The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets
Abstract
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary injury mechanisms. Primary injury causes local brain damage, while secondary damage begins with inflammatory activity followed by disruption of the blood-brain barrier (BBB), peripheral blood cells infiltration, brain edema, and the discharge of numerous immune mediators including chemotactic factors and interleukins. TBI alters molecular signaling, cell structures, and functions. Besides tissue damage such as axonal damage, contusions, and hemorrhage, TBI in general interrupts brain physiology including cognition, decision-making, memory, attention, and speech capability. Regardless of the deep understanding of the pathophysiology of TBI, the underlying mechanisms still need to be assessed with a desired therapeutic agent to control the consequences of TBI. The current review gives a brief outline of the pathophysiological mechanism of TBI and various biochemical pathways involved in brain injury, pharmacological treatment approaches, and novel targets for therapy.
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“The diseases encompass various severe conditions, including neurodegenerative disorders like Alzheimer’s disease (AD) [3, 4] and Parkinson’s disease (PD) [5, 6], as well as traumatic brain injuries (TBI) [7] and spinal cord injuries (SCI) [8].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [7]
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Cohen, J., Mathew, A., Dourvetakis, K. D., Sanchez-Guerrero, E., Pangeni, R. P., Gurusamy, N., Aenlle, K. K., Ravindran, G., Twahir, A., Isler, D., et al. (2024) · Cells · doi:10.3390/cells13060511 · Cited by 103
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Blood-brain barrier disruption: a culprit of cognitive decline?
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Metadata
- Authors
- Thapa, K., Khan, H., Singh, T. G., & Kaur, A.
- Affiliations
- Chitkara University (IN)
- Corresponding author
- Singh, Thakur Gurjeet
- Venue
- Journal of Molecular Neuroscience
- Published
- 2021-05-06
- Volume
- 71
- Issue
- 9
- Pages
- 1725-1742
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W3158138032
- Cited by
- 341
- References
- 171
- Citations by year
- 2026: 55 · 2025: 88 · 2024: 88 · 2023: 60 · 2022: 41 · 2021: 9
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, primary injury, secondary injury, neuroinflammation, blood-brain barrier disruption, cerebral edema, axonal injury, hemorrhagic contusion, cognitive impairment, therapeutic target, pharmacotherapy
- MeSH terms
- Brain Injuries, Traumatic, Animals, Humans, Signal Transduction, NF-kappa B, Oxidative Stress, Neuroprotective Agents
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