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Taurochenodeoxycholic acid activates autophagy and suppresses inflammatory responses in microglia of MPTP-induced Parkinson’s disease mice via AMPK/mTOR, AKT/NFκB and Pink1/Parkin signaling pathways mediated by Takeda G protein-coupled receptor 5

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Pretreatment with Human Lactoferrin Had a Positive Effect on the Dynamics of Mouse Nigrostriatal System Recovery after Acute MPTP Exposure

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Parkinson’s disease and the gut-brain connection: unveiling pathways, mechanisms and promising therapies

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Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury

Wu, S., García‐Rama, C., Romero‐Ramírez, L., de Munter, J., Wolters, E. C., Kramer, B. W. W., & Mey, J. (2022) · Biomedicines · doi:10.3390/biomedicines10071501 · Cited by 15 · see citing works

Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators

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Research progress on intranasal treatment for Parkinson's disease

Wen, P., & Ren, C. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.42 · Cited by 15 · see citing works

The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence

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The role of gut microbiota–mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies

Ju, T., Zhang, Y., Liu, L., Zhao, X., Li, X., Liu, C., Sun, S., & Wu, L. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01419 · Cited by 16 · see citing works

Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies

Deng, Z., Li, L., Jing, Z., Luo, X., Yu, F., Zeng, W., Bi, W., & Zou, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108806 · Cited by 14 · see citing works

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Presotto, L., Bettinardi, V., Mercatelli, D., Picchio, M., Morari, M., Moresco, R. M., & Belloli, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-19872-4 · Cited by 11 · see citing works

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Kwok, A. T., Rosas, S., Bateman, T. A., Livingston, E. W., Smith, T. L., Moore, J., Zawieja, D. C., Hampton, T. G., Mao, X. W., Delp, M. D., et al. (2019) · Life Sciences in Space Research · doi:10.1016/j.lssr.2019.10.010 · Cited by 10 · see citing works

Neuroprotection in Parkinson Disease

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Olive- and Coconut-Oil-Enriched Diets Decreased Secondary Bile Acids and Regulated Metabolic and Transcriptomic Markers of Brain Injury in the Frontal Cortexes of NAFLD Pigs

Maj, M. A., Gehani, T. R., Immoos, C. E., Medrano, M. S., Fanter, R. K., Strand, C. R., Glanz, H., Piccolo, B. D., Abo-Ismail, M. K., Frano, M. R. L., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12091193 · Cited by 9 · see citing works

Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease

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Diagnostic Potential of Alternations of Bile Acid Profiles in the Plasma of Patients with Huntington’s Disease

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Nervonic Acid Ameliorates Motor Disorder in Mice with Parkinson’s Disease

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Weight bearing as a measure of disease progression in experimental autoimmune encephalomyelitis

Segal, J. P., Phillips, S. M., Dubois, R. M., Silva, J. R., Haird, C. M., Gale, D., Hopman, W. M., Gallivan, J. P., Gilron, I., & Ghasemlou, N. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577730 · Cited by 7 · see citing works

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Luxenburger, A., Clemmens, H., Hastings, C., Harris, L. D., Ure, E. M., Cameron, S. A., Aasly, J. O., Bandmann, O., Weymouth‐Wilson, A., Furneaux, R. H., et al. (2022) · Biomolecules · doi:10.3390/biom13010076 · Cited by 7 · see citing works

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The role of the gut microbiome in Parkinson’s disease

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Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease

Nunes, M. J., Carvalho, A. N., Rosa, A. I., Videira, P. A., Gama, M. J., Rodrigues, E., & Castro‐Caldas, M. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02415-3 · Cited by 6 · see citing works

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Wang, M., Ma, Y., Zeng, B., Yang, W., Huang, C., & Tang, B.-Q. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328335219241202142003 · Cited by 7 · see citing works

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

Lavigna, G., Grasso, A., Pasini, C., Grande, V., Mignogna, L., Restelli, E., Masone, A., Fracasso, C., Lucchetti, J., Gobbi, M., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317404 · Cited by 4 · see citing works

Repair effect of the poly (D,L-lactic acid) nanoparticle containing tauroursodeoxycholic acid-eluting stents on endothelial injury after stent implantation

Zhou, J., Weng, J., Huang, X., Sun, S., Yang, Q., Lin, H., Yang, J., Guo, H., & Chi, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1025558 · Cited by 3 · see citing works

The Impact of Bilirubin on 7α- and 7β-Hydroxysteroid Dehydrogenases: Spectra and Docking Analysis

Ji, Q., Chen, J., Zhu, L., Wang, R., & Wang, B. (2023) · Catalysts · doi:10.3390/catal13060965 · Cited by 3 · see citing works

Ursodeoxycholic and tauroursodeoxycholic acids as antiapoptotic agents: modulation of Parkinson's disease

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Endothelial IRE1 signaling maintains blood–brain barrier integrity and limits neuroinflammation after traumatic brain injury

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Corticosterone‐Induced Myocardial Dysfunctions and the Cardioprotective Role of Tauroursodeoxycholic Acid: An Experimental Study in Mice

Zhou, H., Chen, X., Tao, Y., Li, Z., Wu, H., Shi, H., Wu, X., & Huang, F. (2025) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.70027 · Cited by 2 · see citing works

Metabolomic Biomarkers in Parkinson’s Disease

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Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modellingPreprint

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Neuroimaging-based drug discovery for amyloid clearance therapy in Alzheimer's disease using validated causation analysis

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Modulation of the JNK/c-Jun/HSP27 pathway in cardiomyocytes under chronic stress-induced cardiac dysfunction: Therapeutic implications of Tauroursodeoxycholic acid

Zhou, H., Yuan, J., Chen, X., Li, Z., Wu, H., Shi, H., Wu, X., Huang, J. L., & Huang, F. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.10.292 · Cited by 1 · see citing works

The evaluation of 2.3-diazepine influence on tissue respiration of the liver and its exocrine function in rats with a rotenone model of Parkinson’s disease

Khilya, V. P., Yanchuk, I. P., Shtanova, L. Y., Veselsky, S. P., Vovkun, T. V., Tsymbalyuk, О. V., Москвина, В. С., Shablykina, O. V., & Богза, С. Л. (2019) · Biopolymers and Cell · doi:10.7124/bc.000a13 · Cited by 1 · see citing works

Effects of human lactoferrin under conditions of neurotoxic exposure: experimental research

Kopaeva, M. Y., Cherepov, A. B., & Zarayskaya, I. Y. (2022) · Russian Military Medical Academy Reports · doi:10.17816/rmmar111944 · Cited by 1 · see citing works

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Corrigendum to “Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy” [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1–9.]

Mendes, M. O., Rosa, A. I., Carvalho, A. N., Nunes, M. J., Dionísio, P. A., Rodrigues, E., Costa, D., Duarte‐Silva, S., Maciel, P., Rodrigues, C. M. P., et al. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103626

Expanding Options. A Model to Attract Secondary Students into Nontraditional Vocational Programs. For Emphasis in: Building Trades, Electronics, Health Services, Machine Shop, Welding.

Good, J. D., & Devore, M. A. (1981)

Tauroursodeoxycholic Acid Alleviates Secondary Injury in Spinal Cord Injury Mice Through Reducing Oxidative Stress, Apoptosis, and Inflammatory ResponsePreprint

Hou, Y., Luan, J., Deng, T., Huang, T., Li, X., Xiao, Z., Zhan, J., Luo, D., Hou, Y., Xu, L., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-361252/v1

From berries to brain: Assessing the impact of (poly)phenols in the MPTP mouse model of Parkinson’s diseasePreprint

Carecho, R., Raimundo, A., Ávila‐Gálvez, M. Á., Lopes, H., Sequeira, C. O., Pita, C., Pinto, C., Carregosa, D., Marín, A., González‐Sarrías, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.16.670034

Reduced cerebrospinal fluid taurine is associated with nigrostriatal dopaminergic deficits in drug-naïve Parkinson’s disease

Mimori, M., Umehara, T., Takatsu, H., Okumura, M., Masui, M., Kida, H., Ozawa, M., Motegi, H., Onda, A., Matsuno, H., et al. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-03027-6

Bariatric Surgery and Neurologic Diagnoses in Adults With Obesity: A Retrospective Cohort StudyPreprint

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EFFICACY OF TAUROURSODEOXYCHOLIC ACID ON BIOCHEMICAL AND HISTOPATHOLOGICAL CHANGES IN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE INDUCED PARKINSON’S DISEASE MICE MODEL

RAJAN, M., Sivanesan, S., Ramachandran, K., & ASHOKVARDHAN, N. (2025) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2025v18i12.57160

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Carvalho, A. N., Nunes, M. J., Gama, M. J., Rodrigues, E., Videira, P. A., & Castro‐Caldas, M. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781837676101-00062

Dynamic alterations and potential roles of gut microbiota and metabolites in Angiostrongylus cantonensis-infected mice and rats

Hu, Y., Chen, J.-S., Zhou, M., Huang, H., Zhou, Y.-F., Zhou, H.-Y., & Lv, Z. (2026) · Infectious Diseases of Poverty · doi:10.1186/s40249-026-01436-7

Blood-Mediated Gut–Brain Axis in Parkinson’s Disease: Focus on α-Synuclein Transport and Microbiota Dysbiosis-Induced Inflammation

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Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease

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