The DOI matches its Crossref record; 266 of the 266 references it cites were found in a registry or an index.
Intestinal microbiota in human health and disease: the impact of probiotics
Open accessAbstract
The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis.
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“Some researchers indicated that high villus height and high villus height crypt ratio could be the indicators of intestinal epithelial development [6][7][8].”
From The prevention role of Spirulina platensis (Arthrospira platensis) on intestinal health (2022) · cites this paper as [6]
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“The gut microbiota has a key role in metabolic, nutritional, physiological, defensive and immunological processes in the human body, and its composition is closely connected to individuals’ health and the diseases they experience[12,13].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [13]
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An obesity-associated gut microbiome with increased capacity for energy harvest
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A human gut microbial gene catalogue established by metagenomic sequencing
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Human gut microbes associated with obesity
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Diversity of the Human Intestinal Microbial Flora
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A core gut microbiome in obese and lean twins
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Changes of Intestinal Functions in Liver Cirrhosis
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The gut microbiota as an environmental factor that regulates fat storage
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Obesity alters gut microbial ecology
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Cited by
Sorted by citations
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055
The gut microbiota in anxiety and depression—A systematic review
Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
Profile of the gut microbiota of adults with obesity: a systematic review
Crovesy, L., Masterson, D., & Rosado, E. L. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0607-6 · Cited by 610
Metadata
- Authors
- Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M.
- Affiliations
- Wageningen University & Research (NL)
- Radboud University Medical Center (NL)
- Corresponding author
- Gerritsen, Jacoline
- Venue
- Genes & Nutrition
- Published
- 2011-05-27
- Volume
- 6
- Issue
- 3
- Pages
- 209-240
- ISSN
- 1555-8932 (ISSN-L)
- 1865-3499
- PMC
- PMC3145058
- OpenAlex
- W2116844657
- Cited by
- 724
- References
- 266
- Citations by year
- 2026: 13 · 2025: 40 · 2024: 60 · 2023: 35 · 2022: 50 · 2021: 54 · 2020: 69 · 2019: 63 · 2018: 70 · 2017: 75 · 2016: 63 · 2015: 49 · 2014: 32 · 2013: 32 · 2012: 15
- FWCI
- 10.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Genes & Nutrition (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Agentschap NL
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- gut microbiota, probiotics, dysbiosis, gut microbiota composition, gut microbiota diversity, gastrointestinal diseases, probiotic consumption
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