The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders
Open accessAbstract
In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes. Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Many studies clearly demonstrate that activation ofNrf2 target genes, and particularly HO-1, in astrocytes and neurons is strongly protective against inflammation, oxidative damage, and cell death. In the central nervous system, the HO system has been reported to be very active, and its modulation seems to play a crucial role in the pathogenesis of neurodegenerative disorders. Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages. Furthermore, we have demonstrated that other phenolics, such as caffeic acid phenethyl ester and ethyl ferulate, are also able to protect neurons via HO-1 induction. These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.
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Cites
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Brain foods: The effects of nutrients on brain function.
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Antioxidant potential of ferulic acid
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Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
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Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease
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“polyphenols healing activity, correlated to their ability to overexpress highly protective inducible genes, is their involvement in the cellular stress response [56].”
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“Accordingly, other studies [110] have shown that EFE exerts strong neuroprotection against the oxidative stress and neurotoxicity induced by amyloid β1–42.”
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“It also induces apoptosis in several types of cancer cells by inactivating some transcription factors, such as NF–κB, AP-1, and STAT-1 [ 119 ].”
Cited by
Niture, S. K., Khatri, R., & Jaiswal, A. K. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.008 · Cited by 868
Sivandzade, F., Prasad, S., Bhalerao, A., & Cucullo, L. (2019) · Redox Biology · doi:10.1016/j.redox.2018.11.017 · Cited by 639
Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325
Self-citationDocosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases
Sun, G. Y., Simonyi, A., Fritsche, K. L., Chuang, D. Y., Hannink, M., Gu, Z., Greenlief, C. M., Yao, J. K., Lee, J. C., & Beversdorf, D. Q. (2018) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.03.006 · Cited by 309
Effects of natural antioxidants in neurodegenerative disease
Albarracin, S. L., Stab, B., Casas, Z., Sutachan, J. J., Samudio, I., Gonzalez, J., Gonzalo, L., Capani, F., Morales, L., & Barreto, G. E. (2012) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000028 · Cited by 271
Metadata
- Authors
- Scapagnini, G., Sonya, V., Nader, A. G., Calogero, C., Zella, D., & Fabio, G.
- Venue
- Molecular Neurobiology
- Published
- 2011-04-19
- Volume
- 44
- Issue
- 2
- Pages
- 192-201
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2110857736
- Cited by
- 402
- References
- 10
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Scapagnini, G., Sonya, V., Nader, A. G., Calogero, C., Zella, D., & Fabio, G. (2011). Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders. Molecular Neurobiology. https://doi.org/10.1007/s12035-011-8181-5
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