Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells

Kim, Su-Jin; Jeong, Hyun-Ja; Lee, Kang-Min; Myung, Noh-Yil; An, Nyeon-Hyoung; Mo Yang, Woong; Kyu Park, Seong; Lee, Hye-Jung; Hong, Seung-Heon; Kim, Hyung-Min; Um, Jae-Young

doi:10.1016/j.jnutbio.2006.11.001

Cited by 117Tea Polyphenols and EffectsAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells

Kim, Su-Jin, Jeong, Hyun-Ja, Lee, Kang-Min, Myung, Noh-Yil, An, Nyeon-Hyoung, Mo Yang, Woong, Kyu Park, Seong, Lee, Hye-Jung +3 more·2007·The Journal of Nutritional Biochemistry

DOI 10.1016/j.jnutbio.2006.11.001

Open this paper in CoChat — free account

Abstract

Epigallocatechin-3-gallate (EGCG) is the major polyphenol component of green tea and is primarily responsible for the green tea effect. EGCG possesses two triphenolic groups in its structure. These groups are reported to be important with respect to anticarcinogenic and antioxidant effects. However, the anti-inflammatory effect of EGCG on Alzheimer's disease (AD) is still not fully understood. In this study, we investigated the effects of EGCG in attenuating the inflammatory response induced by interleukin (IL)-1beta+beta-amyloid (25-35) fragment (Abeta) in human astrocytoma, U373MG cells. EGCG significantly inhibited the IL-1beta+Abeta (25-35)-induced IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin (PG)E(2) production at 24 h (P<.01). The maximal inhibition rate of IL-6, IL-8, VEGF and PGE(2) production by EGCG was approximately 54.40%, 56.01%, 69.06% and 47.03%, respectively. EGCG also attenuated the expression of cyclooxygenase-2 and activation of nuclear factor-kappaB induced by IL-1beta+Abeta (25-35). We demonstrated that EGCG suppresses IL-1beta+Abeta (25-35)-induced phosphorylation of the mitogen-activated protein kinase p38 and the c-Jun N-terminal kinase. In addition, EGCG induced the expression of mitogen-activated protein kinase phosphatase-1. These results provide new insight into the pharmacological actions of EGCG and its potential therapeutic application to various neurodegenerative diseases such as AD.

Integrity signals

Registry

Crossref · 10.1016/j.jnutbio.2006.11.001

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Leptin is preferentially expressed and secreted by subcutaneous adipose tissue, while adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogene, CCL5 and MIP-1b are expressed more in abdominal fat.
“Thus, leptin is preferentially expressed and secreted by subcutaneous adipose tissue (52) , while the expression of adiponectin, visfatin, omentin, resistin, PAI-1, IL-8, IL-7, IL-1a, MCP-1, TGF-b, growth-related oncogena, CCL5 and MIP-1b is higher in abdominal fat.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [54]
IL-6 and TNF-a appear to be synthesised equally by different adipose tissue sites.
“In contrast to such distributions, there are reports that IL-6 and TNF-a seem to be equally synthesised by the different sites (28,36,53 -59) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [54]
Adipokine secretion profiles differ between subcutaneous and abdominal adipose tissues.
“In addition, the profile of adipokines produced is dissimilar between the subcutaneous and abdominal adipose tissues.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [54]

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699 · see citing works
Role of vascular endothelial growth factor in regulation of physiological angiogenesis
Ferrara, N. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.6.c1358 · Cited by 1,084 · see citing works
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
Raivich, G., Bohatschek, M., Kloss, C. U. A., Werner, A., Jones, L. L., & Kreutzberg, G. W. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00007-7 · Cited by 843 · see citing works
Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
Tegeder, I., Pfeilschifter, J. M., & Geißlinger, G. (2001) · The FASEB Journal · doi:10.1096/fj.01-0390rev · Cited by 748 · see citing works
Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-05.2005 · Cited by 713 · see citing works
Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
Marti, H. J. H., Bernaudin, M., Bellail, A., Schoch, H., Euler, M., Petit, E., & Risau, W. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64964-4 · Cited by 680 · see citing works
Polyphenols as cancer chemopreventive agents
Stoner, G. D., & Mukhtar, H. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590822 · Cited by 605 · see citing works
Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent
Thomas, K. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.603 · Cited by 556 · see citing works
Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
Suganuma, M. (1998) · Carcinogenesis · doi:10.1093/carcin/19.10.1771 · Cited by 527 · see citing works
A review of latest research findings on the health promotion properties of tea
Dufresne, C., & Farnworth, E. R. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00155-3 · Cited by 522 · see citing works
β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand
MORISHIMA, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R. A., Davis, R. J., Shirasaki, Y., & Greenberg, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07551.2001 · Cited by 484 · see citing works
Alzheimer’s disease pathogenesis and therapeutic interventions
Parihar, M. S., & Hemnani, T. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.12.007 · Cited by 434 · see citing works
The toxicity in vitro of β-amyloid protein
Iversen, L. L., Mortishire‐Smith, R. J., Pollack, S. J., & Shearman, M. S. (1995) · Biochemical Journal · doi:10.1042/bj3110001 · Cited by 425 · see citing works
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors
Marti, H. H., & Risau, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15809 · Cited by 410 · see citing works
Physiological and pathological roles of interleukin-6 in the central nervous system
Gruol, D. L., & Nelson, T. E. (1997) · Molecular Neurobiology · doi:10.1007/bf02740665 · Cited by 404 · see citing works
Dexamethasone Causes Sustained Expression of Mitogen-Activated Protein Kinase (MAPK) Phosphatase 1 and Phosphatase-Mediated Inhibition of MAPK p38
Lasa, M., Abraham, S., Boucheron, C., Saklatvala, J., & Clark, A. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7802-7811.2002 · Cited by 381 · see citing works
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Hensley, K., Floyd, R. A., Zheng, N., Nael, R., Robinson, K. A., Nguyen, X., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722053.x · Cited by 373 · see citing works
Tea and Tea Polyphenols in Cancer Prevention
Yang, C. S., Chung, J. Y., Yang, G., Chhabra, S. K., & Lee, M. (2000) · Journal of Nutrition · doi:10.1093/jn/130.2.472s · Cited by 372 · see citing works
Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea
Haqqi, T. M., Anthony, D. D., Gupta, S., Ahmad, N., Lee, M.-S., Kumar, G. K., & Mukhtar, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4524 · Cited by 366 · see citing works
β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism
Akama, K. T., & Eldik, L. J. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7918 · Cited by 354 · see citing works
The green tea polyphenol (−)-epigallocatechin gallate attenuates β-amyloid-induced neurotoxicity in cultured hippocampal neurons
Choi, Y.-T., Jung, C., Lee, S., Bae, J., Baek, W., Suh, M., Park, J., Park, C., & Suh, S. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01438-2 · Cited by 342 · see citing works
Green Tea Epigallocatechin-3-Gallate Mediates T Cellular NF-κB Inhibition and Exerts Neuroprotection in Autoimmune Encephalomyelitis
Aktaş, O., Prozorovski, T., Тихоновна, С. А., Savaskan, N. E., Lauster, R., Kloetzel, P., Infante‐Duarte, C., Brocke, S., & Zipp, F. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5794 · Cited by 316 · see citing works
Restraint of Proinflammatory Cytokine Biosynthesis by Mitogen-Activated Protein Kinase Phosphatase-1 in Lipopolysaccharide-Stimulated Macrophages
Chen, P., Li, J., Barnes, J., Kokkonen, G. C., Lee, J. C., & Liu, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6408 · Cited by 285 · see citing works
Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
Lee, S., Suh, S., & Kim, S.-P. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01159-9 · Cited by 245 · see citing works
Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.
Gitter, B. D., Cox, L. M., Rydel, R. E., & May, P. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10738 · Cited by 178 · see citing works
Green tea catechins as a BACE1 (β-Secretase) inhibitor
Jeon, S.-Y., Bae, K., Seong, Y.-H., & Song, K. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.09.018 · Cited by 168 · see citing works
Green tea polyphenol (−)‐epigallocatechin‐3‐gallate inhibits cyclooxygenase‐2 expression in colon carcinogenesis
Peng, G., Dixon, D. A., Muga, S. J., Smith, T. J., & Wargovich, M. J. (2006) · Molecular Carcinogenesis · doi:10.1002/mc.20166 · Cited by 156 · see citing works
Modulation of Nuclear Factor-κB Activity by Indomethacin Influences Aβ Levels but Not Aβ Precursor Protein Metabolism in a Model of Alzheimer's Disease
Sung, S., Yang, H., Uryu, K., Lee, E. B., Zhao, L., Shineman, D. W., Trojanowski, J. Q., Lee, V. M. ‐., & Praticò, D. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63269-5 · Cited by 154 · see citing works
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
Zhu, X.-W., Rottkamp, C., Hartzler, A., Sun, Z., Takeda, A., Boux, H., Shimohama, S., Perry, G., & Smith, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00597.x · Cited by 151 · see citing works
Amyloid β-Peptide [1-42]-Associated Free Radical-Induced Oxidative Stress And Neurodegeneration in Alzheimers Disease Brain: Mechanisms and Consequences
Butterfield, D. A. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456422 · Cited by 149 · see citing works
Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid
Schoonbroodt, S., Legrand-Poels, S., Best‐Belpomme, M., & Piette, J. G. (1997) · Biochemical Journal · doi:10.1042/bj3210777 · Cited by 143 · see citing works
Inflammatory mediator and β-amyloid (25–35)-induced ceramide generation and iNOS expression are inhibited by vitamin E
Ayasolla, K., Khan, M., Singh, A. K., & Singh, I. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.007 · Cited by 115 · see citing works
(−)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant
Nagai, K., Jiang, M. H., Hada, J., Nagata, T., Yajima, Y., Yamamoto, S., & Nishizaki, T. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03564-3 · Cited by 106 · see citing works
Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
Yoshino, Y., Aoyagi, M., Tamaki, M., Duan, L., Morimoto, T., & Ohno, K. (2006) · International Journal of Oncology · doi:10.3892/ijo.29.4.981 · Cited by 84 · see citing works
β-AMYLOID FRAGMENT POTENTIATES IL-6 AND TNF-α SECRETION BY LPS IN ASTROCYTES BUT NOT IN MICROGLIA
Forloni, G., Mangiarotti, F., Angeretti, N., Lucca, E., & Simoni, M. G. D. (1997) · Cytokine · doi:10.1006/cyto.1997.0232 · Cited by 84 · see citing works
Role of MAPK Phosphatase-1 (MKP-1) in Adipocyte Differentiation
Sakaue, H., Ogawa, W., Nakamura, T., Mori, T., Nakamura, K., & Kasuga, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407353200 · Cited by 79 · see citing works
Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., Arendt, T., & Eikelenboom, P. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.028 · Cited by 60 · see citing works
Involvement of ERK and Protein Tyrosine Phosphatase Signaling Pathways in EGCG-Induced Cyclooxygenase-2 Expression in Raw 264.7 Cells
Park, J. W., Choi, Y. J., Suh, S., & Kwon, T. K. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5415 · Cited by 59 · see citing works
Inhibition of the Stem Cell Factor-Induced Migration of Mast Cells by Dexamethasone
Jeong, H., Na, H.-J., Hong, S., & Kim, H. (2003) · Endocrinology · doi:10.1210/en.2003-0115 · Cited by 59 · see citing works
Effects of delayed administration of (−)-epigallocatechin gallate, a green tea polyphenol on the changes in polyamine levels and neuronal damage after transient forebrain ischemia in gerbils
Lee, S., Kim, C.-Y., Lee, J.-J., Jung, J., & Lee, S.-R. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00139-4 · Cited by 57 · see citing works
β-Amyloid(25–35) induces the production of interleukin-8 from human monocytes
Meda, L., Bonaiuto, C., Szendrei, G. I., Ceska, M., Rossi, F., & Cassatella, M. A. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00021-s · Cited by 43 · see citing works
Phospholipase D Isozymes Mediate Epigallocatechin Gallate-induced Cyclooxygenase-2 Expression in Astrocyte Cells
Kim, S. Y., Ahn, B., Min, K. J., Lee, Y. H., Joe, E. H., & Min, D. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402085200 · Cited by 43 · see citing works
Regulation of c-Jun N-terminal Kinase and p38 Kinase Pathways in Endothelial Cells
Wadgaonkar, R., Pierce, J. W., Somnay, K., Damico, R. L., Crow, M. T., Collins, T., & Garcia, J. G. N. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0384oc · Cited by 42 · see citing works
Upregulation of COX-2 and CGRP Expression in Resident Cells of the Borna Disease Virus-Infected Brain Is Dependent upon Inflammation
Röhrenbeck, A. M., Bette, M., Hooper, D. C., Nyberg, F., Eiden, L. E., Dietzschold, B., & Weihe, E. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0225 · Cited by 34 · see citing works
Alzheimer's disease, inflammation and non-steroidal anti-inflammatory drugs
Ferencĭk, M., Novák, M., Rovensky, J., & Rybár, I. (2001) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656411 · Cited by 29 · see citing works
MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy
Winter, C., Schenkel, J., Zimmermann, M., & Herdegen, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00601-5 · Cited by 20 · see citing works

Flagged first, then by citations

2 of the 50 references couldn’t be matched to a known paper.

Sorted by citations

Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Dietary polyphenols and their biological significance
Han, X., Shen, T., & Lou, H. (2007) · International Journal of Molecular Sciences · doi:10.3390/i8090950 · Cited by 1,081 · see citing works
Herbal extracts and phytochemicals: Plant secondary metabolites and the enhancement of human brain function
Kennedy, D. O., & Wightman, E. L. (2011) · Advances in Nutrition · doi:10.3945/an.110.000117 · Cited by 684 · see citing works
“The potentially neuropotective effects of EGCG include direct effects seen in vitro in metal chelation (238), as an antiinflammatory agent (239), and in the reduction of amyloid-b and amelioration of amyloid-b induced neurotoxicity (240,241), with these neuroprotectant properties being in part mediated via the activat…”
Background
Effects of Flavonoids and other Polyphenols on Inflammation
González, R., Ballester, I., López-Posadas, R., Suárez, M. D., Zarzuelo, A., Martínez‐Augustin, O., & de Medina, F. S. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903584094 · Cited by 572 · see citing works
“The SAR of chalcones for NO/iNOS inhibition was studied by Kim et al. (2007c), finding that the activity was favored by a methoxyl substitution in the A-ring at an adjacent position to the carbonyl moiety and a 3-halogen substitution in the B-ring.”
BackgroundInfluential
Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms
Singh, M., Arseneault, M., Sanderson, J. T., Murthy, V., & Ramassamy, C. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0735073 · Cited by 438 · see citing works
Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders
Scapagnini, G., Vasto, S., Nader, A. G., Caruso, C., Zella, D., & Galvano, F. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8181-5 · Cited by 403 · see citing works
“It also induces apoptosis in several types of cancer cells by inactivating some transcription factors, such as NF–κB, AP-1, and STAT-1 [ 119 ].”
Epigallocatechin-3-Gallate, a Histone Acetyltransferase Inhibitor, Inhibits EBV-Induced B Lymphocyte Transformation via Suppression of RelA Acetylation
Choi, K., Jung, M. G., Lee, Y., Yoon, J. C., Kwon, S. H., Kang, H., Kim, M., Cha, J., Kim, Y. J., Jun, W. J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2442 · Cited by 354 · see citing works
Naturally occurring phytochemicals for the prevention of Alzheimer’s disease
Kim, J., Lee, H. J., & Lee, K. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06562.x · Cited by 354 · see citing works
Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)
Singh, N. A., Mandal, A. K. A., & Khan, Z. A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0179-4 · Cited by 319 · see citing works
“9 Modulation of Signalling Pathways EGCG • Inflammatory response induced by IL -1β and Aβ [25–35] in human astrocytoma, U373MG cells • Modulates NF-kB signaling pathway [180]”
Background
Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls
Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 276 · see citing works
Neuroinflammation in Alzheimer&rsquo;s disease
Zhang, F., & Jiang, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75546 · Cited by 276 · see citing works
Cellular signaling perturbation by natural products
Sarkar, F. H., Li, Y., Wang, Z. P., & Kong, D. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.03.009 · Cited by 248 · see citing works
Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease
Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234 · see citing works
Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages
Zhong, Y., Chiou, Y., Pan, M., & Shahidi, F. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.02.172 · Cited by 221 · see citing works
“The inhibition of iNOS and COX-2 induction by EGCG–DPA esters may be due to the downregulation of their gene expression at the transcriptional level, as reported for EGCG and other tea catechins (Lin & Lin, 1997; Kim et al., 2007).”
Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse
Wang, Y., Thomas, P., Zhong, J., Bi, F., Kosaraju, S. L., Pollard, A., Fenech, M. F., & Zhou, X. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9000-x · Cited by 221 · see citing works
Neurotherapeutic applications of nanoparticles in Alzheimer’s disease
Sahni, J. K., Doggui, S., Ali, J., Baboota, S., Dao, L., & Ramassamy, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.033 · Cited by 219 · see citing works
Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells.
Cavet, M. E., Harrington, K. L., Vollmer, T. R., Ward, K. W., & Zhang, J.-Z. (2011) · PubMed Central · Cited by 215 · see citing works
The effects of bioactive compounds from plant foods on mitochondrial function: A focus on apoptotic mechanisms
Forbes-Hernández, T. Y., Giampieri, F., Gasparrini, M., Mazzoni, L., Quiles, J. L., Álvarez-Suárez, J. M., & Battino, M. A. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.03.017 · Cited by 200 · see citing works
“also down-regulating NF-kB activation (Kim et al., 2007).”
Background
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds
Li, Y., Wicha, M. S., Schwartz, S. J., & Sun, D. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.11.001 · Cited by 179 · see citing works
“Additionally, EGCG has been found to negatively regulate NF-κB activity and inhibit the ATP- or IL-1β-induced activation of NFκB [141,157–160].”
Background
Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis
Srinivasan, M., & Lahiri, D. K. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.989834 · Cited by 164 · see citing works
“The localized increase in free radical generation promotes increased APP processing, Ab deposition, and tau phosphorylation.”
BackgroundInfluential
Potential role of green tea catechins in various disease therapies: Progress and promise
Mak, J. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05673.x · Cited by 145 · see citing works
Design and Development of Nanovehicle-Based Delivery Systems for Preventive or Therapeutic Supplementation with Flavonoids
Leonarduzzi, G., Testa, G., Sottero, B., Gamba, P., & Poli, G. (2009) · Current Medicinal Chemistry · doi:10.2174/092986710789957760 · Cited by 140 · see citing works
Oxidant/antioxidant imbalance and the risk of Alzheimer's disease
Moneim, A. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150325182702 · Cited by 136 · see citing works
“Pomegranate is also known as a good inhibitor of gene expression of inflammatory cytokines such as IL-6, IL-8, vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2), COX-2, and iNOS by influence of inhibition of JUN and NF-κB-mediated gene transcription [104-105].”
Background
Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms
Verri, W. A., Jr., Vicentini, F. T. M. C., Baracat, M. M., Georgetti, S. R., Cardoso, R. D. R., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., Fonseca, M. J. V., & Casagrande, R. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-53836-9.00026-8 · Cited by 136 · see citing works
Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Ansari, N., & Khodagholi, F. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311040005 · Cited by 131 · see citing works
“EGCG (2 and 20 M) also inhibited vascular endothelial growth factor, prostaglandin E2, p38, JNK, and MAPK phosphatase-1 [97].”
Background
Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
Owona, V. B. A., Ebrahimi, A., & Schluesener, H. J. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300195 · Cited by 125 · see citing works
Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double‐blind, placebo‐controlled, crossover investigation
Wightman, E. L., Haskell‐Ramsay, C. F., Forster, J. S., Veasey, R. C., & Kennedy, D. O. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1263 · Cited by 116 · see citing works
“…including effects on cholinergic transmission (Katayama et al., 2002), neurite outgrowth (Reznichenko et al., 2005), inflammatory parameters (Kim et al., 2007), metal chelation (Mandel et al., 2008) and an ability to act as an antioxidant (Unno et al., 2007) and to upregulate endogenous…”
Background
Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease
Davinelli, S., Sapere, N., Zella, D., Bracale, R., Intrieri, M., & Scapagnini, G. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/386527 · Cited by 111 · see citing works
“EGCG in human astrocytoma U373MG cells suppressed NF-kβ activation and phosphorylation of MAPK p38 and the c-Jun N-terminal kinase [71].”
Method
Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products
Rather, M. A., Khan, A., Alshahrani, S., Rashid, H., Qadri, M. M., Rashid, S., Alsaffar, R. M., Kamal, M. A., & Rehman, M. U. (2021) · Mediators of Inflammation · doi:10.1155/2021/9982954 · Cited by 112 · see citing works
“It also exhibited the secretion of BDNF and NGF and reduced the levels of caspase-3 and ROS in human astrocytoma U373MG cells [207].”
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E. (2016) · Molecules · doi:10.3390/molecules21040518 · Cited by 107 · see citing works
“Activation of NFκB, MAPK and JNK signaling pathways were also inhibited by EGCG [78].”
Background
RETRACTED ARTICLE: The Major Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate, Induces Heme Oxygenase in Rat Neurons and Acts as an Effective Neuroprotective Agent against Oxidative Stress
Romeo, L., Intrieri, M., D’Agata, V., Mangano, N. G., Oriani, G., Ontario, M. L., & Scapagnini, G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718116 · Cited by 105 · see citing works
Retracted
Small molecule inhibitors of Aβ‐aggregation and neurotoxicity
Hawkes, C. A., Ng, V., & McLaurin, J. (2009) · Drug Development Research · doi:10.1002/ddr.20290 · Cited by 103 · see citing works
“A variety of mechanisms, including antiaggregation, anti-inflammatory, antioxidative, and iron-chelating capabilities have been proposed to mediate these neuroprotective effects [Bastianetto et al., 2006; Kim et al., 2007; Levites et al., 2003; Obregon et al., 2006; Rezai-Zadeh et al., 2005; Reznichenko et al., 2006].”
Background
Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management
Siddiqi, K. S., Husen, A., Sohrab, S. S., & Yassin, M. O. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2638-7 · Cited by 103 · see citing works
Chemico-biological aspects of (−)- epigallocatechin- 3 -gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects
Sahadevan, R., Singh, S. K., Binoy, A., & Sadhukhan, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2068500 · Cited by 103 · see citing works
“EGCG has also been found to suppress the MAPK and insulin-like growth factor 1 receptor (IGF1R) signaling pathways (Kim et al. 2007; Shimizu et al. 2005).”
Background
Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells
Hirao, K., Yumoto, H., Nakanishi, T., Mukai, K., Takahashi, K., Takegawa, D., & Matsuo, T. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.02.017 · Cited by 93 · see citing works
“…(Ahmed et al. 2002; Peng et al. 2006); therefore, our results and previous studies suggest that EGCG regulates COX-2-mediated inflammation through different mechanisms in different cell systems and EGCG-treated regulation of the inflammatory pathway might be cell-type specific (Kim et al. 2007).”
BackgroundResult
The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products
Wang, R., Zhou, M., Ma, H., Qiao, Y., & Li, Q. (2021) · ChemMedChem · doi:10.1002/cmdc.202000996 · Cited by 86 · see citing works
Voluntary wheel running, but not a diet containing (−)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice
Gibbons, T. E., Pence, B. D., Petr, G. T., Ossyra, J. M., Mach, H. C., Bhattacharya, T. K., Perez, S., Martin, S. A., McCusker, R. H., Kelley, K. W., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.049 · Cited by 80 · see citing works
A review for physiological activities of EGCG and the role in improving fertility in humans/mammals
Zhang, Y., Lin, H., Liu, C., Huang, J., & Liu, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110186 · Cited by 81 · see citing works
Multifaceted neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) in Alzheimer’s disease: an overview of pre-clinical studies focused on β-amyloid peptide
Youn, K., Ho, C., & Jun, M. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.12.006 · Cited by 74 · see citing works
Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review
Brodzikowska, A., Ciechanowska, M., Kopka, M., Stachura, A., & Wlodarski, P. K. (2022) · Biomolecules · doi:10.3390/biom12010138 · Cited by 65 · see citing works
On the Development of a Cutaneous Flavonoid Delivery System: Advances and Limitations
Costa, R., Lima, S. A. C., Gameiro, P., & Reis, S. (2021) · Antioxidants · doi:10.3390/antiox10091376 · Cited by 63 · see citing works
Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade
Singh, B. N., Singh, H., Singh, A., Naqvi, A., & Singh, B. R. (2014) · Cancer Metastasis Review · doi:10.1007/s10555-013-9457-1 · Cited by 61 · see citing works
Natural Products That Target Cancer Stem Cells.
Moselhy, J., Srinivasan, S., Ankem, M. K., & Damodaran, C. (2015) · PubMed · Cited by 57 · see citing works
Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers
Yun, J., Jialal, I., & Devaraj, S. (2010) · British Journal Of Nutrition · doi:10.1017/s000711451000005x · Cited by 56 · see citing works
Role of oxidation‐triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells
Bhattacharya, U., Halder, B., Mukhopadhyay, S., & Giri, A. K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01251.x · Cited by 53 · see citing works
Catechin Derivatives from Parapiptadenia rigida with in Vitro Wound-Healing Properties
Schmidt, C. A., Murillo, R., Bruhn, T., Bringmann, G., Goettert, M. I., Heinzmann, B. M., Brecht, V., Laufer, S., & Merfort, I. (2010) · Journal of Natural Products · doi:10.1021/np100523s · Cited by 52 · see citing works
Plants traditionally used in age-related brain disorders (dementia): an ethanopharmacological survey
Suganthy, N., Pandian, S. K., & Kasi, P. D. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2012.738423 · Cited by 53 · see citing works
“Therefore, dietary polyphenols are termed as neuroprotector (Kim et al., 2007).”
Background
Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives
Ayaz, M., Mosa, O. F., Nawaz, A., Hamdoon, A. A. E., Elkhalifa, M. E. M., Sadiq, A., Ullah, F., Ahmed, A., Kabra, A., Khan, H. Z., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155272 · Cited by 49 · see citing works
Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
Angeloni, C., Malaguti, M., Prata, C., Freschi, M., Barbalace, M. C., & Hrelia, S. (2022) · Antioxidants · doi:10.3390/antiox12010094 · Cited by 52 · see citing works
Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
Scapagnini, G., Caruso, C., & Calabrese, V. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-7347-4_3 · Cited by 42 · see citing works
Epigallocatechin gallate suppresses peritoneal fibrosis in mice
Kitamura, M., Nishino, T., Obata, Y., Furusu, A., Hishikawa, Y., Koji, T., & Kohno, S. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.11.002 · Cited by 41 · see citing works
“Southwestern histochemistry for NF-B EGCG has been shown to suppress NF-B signaling [31, 32].”
Background
Nanotechnology-Based Advancements In NF-κB Pathway Inhibition for the Treatment of Inflammatory Lung Diseases
Bhat, A. A., Gupta, G., Singh, S. K., Yadav, H. K. S., Saini, M., Salfi, R., Singh, S. K., & Dua, K. (2022) · Nanomedicine · doi:10.2217/nnm-2022-0220 · Cited by 40 · see citing works
Effects of green tea supplementation on inflammation markers, antioxidant status and blood pressure in NaCl-induced hypertensive rat model
Szulińska, M., Stępień, M., Kręgielska-Narożna, M., Suliburska, J., Skrypnik, D., Bąk‐Sosnowska, M., Kujawska-Łuczak, M., Grzymisławska, M., & Bogdański, P. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2017.1295525 · Cited by 40 · see citing works
Accurate Assessment of the Bioactivities of Redox-Active Polyphenolics in Cell Culture
Wisman, K. N., Perkins, A. A., Jeffers, M. D., & Hagerman, A. E. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8011954 · Cited by 39 · see citing works
Epigallocatechin gallate for Parkinson's disease
Sergi, C. M. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13691 · Cited by 38 · see citing works
“Modulation of the NFκB signalling pathway was identified using an IL -1β and Aβ-inflammatory response in human astrocytoma (U373MG) cells.(136) Also, EGCG promoted the F IGURE 1 Some intracellular signalling pathways have been described to play central functions in EGCG-promoted neuronal protection against various ext…”
BackgroundMethodInfluential
Molecular interaction studies of green tea catechins as multitarget drug candidates for the treatment of Parkinson’s disease: computational and structural insights
Azam, F., Najah, M., & Alhussen, F. (2015) · Network Computation in Neural Systems · doi:10.3109/0954898x.2016.1146416 · Cited by 36 · see citing works
“Kim et al., 2007 ʺ Decreases the expression of cyclooxygenase-2 and activation of nuclear factor-κB induced by IL-1β +Aβ25–35.”
Background
The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc
Hegedüs, I., Andreidesz, K., Szentpéteri, J. L., Kaleta, Z., Szabó, L. G., Szigeti, K., Gulyás, B. Z., Padmanabhan, P., Budán, F., & Máthé, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911165 · Cited by 35 · see citing works
“EGCG, ECG, Myricetin Inhibition of IL-6, IL-8, VEGF and PGE2 2 production Attenuation of COX-2 expression and NF-κB 3 activation Induction of MAPK phosphatase 1 expression Inhibition of phosphorylation of MAPK (p38 and JNK 4) Human astrocytoma U373MG cell culture In vitro [67]”
Background
Three Pathways Assess Anti-Inflammatory Response of Epicatechin with Lipopolysaccharide-Mediated Macrophage RAW264.7 Cells
Yang, D., Liu, S., Chen, Y., Hsu, S.-H., Chang, Y.-P., & Lin, J.-T. (2015) · Journal of Food Biochemistry · doi:10.1111/jfbc.12134 · Cited by 35 · see citing works
Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease
Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2018) · BioMed Research International · doi:10.1155/2018/1483791 · Cited by 35 · see citing works
“EGCG interferes with IKKβ activation and suppresses NFκB mediated activation of β-secretase, thereby inhibiting Aβ fibrillization [421].”
Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting Inflammation
Tu, S., Xiao, F., Min, X., Chen, H., Fan, X., & Cao, K. (2018) · Cardiovascular Toxicology · doi:10.1007/s12012-018-9449-z · Cited by 32 · see citing works
Defects in Tongue Papillae and Taste Sensation Indicate a Problem with Neurotrophic Support in Various Neurological Diseases
Gardiner, J. C., Barton, D., Vanslambrouck, J. M., Braet, F., Hall, D. H., Marc, J., & Overall, R. L. (2007) · The Neuroscientist · doi:10.1177/1073858407312382 · Cited by 30 · see citing works
Chemical biology of Histone acetyltransferase natural compounds modulators
Piaz, F. D., Vassallo, A., Cuesta‐Rubio, O., Castellano, S., Sbardella, G., & Tommasi, N. D. (2010) · Molecular Diversity · doi:10.1007/s11030-010-9299-5 · Cited by 30 · see citing works
“EGCG has been shown to inhibit the production of nitric oxide synthase (NOS2)byblockingtheNF- κBsignaltransductionpathway [100, 101 ].”
Background
Anti-inflammatory effect of phenethyl isothiocyanate, an active ingredient of Raphanus sativus Linne
Moon, P., & Kim, H. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.09.127 · Cited by 29 · see citing works
Anti-inflammatory Activity of n-Propyl Gallate Through Down-regulation of NF-κB and JNK Pathways
Jung, H., Kim, S., Jeon, W.-K., Kim, B.-C., Ahn, K., Kim, K., Kim, Y., Park, E.-H., & Lim, C. (2010) · Inflammation · doi:10.1007/s10753-010-9241-0 · Cited by 28 · see citing works
“Epigallocatechin-3gallate has been shown to suppress NF-κB activation and phosphorylation of p38 MAPK and JNK1/2 in human astrocytoma U373MG cells [38].”
Background
Catechins inhibit vascular endothelial growth factor production and cyclooxygenase‐2 expression in human dental pulp cells
Nakanishi, T., Mukai, K., Hosokawa, Y., Takegawa, D., & Matsuo, T. (2014) · International Endodontic Journal · doi:10.1111/iej.12312 · Cited by 28 · see citing works
Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease
Balakrishnan, R., Jannat, K., & Choi, D. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103105 · Cited by 27 · see citing works
“A similar study reported that EGCG administration significantly inhibited IL-6, IL-8, VEGF, and PGE2 production, decreased COX-2 expression, and inhibited NF-κ B activation, with subsequent inhibition of phosphorylation of p38, JNK, and ERK in IL-1 β + A β (25-35) -induced U373MG cells [219].”
Background
Impact of polyphenols in phagocyte functions
da Cunha, L. R., Muniz‐Junqueira, M. I., & Borges, T. K. D. S. (2019) · Journal of Inflammation Research · doi:10.2147/jir.s193749 · Cited by 26 · see citing works
“p38 and JNK, preventing apoptosis in human astrocytoma U373MG cells.(101) In rats, curcumin also blocks JNK-related signaling and reduces activation of MAPK p38 on a chronic experimental colitis model.”
Background
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
Wu, Z., Zhang, T., Ma, X., Guo, S., Zhou, Q., Zahoor, A., & Deng, G. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01369-9 · Cited by 24 · see citing works
Molecular mechanism underlying anti-apoptotic and anti-inflammatory effects of Mamao (Antidesma thwaitesianum Müll. Arg.) polyphenolics in human breast epithelial cells
Puangpronpitag, D., Yongvanit, P., Boonsiri, P., Suttajit, M., Areejitranusorn, P., Na, H.-K., & Surh, Y. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.01.099 · Cited by 23 · see citing works
Evaluation of polyphenols as possible therapeutics for amyloidoses: Comparative analysis of Kaempferol and Catechin
Bhat, W. F., Bhat, S. A., & Bano, B. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.07.052 · Cited by 23 · see citing works
Tea polyphenols and Levofloxacin alleviate the lung injury of hepatopulmonary syndrome in common bile duct ligation rats through Endotoxin -TNF signaling
Zhu, J., Qiu, J., Chen, K., Wang, W., & Zheng, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111263 · Cited by 22 · see citing works
Flavonoids as Potential Therapeutics Against Neurodegenerative Disorders: Unlocking the Prospects
Faysal, M. F., Dehbia, Z., Zehravi, M., Sweilam, S. H., Haque, M. A., Kumar, K. P., Chakole, R. D., Shelke, S. P., Sirikonda, S., Nafady, M. H., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04177-x · Cited by 23 · see citing works
Medicinal herbal remedies in neurodegenerative diseases: an update on antioxidant potential
Sarkar, B., Rana, N., Singh, C., & Singh, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03027-5 · Cited by 21 · see citing works
“…such as human astrocytoma U373MG cells, EGCG suppresses the activation of MAPK and NF-B, which then leads to a reduction in the production of IL-6, IL-8, and vascular endothelial growth factor along with that EGCG increases the synthesis of an antiapoptotic molecule such as Bcl-2 (Kim et al. 2007).”
Inhibitory Effects of BiRyuChe-Bang on Mast Cell-Mediated Allergic Reactions and Inflammatory Cytokines Production
Moon, P., Choi, I. S., Go, J.-H., Lee, B.-J., Kang, S. W., Yoon, S., Han, S.-J., Nam, S., Oh, H., Han, N., et al. (2013) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x13500857 · Cited by 21 · see citing works
Epigallocatechin-3-gallate prevents tumor cell implantation/growth in an experimental rat bladder tumor model
Jankun, J., Keck, R. W., & Selman, S. H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2174 · Cited by 20 · see citing works
Green tea catechins suppress NF-κB-mediated inflammatory responses: relevance to nutritional management of inflammation
Ravindranath, N. H., & Ravindranath, M. H. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510005611 · Cited by 19 · see citing works
Antioxidants and Human Health
Shahidi, F., Zhong, Y., & Chandrasekara, A. (2012) · Wiley eBooks · doi:10.1002/9781118229415.ch19 · Cited by 18 · see citing works
Behavioural effects of compounds co-consumed in dietary forms of caffeinated plants
Haskell‐Ramsay, C. F., Dodd, F. L., Wightman, E. L., & Kennedy, D. O. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000036 · Cited by 17 · see citing works
Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?
Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17 · see citing works
Transcription Factors as Targets of Natural Compounds in Age-Related Diseases and Cancer: Potential Therapeutic Applications
Kim, M. E., Kim, D. H., & Lee, J. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213882 · Cited by 15 · see citing works
Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice
Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S., et al. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.020 · Cited by 15 · see citing works
“flammation (Kim et al., 2007) and to increase neuronal survival (Ortiz-”
BackgroundInfluential
Epigallocatechin-3-gallate inhibits TF and TNF-α expression induced by the anti-β2GPI/β2GPI complex in human THP-1 cells
WANG, T., Zhou, H., Xie, H., MU, Y., Xu, Y. T., Liu, J., & Zhang, X. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1635 · Cited by 15 · see citing works
Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches
Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works
“[197] Additionally, EGCG inhibits the pro-inflammatory effects of several cytokines [198,199] and reduces COX-2 expression and prostaglandin E2 production that are triggered by IL-1 and Aβ.”
Background
Neuroprotective potential of epigallocatechin gallate in Neurodegenerative Diseases: Insights into molecular mechanisms and clinical Relevance
Al-Amin, M., Zehravi, M., Sweilam, S. H., Shatu, M. M., Durgawale, T. P., Qureshi, M. S., Durgapal, S., Haque, M. A., Vodeti, R., Panigrahy, U. P., et al. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149693 · Cited by 15 · see citing works
The Use of Polyphenols for the Treatment of Alzheimer’s Disease
Sathya, S., & Devi, K. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00015-8 · Cited by 15 · see citing works
The Mechanism Study of Common Flavonoids on Antiglioma Based on Network Pharmacology and Molecular Docking
Li, T., Xiao, Y., Wang, Z., Xiao, H., & Liu, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2198722 · Cited by 14 · see citing works
Effect of Topical Epigallocatechin Gallate on Corneal Neovascularization in Rabbits
Koh, C. H., Lee, H. S., & Chung, S. K. (2014) · Cornea · doi:10.1097/ico.0000000000000104 · Cited by 14 · see citing works
(−)-Epigallocatechin 3-gallate (EGCG) at the ocular surface inhibits corneal neovascularization
Sánchez-Huerta, V., Gutiérrez-Sánchez, L., & Flores‐Estrada, J. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.09.020 · Cited by 13 · see citing works
Mechanistic comparison of current pharmacological treatments and novel phytochemicals to target amyloid peptides in Alzheimer’s and neurodegenerative diseases
Ayyalasomayajula, N., & Challa, S. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1345425 · Cited by 13 · see citing works
Reversal of cisplatin triggered neurotoxicity by Acacia hydaspica ethyl acetate fraction via regulating brain acetylcholinesterase activity, DNA damage, and pro-inflammatory cytokines in the rodent model
Afsar, T., Razak, S., & Almajwal, A. M. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03657-3 · Cited by 13 · see citing works
“Antiinflammatory activities of various cytokines are suppressed by EGCG by a decline of IL-1β and Aβ-induced COX-2 expression [47].”
Background
NF-κΒ inhibition is ineffective in blocking cytokine-induced IL-8 production but P38 and STAT1 inhibitors are effective
Wang, Q., Huber, N. L., Noel, G. J., Haar, L., Shan, Y., Pritts, T. A., & Ogle, C. K. (2012) · Inflammation Research · doi:10.1007/s00011-012-0490-2 · Cited by 11 · see citing works
Therapeutic potential and microRNA regulating properties of phytochemicals in Alzheimer’s disease
Kumari, A., Rahaman, A., Zeng, X., & Baloch, Z. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102439 · Cited by 9 · see citing works
A Review on the Role of Nutraceuticals as Simple as Se2+ to Complex Organic Molecules Such as Glycyrrhizin That Prevent as Well as Cure Diseases
Jose, R., Sajitha, G. R., & Augusti, K. T. (2013) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-013-0362-8 · Cited by 8 · see citing works
Polyphenol-Loaded Nanodevices as Innovative Therapeutic Strategies for Dry Eye Disease: Advances and Perspectives
Conte, R., Luca, I. D., Calarco, A., Finicelli, M., & Peluso, G. (2025) · Antioxidants · doi:10.3390/antiox14111280 · Cited by 7 · see citing works
“These findings confirm the compound’s potential therapeutic efficacy in attenuating inflammatory and oxidative damage associated with DED and other ocular inflammatory conditions [113].”
Caffeic acid derivative WSY6 protects melanocytes from oxidative stress by reducing ROS production and MAPK activation
Jin, R., Hu, W., Zhou, M., Lin, F., & Xu, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24843 · Cited by 6 · see citing works
“EGCG inhibits the expression of anti-apoptosis-related proteins by down-regulating NF κ B [39,40], promotes tumor cell apoptosis [12].”
Background
Nanotherapeutic smart approaches for combating Alzheimer’s disease and overcoming existing obstacles: A novel eco-friendly green approach
Almehdi, A. M., Baker, D. H. A., Hamdy, R., & El‐Keblawy, A. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101906 · Cited by 6 · see citing works
Biomimetic cell membrane vesicles as promising delivery carriers for dietary polyphenols in neurodegenerative diseases
Wang, Y., Liu, J., Jiang, Q., Mi, Y., Meng, Q., Mu, D., & Hou, Y. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105418 · Cited by 6 · see citing works
Cosmeceuticals in Dermatology
Tedeschi, A., West, L. E., Guzzardi, L., Bhatt, K., Reid, E. E., Scapagnini, G., & Micali, G. (2013) · Springer eBooks · doi:10.1007/978-3-642-34029-1_7 · Cited by 5 · see citing works
Palmitoyl-Epigallocatechin Gallate Modulates COX-2-Based Production of Inflammation-Related Oxylipins: Synthesis, Characterization, and Bioevaluation In Vitro and In Silico
Medrano‐Padial, C., Fuentes-Soriano, P., Hernández-Prieto, D., García‐Viguera, C., Domínguez‐Perles, R., Romero‐Nieto, C., & Medina, S. (2025) · ACS Omega · doi:10.1021/acsomega.5c04117 · Cited by 4 · see citing works
Green Tea and Neurodegeneration in Alzheimer’s Disease
Ho, J. Y. S., Hung, C. H.-L., & Chang, R. C. (2012) · Tea in Health and Disease Prevention · doi:10.1016/b978-0-12-384937-3.00058-6 · Cited by 4 · see citing works

The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-κB suppression
Navarro-Perán, E., Cabezas‐Herrera, J., Sánchez‐del‐Campo, L., Garcı́a-Cánovas, F., & Rodríguez‐López, J. N. (2008) · Inflammation Research · doi:10.1007/s00011-008-8013-x · Cited by 48 · see citing works
Epigallocatechin-3-gallate, a Green Tea–Derived Polyphenol, Inhibits IL-1β-Dependent Proinflammatory Signal Transduction in Cultured Respiratory Epithelial Cells
Wheeler, D. S., Catravas, J. D., Odoms, K., Denenberg, A. G., Malhotra, V., & Wong, H. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.5.1039 · Cited by 156 · see citing works
Epigallocatechin 3‐Gallate Inhibitory Effects on Inflammatory Mediators in BV‐2 Microglial Cells
Payne, A., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r2294 · Cited by 4 · see citing works
Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia
Wei, J. C., Huang, H., Chen, W. J., Huang, C., Peng, C., & Lin, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.048 · Cited by 128 · see citing works
Epigallocatechin-3-gallate Inhibits LPS/AβO-induced Neuroinflammation in BV2 Cells through Regulating the ROS/TXNIP/NLRP3 Pathway
Xiao, Y., Yang, C., Si, N., Chu, T., Yu, J., Yuan, X., & Chen, X.-T. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10131-z · Cited by 20 · see citing works

Authors: Kim, S.-J., Jeong, H.-J., Lee, K.-M., Myung, N.-Y., An, N.-H., Mo Yang, W., Kyu Park, S., Lee, H.-J., Hong, S.-H., Kim, H.-M., & Um, J.-Y.
Affiliations: Kyung Hee University (KR)
Jeonbuk National University (KR)
Wonkwang University (KR)
Corresponding author: Um, Jae-Young
ORCID: Kim, Su-Jin
Jeong, Hyun-Ja
Lee, Kang-Min
Hong, Seung-Heon
Kim, Hyung-Min
Um, Jae-Young
Venue: The Journal of Nutritional Biochemistry
Publisher: Elsevier BV
Published: 2007-09
Volume: 18
Issue: 9
Pages: 587-596
ISSN: 0955-2863 (ISSN-L)
DOI: 10.1016/j.jnutbio.2006.11.001
OpenAlex: W2017180972
Cited by: 116
References: 50
Citations by year: 2026: 1 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 10 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 10
FWCI: 5.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Nutritional Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Korea Science and Engineering Foundation
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: epigallocatechin gallate, green tea polyphenols, NF-κB activation, p38 MAPK, JNK, astrocytoma, Alzheimer's disease, IL-1β, amyloid-beta, neuroinflammation, cyclooxygenase-2, MAPK phosphatase-1, vascular endothelial growth factor, prostaglandin E2, interleukin-6, interleukin-8
MeSH terms: Anti-Inflammatory Agents, Astrocytoma, Catechin, Humans, Peptide Fragments, Phosphorylation, Tumor Cells, Cultured, Dinoprostone, Interleukin-6, Interleukin-8, Amyloid beta-Peptides, NF-kappa B, Vascular Endothelial Growth Factor A, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Cyclooxygenase 2, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks