Cited by 192Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMedicinal Plants and Neuroprotection

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

Nunes, Ana F., Amaral, Joana D., Lo, Adrian C., Fonseca, Maria B., Viana, Ricardo J. S., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Rodrigues, Cecília M. P.·2012·Molecular Neurobiology

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to progressive cognitive decline. The endogenous bile acid tauroursodeoxycholic acid (TUDCA) is a strong neuroprotective agent in several experimental models of disease, including neuronal exposure to Aβ. Nevertheless, the therapeutic role of TUDCA in AD pathology has not yet been ascertained. Here we report that feeding APP/PS1 double-transgenic mice with diet containing 0.4 % TUDCA for 6 months reduced accumulation of Aβ deposits in the brain, markedly ameliorating memory deficits. This was accompanied by reduced glial activation and neuronal integrity loss in TUDCA-fed APP/PS1 mice compared to untreated APP/PS1 mice. Furthermore, TUDCA regulated lipid-metabolism mediators involved in Aβ production and accumulation in the brains of transgenic mice. Overall amyloidogenic APP processing was reduced with TUDCA treatment, in association with, but not limited to, modulation of γ-secretase activity. Consequently, a significant decrease in Aβ(1-40) and Aβ(1-42) levels was observed in both hippocampus and frontal cortex of TUDCA-treated APP/PS1 mice, suggesting that chronic feeding of TUDCA interferes with Aβ production, possibly through the regulation of lipid-metabolism mediators associated with APP processing. These results highlight TUDCA as a potential therapeutic strategy for the prevention and treatment of AD.

Integrity signals

Registry

Crossref · 10.1007/s12035-012-8256-y

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J. S., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. P.
Affiliations
  • University of Lisbon (PT)
  • KU Leuven (BE)
Corresponding author
Rodrigues, Cecília M. P.
Venue
Molecular Neurobiology
Published
2012-03-23
Volume
45
Issue
3
Pages
440-454
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
OpenAlex
W2005971787
Cited by
192
References
55
Citations by year
2026: 10 · 2025: 11 · 2024: 24 · 2023: 15 · 2022: 25 · 2021: 21 · 2020: 17 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 12 · 2015: 5 · 2014: 8 · 2013: 6 · 2012: 4
FWCI
4.93
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
tauroursodeoxycholic acid, bile acids, Alzheimer's disease, amyloid-beta deposition, APP/PS1 mice, APP processing, gamma-secretase, lipid metabolism, glial activation, memory impairment, neuroprotection, dietary supplementation
MeSH terms
Alzheimer Disease, Animals, Astrocytes, Bile Acids and Salts, Brain, Cognition Disorders, DNA-Binding Proteins, Humans, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Nuclear Proteins, Protein Processing, Post-Translational, Taurochenodeoxycholic Acid, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Microglia, Lipid Metabolism, Mice, Synucleins, Presenilin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review