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Cited by 137Cancer-related molecular mechanisms researchGenetics and Neurodevelopmental DisordersRNA Research and Splicing

Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

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Aliperti, Vincenza, Skonieczna, Justyna, Cerase, Andrea·2021·Non-Coding RNA
DOI 10.3390/ncrna7020036PMC PMC8293397
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Abstract

Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.

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  • Several recent studies have indicated that lncRNAs are crucial in the development of numerous neurological disorders, including autism, schizophrenia, and depression.

    “Several recent studies have indicated that lncRNAs are crucial in the development of numerous neurological disorders, including autism, schizophrenia, and depression.306–309”

    From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [306]

    Section 4 links aberrant lncRNA expression to autism and schizophrenia, and section 4.2 discusses lncRNAs associated with schizophrenia pathophysiology. The copy does not establish a role for lncRNAs in depression as a separate disorder: its references to depression concern a symptom of schizophrenia or synaptic long-term depression. No page numbers were provided for these passages. (LLM, conf=0.89)

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Cited by

Sorted by citations

Authors
Aliperti, V., Skonieczna, J., & Cerase, A.
Affiliations
  • University of Naples Federico II (IT)
  • Queen Mary University of London (GB)
Corresponding author
  • Aliperti, Vincenza
  • Cerase, Andrea
ORCID
Venue
Non-Coding RNA
Publisher
MDPI AG
Published
2021-06-17
Volume
7
Issue
2
Pages
36
ISSN
2311-553X (ISSN-L)
DOI
10.3390/ncrna7020036
PMC
PMC8293397
OpenAlex
W3174055566
Cited by
137
References
12
Citations by year
2026: 20 · 2025: 30 · 2024: 33 · 2023: 27 · 2022: 25 · 2021: 2
FWCI
2.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Non-Coding RNA (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
Funders
Barts Charity
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
long non-coding RNA, brain development, neurological disorders, neurodegenerative diseases, mental illness, gene expression regulation, epigenetic regulation, neuronal development

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