Cited by 52Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer’s Disease Via APP Translation

Zhang, Tongmei, Pang, Pei, Fang, Zemin, Guo, Yu, Li, Hao, Li, Xinyan, Tian, Tian, Yang, Xin +12 more·2018·Molecular Neurobiology

Abstract

Aggregation of amyloid-β (Aβ) peptides, which are the cleavage products of amyloid precursor protein (APP), is a major pathological hallmark in the brain of Alzheimer's disease (AD). Now, we know little about the roles of APP translation in the disease progression of AD. Here, we show that BC1, a long noncoding RNA (lncRNA), is expressed in the brain of AD mice. BC1 induces APP mRNA translation via association with a fragile X syndrome protein (FMRP). Inhibition of BC1 or BC1-FMRP association in AD mice blocks aggregation of Aβ in the brain and protects against the spatial learning and memory deficits. Expression of exogenous BC1 in excitatory pyramidal neurons of mice induces Aβ peptides accumulation and the spatial learning and memory impairments. This study provides a novel mechanism underlying aggregation of Aβ peptides via BC1 induction of APP mRNA translation and hence warrants a promising target for AD therapy.

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Crossref · 10.1007/s12035-017-0820-z

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Authors
Zhang, T., Pang, P., Fang, Z., Guo, Y., Li, H., Li, X., Tian, T., Yang, X., Chen, W., Shu, S., Tang, N., Wu, J., Zhu, H., Pei, L., Liu, D., Tian, Q., Wang, J., Wang, L., Zhu, L.-Q., & Lu, Y.
Affiliations
  • Huazhong University of Science and Technology (CN)
  • Tongji Hospital (CN)
  • Wuhan Union Hospital (CN)
Corresponding author
  • Liu, Dan
  • Lu, Youming
Venue
Molecular Neurobiology
Published
2017-11-13
Volume
55
Issue
7
Pages
6007-6020
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
OpenAlex
W2768018325
Cited by
52
References
54
Citations by year
2026: 3 · 2025: 6 · 2024: 1 · 2023: 9 · 2022: 3 · 2021: 12 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 1
FWCI
3.64
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (91632306, 51627807, 31571039, 91632114)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, amyloid-beta aggregation, amyloid precursor protein, FMRP, spatial learning and memory, AD mouse model, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Memory, Memory Disorders, Mice, Inbred C57BL, Mice, Transgenic, RNA, Messenger, Protein Biosynthesis, Amyloid beta-Protein Precursor, Fragile X Messenger Ribonucleoprotein 1, RNA, Long Noncoding, Spatial Learning

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