DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Tu, Weihong; Xu, Xin; Peng, Lisheng; Zhong, Xiaofen; Zhang, Wenfeng; Soundarapandian, Mangala M.; Belal, Cherine; Wang, Manqi; Jia, Nali; Zhang, Wen; Lew, Frank; Chan, Sic Lung; Chen, Yanfang; Lu, Youming

doi:10.1016/j.cell.2009.12.055

Cited by 495Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsAcute Ischemic Stroke Management

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

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Tu, Weihong, Xu, Xin, Peng, Lisheng, Zhong, Xiaofen, Zhang, Wenfeng, Soundarapandian, Mangala M., Belal, Cherine, Wang, Manqi +6 more·2010·Cell

DOI 10.1016/j.cell.2009.12.055PMC PMC2820131

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Abstract

N-methyl-D-aspartate (NMDA) receptors constitute a major subtype of glutamate receptors at extrasynaptic sites that link multiple intracellular catabolic processes responsible for irreversible neuronal death. Here, we report that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice. DAPK1 directly binds with the NMDA receptor NR2B C-terminal tail consisting of amino acid 1292-1304 (NR2B(CT)). A constitutively active DAPK1 phosphorylates NR2B subunit at Ser-1303 and in turn enhances the NR1/NR2B receptor channel conductance. Genetic deletion of DAPK1 or administration of NR2B(CT) that uncouples an activated DAPK1 from an NMDA receptor NR2B subunit in vivo in mice blocks injurious Ca(2+) influx through NMDA receptor channels at extrasynaptic sites and protects neurons against cerebral ischemic insults. Thus, DAPK1 physically and functionally interacts with the NMDA receptor NR2B subunit at extrasynaptic sites and this interaction acts as a central mediator for stroke damage.

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Phosphorylation of S1303 in heterologous cells enhances NMDAR current.
“Phosphorylation of S1303 in heterologous cells enhances NMDAR current (127, 128)”
From Synaptic memory and CaMKII (2023) · cites this paper as [128]
DAPK1 is a calcium-dependent serine/threonine kinase highly expressed in the cortex in Alzheimer's disease, after ischemic damage, and in physiological ageing where it may play a role in the decay of learning and memory.
“DAPK1 (FC = 1.08, p = 0.05) is a calcium-dependent serine/threonine kinase that is highly expressed in the cortex in AD [167], after ischemic damage [154], and in physiological ageing where it has been suggested to play a role in the decay of learning and memory with age [51].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [154]

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Authors: Tu, W., Xu, X., Peng, L., Zhong, X., Zhang, W., Soundarapandian, M. M., Belal, C., Wang, M., Jia, N., Zhang, W., Lew, F., Chan, S. L., Chen, Y., & Lu, Y.
Affiliations: University of Central Florida (US)
Louisiana State University (US)
Wright State University (US)
Corresponding author: Lu, Youming
ORCID: Xu, Xin
Peng, Lisheng
Zhong, Xiaofen
Zhang, Wen
Chen, Yanfang
Lu, Youming
Venue: Cell
Publisher: Elsevier BV
Published: 2010-01
Volume: 140
Issue: 2
Pages: 222-234
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.12.055
PMC: PMC2820131
OpenAlex: W2112215250
Cited by: 493
References: 54
Citations by year: 2026: 15 · 2025: 27 · 2024: 24 · 2023: 37 · 2022: 28 · 2021: 38 · 2020: 35 · 2019: 24 · 2018: 35 · 2017: 45 · 2016: 35 · 2015: 20 · 2014: 35 · 2013: 34 · 2012: 21
FWCI: 12.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1293 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
Journal of International Crisis and Risk Communication Research (submittedVersion)
Funders: National Institute on Aging (R01AG033282YL, R01AG033282)
National Institute of Neurological Disorders and Stroke (R01NS5051383YL, R01NS051383)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords: DAPK1, NMDA receptor, NR2B subunit, cerebral ischemia, stroke, extrasynaptic NMDA receptors, neuronal cell death, calcium influx, protein phosphorylation, neuroprotection
MeSH terms: Animals, Brain, Brain Ischemia, Neurons, Peptides, Recombinant Proteins, Receptors, N-Methyl-D-Aspartate, Cell Death, Calcium-Calmodulin-Dependent Protein Kinases, Stroke, Apoptosis Regulatory Proteins, Mice, tat Gene Products, Human Immunodeficiency Virus, Death-Associated Protein Kinases

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

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