The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Laryngeal Tuberculosis: Current Patterns of Presentation and Management
Open accessAbstract
Background Laryngeal tuberculosis (TB) is the commonest granulomatous condition found in the larynx and may be primary or secondary. With the recrudescence of tuberculosis and development of multidrug resistance, the classical disease trend of laryngeal tuberculosis is changing its manifestations. The aim of our study is to describe the various patterns of presentations of laryngeal tuberculosis in the current era and consequently its changing management protocols.Results In this retrospective study, out of 890 patients who visited our voice and swallowing clinic in our study period, 10 were diagnosed as granulomatous conditions [1.1%] and 3 of these were confirmed cases of tuberculosis involving the larynx [0.3%]. Secondary laryngeal TB was found in 1 of our patients with a "dirty larynx picture". Primary laryngeal TB was seen in 2 patients, one patient presented with a unilateral congested vocal fold and the other with bilateral striking zone leukoplakia.Conclusion The clinical pattern of presentation of laryngeal tuberculosis has changed over the years. None of the patients of primary or secondary laryngeal tuberculosis had the classical constitutional symptoms of tuberculosis. In patients with laryngeal tuberculosis along with routine TB workup, surgical excision with histopathological testing is essential for accurate diagnosis in primary laryngeal TB and the "dirty larynx" picture aids in the diagnosis of secondary laryngeal TB. The healing and vocal outcomes are good in both primary and secondary laryngeal TB, once the appropriate antitubercular regimen has been started.
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TB is the main cause of granulomatous inflammatory disease of the larynx, followed by syphilis, amyloidosis, granulomatosis with polyangiitis, actinomycosis, and sarcoidosis.
“TB is the main cause of granulomatous inflammatory disease of the larynx, followed by syphilis, amyloidosis, granulomatosis with polyangiitis, actinomycosis, and sarcoidosis [37,38].”
From Head and Neck Tuberculosis: A Rare Diagnosis and the Role of Surgical Biopsy and Histopathological Evaluation in Extrapulmonary Disease (2025) · cites this paper as [38]
The Discussion calls laryngeal TB the most common granulomatous disease of the larynx and identifies GPA and sarcoidosis as other common differential diagnoses. It lists syphilis, amyloid, and actinomycosis as rare lesions, not as the next most common causes in the claimed order. (LLM, conf=0.87)
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Cites
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Mogoantă, C. A., Osman, A., Georgescu, A.-M., Mitroi, A. M., Busuioc, C. I., Tănase, I., Cioboată, R., Liliac, I. M., Cimpeanu, O. L., & Ciolofan, M. S. (2025) · Pathogens · doi:10.3390/pathogens14050479 · Cited by 2
“TB is the main cause of granulomatous inflammatory disease of the larynx, followed by syphilis, amyloidosis, granulomatosis with polyangiitis, actinomycosis, and sarcoidosis [37,38].”
Metadata
- Authors
- Nerurkar, N. K., & Jahnavi
- Affiliations
- Bombay Hospital (IN)
- Corresponding author
- Nerurkar, Nupur Kapoor
- Venue
- Indian Journal of Otolaryngology and Head & Neck Surgery
- Published
- 2023-10-30
- Volume
- 76
- Issue
- 1
- Pages
- 904-909
- ISSN
- 0019-5421 (ISSN-L)
- 2231-3796
- 0973-7707
- PMC
- PMC10908953
- OpenAlex
- W4388021322
- Cited by
- 2
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Indian Journal of Otolaryngology and Head & Neck Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Health Professions › Speech and Hearing › Voice and Speech Disorders
- Keywords
- laryngeal tuberculosis, leukoplakia, tuberculosis treatment, multidrug resistance, surgical excision, voice outcomes, swallowing outcomes
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