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Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients

Ghafouri-Fard, Soudeh, Namvar, Amir, Arsang-Jang, Shahram, Komaki, Alireza, Taheri, Mohammad·2020·Journal of Molecular Neuroscience
DOI 10.1007/s12031-019-01432-7
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Abstract

Autism spectrum disorder (ASD) as a multifaceted neurological syndrome affects many aspects of neuropsychologic functions. Dysregulated expressions of several genes have been documented in ASD patients. The current project aimed at comparison of transcript levels of brain derived neurotrophic factor (BDNF), beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and their natural occurring antisenses in the peripheral blood of ASD individuals (n = 50, male/female = 38/12, age (mean ± standard deviation (SD)): 6 ± 1.4, age range: 3-8) and matched healthy persons (n = 50, male/female = 37/13, age (mean ± SD): 6 ± 1.74, age range: 3-8). We demonstrated remarkable higher levels of these genes in ASD patients. BACE1 transcript levels were correlated with transcript levels of BACE1-AS in all study participants. However, BACE1 transcript levels were not correlated with participants' age. BACE1-AS and BDNF transcript levels were correlated with age in female participants. Significant correlations were detected between transcript levels of BDNF and those of other genes in all study groups. The current results render further indications for contribution of BDNF, BACE1, and their antisenses in the course of ASD and suggested expression levels of these transcripts as putative markers for this neurobehavioral disorder. Such results might be applied in clinical setting for diagnosis of complicated ASD cases.

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  • The lncRNA species BACE1-AS strongly correlates with BACE1 expression and is measurable in human plasma samples, with levels increased in patients with AD and autism.

    “The lncRNA species BACE1‐AS strongly correlates with BACE1 expression and is also measurable in human plasma samples, with levels increased in patients with AD 193 and autism.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [194]

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Research works printed but not linked: 24

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Metadata

Authors
Ghafouri-Fard, S., Namvar, A., Arsang-Jang, S., Komaki, A., & Taheri, M.
ORCID
Taheri, Mohammad
Venue
Journal of Molecular Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2019-11-23
Volume
70
Issue
2
Pages
194-200
ISSN
  • 0895-8696
  • 1559-1166
DOI
10.1007/s12031-019-01432-7
Cited by
17
References
3
Language
en
Licence

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