The DOI matches its Crossref record; 345 of the 347 references it cites were found in a registry or an index.
Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications
Open accessAbstract
Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and has anti-inflammatory, redox modulatory, and neuroprotective effects. This paper reviews the known physiological role of CoQ10 in cellular metabolism, cell death, differentiation and gene regulation, and examines the potential repercussions of CoQ10 depletion including its role in illnesses such as Parkinson's disease, depression, myalgic encephalomyelitis/chronic fatigue syndrome, and fibromyalgia. CoQ10 depletion may play a role in the pathophysiology of these disorders by modulating cellular processes including hydrogen peroxide formation, gene regulation, cytoprotection, bioenegetic performance, and regulation of cellular metabolism. CoQ10 treatment improves quality of life in patients with Parkinson's disease and may play a role in delaying the progression of that disorder. Administration of CoQ10 has antidepressive effects. CoQ10 treatment significantly reduces fatigue and improves ergonomic performance during exercise and thus may have potential in alleviating the exercise intolerance and exhaustion displayed by people with myalgic encepholamyletis/chronic fatigue syndrome. Administration of CoQ10 improves hyperalgesia and quality of life in patients with fibromyalgia. The evidence base for the effectiveness of treatment with CoQ10 may be explained via its ability to ameliorate oxidative stress and protect mitochondria.
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“CoQ10 has been implicated in the pathophysiology of neuro-immune diseases, including MDD [177].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [177]
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“For example, decreased peripheral levels of CoQ10 have been reported in patients with MDD relative to those measured for controls [177].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [177]
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“As an antioxidant, CoQ10 protects cells from the damaging effects of reactive oxygen species and reactive nitrogen species [177].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [177]
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Items 201–345 of 345
Coenzyme Q10 in Neurodegenerative Diseases
Shults, C. W. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033456882 · Cited by 99
Choi, H., Pokharel, Y. R., Lim, S., Han, H.-K., Ryu, C. S., Kim, S. K., Kwak, M. K., & Kang, K. W. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.030 · Cited by 98
Aboul-Fotouh, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.027 · Cited by 97
Mutations in coenzyme Q10 biosynthetic genes
DiMauro, S., Quinzii, C. M., & Hirano, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31423 · Cited by 95
Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome
Paul, L., Wood, L., Behan, W. M. H., & Maclaren, W. M. (1999) · European Journal of Neurology · doi:10.1046/j.1468-1331.1999.610063.x · Cited by 95
Kunitomo, M., Yamaguchi, Y., Kagota, S., & Otsubo, K. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0072365 · Cited by 95
Jiang, N., Zhang, G., Bo, H., Qu, J., Ma, G., Cao, D., Wen, L., Liu, S., Ji, L. L., & Zhang, Y. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.026 · Cited by 93
Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome
y Keenoy, B. M., Moorkens, G. H., Vertommen, J., & Leeuw, I. D. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01001-3 · Cited by 93
The emerging role of autophagy in Parkinson's disease
Cheung, Z. H., & Ip, N. Y. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-29 · Cited by 92
Professional's handbook of complementary & alternative medicines
Fetrow, C. W., & Avila, J. R. (2001) · Cited by 91
Can Coenzyme Q 10 Improve Clinical and Molecular Parameters in Fibromyalgia?
Cordero, M. D., Alcocer‐Gómez, E., de Miguel, M., Čulić, O., Carrión, Á. M., Álvarez-Suárez, J. M., Bullón, P., Battino, M. A., Fernández-Rodríguez, A., & Sánchez-Alcázar, J. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5260 · Cited by 91
Folkers, K., & Simonsen, R. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00040-b · Cited by 91
Kandhare, A. D., Ghosh, P., Ghule, A. E., & Bodhankar, S. L. (2012) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12003 · Cited by 91
Kamzalov, S., Sohal, R. S., Sumien, N., & Forster, M. J. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3175 · Cited by 89
Total antioxidant capacity and the severity of the pain in patients with fibromyalgia
Altındağ, Ö., & Çelık, H. (2006) · Redox Report · doi:10.1179/135100006x116628 · Cited by 88
Effect of Ezetimibe and/or Simvastatin on Coenzyme Q10 Levels in Plasma
Berthold, H. K., Naini, A., Mauro, S. D., Hallikainen, M., Gylling, H. K., Krone, W., & Gouni‐Berthold, I. (2006) · Drug Safety · doi:10.2165/00002018-200629080-00007 · Cited by 87
Maes, M. H. J., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2011) · Medical Science Monitor · doi:10.12659/msm.881699 · Cited by 87
Self-citationErythrocyte Oxidative Damage in Chronic Fatigue Syndrome
Richards, R. S., Wang, L., & Jelinek, H. F. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.06.008 · Cited by 85
Emre, Y., Hurtaud, C., Karaca, M., Nübel, T., Zavala, F., & Ricquier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709557104 · Cited by 84
A Phospholipid-Dependent NADH-Coenzyme Q Reductase from Liver Plasma Membrane
Navarro, F., Villalba, J. M., Crane, F. L., MacKellar, W. C., & Navas, P. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1947 · Cited by 82
Therapeutic role of coenzyme Q10 in Parkinson's disease
Shults, C. W. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.02.002 · Cited by 81
Jammes, Y., Steinberg, J., Delliaux, S., & Brégeon, F. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02079.x · Cited by 81
Neuroprotective Role of Mitochondrial Uncoupling Protein 2 in Cerebral Stroke
Mehta, S. L., & Li, P. A. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.4 · Cited by 81
Schmelzer, C., Lorenz, G., Rimbach, G. H., & Döring, F. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.08-182 · Cited by 81
Jenkinson, A. M., Collins, A. R., Duthie, S. J., Wahle, K. W. J., & Duthie, G. G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2138 · Cited by 80
Miyamae, T., Seki, M., Naga, T., Uchino, S., Asazuma, H., Yoshida, T., Iizuka, Y., Kikuchi, M., Imagawa, T., Natsumeda, Y., et al. (2013) · Redox Report · doi:10.1179/1351000212y.0000000036 · Cited by 80
Highlights in Ubiquinone research
(1991) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(91)90162-m · Cited by 80
Giardina, T. M., Steer, J. H., Lo, S. Z. Y., & Joyce, D. A. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.11.006 · Cited by 79
Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease
Chao, J., Leung, Y., Wang, M., & Chang, R. C. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00484.x · Cited by 79
Sensing electrons: protein phosphatase redox regulation
Rusnak, F. M., & Reiter, T. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01659-5 · Cited by 78
Nierenberg, A. A., Kansky, C., Brennan, B. P., Shelton, R. C., Perlis, R. H., & Iosifescu, D. V. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412449303 · Cited by 78
Barroso, M. P., Gómez-Dı́az, C., Villalba, J. M., Burón, M. I., López‐Lluch, G., & Navas, P. (1997) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1022462111175 · Cited by 77
González, R., Ferrín, G., Hidalgo, A. B., Ranchal, I., López‐Cillero, P., González, M. S., López‐Lluch, G., Briceño, J., Gómez‐Bravo, M. Á., Poyato, A., et al. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.06.003 · Cited by 76
Abe, K., Fujimura, H., Nishikawa, Y., Yorifuji, S., Mezaki, T., Hirono, N., Nishitani, N., & Kameyama, M. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb03962.x · Cited by 76
Coenzyme Q10and selenium in statin-associated myopathy treatment
Fedacko, J., Pella, D., Fedackova, P., Hänninen, O., Tuomainen, P., Jarcuska, P., Lopuchovsky, T., Jedlickova, L., Merkovska, L., & Littarru, G. P. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0118 · Cited by 76
Díaz‐Castro, J., Guisado, R., Kajarabille, N., García, C., Guisado-Requena, I. M., de Teresa, C., & Ochoa, J. J. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0257-5 · Cited by 75
Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
Singh, R. B., Neki, N. S., Kartikey, K., Pella, D., Kumar, A., Niaz, M. A., & Thakur, A. S. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0298-2_11 · Cited by 74
On the nature of the mitochondrial proton leak
Brown, G. C., & Brand, M. D. (1991) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(05)80187-2 · Cited by 74
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria
Parker, N., Affourtit, C., Vidal‐Puig, A., & Brand, M. D. (2008) · Biochemical Journal · doi:10.1042/bj20080006 · Cited by 73
Nutritional strategies for treating chronic fatigue syndrome.
Werbach, M. R. (2000) · PubMed · Cited by 73
Lee, B., Lin, Y., Huang, Y., Ko, Y., Hsia, S., & Lin, P. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/792756 · Cited by 73
Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation
Langsjoen, P. H., Langsjoen, J., Langsjoen, A. M., & Lucas, L. A. (2005) · BioFactors · doi:10.1002/biof.5520250116 · Cited by 73
Maes, M. H. J., Mihaylova, I., Kubera, M., & Bosmans, E. (2007) · PubMed · Cited by 72
Self-citationUCP2 is highly expressed in pancreatic α-cells and influences secretion and survival
Diao, J., Allister, E. M., Koshkin, V., Lee, S. C., Bhattacharjee, A., Tang, C., Giacca, A., Chan, C. B., & Wheeler, M. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710434105 · Cited by 71
Jammes, Y., Steinberg, J. G., & Delliaux, S. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02488.x · Cited by 70
Maes, M. H. J., Mihaylova, I., & Leunis, J. (2007) · PubMed · Cited by 69
Self-citationAbe, K., Matsuo, Y., Kadekawa, J., Inoue, S., & Yanagihara, T. (1999) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00296-2 · Cited by 67
Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome
Lane, R. J. M., BARRETT, M. C., Woodrow, D. F., Moss, J. W. E., Fletcher, R., & ARCHARD, L. C. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.3.362 · Cited by 67
Talbot, D. A., Hanuise, N., Rey, B., Rouanet, J., Duchamp, C., & Brand, M. D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.022 · Cited by 66
Functional connections and pathways of coenzyme Q10‐inducible genes: An in‐silico study
Döring, F., Schmelzer, C., Lindner, I., Vock, C., & Fujii, K. (2007) · IUBMB Life · doi:10.1080/15216540701545991 · Cited by 66
Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle
Lane, R. J. M., BARRETT, M. C., Taylor, D. J., Kemp, G. J., & Lodi, R. (1998) · Neuromuscular Disorders · doi:10.1016/s0960-8966(98)00021-2 · Cited by 66
Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction
Singh, R. B., Neki, N. S., Kartikey, K., Pella, D., Kumar, A., Niaz, M. A., & Thakur, A. S. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1023408031111 · Cited by 66
(1997) · PubMed · Cited by 65
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.1136/jim-52-01-23 · Cited by 65
Morris, G., & Maes, M. H. J. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.07.034 · Cited by 65
Self-citationProtein turnover and inclusion body formation
Mitra, S. S., Tsvetkov, A. S., & Finkbeiner, S. M. (2009) · Autophagy · doi:10.4161/auto.5.7.9291 · Cited by 65
Goda, S., Hamada, T., Ishimoto, S., Kobayashi, T., Goto, I., & Kuroiwa, Y. (1987) · Journal of Neurology · doi:10.1007/bf00314013 · Cited by 64
Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats
Kon, M., Kimura, F., Akimoto, T., Tanabe, K., Murase, Y., IKEMUNE, S., & Kono, I. (2026) · PubMed · doi:10.22029/eir.2007.1632 · Cited by 63
Ahmadvand, H., Tavafi, M., & Khosrowbeygi, A. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.06.004 · Cited by 63
Metabolic changes in patients with mitochondrial myopathies and effects of coenzyme Q 10 therapy
Chan, A., Reichmann, H., Kögel, A., Beck, A., & Gold, R. (1998) · Journal of Neurology · doi:10.1007/s004150050267 · Cited by 62
Neyal, M. A., Yimenicioglu, F., Aydeniz, A., Taşkın, A., Sağlam, S., Cekmen, M. B., Neyal, A., Gürsoy, S., Erel, Ö., & Balat, A. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.08.028 · Cited by 62
Navas, P., Fernández‐Ayala, D. J. M., Martín, S. F., López‐Lluch, G., de Cabo, R., Rodríguez‐Aguilera, J. C., & Villalba, J. M. (2002) · Free Radical Research · doi:10.1080/10715760290021207 · Cited by 62
Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock
Donnino, M. W., Cocchi, M. N., Salciccioli, J. D., Kim, D., Naini, A., Buettner, C., & Akuthota, P. (2011) · Critical Care · doi:10.1186/cc10343 · Cited by 62
Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease
Beal, M. F., & Shults, C. W. (2003) · BioFactors · doi:10.1002/biof.5520180218 · Cited by 60
Coenzyme Q10 Effects on Creatine Kinase Activity and Mood in Geriatric Bipolar Depression
Forester, B. P., Zuo, C. S., Ravichandran, C. T., Harper, D. G., Du, F., Kim, H., Cohen, B. M., & Renshaw, P. F. (2012) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988712436688 · Cited by 58
One- and Two-Electron Reduction of Quinones by Rat Liver Subcellular Fractions
Nakamura, M., & Hayashi, T. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124470 · Cited by 57
Yamamoto, M., SATO, T. A., Anno, M., Ujike, H., & Takemoto, M. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.11.1475 · Cited by 57
Passi, S., Stancato, A., Aleo, E., Dmitrieva, A., & Littarru, G. P. (2003) · BioFactors · doi:10.1002/biof.5520180213 · Cited by 57
Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases
Beal, M. F. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)82026-3 · Cited by 55
Moreno-Fernández, A. M., Cordero, M. D., Garrido-Maraver, J., Alcocer-Gómez, E., Casas-Barquero, N., Carmona-López, M. I., Sánchez-Alcázar, J. A., & de Miguel, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.002 · Cited by 54
Mitochondrial Biogenesis and the Role of the Protein Import Pathway
Hood, D. A., Adhihetty, P. J., Colavecchia, M., Gordon, J. W., Irrcher, I., JOSEPH, A.-M., LOWE, S. T., & Rungi, A. A. (2003) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200301000-00015 · Cited by 54
Uncoupling protein 2: a novel player in neuroprotection
Paradis, É., Clavel, S., Bouillaud, F., Ricquier, D., & Richard, D. (2003) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2003.10.009 · Cited by 54
Schmelzer, C., Lorenz, G., Rimbach, G. H., & Döring, F. (2007) · BioFactors · doi:10.1002/biof.5520310308 · Cited by 52
Coenzyme Q10: A therapy for hypertension and statin-induced myalgia?
Wyman, M. J., Leonard, M. C., & Morledge, T. J. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77a.09078 · Cited by 52
Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study
Şendur, Ö. F., Turan, Y., Taştaban, E., Yenisey, Ç., & Serter, M. (2008) · Rheumatology International · doi:10.1007/s00296-008-0738-x · Cited by 51
Gökbel, H., Gül, İ., Belviranlı, M., & Okudan, N. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181a61a50 · Cited by 51
Targeting PGC-1α to control energy homeostasis
Wu, Z., & Boss, O. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.10.1329 · Cited by 50
Fulle, S., Pietrangelo, T., Mancinelli, R., Saggini, R., & Fanò, G. (2007) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-008-9128-y · Cited by 49
Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome
Plioplys, A. V., & Plioplys, S. (2008) · Neuropsychobiology · doi:10.1159/000119233 · Cited by 49
Wagner, A. E., Ernst, I. M. A., Birringer, M., Sancak, O., Barella, L., & Rimbach, G. H. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/835970 · Cited by 49
Cordero, M. D., Cotán, D., Martín, Y. D. P., Carrión, Á. M., de Miguel, M., Bullón, P., & Sánchez-Alcázar, J. A. (2012) · Nutrition · doi:10.1016/j.nut.2012.03.018 · Cited by 48
Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients
Smirnova, I. V., & Pall, M. L. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024176016962 · Cited by 46
Coenzyme Q10 levels in Prader‐Willi syndrome: Comparison with obese and non‐obese subjects
Butler, M. G., Dasouki, M., Bittel, D., Hunter, S., Naini, A., & DiMauro, S. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.10055 · Cited by 46
Coenzyme Q10: A novel therapeutic approach for Fibromyalgia? Case series with 5 patients
Cordero, M. D., Alcocer‐Gómez, E., de Miguel, M., Cano‐García, F. J., Luque, C. M., Riejos, P. F., Moreno‐Fernández, A. M., & Sánchez-Alcázar, J. A. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.122 · Cited by 44
Miwa, K., & Fujita, M. (2010) · Heart and Vessels · doi:10.1007/s00380-009-1206-6 · Cited by 42
Protective Effects of Coenzyme Q10 on Decreased Oxidative Stress Resistance Induced by Simvastatin
Kettawan, A., Takahashi, T., Kongkachuichai, R., Charoenkiatkul, S., Kishi, T., & Okamoto, T. (2007) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.40.194 · Cited by 41
Schmelzer, C., Niklowitz, P., Okun, J. G., Haas, D., Menke, T., & Döring, F. (2011) · IUBMB Life · doi:10.1002/iub.413 · Cited by 41
UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes
Barreiro, E., Garcia‐Martínez, C., Mas, S., Ametller, E., Gea, J., Argilés, J. M. A., Busquets, S., & López-Soriano, F. J. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.12.023 · Cited by 41
Lister, R. (2002) · Journal of International Medical Research · doi:10.1177/147323000203000213 · Cited by 39
Esteves, T. C., Parker, N., & Brand, M. D. (2006) · Biochemical Journal · doi:10.1042/bj20052004 · Cited by 39
αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease?
Protter, D. S. W., Lang, C., & Cooper, A. A. (2012) · Parkinson s Disease · doi:10.1155/2012/829207 · Cited by 38
Nonlinear Response of the Reticuloendothelial System upon Stimulation
Bliznakov, E. G., & Adler, A. D. (2008) · Pathologia et Microbiologia · doi:10.1159/000162456 · Cited by 37
Coenzyme Q10, exercise lactate and CTG trinucleotide expansion in myotonic dystrophy
Siciliano, G., Mancuso, M., Tedeschi, D., Manca, M. L., Renna, M. R., Lombardi, V., Rocchi, A., Martelli, F., & Murri, L. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00653-0 · Cited by 37
Folkers, K., Hanioka, T., Xia, L., MCREE, J. T., & Langsjoen, P. H. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80254-2 · Cited by 36
New Agents Promote Neuroprotection in Parkinson’s Disease Models
Santos, C. M. M. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712800792820 · Cited by 35
Identification of LPS‐inducible genes downregulated by ubiquinone in human THP‐1 monocytes
Schmelzer, C., & Döring, F. (2010) · BioFactors · doi:10.1002/biof.93 · Cited by 34
Yang, Y. M., Noh, K., Han, C. Y., & Kim, S. G. (2010) · Molecules · doi:10.3390/molecules15096332 · Cited by 33
Lee, H.-J., Han, Y.-M., Kim, E. H., Kim, Y. J., & Hahm, K. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-143 · Cited by 33
Bliznakov, E. G. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.2.390 · Cited by 32
Anderson, G., & Maes, M. H. J. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113129990082 · Cited by 32
Self-citationLipid peroxidation is elevated in female patients with chronic fatigue syndrome.
Brkic, S. V., Tomić, S., Marić, D., Mikić, A. N., & Turkulov, V. (2010) · PubMed · Cited by 31
Coenzyme Q10 serum levels in Huntington’s disease
Andrich, J., Carsten Saft, C., Gerlach, M., Schneider, B., Arz, A., Kuhn, W., & Müller, T. (2004) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-0579-5_13 · Cited by 31
The antioxidant activity of ubiquinol-3 in homogeneous solution and in liposomes
Landi, L., Cabrini, L., Fiorentini, D., Stefanelli, C., & Pedulli, G. F. (1992) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(92)90004-9 · Cited by 31
Increase in Levels of IgG in Serum of Patients Treated with Coenzyme Q10
Folkers, K., Shizukuishi, S., Takemura, K., Drzewoski, J., Richardson, P., Ellis, J., & Kuzell, W. C. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)52559-8 · Cited by 31
Cellular metabolism as a basis for immune privilege
Newell, M. K., Villalobos‐Menuey, E., Schweitzer, S. C., Harper, M., & Camley, R. E. (2006) · Journal of Immune Based Therapies and Vaccines · doi:10.1186/1476-8518-4-1 · Cited by 30
Degradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome
Ullrich, O., Reinheckel, T., Sitte, N., & Grune, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00060-x · Cited by 30
Cellular redox poise modulation; the role of coenzyme Q10, gene and metabolic regulation
Linnane, A. W., & Eastwood, H. T. (2004) · Mitochondrion · doi:10.1016/j.mito.2004.07.035 · Cited by 30
Miwa, K., & Fujita, M. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.04.051 · Cited by 29
Bonakdar, R. A., & Guarneri, E. M. (2005) · PubMed · Cited by 29
Antifatigue Effect of Coenzyme Q10 in Mice
Fu, X., Ji, R., & Dam, J. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.0049 · Cited by 28
Clinical Laboratory Monitoring of Coenzyme Q10 Use in Neurologic and Muscular Diseases
Steele, P. E., Tang, P., DeGrauw, A. J., & Miles, M. V. (2004) · Pathology Patterns Reviews · doi:10.1309/0um2v45m00m69xpx · Cited by 28
Parkinson’s Disease and Autophagy
Sánchez-Pérez, A. M., Clausell, B. C., Sanchez‐Andrés, J. V., & Herrero, M. T. (2012) · Parkinson s Disease · doi:10.1155/2012/429524 · Cited by 27
Crane, F. L. (2008) · BioFactors · doi:10.1002/biof.5520320102 · Cited by 27
Andersen, C., Henriksen, J. E., Nielsen, O. H., Vaag, A. A., Mortensen, S. A., & Beck‐Nielsen, H. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(97)00010-1 · Cited by 26
Jason, L. A., Sorenson, M., Sebally, K., Alkazemi, D. U. Z., Lerch, A., Porter, N. S., & Kubow, S. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.007 · Cited by 26
Coenzymes Q: Stimulants of the phaǵocytic activity in rats and immune response in mice
Bliznakov, E. G., Casey, A. C., & Premuzic, E. (1970) · Cellular and Molecular Life Sciences · doi:10.1007/bf02114125 · Cited by 26
Effect of dietary Coenzyme Q10 as an antioxidant in human plasma
Weber, C., Jakobsen, T., Mortensen, S. A., Paulsen, G., & Hølmer, G. (1994) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(94)90018-3 · Cited by 25
Chu, C., Kou, H., Lee, C. S., Lee, K., Chen, S., Voon, W., Sheu, S., & Lai, W. (2006) · BioFactors · doi:10.1002/biof.5520280304 · Cited by 25
The influence of oxidation of membrane thiol groups on lysosomal proton permeability
Wan, F.-Y., Wang, Y., & Zhang, G. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600355 · Cited by 23
La disfunción mitocondrial en la fibromialgia y su implicación en la patogénesis de la enfermedad
Cordero, M. D., de Miguel, M., & Moreno‐Fernández, A. M. (2010) · Medicina Clínica · doi:10.1016/j.medcli.2010.01.030 · Cited by 23
The oxidation of ubiquinol by the isolated rieske iron-sulfur protein in solution
Esposti, M. D., Ballester, F., Timoneda, J., Crimi, M., & Lenaz, G. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90640-k · Cited by 22
Yalçın, A., Kilinç, E., Koçtürk, S., Resmi, H., & Sözmen, E. Y. (2004) · International Journal of Neuroscience · doi:10.1080/00207450490475535 · Cited by 22
Cordero, M. D., Moreno‐Fernández, A. M., Carmona-López, M. I., Sánchez-Alcázar, J. A., Rodrı́guez, A., Navas, P., & de Miguel, M. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.06.013 · Cited by 21
Targeting energy metabolism in Huntington's disease
Walker, F. O., & Raymond, L. A. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16739-1 · Cited by 21
Coenzyme Q and the regulation of intracellular steady‐state levels of superoxide in HL‐60 cells
González‐Aragón, D., Burón, M. I., López‐Lluch, G., Herman, M. D., Gómez-Dı́az, C., Navas, P., & Villalba, J. M. (2005) · BioFactors · doi:10.1002/biof.5520250105 · Cited by 21
Increased Metabolic Muscle Fatigue Is Caused by Some but Not All Mitochondrial Mutations
Schulte‐Mattler, W., Müller, T., Deschauer, M., Gellerich, F. N., Iaizzo, P. A., & Zierz, S. (2003) · Archives of Neurology · doi:10.1001/archneur.60.1.50 · Cited by 21
Martín, S. F., Gómez-Dı́az, C., Navas, P., & Villalba, J. M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02222-2 · Cited by 20
Oxidative Stress in Fibromyalgia: Pathophysiology and Clinical Implications
Cordero, M. D. (2011) · Reumatología Clínica (English Edition) · doi:10.1016/j.reumae.2010.12.004 · Cited by 18
Estrés oxidativo en la fibromialgia: fisiopatología e implicaciones clínicas
Cordero, M. D. (2011) · Reumatología Clínica · doi:10.1016/j.reuma.2010.12.007 · Cited by 16
Vega‐López, S., Devaraj, S., & Jialal, I. (2004) · Journal of Investigative Medicine · doi:10.2310/6650.2004.11932 · Cited by 16
Metabolic analysis of 13C‐labeled pyruvate for noninvasive assessment of mitochondrial function
Wu, I., Ohsawa, I., Fuku, N., & Tanaka, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05636.x · Cited by 15
Barbieri, B., Lund, B., Lundström, B., & Scaglione, F. (1999) · BioFactors · doi:10.1002/biof.5520090235 · Cited by 14
Isoprenoid pathway dysfunction in chronic fatigue syndrome
Kurup, R. K., & Kurup, P. A. (2003) · Acta Neuropsychiatrica · doi:10.1034/j.1601-5215.2003.00045.x · Cited by 14
Antioxidant effect of coenzyme Q on hydrogen peroxide-activated myoglobin
Mordente, A., Martorana, G. E., Santini, S. A., Miggiano, G. A. D., Petitti, T., Giardina, B., Battino, M. A., & Littarru, G. P. (1993) · Journal of Molecular Medicine · doi:10.1007/bf00226847 · Cited by 14
Fischer, A., Schmelzer, C., Rimbach, G. H., Niklowitz, P., Menke, T., & Döring, F. (2011) · BMC Research Notes · doi:10.1186/1756-0500-4-245 · Cited by 13
Bandyopadhyay, U., & Cuervo, A. M. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.01.011 · Cited by 12
Chronic fatigue syndrome: la bête noire of the Belgian health care system.
Maes, M. H. J., & Twisk, F. (2009) · PubMed · Cited by 12
Self-citationDo mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinsons Disease?
Kirches, E. (2009) · Current Genomics · doi:10.2174/138920209789503879 · Cited by 11
[Effects of coenzyme Q10 or combined with micronutrients on antioxidant defense system in rats].
Wang, H., Zhao, X., & Yin, S.-A. (2008) · PubMed · Cited by 9
Effect of adrenalectomy on the response of rat liver polyribosomes to whole-body gamma radiation
Yatvin, M. B. (1970) · Cellular and Molecular Life Sciences · doi:10.1007/bf01900077 · Cited by 9
Kawase, I., Niitani, H., Saijo, N., Sasaki, H., & Morita, T. (1978) · PubMed · Cited by 8
Tsao, C., & Mendell, J. R. (2002) · Journal of Child Neurology · doi:10.1177/088307380201700414 · Cited by 7
Potgieter, M., Pretorius, E., & Oberholzer, H. M. (2009) · Ultrastructural Pathology · doi:10.1080/01913120902889146 · Cited by 5
Cellular coenzyme Q10 redox poise constitutes a major cell metabolic and gene regulatory system
Linnane, A. W. (2002) · Biogerontology · doi:10.1023/a:1015266204771 · Cited by 4
Application of Coenzyme Q10 in Clinical Practice
(2012) · The Internet Journal of Internal Medicine · doi:10.5580/2b24 · Cited by 2
Flagged first, then by citations
2 of the 347 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Jelin JM, Gregory PJ et al (2009) Natural medicines comprehensive database/compiled by the editors of Pharmacist’s Letter, Prescriber’s Letter, 11th edn. Therapeutic Research Faculty, Stockton, CA, pp 452–457
- Nathan N, Van Konynenburg RA (2009) Treatment study of methylation cycle support in patients with chronic fatigue syndrome and fibromyalgia. 9th International IACFS/ME Conference, Reno, Nevada
- Moreno-Fernández AM, Cordero MD, Garrido-Maraver J, Alcocer-Gómez E, Casas-Barquero N, Carmona-López MI, Sánchez-Alcázar JA, de Miguel M (2012) Oral treatment with amitriptyline induces coenzyme Q deficiency and oxidative stress in psychiatric patients. J Psychiatr Res 46:341–345 · DOI · Paper page
Cited by
Sorted by citations
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252
Self-citationde Melo, Nunes, S. O. V., Anderson, G., Vargas, H. O., Barbosa, D. S., Gałecki, P., Carvalho, A. F., & Maes, M. H. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.027 · Cited by 194
Self-citationScaini, G., Rezin, G. T., Carvalho, A. F., STRECK, E. L., Berk, M., & Quevedo, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.040 · Cited by 187
Self-citationMorris, G., Berk, M., Gałecki, P., Walder, K. R., & Maes, M. H. J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9090-9 · Cited by 163
Self-citationMorris, G., Berk, M., Carvalho, A. F., Maes, M. H. J., Walker, A. J., & Puri, B. K. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.036 · Cited by 155
Self-citation
Metadata
- Authors
- Morris, G., Anderson, G., Berk, M., & Maes, M.
- Affiliations
- Deakin University (AU)
- Corresponding author
- Maes, Michael
- Venue
- Molecular Neurobiology
- Published
- 2013-06-13
- Volume
- 48
- Issue
- 3
- Pages
- 883-903
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2058368383
- Cited by
- 96
- References
- 347
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 7 · 2014: 3 · 2013: 2
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Servier
- H. Lundbeck A/S
- Cilag
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- coenzyme Q10, Parkinson's disease, depression, chronic fatigue syndrome, fibromyalgia, oxidative stress, mitochondrial dysfunction, neuroprotection, antioxidants, uncoupling proteins, hydrogen peroxide, exercise intolerance, hyperalgesia, mitochondrial electron transport chain, apoptosis, gene expression regulation
- MeSH terms
- Mental Disorders, Humans, Ubiquinone, Signal Transduction, Nitrosation, Oxidative Stress
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