The DOI matches its Crossref record; 309 of the 309 references it cites were found in a registry or an index.
The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease
Open accessAbstract
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various mechanisms have been proposed and several pieces of evidence are supportive for an important role of mitochondrial dysfunction. The present review provides a comprehensive and up-to-date overview about the role of mitochondria in the two most common neurodegenerative disorders: Alzheimer's disease (AD) and Parkinson's disease (PD). Mitochondrial involvement in AD is supported by clinical features like reduced glucose and oxygen brain metabolism and by numerous microscopic and molecular findings, including altered mitochondrial morphology, impaired respiratory chain function, and altered mitochondrial DNA. Furthermore, amyloid pathology and mitochondrial dysfunction seem to be bi-directionally correlated. Mitochondria have an even more remarkable role in PD. Several hints show that respiratory chain activity, in particular complex I, is impaired in the disease. Mitochondrial DNA alterations, involving deletions, point mutations, depletion, and altered maintenance, have been described. Mutations in genes directly implicated in mitochondrial functioning (like Parkin and PINK1) are responsible for rare genetic forms of the disease. A close connection between alpha-synuclein accumulation and mitochondrial dysfunction has been observed. Finally, mitochondria are involved also in atypical parkinsonisms, in particular multiple system atrophy. The available knowledge is still not sufficient to clearly state whether mitochondrial dysfunction plays a primary role in the very initial stages of these diseases or is secondary to other phenomena. However, the presented data strongly support the hypothesis that whatever the initial cause of neurodegeneration is, mitochondrial impairment has a critical role in maintaining and fostering the neurodegenerative process.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Mitochondrial dysfunction has been reported in a number of neurodegenerative diseases [3–6] and correlates with dendritic pathology and synapse disassembly [7–10].”
From AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma (2021) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease
Bender, A., Desplats, P., Spencer, B. J., Rockenstein, E. M., Adame, A., Elstner, M., Laub, C., Mueller, S. K., Koob, A. O., Mante, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062277 · Cited by 151
Self-citationRetractedThe Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469
Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
Cited by
Sorted by citations
Items 101–200 of 388
Yang, Y.-N., Zhang, M.-Q., Yu, F.-L., Han, B., Bao, M.-Y., Yan-He, Yan-he, & Zhang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115717 · Cited by 26
Mitochondrial dynamics in the neonatal brain – a potential target following injury?
Jones, A., & Thornton, C. (2022) · Bioscience Reports · doi:10.1042/bsr20211696 · Cited by 25
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration
O’Reilly, C. L., Miller, B. F., & Lewis, T. L. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00611.2022 · Cited by 25
Mitochondrial Protein Import Dysfunction in Pathogenesis of Neurodegenerative Diseases
Goyal, S., & Chaturvedi, R. K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02200-0 · Cited by 25
Qiao, J., Wang, C., Chen, Y., Yu, S., Liu, Y., Yu, S., Jiang, L., Jin, C., Wang, X., Zhang, P., et al. (2023) · Antioxidants · doi:10.3390/antiox12040920 · Cited by 23
Redox Imbalance in Neurological Disorders in Adults and Children
Rey, F., Berardo, C., Maghraby, E., Mauri, A., Messa, L., Esposito, L., Casili, G., Ottolenghi, S., Bonaventura, E., Cuzzocrea, S., et al. (2023) · Antioxidants · doi:10.3390/antiox12040965 · Cited by 23
Small RNA-big impact: exosomal miRNAs in mitochondrial dysfunction in various diseases
Li, X., Han, Y., Meng, Y., & Yin, L. (2024) · RNA Biology · doi:10.1080/15476286.2023.2293343 · Cited by 24
Sanna, P. P., Fu, Y., Masliah, E., Lefèbvre, C., & Repunte‐Canonigo, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-88052-7 · Cited by 23
Self-citationTargeting Mitochondria as a Therapeutic Approach for Parkinson’s Disease
Abrishamdar, M., Jalali, M. S., & Farbood, Y. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01265-w · Cited by 22
Chen, J., Gao, X., Zheng, C., Zhang, C., Li, P., He, K., Liu, G., Huang, X., Liu, J., Xie, Y., et al. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.09.004 · Cited by 22
Nabi, S. U., Rehman, M. U., Arafah, A. M., Taifa, S., Khan, I. S., Khan, A., Rashid, S., Jan, F., Wani, H. A., & Ahmad, S. F. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221121095618 · Cited by 22
Ding, Z., Gao, J., Feng, Y., Wang, M., Zhao, H., Wu, R., Zheng, X., Feng, X., & Lai, M. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s436177 · Cited by 21
DNA repair deficiencies and neurodegeneration
Ropert, B., Gallrein, C., & Schumacher, B. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103679 · Cited by 21
Türer, B. Y., & Şanlıer, N. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae079 · Cited by 23
Finnegan, L. K., Chadderton, N., Kenna, P. F., Palfi, A., Carty, M., Bowie, A., Millington‐Ward, S., & Farrar, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031606 · Cited by 20
Neuroimaging studies of acupuncture on Alzheimer’s disease: a systematic review
Yin, Z., Wang, Z., Li, Y., Zhou, J., Chen, Z., Xia, M., Zhang, X., Wu, J., Zhao, L., & Liang, F. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-03888-y · Cited by 20
Katariya, R., Sammeta, S. S., Kale, M. B., Kotagale, N. R., Umekar, M. J., & Taksande, B. G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102269 · Cited by 20
D’Errico, M., Parlanti, E., Pascucci, B., Filomeni, G., Mastroberardino, P. G., & Dogliotti, E. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108977 · Cited by 20
A Review of ApoE4 Interference Targeting Mitophagy Molecular Pathways for Alzheimer's Disease
Chen, H., Chen, F., Jiang, Y., Zhang, L., Hu, G., Sun, F., Zhang, M., Ji, Y., Chen, Y., Che, G., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.881239 · Cited by 19
Hou, K., Liu, T., Li, J., Xian, M., Sun, L., & Wei, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1250532 · Cited by 22
Michel, L., Auvray, M., Askenatzis, L., Badet‐Denisot, M., Bignon, J. S., Durand, P., Mahuteau‐Betzer, F., & Chevalier, A. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c05030 · Cited by 19
Javadpour, P., Abbaszadeh, F., Ahmadiani, A., Rezaei, M., & Ghasemi, R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04009-7 · Cited by 21
Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases
Liu, Y., & Chern, Y. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.668500 · Cited by 20
Kessas, K., Chouari, Z., Ghzaiel, I., Zarrouk, A., Ksila, M., Ghrairi, T., Midaoui, A. E., Lizard, G., & Kharoubı, O. (2022) · Cells · doi:10.3390/cells11020257 · Cited by 21
Onikanni, S. A., Lawal, B., Oyinloye, B. E., Ajiboye, B. O., Sukhbat, U., Wang, C., Emran, T. B., & Simal‐Gándara, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121247 · Cited by 19
A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson’s disease
Cesur, M. F., Basile, A., Patil, K. R., & Çakır, T. (2023) · Life Science Alliance · doi:10.26508/lsa.202201695 · Cited by 18
Platelet mitochondria, a potent immune mediator in neurological diseases
Ma, Y., Jiang, Q., Yang, B., Hu, X., Shen, G., Shen, W., & Xu, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1210509 · Cited by 18
The link between impaired oxygen supply and cognitive decline in peripheral artery disease
Burtscher, J., Millet, G. P., Fresa, M., Lanzi, S., Mazzolai, L., & Pellegrin, M. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.12.002 · Cited by 18
A promising therapeutic: Exosome-mediated mitochondrial transplantation
Cao, M., Zou, J., Shi, M., Zhao, D., Liu, C., Liu, Y., Li, L., & Jiang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113104 · Cited by 18
The etiopathogenetic and pathophysiological spectrum of parkinsonism
Bologna, M., Truong, D. D., & Jankovic, J. J. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120012 · Cited by 18
Evinová, A., Hatoková, Z., Tatarková, Z., Brodňanová, M., Dibdiaková, K., & Račay, P. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04344-6 · Cited by 18
Emerging nano-delivery systems for targeting mitochondria
Burska, A. N., Raish, K., Bayandy, D., & Paunov, V. N. (2025) · Nanoscale · doi:10.1039/d5nr03935e · Cited by 18
A near-infrared fluorescent probe for sensing cuprous ions
Yi, M., Zhao, J., Shen, R., Ma, T., Tu, J., Li, X., Zhang, B., & Fang, J. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136982 · Cited by 17
Mitochondrial mutations in Caenorhabditis elegans show signatures of oxidative damage and an AT-bias
Waneka, G., Svendsen, J. M., Havird, J. C., & Sloan, D. B. (2021) · Genetics · doi:10.1093/genetics/iyab116 · Cited by 19
Ju, T., Zhang, Y., Liu, L., Zhao, X., Li, X., Liu, C., Sun, S., & Wu, L. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01419 · Cited by 16
Colca, J. R., & Finck, B. N. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.929328 · Cited by 16
Recent Nanoscale Carriers for Therapy of Alzheimer's Disease: Current Strategies and Perspectives
Zakharova, L. Y., Gaynanova, G. A., Vasilieva, E. A., Vasileva, L. A., Pavlov, R. V., Kashapov, R. R., Petrov, K. A., & Sinyashin, O. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221115103513 · Cited by 16
Siddiqui, N., Sharma, A. K., Kesharwani, A., Anurag, & Parihar, V. K. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102282 · Cited by 16
Dopamine‑iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease
Buoso, C., Seifert, M., Lang, M., Griffith, C. M., Andújar, B. T., Rueda, M. P. C., Fischer, C., Doerrier, C., Talasz, H., Zanon, A., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106506 · Cited by 16
The Role of Non-Coding RNAs in Mitochondrial Dysfunction of Alzheimer’s Disease
Abed, S., Ebrahimi, A., Fattahi, F., Kouchakali, G., Khaniani, M. S., & Derakhshan, S. M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02262-y · Cited by 16
Dang, M., Wu, L., & Zhang, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141677 · Cited by 16
Chen, Z., Shi, J., & Li, L. (2025) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00015 · Cited by 16
Lee, Y., Heo, J. Y., Ju, X., Cui, J., Ryu, M. J., Lee, M. J., Hong, B., Yoo, S., Ahn, J., Kim, Y. H., et al. (2020) · NeuroToxicology · doi:10.1016/j.neuro.2020.10.012 · Cited by 16
The Role of Mitochondrial Genes in Neurodegenerative Disorders
Kumar, R., Harilal, S., Parambi, D. G. T., Kanthlal, S. K., Rahman, M. A., Alexiou, A. T., Batiha, G. E., & Mathew, B. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210908163839 · Cited by 16
PINK1 signalling in neurodegenerative disease
Whiten, D. R., Cox, D., & Sue, C. M. (2021) · Essays in Biochemistry · doi:10.1042/ebc20210036 · Cited by 15
Bonzano, S., Dallorto, E., Molineris, I., Michelon, F., Crisci, I., Gambarotta, G., Neri, F., Oliviero, S., Beckervordersandforth, R., Lie, D. C., et al. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049854 · Cited by 16
Kamradt, M. L., & Makarewich, C. A. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00189.2023 · Cited by 15
Huo, S., Zhang, X., Xu, J., Zhang, J., Du, J., Li, B., Song, M., Shao, B., Li, Y., & Xu, F. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115459 · Cited by 16
Mitochondrial Genetics Reinforces Multiple Layers of Interaction in Alzheimer’s Disease
Cavalcante, G. C., Brito, L. M., Schaan, A. P., Ribeiro‐dos‐Santos, Â., de Araújo, G. S., & Initiative, O. B. O. A. D. N. (2022) · Biomedicines · doi:10.3390/biomedicines10040880 · Cited by 15
REC drives recombination to repair double-strand breaks in animal mtDNA
Klucnika, A., Mu, P., Jezek, J., McCormack, M., Di, Y., Bradshaw, C. R., & Ma, H. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202201137 · Cited by 14
Korewo-Labelle, D., Karnia, M. J., Myślińska, D., & Kaczor, J. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813941 · Cited by 14
Review of Phytochemical Potency as a Natural Anti-Helicobacter pylori and Neuroprotective Agent
Tandoro, Y., Chen, B.-K., Ali, A., & Wang, C. (2023) · Molecules · doi:10.3390/molecules28207150 · Cited by 15
Mitochondria-lysosome-extracellular vesicles axis and nanotheranostics in neurodegenerative diseases
Kou, L., Wang, Y., Li, J., Zou, W., Jin, Z., Yin, S., Chi, X., Sun, Y., Wu, J., Wang, T., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114757 · Cited by 14
Puigròs, M., Calderón, A. M., Martín-Ruiz, D., Serradell, M., Fernández, M., Lopetegi, A. M., Mayà, G., Santamaría, J., Gaig, C., Colell, A., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105065 · Cited by 14
Actin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Jackson, J., Hoffmann, C., Scifo, E., Wang, H., Wischhof, L., Piazzesi, A., Mondal, M., Shields, H., Zhou, X., Mondin, M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06686-7 · Cited by 14
Новиков, Н. Ю., Brazhnik, E. S., & Kitchigina, V. F. (2023) · Biochemistry (Moscow) · doi:10.1134/s0006297923110172 · Cited by 14
NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology
Cunningham, A., Barrett, E., Risch, S., Lee, P. H. U., Lee, C. M., Moghekar, A., Patra, P., & Shim, J. W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1589857 · Cited by 14
Visualizing liquid-liquid phase separation and protein aggregates
Xue, J., Cao, X.-W., Jia, X.-L., Chen, X., Guo, W., & Yin, D. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01756-z · Cited by 15
Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila
Salminen, T. S., Vesala, L., Basikhina, Y., Kutzer, M. A. M., Tuomela, T., Lucas, R., Monteith, K., Prakash, A., Tietz, T., & Vale, P. F. (2024) · BMC Biology · doi:10.1186/s12915-024-01858-5 · Cited by 15
Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease
Roberts, C.-T., Raabe, N., Wiegand, L., Shahib, A. K., & Rastegar, M. (2024) · Pharmaceuticals · doi:10.3390/ph17121601 · Cited by 13
Apparoo, Y., Phan, C., Kuppusamy, U. R., & Chan, E. W. C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.082 · Cited by 13
Dang, X., Zhang, L., Franco, A., & Dorn, G. W. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac287 · Cited by 13
Kaur, P., Attri, S., Singh, D. P., Rashid, F., Singh, S., Kumar, A., Kaur, H., Bedi, N., & Arora, S. (2023) · Scientific Reports · doi:10.1038/s41598-023-31716-3 · Cited by 13
Amodeo, G. F., & Pavlov, E. V. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183531 · Cited by 13
Brodňanová, M., Hatoková, Z., Evinová, A., Cibulka, M., & Račay, P. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174073 · Cited by 13
Kachouei, R. A., Doagoo, A., Jalilzadeh, M., Khatami, S. H., Rajaei, S., Jahan‐Abad, A. J., Salmani, F., Pakrad, R., Baram, S. M., Nourbakhsh, M., et al. (2023) · Inflammation · doi:10.1007/s10753-023-01853-y · Cited by 12
Giudice, L. D., Pontieri, P., Aletta, M., & Calcagnile, M. (2023) · Biology · doi:10.3390/biology12070972 · Cited by 12
Dendrimers—Novel Therapeutic Approaches for Alzheimer’s Disease
Mroziak, M., Kozłowski, G., Kołodziejczyk, W., Pszczołowska, M., Walczak, K., Beszłej, J. A., & Leszek, J. (2024) · Biomedicines · doi:10.3390/biomedicines12081899 · Cited by 12
Ülger, Ö., Eş, İ., Proctor, C. M., & Algın, O. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102469 · Cited by 12
Cogan, G., Daida, K., Blauwendraat, C., Billingsley, K. J., & Brice, A. (2025) · Movement Disorders · doi:10.1002/mds.30151 · Cited by 12
Ratiometric Imaging of Mitochondrial Hydrogen Peroxide in Aβ42-Mediated Neurotoxicity
Li, X., Zhang, Y., & Ai, H. (2022) · ACS Sensors · doi:10.1021/acssensors.1c01381 · Cited by 12
Mandik, F., Kanana, Y., Rody, J., Misera, S., Wilken, B., Laabs, B., Klein, C., & Vos, M. H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1000553 · Cited by 13
Ramasubramanian, B., Reddy, V. S., Chellappan, V., & Ramakrishna, S. (2022) · Biosensors · doi:10.3390/bios12121176 · Cited by 13
Aleksandrova, Y. R., Chaprov, K., Podturkina, A. V., Ardashov, O. V., Yandulova, E. Y., Volcho, K. P., Salakhutdinov, N. F., & Неганова, М. Е. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065842 · Cited by 12
Rey, F., Messa, L., Maghraby, E., Casili, G., Ottolenghi, S., Barzaghini, B., Raimondi, M. T., Cereda, C., Cuzzocrea, S., Zuccotti, G., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0046 · Cited by 11
Molecular Targets Underlying the Neuroprotective Effects of Boswellic Acid: A Systematic Review
Khaafi, F., & Javadi, B. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230330113611 · Cited by 11
Mitochondrial Dysfunction in Parkinson’s Disease: A Contribution to Cognitive Impairment?
Scorziello, A., Sirabella, R., Sisalli, M. J., Tufano, M., Giaccio, L., D’Apolito, E., Castellano, L., & Annunziato, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111490 · Cited by 11
Haessler, A., Candlish, M., Hefendehl, J. K., Jung, N., & Windbergs, M. (2024) · Communications Biology · doi:10.1038/s42003-024-07182-6 · Cited by 10
Chao, Y., Li, Y., Zhang, H., Pang, S., Hao, S., Hu, S., & Zhao, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1488820 · Cited by 11
Liu, Y., Dong, Y., Cao, Z., Ji, Y., Cheng, X., & Zheng, X. (2025) · Nutrients · doi:10.3390/nu17213451 · Cited by 12
Hypoxia, Acidification and Inflammation: Partners in Crime in Parkinson’s Disease Pathogenesis?
Burtscher, J., & Millet, G. P. (2021) · Immuno · doi:10.3390/immuno1020006 · Cited by 13
Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats
Wang, Y., Miao, Z., Xu, C., Cai, Y., Yang, Y., Hu, Y., Zhao, M., Shao, Y., Li, Z., Chen, J., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05846-5 · Cited by 12
Castillo‐Armengol, J., Marzetta, F., Sánchez-Archidona, A. R., Fledelius, C., Evans, M. L., McNeilly, A. D., McCrimmon, R. J., Ibberson, M. R., & Thorens, B. (2023) · Diabetologia · doi:10.1007/s00125-023-06043-x · Cited by 11
Tian, Q., Greig, E. E., Davatzikos, C. A., Landman, B. A., Resnick, S. M., & Ferrucci, L. (2024) · Nature Communications · doi:10.1038/s41467-024-55009-z · Cited by 10
Wang, Y., Zhang, X., Zhang, W., Han, M., Jia, Q., Bo, C., Shao, H., Sai, L., & Peng, C. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115600 · Cited by 10
Sultana, O. F., Bandaru, M., Bushra, M. A., Reddy, P. H., & Reddy, A. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102957 · Cited by 11
Aging and Alzheimer’s: the critical role of mitochondrial dysfunction and synaptic alterations
Pinky, Wali, Z., Neha, Tiwari, P., El‐Tanani, M., Rabbani, S. A., & Parvez, S. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1676317 · Cited by 11
Endophytic fungi: a potential source for drugs against central nervous system disorders
Pant, A., & Vasundhara, M. (2023) · Brazilian Journal of Microbiology · doi:10.1007/s42770-023-00997-1 · Cited by 10
A Nanobody-Based Toolset to Monitor and Modify the Mitochondrial GTPase Miro1
Fagbadebo, F. O., Kaiser, P. D., Zittlau, K. I., Bartlick, N., Wagner, T. R., Fröhlich, T., Jarjour, G., Nueske, S., Scholz, A. M., Traenkle, B., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.835302 · Cited by 10
Singh, L. N., Kao, S.-H., & Wallace, D. C. (2021) · Cells · doi:10.3390/cells10123460 · Cited by 10
Leeming, P. J., Mercuri-Svik, J., & Stojanovski, D. (2025) · Molecular and Cellular Biology · doi:10.1080/10985549.2025.2566671 · Cited by 10
Mitochondrial dynamics in neurodegenerative diseases: Research hotspots and trends from 2005 to 2025
Hu, S., Yang, Z., Bao, K., Hou, W., Qin, Y., Wu, C., Wang, Q., Luo, X., & Luo, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102987 · Cited by 13
Alzheimer's disease: from molecular pathways to therapies
Feng, J.-Q., Yang, L.-L., Ya-xi, L., & Yao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00443-2 · Cited by 10
Ibork, H., Idrissi, S. E., Zulu, S. S., Miller, R. G., Hajji, L., Morgan, A. M., Taghzouti, K., & Abboussi, O. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00671-2 · Cited by 9
Zhao, J., Qiu, Y.-K., Xie, Y.-X., Li, X.-Y., Li, Y., Wu, B., Wang, Y., Tian, X.-Y., Lv, Y.-L., Zhang, L.-H., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.174313 · Cited by 9
Ca2+ signalling: A common language for organelles crosstalk in Parkinson's disease
Peggion, C., Barazzuol, L., Poggio, E., Calí, T., & Brini, M. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102783 · Cited by 10
Tu, H., Yeo, X. Y., Zhang, Z.-W., Zhou, W., Tan, J. Y., Chi, L., Chia, S., Li, Z., Sim, A. Y., Singh, B. K., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00780-2 · Cited by 8
Tiny Fish, Big Hope: Zebrafish Unlocking Secrets to Fight Parkinson’s Disease
Manjunatha, B., Manjunath, A., Srinivasa, A., & Lee, S. J. (2025) · Biology · doi:10.3390/biology14101397 · Cited by 8
Guo, S., Yu, F., Wang, C., Zhao, W., Li, X., Liu, J., & Lyu, Z. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1781376 · Cited by 8
The role of mitochondria and mitophagy in cell senescence
Ali, T., Hussain, F., Kayani, H. U. R., Naeem, M., & Anjum, F. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.001 · Cited by 9
Metadata
- Authors
- Monzio Compagnoni, G., Di Fonzo, A., Corti, S., Comi, G. P., Bresolin, N., & Masliah, E.
- Affiliations
- University of Milan (IT)
- National Institutes of Health (US)
- Venue
- Molecular Neurobiology
- Published
- 2020-05-22
- Volume
- 57
- Issue
- 7
- Pages
- 2959-2980
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC9047992
- OpenAlex
- W3027900078
- Cited by
- 378
- References
- 309
- Citations by year
- 2026: 44 · 2025: 71 · 2024: 96 · 2023: 61 · 2022: 57 · 2021: 38 · 2020: 11
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Fresco Institute for Parkinson's and Movement Disorders (not available)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- mitochondria, mitochondrial dysfunction, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, mitochondrial DNA, electron transport chain, complex I, Parkin, PINK1, alpha-synuclein, amyloid pathology, multiple system atrophy, atypical parkinsonism, brain metabolism
- MeSH terms
- Alzheimer Disease, Animals, Brain, DNA, Mitochondrial, Humans, Mitochondria, Parkinson Disease, Electron Transport Complex I
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
