Cited by 97Coenzyme Q10 studies and effectsTreatment of Major DepressionAntioxidant Activity and Oxidative Stress

Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

Aboul-Fotouh, Sawsan·2013·Pharmacology Biochemistry and Behavior

Abstract

Unlabelled Multiple evidences suggest that depression is accompanied by an induction of oxidative/nitrosative stress (O&NS) pathways and by a reduced antioxidant status. Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway and has a powerful antioxidant capacity.Methods This study investigated the effect of chronic treatment with CoQ10 (25, 50, 100 and 150 mg/kg/day, i.p. for 3 weeks) on depressive-like behavior and hippocampal, O&NS, and DNA damage, induced by chronic restraint stress (CRS), an experimental model of depression, in rats.Results CoQ10 showed a significant antidepressant effect, as evidenced by amelioration of CRS-induced behavioral aberrations in forced swimming and open field tests, elevated corticosterone level and body weight loss. Moreover, CoQ10 dose-dependently restored the hippocampal catalase, glutathione peroxidase and reduced glutathione and decreased the hippocampal malondialdehyde, nitric oxide and 8-hydroxy-2'-deoxyguanosine levels, which indicated a potential protective effect of CoQ10 against hippocampal O&NS lipid peroxidation and DNA damage.Conclusion CoQ10 possesses antidepressant activity and can protect against CRS-induced hippocampal DNA damage which could be mediated in part by maintaining mitochondrial function and its well documented antioxidant properties. Therefore, CoQ10 may have a potential therapeutic value for the management of depressive disorders. However, further research, is still required to characterize the mechanism of the antidepressant effect of CoQ10 and extend these results before the safe application in humans.

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Crossref · 10.1016/j.pbb.2012.12.027

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  • Coenzyme Q10 displays antidepressant-like effects in chronically stressed rats, with a reduction in hippocampal oxidative/nitrosative DNA damage.

    “CoQ10 displays antidepressant-like effects in chronically stressed rats, with a reduction in hippocampal oxidative/nitrosative DNA damage [181].”

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Authors
Aboul-Fotouh, S.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2013-03
Volume
104
Pages
105-112
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2133230932
Cited by
97
References
60
Citations by year
2026: 5 · 2025: 8 · 2024: 10 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 3
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
coenzyme Q10, antidepressant-like effects, chronic restraint stress, depression, oxidative stress, nitrosative stress, hippocampus, DNA damage, lipid peroxidation, antioxidant enzymes, mitochondrial function, anxiolytic-like behavior, corticosterone, 8-hydroxy-2'-deoxyguanosine
MeSH terms
Animals, Antidepressive Agents, Antioxidants, Behavior, Animal, Corticosterone, Depression, Disease Models, Animal, DNA Damage, Hippocampus, Male, Restraint, Physical, Stress, Physiological, Ubiquinone, Rats, Wistar, Oxidative Stress, Reactive Nitrogen Species, Rats

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