Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats
Abstract
Unlabelled Multiple evidences suggest that depression is accompanied by an induction of oxidative/nitrosative stress (O&NS) pathways and by a reduced antioxidant status. Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway and has a powerful antioxidant capacity.Methods This study investigated the effect of chronic treatment with CoQ10 (25, 50, 100 and 150 mg/kg/day, i.p. for 3 weeks) on depressive-like behavior and hippocampal, O&NS, and DNA damage, induced by chronic restraint stress (CRS), an experimental model of depression, in rats.Results CoQ10 showed a significant antidepressant effect, as evidenced by amelioration of CRS-induced behavioral aberrations in forced swimming and open field tests, elevated corticosterone level and body weight loss. Moreover, CoQ10 dose-dependently restored the hippocampal catalase, glutathione peroxidase and reduced glutathione and decreased the hippocampal malondialdehyde, nitric oxide and 8-hydroxy-2'-deoxyguanosine levels, which indicated a potential protective effect of CoQ10 against hippocampal O&NS lipid peroxidation and DNA damage.Conclusion CoQ10 possesses antidepressant activity and can protect against CRS-induced hippocampal DNA damage which could be mediated in part by maintaining mitochondrial function and its well documented antioxidant properties. Therefore, CoQ10 may have a potential therapeutic value for the management of depressive disorders. However, further research, is still required to characterize the mechanism of the antidepressant effect of CoQ10 and extend these results before the safe application in humans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Coenzyme Q10 displays antidepressant-like effects in chronically stressed rats, with a reduction in hippocampal oxidative/nitrosative DNA damage.
“CoQ10 displays antidepressant-like effects in chronically stressed rats, with a reduction in hippocampal oxidative/nitrosative DNA damage [181].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [181]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
[42] Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal
Esterbauer, H., & Cheeseman, K. H. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86134-h · Cited by 3,365 · see citing works
Jollow, D. J., Mitchell, J. R., ZAMPAGLIONE, N. G., & Gillette, J. R. (2008) · Pharmacology · doi:10.1159/000136485 · Cited by 3,291 · see citing works
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,232 · see citing works
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Biochemical Functions of Coenzyme Q <sub>10</sub>
Crane, F. L. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719063 · Cited by 869 · see citing works
Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders
Floyd, R. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-140.x · Cited by 824 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Chiba, S., Numakawa, T., Ninomiya, M., Richards, M. C., Wakabayashi, C., & Kunugi, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.018 · Cited by 673 · cited 1× · see citing works
“In accordance, recent studies have noted CRS-induced anxiety- and depressive-like behaviors (Chiba et al., 2012; Hennebelle et al., 2012; Huynh et al., 2011; Pechlivanova et al., 2011).”
ResultDetermination of nitrite/nitrate in human biological material by the simple Griess reaction
Guevara, I., Iwanejko, J., Dembinska-Kiec, A., Pankiewicz, J. E., Wanat, A., Anna, P., Leszczynska-Golabek, I., Bartuś, S., Malczewska-Malec, M., & Szczudlik, A. (1998) · Clinica Chimica Acta · doi:10.1016/s0009-8981(98)00060-6 · Cited by 647 · see citing works
Bioenergetic and Antioxidant Properties of Coenzyme Q10: Recent Developments
Littarru, G. P., & Tiano, L. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0052-y · Cited by 465 · see citing works
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works
Mitochondrial Dysfunction and Psychiatric Disorders
Rezin, G. T., Amboni, G., Zugno, A. I., Quevedo, J., & STRECK, E. L. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9865-8 · Cited by 443 · see citing works
Madrigal, J. L. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00208-6 · Cited by 381 · see citing works
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works
Mitochondrial Approaches for Neuroprotection
Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works
Cutler, R. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.1.373s · Cited by 280 · see citing works
Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272 · see citing works
Effects of chronic mild stress on the oxidative parameters in the rat brain
Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Dal‐Pizzol, F., Gavioli, E. C., & Quevedo, J. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.001 · Cited by 265 · see citing works
Neurobehavioral studies of forced swimming: The role of learning and memory in the forced swim test
West, A. P. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90073-p · Cited by 238 · see citing works
Zhang, J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397155-5.00029-5 · Cited by 233 · see citing works
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works
Behr, G. A., Moreira, J. C. F., & Frey, B. N. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/609421 · Cited by 205 · see citing works
Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.09.012 · Cited by 197 · see citing works
Antioxidative enzymes and increased oxidative stress in depressive women
Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works
In vivo antioxidant status: A putative target of antidepressant action
Zafir, A., Ara, A., & Banu, N. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.11.010 · Cited by 183 · see citing works
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 160 · see citing works
Coenzyme Q 10 as a Possible Treatment for Neurodegenerative Diseases
Beal, M. F. (2002) · Free Radical Research · doi:10.1080/10715760290021315 · Cited by 160 · see citing works
Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 157 · see citing works
Zhang, J., Huang, X., Ye, M.-L., Luo, C., Wu, H., Hu, Y. F., Zhou, Q., Wu, D., Zhu, L., & Zhu, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5880-09.2010 · Cited by 141 · see citing works
Coenzyme Q10 in Neuromuscular and Neurodegenerative Disorders
Mancuso, M., Orsucci, D., Volpi, L., Calsolaro, V., Siciliano, G., Spinelli, A., Correale, C., Szabó, H., & Montorsi, M. (2009) · Current Drug Targets · doi:10.2174/138945010790031018 · Cited by 139 · see citing works
Lucca, G., Comim, C. M., Valvassori, S. S., Réus, G. Z., Vuolo, F. S., Petronilho, F. C., Gavioli, E. C., Dal‐Pizzol, F., & Quevedo, J. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.11.002 · Cited by 137 · see citing works
Hosoe, K., Kitano, M., Kishida, H., Kubo, H., Fujii, K., & Kitahara, M. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.07.001 · Cited by 133 · see citing works
Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the 'recoupling hypothesis'
Chew, G., & Watts, G. F. (2004) · QJM · doi:10.1093/qjmed/hch089 · Cited by 132 · see citing works
Stress-induced oxidative changes in brain.
Madrigal, J. L., García-Bueno, B., Caso, J., Perez-Nievas, B., & Leza, J. (2006) · CNS and Neurological Disorders - Drug Targets · doi:10.2174/187152706778559327 · Cited by 129 · see citing works
Huynh, T. N., Krigbaum, A. M., Hanna, J. J., & Conrad, C. D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.038 · Cited by 129 · see citing works
Liu, W.-N., & Zhou, C.-L. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.003 · Cited by 126 · see citing works
Tomasetti, M., Alleva, R., & Collins, A. R. (2001) · The FASEB Journal · doi:10.1096/fj.00-0694fje · Cited by 121 · see citing works
Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus
Réus, G. Z., Stringari, R. B., de Souza, B., Petronilho, F., Dal-Pizzol, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.5.13109 · Cited by 110 · see citing works
Coenzyme Q10:A Review of Its Promise as a Neuroprotectant
Young, A. J., Johnson, S., Steffens, D. C., & Doraiswamy, P. M. (2007) · CNS Spectrums · doi:10.1017/s1092852900020538 · Cited by 97 · see citing works
Influence of Omega-3 Fatty Acid Status on the Way Rats Adapt to Chronic Restraint Stress
Hennebelle, M., Balasse, L., Latour, A., Champeil‐Potokar, G., Denis, S., Lavialle, M., Gisquet-Verrier, P., Denis, I., & Vancassel, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042142 · Cited by 89 · see citing works
Abdel-Wahab, B. A., & Salama, R. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.015 · Cited by 86 · see citing works
Posser, T., Kaster, M. P., Baraúna, S. C., Rocha, J. B. T., Rodrigues, A. L. S., & Leal, R. B. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.055 · Cited by 86 · see citing works
Quiles, J. L., Ochoa, J. J., Huertas, J. R., & Mataix, J. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.002 · Cited by 82 · see citing works
Abdin, A. A., & Hamouda, H. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.033 · Cited by 77 · see citing works
Rojas, P., Serrano-García, N., Medina-Campos, O. N., Pedraza-Chaverri, J., Ögren, S. O., & Rojas, C. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.05.007 · Cited by 76 · see citing works
Context and strain-dependent behavioral response to stress
Nosek, K. S., Dennis, K. L., Andrus, B. M., Ahmadiyeh, N., Baum, A. E., Woods, L. C. S., & Redei, E. E. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-23 · Cited by 70 · see citing works
Lobato, K. R., Cardoso, C. C., Binfaré, R. W., Budni, J., Wagner, C. L. R., Brocardo, P. S., de Souza, L. F., Brocardo, C., Flesch, S., Freitas, A. E., et al. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.002 · Cited by 67 · see citing works
Tõnissaar, M., Mällo, T., Eller, M., Häidkind, R., Kõiv, K., & Harro, J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.001 · Cited by 66 · see citing works
Swiergiel, A. H., ZHOU, Y., & DUNN, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.06.006 · Cited by 64 · see citing works
Tawfik, M. K. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.09.018 · Cited by 55 · see citing works
Coenzyme Q10 levels in Prader‐Willi syndrome: Comparison with obese and non‐obese subjects
Butler, M. G., Dasouki, M., Bittel, D., Hunter, S., Naini, A., & DiMauro, S. (2003) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.10055 · Cited by 46 · see citing works
Li, G., Zou, L., Cao, C., & Yang, E. S. (2005) · BioFactors · doi:10.1002/biof.5520250111 · Cited by 41 · see citing works
Calixto, A. V., Duarte, F. S., Duzzioni, M., Häckl, L. P. N., Faria, M. S., & de Lima, T. C. M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.037 · Cited by 37 · see citing works
Linck, V. M., Costa-Campos, L., Pilz, L. K., Garcia, C. R. L., & Elisabetsky, E. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283512c3a · Cited by 26 · see citing works
Pechlivanova, D., Stoynev, A. G., & Tchekalarova, J. D. (2011) · Folia Medica · doi:10.2478/v10153-010-0040-z · Cited by 24 · see citing works
Al-Attar (2010) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2010.14.23 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of oxidative stress in Alzheimer’s disease
HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works
A Meta-analysis of oxidative stress markers in depression
Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., & Jia, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138904 · Cited by 485 · see citing works
Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96 · see citing works
Mehrpooya, M., Yasrebifar, F., Haghighi, M., Mohammadi, Y., & Jahangard, L. (2018) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000938 · Cited by 57 · see citing works
Ershadi, A. S. B., Amini-Khoei, H., Hosseini, M.-J., & Dehpour, A. R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03263-8 · Cited by 25 · see citing works
- Authors
- Aboul-Fotouh, S.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 104
- Pages
- 105-112
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2133230932
- Cited by
- 97
- References
- 60
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 3
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- coenzyme Q10, antidepressant-like effects, chronic restraint stress, depression, oxidative stress, nitrosative stress, hippocampus, DNA damage, lipid peroxidation, antioxidant enzymes, mitochondrial function, anxiolytic-like behavior, corticosterone, 8-hydroxy-2'-deoxyguanosine
- MeSH terms
- Animals, Antidepressive Agents, Antioxidants, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, DNA Damage, Hippocampus, Male, Restraint, Physical, Stress, Physiological, Ubiquinone, Rats, Wistar, Oxidative Stress, Reactive Nitrogen Species, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review