The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

Yasuda, S; Liang, M-H; Marinova, Z; Yahyavi, A; Chuang, D-M

doi:10.1038/sj.mp.4002099

Cited by 358Bipolar Disorder and TreatmentTreatment of Major DepressionNerve injury and regeneration

The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

Yasuda, S, Liang, M-H, Marinova, Z, Yahyavi, A, Chuang, D-M·2009·Molecular Psychiatry

DOI 10.1038/sj.mp.4002099

Open this paper in CoChat — free account

Abstract

Brain-derived neurotrophic factor (BDNF) has been strongly implicated in the synaptic plasticity, neuronal survival and pathophysiology of depression. Lithium and valproic acid (VPA) are two primary mood-stabilizing drugs used to treat bipolar disorder. Treatment of cultured rat cortical neurons with therapeutic concentrations of LiCl or VPA selectively increased the levels of exon IV (formerly rat exon III)-containing BDNF mRNA, and the activity of BDNF promoter IV. Surprisingly, lithium- or VPA-responsive element(s) in promoter IV resides in a region upstream from the calcium-responsive elements (CaREs) responsible for depolarization-induced BDNF induction. Moreover, activation of BDNF promoter IV by lithium or VPA occurred in cortical neurons depolarized with KCl, and deletion of these three CaREs did not abolish lithium- or VPA-induced activation. Lithium and VPA are direct inhibitors of glycogen synthase kinase-3 (GSK-3) and histone deacetylase (HDAC), respectively. We showed that lithium-induced activation of promoter IV was mimicked by pharmacological inhibition of GSK-3 or short interfering RNA (siRNA)-mediated gene silencing of GSK-3alpha or GSK-3beta isoforms. Furthermore, treatment with other HDAC inhibitors, sodium butyrate and trichostatin A, or transfection with an HDAC1-specific siRNA also activated BDNF promoter IV. Our study demonstrates for the first time that GSK-3 and HDAC are respective initial targets for lithium and VPA to activate BDNF promoter IV, and that this BDNF induction involves a novel responsive region in promoter IV of the BDNF gene. Our results have strong implications for the therapeutic actions of these two mood stabilizers.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4002099

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Treatment with mood stabilizers increases BDNF levels in prefrontal cortex and hippocampus of animals by inducing promoter IV-driven expression.
“It is known that treatment with mood stabilizers increases BDNF levels in prefrontal cortex and hippocampus of animals by inducing promoter IV-driven expression [90, 91].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [90]

A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758 · see citing works
Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism
Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works
The renaissance of GSK3
Cohen, P., & Frame, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096075 · Cited by 1,478 · see citing works
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321 · see citing works
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Calcium regulation of neuronal gene expression
West, A. E., Chen, W. G., Dalva, M., Dolmetsch, R., Kornhauser, J., Shaywitz, A. J., Takasu, M., Tao, X., & Greenberg, M. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191352298 · Cited by 1,115 · see citing works
BDNF and Activity-Dependent Synaptic Modulation: Figure 1.
Lu, B. (2003) · Learning & Memory · doi:10.1101/lm.54603 · Cited by 945 · see citing works
Mouse and rat BDNF gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877 · see citing works
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A
Fang, X., Yu, S. X., Lu, Y., Bast, R. C., Woodgett, J. R., & Mills, G. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220413597 · Cited by 833 · see citing works
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family
Ernfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819 · see citing works
Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
Beaulieu, J., Sotnikova, T. D., Yao, W., Kockeritz, L. K., Woodgett, J. R., Gainetdinov, R. R., & Caron, M. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307921101 · Cited by 792 · see citing works
Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764 · see citing works
The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study
Neves-Pereira, M., Mundo, E., Muglia, P., King, N. A., Macciardi, F. M., & Kennedy, J. L. (2002) · The American Journal of Human Genetics · doi:10.1086/342288 · Cited by 594 · see citing works
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
Jope, R. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00206-2 · Cited by 501 · see citing works
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Histone Deacetylase Is a Target of Valproic Acid-Mediated Cellular Differentiation
Gurvich, N., Tsygankova, O. M., Meinkoth, J. L., & Klein, P. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-0799 · Cited by 460 · see citing works
CREB DNA binding activity is inhibited by glycogen synthase kinase‐3β and facilitated by lithium
Grimes, C. A., & Jope, R. S. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00495.x · Cited by 437 · see citing works
Glycogen Synthase Kinase-3β Haploinsufficiency Mimics the Behavioral and Molecular Effects of Lithium
O'Brien, W. T., Harper, A. D., Jove, F. A., Woodgett, J. R., Maretto, S., Piccolo, S., & Klein, P. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4753-03.2004 · Cited by 415 · see citing works
Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis
Hao, Y., Creson, T. K., Zhang, L., Li, P., Du, F., Yuan, P., Gould, T. D., Manji, H. K., & Chen, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5747-03.2004 · Cited by 405 · see citing works
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
Fukumoto, T., Morinobu, S., Okamoto, Y., Kagaya, A., & Yamawaki, S. (2001) · Psychopharmacology · doi:10.1007/s002130100871 · Cited by 377 · see citing works
A Calcium-Responsive Transcription Factor, CaRF, that Regulates Neuronal Activity-Dependent Expression of BDNF
Tao, X., West, A. E., Chen, W. G., Corfas, G., & Greenberg, M. E. (2002) · Neuron · doi:10.1016/s0896-6273(01)00561-x · Cited by 339 · see citing works
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
Gould, T. D., Einat, H., Bhat, R. V., & Manji, H. K. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004535 · Cited by 314 · see citing works
Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine
Liu, Q., Lü, L., Zhu, X.-G., Gong, J.-P., Shaham, Y., & Uhl, G. R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.004 · Cited by 297 · see citing works
A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression.
Fiol, C. J., Williams, J. S., Chou, C. H., Wang, Q. M., Roach, P. J., & ANDRISANI, O. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31619-3 · Cited by 278 · see citing works
Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus
Kaidanovich‐Beilin, O., Milman, A., Weizman, A., Pick, C. G., & Eldar-Finkelman, H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.008 · Cited by 276 · see citing works
Altered Histone Acetylation atGlutamate Receptor 2andBrain-Derived Neurotrophic FactorGenes Is an Early Event Triggered by Status Epilepticus
Huang, Y., Doherty, J., & Dingledine, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08422.2002 · Cited by 261 · see citing works
Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: An essential step for neuroprotection against glutamate excitotoxicity
Hashimoto, R., Takei, N., Shimazu, K., Christ, L. A., Lu, B., & Chuang, D. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00217-4 · Cited by 257 · see citing works
Self-citation
Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death
Bolger, T. A., & Yao, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1826-05.2005 · Cited by 190 · see citing works
Endogenous α-Synuclein Is Induced by Valproic Acid through Histone Deacetylase Inhibition and Participates in Neuroprotection against Glutamate-Induced Excitotoxicity
Leng, Y., & Chuang, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0096-06.2006 · Cited by 188 · see citing works
Self-citation
Remodeling Chromatin and Stress Resistance in the Central Nervous System: Histone Deacetylase Inhibitors as Novel and Broadly Effective Neuroprotective Agents
Langley, B. C., Gensert, J. M., Beal, M. F., & Ratan, R. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005091 · Cited by 169 · see citing works
Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons
Chen, W., West, A. E., Xu, T., Corfas, G., Szentirmay, M. N., Sawadogo, M., Vinson, C., & Greenberg, M. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02572.2003 · Cited by 161 · see citing works
Regulation and Function of Glycogen Synthase Kinase-3 Isoforms in Neuronal Survival
Liang, M., & Chuang, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605178200 · Cited by 136 · see citing works
Self-citation
Differential Roles of Glycogen Synthase Kinase-3 Isoforms in the Regulation of Transcriptional Activation
Liang, M., & Chuang, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607468200 · Cited by 129 · see citing works
Self-citation
Calcium regulation of the brain-derived neurotrophic factor gene
Finkbeiner, S. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000701 · Cited by 102 · see citing works
Lithium protection from glutamate excitotoxicity: therapeutic implications
Chuang, D. (2004) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2004.09.016 · Cited by 10 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Major depressive disorder
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Multiple roles of HDAC inhibition in neurodegenerative conditions
Chuang, D.-M., Leng, Y., Marinova, Z., Kim, H.-J., & Chiu, C.-T. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.06.002 · Cited by 676 · see citing works
Self-citation
BDNF signaling in context: From synaptic regulation to psychiatric disorders
Wang, C. S., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell · doi:10.1016/j.cell.2021.12.003 · Cited by 629 · see citing works
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606 · see citing works
Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives
Dias, M. F., Joo, K., Kemp, J. A., Fialho, S. L., Silva‐Cunha, A., Woo, S. J., & Kwon, Y. J. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.10.004 · Cited by 420 · see citing works
Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404 · see citing works
Self-citation
DNA Methylation Profiles of the Brain-Derived Neurotrophic Factor (BDNF) Gene as a Potent Diagnostic Biomarker in Major Depression
Fuchikami, M., Morinobu, S., Segawa, M., Okamoto, Y., Yamawaki, S., Ozaki, N., Inoue, T., Kusumi, I., Koyama, T., Tsuchiyama, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023881 · Cited by 378 · see citing works
The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis
Machado‐Vieira, R., Manji, H. K., & Zarate, C. A. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00714.x · Cited by 370 · see citing works
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS
Eldar-Finkelman, H., & Martı́nez, A. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00032 · Cited by 356 · see citing works
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain
Kim, H. J., Leeds, P., & Chuang, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06212.x · Cited by 332 · see citing works
Self-citation
Post‐stroke depression: mechanisms, translation and therapy
Loubinoux, I., Kronenberg, G., Endres, M., Schumann‐Bard, P., Fréret, T., Filipkowski, R. K., Kaczmarek, L., & Popa‐Wagner, A. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01555.x · Cited by 317 · see citing works
Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?
Li, X., & Jope, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.105 · Cited by 294 · see citing works
Review of Lithium Effects on Brain and Blood
Young, W. (2009) · Cell Transplantation · doi:10.3727/096368909x471251 · Cited by 287 · see citing works
Epigenetic Regulation of the BDNF Gene: Implications for Psychiatric Disorders
Boulle, F., van den Hove, D. L. A., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., Lesch, K.-P., Lanfumey, L., Steinbusch, H. W., & Kenis, G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.107 · Cited by 282 · see citing works
Fear extinction and BDNF: translating animal models of PTSD to the clinic
Andero, R., & Ressler, K. J. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00801.x · Cited by 275 · see citing works
Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection
Monti, B., Polazzi, E., & Contestabile, A. (2009) · Current Molecular Pharmacology · doi:10.2174/1874467210902010095 · Cited by 241 · see citing works
Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers
Ernst, C., Deleva, V., Deng, X., Sequeira, A., Pomarenski, A., Klempan, T., Ernst, N., Quirion, R., Gratton, A., Szyf, M., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.22 · Cited by 235 · see citing works
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Chiu, C., & Chuang, D. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.006 · Cited by 226 · see citing works
Self-citation
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
Feng, H., Leng, Y., Ma, C., Zhang, J., Ren, M., & Chuang, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.040 · Cited by 228 · see citing works
Self-citation
Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects
Quiroz, J. A., Machado‐Vieira, R., Zarate, C. A., & Manji, H. K. (2010) · Neuropsychobiology · doi:10.1159/000314310 · Cited by 225 · see citing works
Divalproex Sodium vs Placebo for the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorders
Hollander, E., Chaplin, W. F., Soorya, L. V., Wasserman, S., Novotny, S., Rusoff, J., Feirsen, N., Pepa, L., & Anagnostou, E. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.202 · Cited by 227 · see citing works
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases
Yao, W., Hu, X., & Wang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01918-w · Cited by 229 · see citing works
Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition
Leng, Y., Liang, M., Ren, M., Marinova, Z., Leeds, P. R., & Chuang, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5467-07.2008 · Cited by 215 · see citing works
Self-citation
Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid
Roullet, F., Wollaston, L., deCatanzaro, D., & Foster, J. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.069 · Cited by 200 · see citing works
Behavior genetics and postgenomics
Charney, E. (2012) · Behavioral and Brain Sciences · doi:10.1017/s0140525x11002226 · Cited by 207 · see citing works
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome
Yuskaitis, C. J., Mines, M. A., King, M. K., Sweatt, J. D., Miller, C. A., & Jope, R. S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.023 · Cited by 187 · see citing works
Dietary fiber and its associations with depression and inflammation
Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185 · see citing works
The theory of bipolar disorder as an illness of accelerated aging: implications for clinical care and research
Rizzo, L. B., Costa, L. G., Mansur, R. B., Swardfager, W., Belangero, S. I., Grassi-Oliveira, R., McIntyre, R. S., Bauer, M. E., & Brietzke, E. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.004 · Cited by 183 · see citing works
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
Kapczinski, F., Frey, B. N., Kauer-Sant’Anna, M., & Grassi-Oliveira, R. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1101 · Cited by 181 · see citing works
Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived neurotrophic factor ( BDNF) gene and histone acetylation at its promoters in the rat hippocampus
Fuchikami, M., Morinobu, S., Kurata, A., Yamamoto, S., & Yamawaki, S. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008997 · Cited by 178 · see citing works
Prenatal stress decreases Bdnf expression and increases methylation of Bdnf exon IV in rats
Boersma, G. J., Lee, R. S., Cordner, Z. A., Ewald, E. R., Purcell, R. H., Moghadam, A. A., & Tamashiro, K. L. (2014) · Epigenetics · doi:10.4161/epi.27558 · Cited by 172 · see citing works
Does Lithium Prevent Alzheimerʼs Disease?
Forlenza, O. V., de Paula, V. D. J. R., Machado‐Vieira, R., Diniz, B. S., & Gattaz, W. F. (2012) · Drugs & Aging · doi:10.2165/11599180-000000000-00000 · Cited by 172 · see citing works
Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders
Grayson, D. R., Kundakovic, M., & Sharma, R. P. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.061333 · Cited by 171 · see citing works
GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke
Chuang, D., Wang, Z., & Chiu, C. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00015 · Cited by 171 · see citing works
Self-citation
Depression research: where are we now?
Lee, S., Jeong, J., Kwak, Y., & Park, S. K. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-8 · Cited by 170 · see citing works
The Role of BDNF as a Mediator of Neuroplasticity in Bipolar Disorder
Grande, I., Fries, G. R., Kunz, M., & Kapczinski, F. P. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.243 · Cited by 161 · see citing works
Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity
Sharma, S., Taliyan, R., & Singh, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.052 · Cited by 142 · see citing works
Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease
Chiu, C., Liu, G., Leeds, P. R., & Chuang, D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.128 · Cited by 141 · see citing works
Self-citation
Lithium: the pharmacodynamic actions of the amazing ion
Brown, K. M., & Tracy, D. K. (2013) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125312471963 · Cited by 140 · see citing works
Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder
Reinhart, V., Bove, S. E., Volfson, D., Lewis, D. A., Kleiman, R. J., & Lanz, T. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.011 · Cited by 139 · see citing works
Lithium Ameliorates Neurodegeneration, Suppresses Neuroinflammation, and Improves Behavioral Performance in a Mouse Model of Traumatic Brain Injury
Yu, F., Wang, Z., Tchantchou, F., Chiu, C., Zhang, Y., & Chuang, D. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1942 · Cited by 138 · see citing works
Self-citation
A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137 · see citing works
Current understanding of bipolar disorder: Toward integration of biological basis and treatment strategies
Kato, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12852 · Cited by 138 · see citing works
Lithium and neuroprotection: translational evidence and implications for the treatment of neuropsychiatric disorders
Diniz, B., Machado-Vieira, R., & Forlenza (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s33086 · Cited by 128 · see citing works
The neurotrophic and neuroprotective effects of psychotropic agents
Hunsberger, J. G., Austin, D. R., Henter, I. D., & Chen, G. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/jhunsberger · Cited by 122 · see citing works
What We Have Learned about Autism Spectrum Disorder from Valproic Acid
Chomiak, T., Turner, N. R., & Hu, B. (2013) · Pathology Research International · doi:10.1155/2013/712758 · Cited by 121 · see citing works
HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: Where do we stand?
Whittle, N., & Singewald, N. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130233 · Cited by 117 · see citing works
Sodium Butyrate and Mood Stabilizers Block Ouabain-Induced Hyperlocomotion and Increase BDNF, NGF and GDNF Levels in Brain of Wistar Rats
Varela, R. B., Valvassori, S. S., Lopes-Borges, J., Mariot, E., Dal-Pont, G. C., Amboni, R. T., Bianchini, G., & Quevedo, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.11.003 · Cited by 115 · see citing works
Chronic Valproate Treatment Enhances Postischemic Angiogenesis and Promotes Functional Recovery in a Rat Model of Ischemic Stroke
Wang, Z., Tsai, L., Munasinghe, J., Leng, Y., Fessler, E. B., Chibane, F. L., Leeds, P. R., & Chuang, D. (2012) · Stroke · doi:10.1161/strokeaha.112.652545 · Cited by 115 · see citing works
Self-citation
Mood-stabilizing drugs: mechanisms of action
Schloesser, R. J., Martinowich, K., & Manji, H. K. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.009 · Cited by 115 · see citing works
Intracellular pathways underlying the effects of lithium
Pasquali, L., Busceti, C. L., Fulceri, F., Paparelli, A., & Fornai, F. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833da5da · Cited by 112 · see citing works
Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus
Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111 · see citing works
Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties
Zunszain, P. A., Horowitz, M. A., Cattaneo, A., Lupi, M., & Pariante, C. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.87 · Cited by 108 · see citing works
Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors
Koppel, I., & Timmusk, T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.015 · Cited by 108 · see citing works
Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication
Savitz, J. B., Nugent, A. C., Bogers, W., Liu, A., Sills, R., Luckenbaugh, D. A., Bain, E., Price, J. L., Zarate, C. A., Manji, H. K., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.025 · Cited by 109 · see citing works
A New Avenue for Lithium: Intervention in Traumatic Brain Injury
Leeds, P. R., Yu, F., Wang, Z., Chiu, C., Zhang, Y., Leng, Y., Linares, G. R., & Chuang, D. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500040g · Cited by 108 · see citing works
Self-citation
BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity
Rakofsky, J. J., Ressler, K. J., & Dunlop, B. W. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.121 · Cited by 107 · see citing works
Potential Roles of HDAC Inhibitors in Mitigating Ischemia-induced Brain Damage and Facilitating Endogenous Regeneration and Recovery
Fessler, E. B., Chibane, F. L., Wang, Z., & Chuang, D. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319280009 · Cited by 105 · see citing works
Self-citation
Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth
Lahiji, S. F., Seo, S. H., Kim, S., Dangol, M., Shim, J., Li, C. G., Ma, Y., Lee, C., Kang, G., Yang, H., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.019 · Cited by 105 · see citing works
Epigenetic Mechanisms Underlying the Role of Brain-Derived Neurotrophic Factor in Depression and Response to Antidepressants
Duclot, F., & Kabbaj, M. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.107086 · Cited by 103 · see citing works
Physical exercise and antidepressants enhance BDNF targeting in hippocampal CA3 dendrites: further evidence of a spatial code for BDNF splice variants.
Baj, G., D'Alessandro, V., Musazzi, L., Mallei, A., Sartori, C. R., Sciancalepore, M., Tardito, D., Langone, F., Popoli, M., & Tongiorgi, E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.5 · Cited by 103 · see citing works
Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
Haggarty, S. J., & Tsai, L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.009 · Cited by 99 · see citing works
Epigenetic regulation of reelin and brain-derived neurotrophic factor genes in long-term potentiation in rat medial prefrontal cortex
Sui, L., Wang, Y., Ju, L.-H., & Chen, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.007 · Cited by 99 · see citing works
Brain lithium, N‐acetyl aspartate and myo‐inositol levels in older adults with bipolar disorder treated with lithium: a lithium‐7 and proton magnetic resonance spectroscopy study
Forester, B. P., Finn, C. T., Berlow, Y. A., Wardrop, M., Renshaw, P. F., & Moore, C. M. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00627.x · Cited by 98 · see citing works
Preliminary Findings Regarding Proinflammatory Markers and Brain-Derived Neurotrophic Factor Among Adolescents with Bipolar Spectrum Disorders
Goldstein, B. I., Collinger, K. A., Lotrich, F. E., Marsland, A. L., Gill, M., Axelson, D., & Birmaher, B. B. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0009 · Cited by 97 · see citing works
A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
Carmassi, C., Grande, C. D., Gesi, C., Musetti, L., & Dell’Osso, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106479 · Cited by 97 · see citing works
Increased BDNF expression in fetal brain in the valproic acid model of autism
Almeida, L. E. F., Roby, C. D., & Krueger, B. K. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.01.007 · Cited by 95 · see citing works
NF-κB in Innate Neuroprotection and Age-Related Neurodegenerative Diseases
Lanzillotta, A., Porrini, V., Bellucci, A., Benarese, M., Branca, C., Parrella, E., Spano, P., & Pizzi, M. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00098 · Cited by 92 · see citing works
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons
Marinova, Z., Leng, Y., Leeds, P. R., & Chuang, D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.022 · Cited by 91 · see citing works
Self-citation
Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and ΔFosB expression in the striatum and locomotor sensitization in mice
Shen, H.-Y., Kalda, A., Yu, L., Ferrara, J., Zhu, J., & Chen, J.-F. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.019 · Cited by 91 · see citing works
The potential use of histone deacetylase inhibitors in the treatment of depression
Fuchikami, M., Yamamoto, S., Morinobu, S., Okada, S., Yamawaki, Y., & Yamawaki, S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.010 · Cited by 111 · see citing works
Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus
Tran, P. V., Kennedy, B. C., Lien, Y., Simmons, R. A., & Georgieff, M. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00429.2014 · Cited by 89 · see citing works
Current status and future prospects for epigenetic psychopharmacology
Boks, M. P., de Jong, N. M., Kas, M. J. H., Vinkers, C. H., Fernandes, C., Kahn, R. S., Mill, J., & Ophoff, R. A. (2012) · Epigenetics · doi:10.4161/epi.7.1.18688 · Cited by 89 · see citing works
Histone deacetylases inhibitors (HDACis) as novel therapeutic application in various clinical diseases
Qiu, X., Xiao, X., Li, N., & Li, Y. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.002 · Cited by 89 · see citing works
Diet and lifestyle impact the development and progression of Alzheimer’s dementia
Arora, S., Santiago, J. A., Bernstein, M., & Potashkin, J. A. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1213223 · Cited by 96 · see citing works
DNA Methylation Signatures of Mood Stabilizers and Antipsychotics in Bipolar Disorder
Houtepen, L. C., van Bergen, A. H., Vinkers, C. H., & Boks, M. P. (2016) · Epigenomics · doi:10.2217/epi.15.98 · Cited by 87 · see citing works
Chronic Administration of Mood Stabilizers Upregulates BDNF and Bcl-2 Expression Levels in Rat Frontal Cortex
Chang, Y. C., Rapoport, S. I., & Rao, J. S. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9817-3 · Cited by 86 · see citing works
Lithium Upregulates Vascular Endothelial Growth Factor in Brain Endothelial Cells and Astrocytes
Guo, S., Arai, K., Stins, M. F., Chuang, D., & Lo, E. H. (2008) · Stroke · doi:10.1161/strokeaha.108.524504 · Cited by 86 · see citing works
Self-citation
Dissecting bipolar disorder complexity through epigenomic approach
Ludwig, B., & Dwivedi, Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.123 · Cited by 85 · see citing works
Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease
Nunes, M. A., Schöwe, N. M., Monteiro-Silva, K. C., Baraldi-Tornisielo, T., Souza, S. I. G., Balthazar, J., Albuquerque, M. S., Caetano, A. L., Viel, T. A., & Buck, H. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142267 · Cited by 83 · see citing works
Association Studies of the BDNF and the NTRK2 Gene Polymorphisms with Prophylactic Lithium Response in Bipolar Patients
Dmitrzak‐Węglarz, M., RYBAKOWSKI, J. K., Suwalska, A., Skibińska, M., Leszczyńska-Rodziewicz, A., Szczepankiewicz, A., & Hauser, J. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.11.1595 · Cited by 80 · see citing works
Dose-dependent effects of wheel running on cocaine-seeking and prefrontal cortex Bdnf exon IV expression in rats
Peterson, A. B., Abel, J. M., & Lynch, W. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3321-4 · Cited by 77 · see citing works
Oroxylin A increases BDNF production by activation of MAPK–CREB pathway in rat primary cortical neuronal culture
Jeon, S. J., Rhee, S. Y., Seo, J. E., Bak, H.-R., Lee, S. H., Ryu, J. H., Cheong, J. H., Shin, C. Y., Kim, G., Lee, Y. S., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.11.008 · Cited by 77 · see citing works
Neuroprotective action of lithium in disorders of the central nervous system.
Chiu, C., & Chuang, D. (2011) · PubMed · doi:10.3969/j.issn.1672-7347.2011.06.001 · Cited by 78 · see citing works
Self-citation
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha, J., Dwivedi, Y., & Brennand, K. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.30 · Cited by 76 · see citing works
Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress
Fumagalli, F., Calabrese, F., Luoni, A., Bolis, F., Racagni, G., & Riva, M. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000150 · Cited by 75 · see citing works
Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions
Keshavan, M. S., Mehta, U. M., Padmanabhan, J. L., & Shah, J. L. (2015) · Development and Psychopathology · doi:10.1017/s095457941500019x · Cited by 76 · see citing works
Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils
Bian, Q., Shi, T., Chuang, D., & Qian, Y. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.054 · Cited by 74 · see citing works
Self-citation
Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia
Ziemka‐Nałęcz, M., Jaworska, J., Sypecka, J., Polowy, R., Filipkowski, R. K., & Zalewska, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0049-2 · Cited by 75 · see citing works
Retinitis Pigmentosa: Review of Current Treatment
Wang, A. L., Knight, D. K., Vu, T.-T. T., & Mehta, M. C. (2018) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000256 · Cited by 73 · see citing works
Targeting Histone Deacetylases: A Novel Approach in Parkinson’s Disease
Sharma, S., & Taliyan, R. (2015) · Parkinson s Disease · doi:10.1155/2015/303294 · Cited by 70 · see citing works
Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor‐mediated activation of Bdnf gene promoter 1
Tian, F., Hu, X., Wu, X., Jiang, H., Pan, H., Marini, A. M., & Lipsky, R. H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06058.x · Cited by 70 · see citing works
Glycogen synthase kinase 3 substrates in mood disorders and schizophrenia
Cole, A. R. (2013) · FEBS Journal · doi:10.1111/febs.12407 · Cited by 69 · see citing works
Correction
Elgohary, M. A., McCluskey, P., Towler, H. M. A., Okhravi, N., Singh, R., Obikpo, R., & Lightman, S. (2007) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.114801 · Cited by 68 · see citing works
Pharmacology of epigenetics in brain disorders
Narayan, P. J., & Dragunow, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00526.x · Cited by 67 · see citing works
Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 65 · see citing works
The Mood Stabilizer Lithium Potentiates the Antidepressant-Like Effects and Ameliorates Oxidative Stress Induced by Acute Ketamine in a Mouse Model of Stress
Chiu, C., Scheuing, L., Liu, G., Liao, H., Linares, G. R., Lin, D. H., & Chuang, D. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu102 · Cited by 66 · see citing works
Self-citation
Antidepressant mechanism of ketamine: perspective from preclinical studies
Scheuing, L., Chiu, C., Liao, H., & Chuang, D. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00249 · Cited by 65 · see citing works
Self-citation

ORIGINAL ARTICLE The
Yasuda, S., Liang, M.-H., Marinova, Z., Yahyavi, A., & Chuang, D.-M. (2014)
Self-citation
Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic concentrations
Nishino, S., Ohtomo, K., Numata, Y., Sato, T., Nakahata, N., & Kurita, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.07.008 · Cited by 25 · see citing works
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
Fukumoto, T., Morinobu, S., Okamoto, Y., Kagaya, A., & Yamawaki, S. (2001) · Psychopharmacology · doi:10.1007/s002130100871 · Cited by 377 · see citing works
Effects of Lithium and Valproic Acid on the Production of Brain-Derived Neurotrophic Factor in
Ohtomo, K., Nishino, S., Kurita, M., Mashiko, H., & Niwa, S.-I. (2014)
BDNF‐mediated signal transduction is modulated by GSK3β and mood stabilizing agents
Mai, L., Jope, R. S., & Li, X. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00939.x · Cited by 195 · see citing works

Authors: Yasuda, S., Liang, M.-H., Marinova, Z., Yahyavi, A., & Chuang, D.-M.
Affiliations: National Institutes of Health (US)
Corresponding author: Chuang, D-M
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2007-10-09
Volume: 14
Issue: 1
Pages: 51-59
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4002099
OpenAlex: W2104411593
Cited by: 358
References: 48
Citations by year: 2026: 3 · 2025: 7 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 14 · 2020: 14 · 2019: 16 · 2018: 16 · 2017: 19 · 2016: 21 · 2015: 27 · 2014: 32 · 2013: 34 · 2012: 26
FWCI: 13.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health
National Institute of Mental Health
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: brain-derived neurotrophic factor, BDNF promoter, lithium, valproic acid, mood stabilizers, glycogen synthase kinase-3, histone deacetylase, HDAC1, cortical neurons, neuronal depolarization, bipolar disorder, gene expression regulation
MeSH terms: Animals, Cells, Cultured, Cerebral Cortex, Dose-Response Relationship, Drug, Embryo, Mammalian, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Membrane Potentials, Neurons, Potassium Chloride, Promoter Regions, Genetic, RNA, Messenger, Time Factors, Transfection, Valproic Acid, Lithium Chloride, Patch-Clamp Techniques, Antimanic Agents, Brain-Derived Neurotrophic Factor, RNA, Small Interfering, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks