. S., Prickaerts, J., & Briedé, J. J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101732 · Cited by 253 · see citing works
Blood microRNA changes in depressed patients during antidepressant treatment
Bocchio-Chiavetto, L., Maffioletti, E., Bettinsoli, P., Giovannini, C., Bignotti, S., Tardito, D., Corrada, D., Milanesi, L., & Gennarelli, M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.013 · Cited by 238 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
“235 Likewise, miR-34 dysregulation is related to different psychiatric disorders, including schizophrenia 236 , Alzheimer ’ s disease, 237 and MDD. 238 241 The depression susceptibility is highly associated with the miRNA polymorphisms.”
BackgroundAn epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works
MicroRNAs as biomarkers for CNS disease
Rao, P., Benito, E., & Fischer, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00039 · Cited by 226 · see citing works
Belzeaux-R, R., Bergon, A., Jeanjean, V., Loriod, B., Formisano‐Tréziny, C., Verrier, L., Loundou, A., Baumstarck, K., Boyer, L., Gall, V., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.112 · Cited by 222 · see citing works
microRNAs in Parkinson’s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches
Leggio, L., Vivarelli, S., L’Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Marchetti, B., & Iraci, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122698 · Cited by 216 · see citing works
The State of Molecular Biomarkers for the Early Detection of Lung Cancer
Hassanein, M., Callison, J. C., Callaway‐Lane, C., Aldrich, M. C., Grogan, E. L., & Massion, P. P. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0441 · Cited by 213 · see citing works
MicroRNA dysregulation in schizophrenia
Beveridge, N. J., & Cairns, M. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.029 · Cited by 206 · see citing works
Serum microRNA profiles in children with autism
Vasu, M. M., Anitha, A., Thanseem, I., Suzuki, K., Yamada, K., Takahashi, T., Wakuda, T., Iwata, K., Tsujii, M., Sugiyama, T., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-40 · Cited by 206 · see citing works
MicroRNA and Posttranscriptional Dysregulation in Psychiatry
Geaghan, M. P., & Cairns, M. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.009 · Cited by 193 · see citing works
Circulating microRNAs: Biomarkers of disease
Wu, Y., Li, Q., Zhang, R., Dai, X., Chen, W., & Xing, D. (2021) · Clinica Chimica Acta · doi:10.1016/j.cca.2021.01.008 · Cited by 182 · see citing works
Self-citationRichetto, J., & Meyer, U. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.03.008 · Cited by 183 · see citing works
Smigielski, L., Jagannath, V., Rössler, W., Walitza, S., & Grünblatt, E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0601-3 · Cited by 168 · see citing works
MicroRNAs in Parkinson's disease
Harraz, M. M., Dawson, T. M., & Dawson, V. L. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.01.005 · Cited by 160 · see citing works
Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics
Lai, C.-Y., Scarr, E., Udawela, M., Everall, I., Chen, W. J., & Dean, B. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.102 · Cited by 153 · see citing works
Self-citationGenome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia
Du, Y., Yu, Y., Hu, Y., Li, X., Wei, Z., Pan, R., Li, X.-S., Zheng, G.-E., Qin, X., Liu, Q., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby191 · Cited by 152 · see citing works
Guan, F., Zhang, B., Yan, T., Li, L., Liu, F., Li, T., Feng, Z., Zhang, B., Liu, X., & Li, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.11.004 · Cited by 135 · see citing works
miRNAs and long noncoding RNAs as biomarkers in human diseases
Roosbroeck, K. V., Pollet, J. B. K., & Călin, G. A. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.12.134 · Cited by 135 · see citing works
Fan, H., Sun, X., Guo, W., Zhong, A., Niu, W., Zhao, L., Dai, Y.-H., Guo, Z.-M., Zhang, L.-Y., & Lu, J. Z. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.007 · Cited by 129 · see citing works
The Pattern of Cortical Dysfunction in a Mouse Model of a Schizophrenia-Related Microdeletion
Fénelon, K., Xu, B., Lai, C. S., Mukai, J., Markx, S., Stark, K. L., Hsu, P.-K., Gan, W.-B., Fischbach, G. D., MacDermott, A. B., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1611-13.2013 · Cited by 116 · see citing works
Self-citationPotential Impact of miR-137 and Its Targets in Schizophrenia
Wright, C., Turner, J., Calhoun, V., & Perrone-Bizzozero, N. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00058 · Cited by 124 · see citing works
Maffioletti, E., Tardito, D., Gennarelli, M., & Bocchio‐Chiavetto, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00075 · Cited by 121 · see citing works
The emerging role of microRNAs in schizophrenia and autism spectrum disorders
Mellios, N., & Sur, M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00039 · Cited by 120 · see citing works
Prata, J., Santos, S. G., Almeida, M. I., Coelho, R., & Barbosa, M. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0938-y · Cited by 115 · see citing works
A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer
Shin, V. Y., Ng, E. K. O., Chan, V. W., Kwong, A., & Chu, K. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0473-3 · Cited by 108 · see citing works
Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers
Khavari, B., & Cairns, M. J. (2020) · Cells · doi:10.3390/cells9081837 · Cited by 106 · see citing works
Zhao, D., Lin, M., Chen, J., Pedrosa, E., Hrabovsky, A., Fourcade, H. M., Zheng, D., & Lachman, H. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132387 · Cited by 103 · see citing works
Song, H., Sun, X., Zhang, L., Zhao, L., Guo, Z.-M., Fan, H., Zhong, A., Niu, W., Dai, Y., Zhang, L.-Y., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.008 · Cited by 97 · see citing works
He, S., Liu, X., Jiang, K., Peng, D., Hong, W., Fang, Y., Qian, Y., Yu, S., & Li, H. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.015 · Cited by 94 · see citing works
Self-citationBalakathiresan, N. S., Chandran, R., Bhomia, M., Jia, M., Li, H., & Maheshwari, R. K. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.05.020 · Cited by 91 · see citing works
Utility of Circulating MicroRNAs as Clinical Biomarkers for Cardiovascular Diseases
Kondkar, A. A., & Abu‐Amero, K. K. (2015) · BioMed Research International · doi:10.1155/2015/821823 · Cited by 91 · see citing works
Darcq, E., Warnault, V., Phamluong, K., Besserer, G. M., Liu, F., & Dorit Ron, A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.120 · Cited by 90 · see citing works
A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia
Sun, X., Zhang, J., Niu, W., Guo, W., Song, H., Li, H., Fan, H., Zhao, L., Zhong, A., Dai, Y., et al. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32292 · Cited by 89 · see citing works
Darcq, E., Warnault, V, Phamluong, K., Besserer, G. M., Liu, F., & Ron, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.155 · Cited by 87 · see citing works
Decreased DGCR8 Expression and miRNA Dysregulation in Individuals with 22q11.2 Deletion Syndrome
Sellier, C., Hwang, V. J., Dandekar, R., Durbin-Johnson, B. P., Charlet‐Berguerand, N., Ander, B. P., Sharp, F. R., Angkustsiri, K., Simon, T. J., & Tassone, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103884 · Cited by 86 · see citing works
Jovičić, A., & Gitler, A. D. (2017) · PLOS ONE · doi:10.1371/journal.pone.0171418 · Cited by 86 · see citing works
Circulating exosomal microRNAs in bipolar disorder
Ceylan, D., Tüfekçi, K. U., Keskinoğlu, P., Genç, Ş., & Özerdem, A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.10.038 · Cited by 81 · see citing works
Gene expression analysis in RA: towards personalized medicine
Burska, A. N., Roget, K., Blits, M., Gómez, L. S., van de Loo, F., Hazelwood, L. D., Verweij, C. L., Rowe, A., Goulielmos, G. N., van Baarsen, L. G. M., et al. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.48 · Cited by 82 · see citing works
Ma, J., Shang, S.-S., Wang, J., Zhang, T., Nie, F., Song, X., Zhao, H., Zhu, C., Zhang, R., & Hao, D. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.080 · Cited by 81 · see citing works
Lai, C.-Y., Lee, S.-Y., Scarr, E., Yu, Y., Lin, Y.-T., Liu, C.-M., Hwang, T.-J., Hsieh, M. H., Liu, C.-C., Chien, Y.-L., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.213 · Cited by 80 · see citing works
Self-citationAzevedo, J. A., Carter, B. S., Meng, F., Turner, D. L., Dai, M., Schatzberg, A. F., Barchas, J. D., Jones, E. G., Bunney, W. E., Myers, R., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.012 · Cited by 79 · see citing works
MiRNA Profile in the Substantia Nigra of Parkinson’s Disease and Healthy Subjects
Cardo, L. F., Coto, E., Ribacoba, R., Menéndez, M., Moris, G., Suárez, E., & Alvarez, V. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0428-y · Cited by 75 · see citing works
Dysregulation of mi RNA and its potential therapeutic application in schizophrenia
Cao, T., & Zhen, X. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12840 · Cited by 71 · see citing works
Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome
Napoli, E., Tassone, F., Wong, S., Angkustsiri, K., Simon, T. J., Song, G., & Giulivi, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.672360 · Cited by 68 · see citing works
MicroRNAs in Parkinson’s disease
Singh, A., & Sen, D. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-4989-1 · Cited by 72 · see citing works
Alural, B., Genç, Ş., & Haggarty, S. J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.010 · Cited by 74 · see citing works
Mutlu, M., Saatci, Ö., Ansari, S. A., Yurdusev, E., Shehwana, H., Konu, Ö., Raza, U., & Şahin, Ö. (2016) · Scientific Reports · doi:10.1038/srep32541 · Cited by 72 · see citing works
Srivastava, A., Dada, O. O., Qian, J., Al-Chalabi, N., Fatemi, A. B., Gerretsen, P., Graff, A., & Luca, V. D. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114218 · Cited by 71 · see citing works
Choi, S., Pang, K., Kim, J. Y., Ryu, J. R., Kang, H., Liu, Z., Kim, W.-K., Sun, W., Kim, H., & Han, K. (2015) · Molecular Brain · doi:10.1186/s13041-015-0165-3 · Cited by 69 · see citing works
The value of interleukin 6 as a peripheral diagnostic marker in schizophrenia
Chase, K. A., Cone, J. J., Rosen, C., & Sharma, R. P. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0866-x · Cited by 69 · see citing works
Understanding epigenetics of schizophrenia in the backdrop of its antipsychotic drug therapy
Swathy, B., & Banerjee, M. (2017) · Epigenomics · doi:10.2217/epi-2016-0106 · Cited by 69 · see citing works
Liu, S., Zhang, F., Wang, X., Shugart, Y. Y., Zhao, Y., Li, X., Liu, Z., Sun, N., Yang, C., Zhang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15751-5 · Cited by 69 · see citing works
Liu, Y., Chang, X., Hahn, C.-G., Gur, R. E., Abou‐Sleiman, P. M., & Hakonarson, H. H. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0030-5 · Cited by 68 · see citing works
Linnstaedt, S. D., Riker, K. D., Rueckeis, C. A., Kutchko, K. M., Lackey, L., McCarthy, K. R., Tsai, Y.-H., Parker, J. S., Kurz, M. C., Hendry, P. L., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3458-17.2018 · Cited by 66 · see citing works
MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients
Mor, E., Kano, S., Colantuoni, C., Sawa, A., Navon, R., & Shomron, N. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.03.011 · Cited by 66 · see citing works
Liu, S., Zhang, F., Shugart, Y. Y., Yang, L., Li, X., Liu, Z., Sun, N., Yang, C., Guo, X., Shi, J., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.268 · Cited by 65 · see citing works
Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia
Gibbons, A. S., Udawela, M., & Dean, B. (2018) · Non-Coding RNA · doi:10.3390/ncrna4020011 · Cited by 64 · see citing works
MicroRNAs and psychiatric disorders: From aetiology to treatment
Luoni, A., & Riva, M. A. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.07.006 · Cited by 62 · see citing works
Cattane, N., Mora, C., Lopizzo, N., Borsini, A., Maj, C., Pedrini, L., Rossi, R., Riva, M. A., Pariante, C. M., & Cattaneo, A. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.07.030 · Cited by 60 · see citing works
DNA Methylation and Schizophrenia: Current Literature and Future Perspective
Magwai, T., Shangase, K. B., Oginga, F. O., Chiliza, B., Mpofana, T., & Xulu, K. R. (2021) · Cells · doi:10.3390/cells10112890 · Cited by 62 · see citing works
Maternal and Neonatal Plasma Micro RNA Biomarkers for Fetal Alcohol Exposure in an Ovine Model
Balaraman, S., Lunde, E. R., Sawant, O., Cudd, T. A., Washburn, S. E., & Miranda, R. C. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12378 · Cited by 59 · see citing works
Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior
Misiewicz, Z., Iurato, S., Kulesskaya, N., Salminen, L., Rodrigues, L., Maccarrone, G., Martins, J., Czamara, D., Laine, M. A., Sokolowska, E., et al. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008358 · Cited by 56 · see citing works
Wu, S., Zhang, R., Nie, F., Wang, X., Jiang, C., Liu, M., Valenzuela, R. K., Liu, W., Shi, Y., & Ma, J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.09.012 · Cited by 55 · see citing works
Taddei, R. N., Çankaya, Ş., Dhaliwal, S., & Chaudhuri, К. R. (2017) · Parkinson s Disease · doi:10.1155/2017/3256542 · Cited by 55 · see citing works
Beveridge, N. J., Santarelli, D. M., Wang, X., Tooney, P. A., Webster, M. J., Weickert, C. S., & Cairns, M. J. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs198 · Cited by 52 · see citing works
The Path to microRNA Therapeutics in Psychiatric and Neurodegenerative Disorders
Chan, A. W. S., & Kocerha, J. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00082 · Cited by 51 · see citing works
Barnett, M. M., Reay, W. R., Geaghan, M. P., Kiltschewskij, D. J., Green, M. J., Weidenhofer, J., Glatt, S. J., & Cairns, M. J. (2023) · Science Advances · doi:10.1126/sciadv.adi4386 · Cited by 51 · see citing works
Micro-RNAs in cognition and cognitive disorders: Potential for novel biomarkers and therapeutics
Woldemichael, B. T., & Mansuy, I. M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.021 · Cited by 49 · see citing works
Hunsberger, J. G., Fessler, E. B., Chibane, F. L., Leng, Y., Maric, D., ELKAHLOUN, A. G., & Chuang, D. (2013) · Europe PMC (PubMed Central) · Cited by 48 · see citing works
Xiao, Y., YONG, X., FAN, Y.-H., Lü, M., Yang, S., & Hu, C.-J. (2013) · Oncology Reports · doi:10.3892/or.2013.2525 · Cited by 48 · see citing works
MicroRNA Schizophrenia: Etiology, Biomarkers and Therapeutic Targets.
Zhang, H., Du, Y., Chen, L., Yuan, Z.-Q., & Cheng, Y. (2023) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105064 · Cited by 43 · see citing works
Ghafouri‐Fard, S., Eghtedarian, R., Taheri, M. N., Brühl, A. B., Bahmani, D. S., & Brand, S. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.640463 · Cited by 46 · see citing works
Pilbrow, A. P., Cordeddu, L., Cameron, V. A., Frampton, C. M., Troughton, R. W., Doughty, R. N., WHALLEY, G. A., Ellis, C., Yandle, T. G., Richards, M., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.07.068 · Cited by 46 · see citing works
MiRNAs of peripheral blood as the biomarker of schizophrenia
He, K., Guo, C., He, L., & Shi, Y. (2017) · Hereditas · doi:10.1186/s41065-017-0044-2 · Cited by 46 · see citing works
Biomarker investigations related to pathophysiological pathways in schizophrenia and psychosis
Chana, G., Bousman, C., Money, T., Gibbons, A. S., Gillett, P., Dean, B., & Everall, I. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00095 · Cited by 44 · see citing works
Heterogeneity and Individuality: microRNAs in Mental Disorders
Hommers, L. G., Domschke, K., & Deckert, J. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1338-4 · Cited by 45 · see citing works
Circulating microRNA expression profile in B-cell acute lymphoblastic leukemia
Luna-Aguirre, C. M., Martínez‐Fierro, M. L., Mar‐Aguilar, F., Veloz, I. G., Treviño, V., Rojas‐Martínez, A., Jaime‐Pérez, J. C., Malagón‐Santiago, G. I., Gutiérrez‐Aguirre, C. H., González‐Llano, Ó., et al. (2015) · Cancer Biomarkers · doi:10.3233/cbm-150465 · Cited by 45 · see citing works
When less is more – microRNAs and psychiatric disorders
Kolshus, E., Dalton, V. S., Ryan, K. M., & McLoughlin, D. M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12191 · Cited by 44 · see citing works
Walker, R. M., Rybka, J., Anderson, S. M., Torrance, H. S., Boxall, R., Sussmann, J. E., Porteous, D. J., McIntosh, A. M., & Evans, K. L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.01.006 · Cited by 44 · see citing works
The alterations of circular RNA expression in plasma exosomes from patients with schizophrenia
Tan, G., Wang, L., Liu, Y., Zhang, H., Feng, W., & Liu, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29873 · Cited by 45 · see citing works
Vaccaro, T. D. S., Sorrentino, J. M., Salvador, S., Veit, T. D., Souza, D. O., & Almeida, R. F. (2018) · Behavioral Sciences · doi:10.3390/bs8080075 · Cited by 44 · see citing works
Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121122910 · Cited by 42 · see citing works
Predicting novel microRNA: a comprehensive comparison of machine learning approaches
Stegmayer, G. S., Persia, L. E. D., Rubiolo, M., Gerard, M. F., Pividori, M., Yones, C., Bugnon, L. A., Rodriguez, T., Raad, J., & Milone, D. H. (2018) · Briefings in Bioinformatics · doi:10.1093/bib/bby037 · Cited by 42 · see citing works
Chen, S., Sun, X., Niu, W., Kong, L., He, M., Fan, H., Li, W., Zhong, A., Zhang, L.-Y., & Lu, J. Z. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.04.087 · Cited by 40 · see citing works
Zhao, Z., Jinde, S., Koike, S., Tada, M., Satomura, Y., Yoshikawa, A., Nishimura, Y., Takizawa, R., Kinoshita, A., Sakakibara, E., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0609-0 · Cited by 41 · see citing works
Gao, S., Cheng, J., Li, G., Sun, T., Xu, Y., Wang, Y., Du, X., Xu, G., & Duan, S. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.03.002 · Cited by 39 · see citing works
Fan, H., Sun, X., Niu, W., Zhao, L., Zhang, Q., Li, W., Zhong, A., Zhang, L.-Y., & Lu, J. Z. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0503-z · Cited by 40 · see citing works
Lai, C., Wu, Y., Yu, S., Yu, Y., Lee, S., Liu, C., Hsieh, W., Hwu, H., Chen, P., Jeng, S., et al. (2014) · Aging Cell · doi:10.1111/acel.12225 · Cited by 38 · see citing works
“Thefindingofaberrant expression in severalblood-basedmiRNAshasalso raisedthepossibility that these miRNAs serve as novel diagnostic markers for a variety of disorders (Kosaka et al., 2010; Lai et al., 2011).”
InfluentialSelf-citationDombkowski, A. A., Batista, C. E. A., Cukovic, D., Carruthers, N. J., Ranganathan, R., Shukla, U., Stemmer, P. M., Chugani, H. T., & Chugani, D. C. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu276 · Cited by 38 · see citing works
Garbett, K. A., Vereczkei, A., Kalman, J. L., Wang, L., Korade, Ž., Shelton, R. C., & Mirnics, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.14 · Cited by 34 · see citing works
Xu, Y., Xia, Q., Xia, Q., Zhang, X., & Liang, J. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s237116 · Cited by 40 · see citing works
Increased miR-132 level is associated with visual memory dysfunction in patients with depression
Liu, Y., Yang, X. Y., Zhao, L., Zhang, J., Li, T., & Ma, X. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s116287 · Cited by 38 · see citing works
microRNAs as novel biomarkers of schizophrenia (Review)
Wang, J., Wang, Y., YANG, J., & Huang, Y. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2014 · Cited by 36 · see citing works
Self-citationSánchez-Mora, C., Ramos-Quiroga, J., Garcia-Martínez, I., Fernàndez-Castillo, N., Bosch, R., Richarte, V., Palomar, G., Nogueira, M., Corrales, M., Daigre, C., et al. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.07.002 · Cited by 33 · see citing works
- Authors
- Lai, C.-Y., Yu, S.-L., Hsieh, M. H., Chen, C.-H., Chen, H.-Y., Wen, C.-C., Huang, Y.-H., Hsiao, P.-C., Hsiao, C. K., Liu, C.-M., Yang, P.-C., Hwu, H.-G., & Chen, W. J.
- Affiliations
- National Taiwan University (TW)
- Institute of Statistical Science, Academia Sinica (TW)
- Corresponding author
- Chen, Wei J.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-06-29
- Volume
- 6
- Issue
- 6
- Pages
- e21635
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3126851
- OpenAlex
- W2065980876
- Cited by
- 228
- References
- 75
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 6 · 2022: 8 · 2021: 18 · 2020: 10 · 2019: 13 · 2018: 18 · 2017: 20 · 2016: 25 · 2015: 18 · 2014: 29 · 2013: 20 · 2012: 12
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- National Science Council (NSC98-2314-B-002-125-MY3)
- National Health Research Institutes (NHRI-EX99-9511PP)
- National Taiwan University (97R0337, 97HP0071, 97HP0023)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, microRNA expression, peripheral blood biomarkers, microRNA signature, mononuclear leukocytes, miR-34a, negative symptoms, neuropsychological performance, event-related potentials, blood-based diagnosis
- MeSH terms
- Humans, Schizophrenia, Biomarkers, Case-Control Studies, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review