Cited by 724Gut microbiota and healthProbiotics and Fermented FoodsInfant Nutrition and Health

The DOI matches its Crossref record; 266 of the 266 references it cites were found in a registry or an index.

Intestinal microbiota in human health and disease: the impact of probiotics

Open access

Gerritsen, Jacoline, Smidt, Hauke, Rijkers, Ger T., de Vos, Willem M.·2011·Genes & Nutrition

DOI 10.1007/s12263-011-0229-7PMC PMC3145058

Open this paper in CoChat — free account Open PDF

Abstract

The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s12263-011-0229-7

Cites

266 of 266 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856

Show all 266 references

Sorted by citations

The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637
Impacts of gut bacteria on human health and diseases
Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055
The gut microbiota in anxiety and depression—A systematic review
Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., & Cowan, C. S. M. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101943 · Cited by 912
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
Profile of the gut microbiota of adults with obesity: a systematic review
Crovesy, L., Masterson, D., & Rosado, E. L. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0607-6 · Cited by 610
Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials
Kristensen, N. B., Bryrup, T., Allin, K. H., Nielsen, T., Hansen, T. H., & Pedersen, O. (2016) · Genome Medicine · doi:10.1186/s13073-016-0300-5 · Cited by 561
Chicken Gut Microbiota: Importance and Detection Technology
Shang, Y., Kumar, S., Oakley, B. B., & Kim, W. K. (2018) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00254 · Cited by 536
Intestinal microbiota, diet and health
Power, S. E., O'Toole, P. W., Stanton, C., Ross, R. P., & Fitzgerald, G. F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002560 · Cited by 476
Probiotic supplements might not be universally-effective and safe: A review
Kothari, D., Patel, S., & Kim, S.-K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.104 · Cited by 445
Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes
Kong, L.-C., Tap, J., Aron-Wisnewsky, J., Pelloux, V., Basdevant, A., Bouillot, J.-L., Zucker, J.-D., Doré, J., & Clément, K. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058743 · Cited by 416
Paraprobiotics: Evidences on their ability to modify biological responses, inactivation methods and perspectives on their application in foods
de Almada, C. N., de Almada, C. N., Martinez, R. C. R., & Sant’Ana, A. S. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.09.011 · Cited by 425
Exopolysaccharides Produced by Lactic Acid Bacteria: From Health-Promoting Benefits to Stress Tolerance Mechanisms
Caggianiello, G., Kleerebezem, M., & Spano, G. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7471-2 · Cited by 396
The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems
Flandroy, L., Poutahidis, T., Berg, G., Clarke, G. A., Dao, M. C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.288 · Cited by 417
The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?
Lopresti, A. L. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx011 · Cited by 386
The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists
Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 400
Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans
Friedman, M. (2016) · Foods · doi:10.3390/foods5040080 · Cited by 368
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347
Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria
van Zyl, W. F., Deane, S. M., & Dicks, L. M. T. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1831339 · Cited by 357
Robustness of Gut Microbiota of Healthy Adults in Response to Probiotic Intervention Revealed by High-Throughput Pyrosequencing
Kim, S.-W., Suda, W., Kim, S., Oshima, K., Fukuda, S., Ohno, H., Morita, H., & Hattori, M. (2013) · DNA Research · doi:10.1093/dnares/dst006 · Cited by 344
Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics
He, M., & Shi, B. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0183-1 · Cited by 352
Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut
Deng, Y., Yan, Z., Shen, R., Wang, M., Huang, Y., Ren, H., Zhang, Y., & Lemos, B. (2020) · Environment International · doi:10.1016/j.envint.2020.105916 · Cited by 330
Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder
Lin, P., Ding, B., Feng, C., Yin, S., Zhang, T., Qi, X., Lv, H., Guo, X., Dong, K., Zhu, Y., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.051 · Cited by 311
Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in Diet-Induced Obese Mice Is Associated with Gut Microbial Changes and Reduction in Obesity
Park, D.-Y., Ahn, Y.-T., Park, S.-H., Huh, C.-S., Yoo, S.-R., Yu, R., Sung, M.-K., McGregor, R. A., & Choi, M.-S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059470 · Cited by 317
Mitigating amphibian chytridiomycosis with bioaugmentation: characteristics of effective probiotics and strategies for their selection and use
Bletz, M. C., Loudon, A. H., Becker, M. H., Bell, S. C., Woodhams, D. C., Minbiole, K. P. C., & Harris, R. N. (2013) · Ecology Letters · doi:10.1111/ele.12099 · Cited by 311
Comparison of gut microbiota in adult patients with type 2 diabetes and healthy individuals
Sedighi, M., Razavi, S., Navab-Moghadam, F., Khamseh, M. E., Alaei-Shahmiri, F., Mehrtash, A., & Amirmozafari, N. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.08.038 · Cited by 306
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 311
Microbiome of Pacific Whiteleg shrimp reveals differential bacterial community composition between Wild, Aquacultured and AHPND/EMS outbreak conditions
Cornejo-Granados, F., Lopez-Zavala, A. A., Gallardo-Becerra, L., Mendoza-Vargas, A., Sánchez, F., Vichido, R., Brieba, L. G., Viana, M. T., Sotelo-Mundo, R. R., & Ochoa-Leyva, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11805-w · Cited by 302
Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity
Remely, M., Aumueller, E., Merold, C. M., Dworzak, S., Hippe, B., Zanner, J., Pointner, A., Brath, H., & Haslberger, A. G. (2013) · Gene · doi:10.1016/j.gene.2013.11.081 · Cited by 304
Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.
Gerritsen, J., Fuentes, S., Grievink, W., van Niftrik, L., Tindall, B. J., Timmerman, H. M., Rijkers, G. T., & Smidt, H. (2014) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.059543-0 · Cited by 297
Self-citation
A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota
Jayachandran, M., Xiao, J., & Xu, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091934 · Cited by 299
Action and function of Akkermansia muciniphila in microbiome ecology, health and disease
Ottman, N., Geerlings, S. Y., Aalvink, S., de Vos, W. M., & Belzer, C. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.10.001 · Cited by 305
Manipulating the gut microbiota to maintain health and treat disease
Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 293
Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis
Oliva, S., Nardo, G. D., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., Cucchiara, S., & Stronati, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04939.x · Cited by 280
Proteobacteria-specific IgA regulates maturation of the intestinal microbiota
Mirpuri, J., Raetz, M. M., Sturge, C. R., Wilhelm, C. L., Benson, A., Savani, R. C., Hooper, L. V., & Yarovinsky, F. (2013) · Gut Microbes · doi:10.4161/gmic.26489 · Cited by 282
Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases
Oniszczuk, A., Oniszczuk, T., Gancarz, M., & Szymańska, J. (2021) · Molecules · doi:10.3390/molecules26041172 · Cited by 303
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness
Macêdo, D. S., Filho, A. J. M. C., de Sousa, C. N. S., Quevedo, J., Barichello, T., Júnior, H. V. N., & de Lucena, D. F. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.012 · Cited by 269
Synthesis, classification and properties of hydrogels: their applications in drug delivery and agriculture
Khan, F. A., Atif, M., Haseen, M. A., Kamal, S., Khan, M. S., Shahid, S., & Nami, S. A. A. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01345a · Cited by 278
Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine
Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., Dong, W., Wang, S., Yan, F., Jiang, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10835-8 · Cited by 253
Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified
Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258
Functionality and nutritional aspects of microcrystalline cellulose in food
Nsor‐Atindana, J., Chen, M., Goff, H. D., Zhong, F., Sharif, H. R., & Li, Y. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.04.021 · Cited by 256
Effects of dietary Lactobacillus rhamnosus JCM1136 and Lactococcus lactis subsp. lactis JCM5805 on the growth, intestinal microbiota, morphology, immune response and disease resistance of juvenile Nile tilapia, Oreochromis niloticus
Xia, Y. L., Lu, M., Chen, G., Cao, J., Gao, F., Wang, M., Liu, Z., Zhang, D., Zhu, H., & Yi, M. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.03.020 · Cited by 249
Intestinal Microbiota in Healthy U.S. Young Children and Adults—A High Throughput Microarray Analysis
Ringel-Kulka, T., Cheng, J., Ringel, Y., Salojärvi, J., Carroll, I., Palva, A., de Vos, W. M., & Satokari, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064315 · Cited by 230
Probiotics drive gut microbiome triggering emotional brain signatures
Bagga, D., Reichert, J. L., Koschutnig, K., Aigner, C. S., Holzer, P. D., Koskinen, K., Moissl‐Eichinger, C., & Schöpf, V. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1460015 · Cited by 234
The critical role of Faecalibacterium prausnitzii in human health: An overview
Leylabadlo, H. E., Ghotaslou, R., Feizabadi, M. M., Farajnia, S., Moaddab, S. Y., Ganbarov, K., Khodadadi, E., Tanomand, A., Sheykhsaran, E., Yousefi, B., et al. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104344 · Cited by 245
Modulation of Fecal Clostridiales Bacteria and Butyrate by Probiotic Intervention with Lactobacillus paracasei DG Varies among Healthy Adults
Ferrario, C., Taverniti, V., Milani, C., Fiore, W., Laureati, M., De Noni, I., Stuknyte, M., Chouaia, B., Riso, P., & Guglielmetti, S. (2014) · The Journal of Nutrition · doi:10.3945/jn.114.197723 · Cited by 228
The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime
Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218
Update of probiotics in human world: A nonstop source of benefactions till the end of time
Zommiti, M., Feuilloley, M. G. J., & Connil, N. (2020) · Microorganisms · doi:10.3390/microorganisms8121907 · Cited by 225
Environmental enteric dysfunction pathways and child stunting: A systematic review
Harper, K. M., Mutasa, M., Prendergast, A. J., Humphrey, J. H., & Manges, A. R. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006205 · Cited by 225
Causal relationship between diet-induced gut microbiota changes and diabetes: a novel strategy to transplant Faecalibacterium prausnitzii in preventing diabetes
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221
Intestinal microbiota and chronic constipation
Zhao, Y., & Yu, Y. (2016) · SpringerPlus · doi:10.1186/s40064-016-2821-1 · Cited by 216
Sodium butyrate supplementation in high-soybean meal diets for turbot (Scophthalmus maximus L.): Effects on inflammatory status, mucosal barriers and microbiota in the intestine
Liu, Y., Chen, Z., Dai, J., Yang, P., Xu, W., Ai, Q., Zhang, W., Zhang, Y., Zhang, Y., & Mai, K. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.02.064 · Cited by 206
Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy
Ghoshal, U. C., Shukla, R., & Ghoshal, U. (2017) · Gut and Liver · doi:10.5009/gnl16126 · Cited by 218
Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges
Martinez, R. C. R., Bedani, R., & Saad, S. M. I. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003864 · Cited by 217
Akkermansia muciniphila Prevents Fatty Liver Disease, Decreases Serum Triglycerides, and Maintains Gut Homeostasis
Kim, S., Lee, Y., Kim, Y., Seo, Y., Lee, H., Ha, J., Lee, J., Choi, Y., Oh, H., & Yoon, Y. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.03004-19 · Cited by 206
Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species
Vlasova, A. N., Kandasamy, S., Chattha, K. S., Rajashekara, G., & Saif, L. J. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.01.003 · Cited by 198
The Role of Colonic Bacteria in the Metabolism of the Natural Isoflavone Daidzin to Equol
Rafii, F. (2015) · Metabolites · doi:10.3390/metabo5010056 · Cited by 194
Insights into the biodiversity of the gut microbiota of broiler chickens
Mancabelli, L., Ferrario, C., Milani, C., Mangifesta, M., Turroni, F., Duranti, S., Lugli, G. A., Viappiani, A., Ossiprandi, M. C., van Sinderen, D., et al. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13363 · Cited by 193
Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: Targeted and untargeted community analysis with correlation of biomarkers
Kim, D.-H., Kim, H., Jeong, D., Kang, I.-B., Chon, J.-W., Kim, H.-S., Song, K.-Y., & Seo, K.-H. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.014 · Cited by 179
Prebiotic Galacto-Oligosaccharides Mitigate the Adverse Effects of Iron Fortification on the Gut Microbiome: A Randomised Controlled Study in Kenyan Infants
Paganini, D., Uyoga, M. A., Kortman, G. A. M., Cercamondi, C. I., Moretti, D., Barth-Jaeggi, T., Schwab, C., Boekhorst, J., Timmerman, H. M., Lacroix, C., et al. (2017) · Gut · doi:10.1136/gutjnl-2017-314418 · Cited by 172
The interplay among gut microbiota, hypertension and kidney diseases: The role of short-chain fatty acids
Felizardo, R. J. F., Watanabe, I. K. M., Dardi, P., Rossoni, L. V., & Câmara, N. O. S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.019 · Cited by 181
Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?
Jian, H., Liu, Y., Wang, X., Dong, X., & Zou, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043900 · Cited by 186
Genomic and functional analysis of Romboutsia ilealis CRIB T reveals adaptation to the small intestine
Gerritsen, J., Hornung, B., Renckens, B. A. M., van Hijum, S. A. F. T., dos Santos, V. A. P. M., Rijkers, G. T., Schaap, P. J., de Vos, W. M., & Smidt, H. (2017) · PeerJ · doi:10.7717/peerj.3698 · Cited by 178
Self-citation
Probiotics as potential biotherapeutics in the management of type 2 diabetes – prospects and perspectives
Panwar, H., Rashmi, H. M., Batish, V. K., & Grover, S. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2376 · Cited by 167
Effects of dietary probiotic supplementation on the growth, gut health and disease resistance of juvenile Nile tilapia (Oreochromis niloticus)
Xia, Y. L., Wang, M., Gao, F., Lu, M., & Chen, G. (2019) · Animal nutrition · doi:10.1016/j.aninu.2019.07.002 · Cited by 175
Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis
Wang, H., Lü, M., Deng, Y., Liu, Y., Wei, X., Liu, M., Zhou, J., Ma, H., Zheng, P., Yuan, J., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.11.018 · Cited by 167
Viruses and the Microbiota
Robinson, C. M., & Pfeiffer, J. K. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085550 · Cited by 171
Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions
Sajib, M. S., Zahra, F. T., Lionakis, M. S., German, N., & Mikelis, C. M. (2017) · Angiogenesis · doi:10.1007/s10456-017-9583-4 · Cited by 161
Functional Dynamics of the Gut Microbiome in Elderly People during Probiotic Consumption
Eloe-Fadrosh, E. A., Brady, A., Crabtree, J., Drabek, E. F., Ma, B., Mahurkar, A., Ravel, J., Haverkamp, M., Fiorino, A.-M., Botelho, C., et al. (2015) · mBio · doi:10.1128/mbio.00231-15 · Cited by 160
Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children
Cheng, J., Ringel‐Kulka, T., Jong, I. H., Ringel, Y., Carroll, I. M., de Vos, W. M., Salojärvi, J., & Satokari, R. M. (2015) · The ISME Journal · doi:10.1038/ismej.2015.177 · Cited by 167
Fermentable non-starch polysaccharides increases the abundance of Bacteroides–Prevotella–Porphyromonas in ileal microbial community of growing pigs
Ivarsson, E., Roos, S., Liu, H. Y., & Lindberg, J. E. (2014) · animal · doi:10.1017/s1751731114001827 · Cited by 156
Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions
Park, O.-J., Yi, H., Jeon, J. H., Kang, S., Koo, K., Kum, K., Chun, J., Yun, C., & Han, S. H. (2015) · Journal of Dental Research · doi:10.1177/0022034515583531 · Cited by 155
Impact of the gut microbiota, prebiotics, and probiotics on human health and disease
Lai, H.-C., Young, J., Lin, C.-S., Chang, C.-J., Lu, C.-C., Martel, J., Ojcius, D., & Ko, Y.-F. (2014) · Biomedical Journal · doi:10.4103/2319-4170.138314 · Cited by 153
Effect of Daily Consumption of Orange Juice on the Levels of Blood Glucose, Lipids, and Gut Microbiota Metabolites: Controlled Clinical Trials
Lima, A. C. D., Cecatti, C., Fidélix, M. P., Adorno, M. Â. T., Sakamoto, I. K., Cesar, T. B., & Sivieri, K. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.0080 · Cited by 150
Stability of the Maternal Gut Microbiota During Late Pregnancy and Early Lactation
Jost, T., Lacroix, C., Braegger, C., & Chassard, C. (2013) · Current Microbiology · doi:10.1007/s00284-013-0491-6 · Cited by 153
Ursodeoxycholic Acid and Its Taurine- or Glycine-Conjugated Species Reduce Colitogenic Dysbiosis and Equally Suppress Experimental Colitis in Mice
den Bossche, L. V., Hindryckx, P., Devisscher, L., Devriese, S., Welden, S. V., Holvoet, T., Vilchez‐Vargas, R., Vital, M., Pieper, D. H., Bussche, J. V., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.02766-16 · Cited by 146
The association of type II diabetes with gut microbiota composition
Navab-Moghadam, F., Sedighi, M., Khamseh, M. E., Alaei-Shahmiri, F., Talebi, M., Razavi, S., & Amirmozafari, N. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.07.034 · Cited by 149
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 151
Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
BELLIKCI-KOYU, E., SARER-YUREKLI, B. P., AKYON, Y., AYDIN-KOSE, F., KARAGOZLU, C., OZGEN, A. G., BRINKMANN, A., NITSCHE, A., ERGUNAY, K., YILMAZ, E., et al. (2019) · Nutrients · doi:10.3390/nu11092089 · Cited by 144
“Moreover, the microbiota composition of the product (kefir) that was tested [17,18] and the consumption pattern, including the period and frequency of consumption and amount of the product should be considered as the factors that have potential to influence the magnitude of the changes in gut microbiota [62].”
Background
Increased gut microbiota diversity and abundance of Faecalibacterium prausnitzii and Akkermansia after fasting: a pilot study
Remely, M., Hippe, B., Geretschläger, I. C., Stegmayer, S., Höfinger, I., & Haslberger, A. G. (2015) · Wiener klinische Wochenschrift · doi:10.1007/s00508-015-0755-1 · Cited by 142
The Gut and Parkinson's Disease—A Bidirectional Pathway
Santos, S. F., de Oliveira, H. L., Yamada, E. S., Neves, B. C., & Pereira, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00574 · Cited by 148
Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in the rat
Joly, C., Gay-Quéheillard, J., Léké, A., Chardon, K., Delanaud, S., Bach, V., & Khorsi-Cauet, H. (2013) · Environmental Science and Pollution Research · doi:10.1007/s11356-012-1283-4 · Cited by 135
Intestinal dysbiosis in inflammatory bowel disease
Kaur, N. J., Chen, C.-C., Luther, J., & Kao, J. Y. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.17863 · Cited by 145
The influence of in vitro pectin fermentation on the human fecal microbiome
Bang, S.-J., Kim, G., Lim, M. Y., Song, E., Jung, D.-H., Kum, J.-S., Nam, Y., Park, C., & Seo, D. (2018) · AMB Express · doi:10.1186/s13568-018-0629-9 · Cited by 145
Towards biome-specific analysis of meta-omics data
Darzi, Y., Falony, G., Vieira‐Silva, S., & Raes, J. (2015) · The ISME Journal · doi:10.1038/ismej.2015.188 · Cited by 136
Impact of probiotic supplements on microbiome diversity following antibiotic treatment of mice
Grazul, H., Kanda, L. L., & Gondek, D. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1138197 · Cited by 135
Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis
Ferolla, S. M., Couto, C. A., Costa‐Silva, L., Armiliato, G. N. D. A., Pereira, C., Martins, F. S., Ferrari, M. L., Vilela, E. G., Tôrres, H. O. D. G., da Cunha, A. S., et al. (2016) · Nutrients · doi:10.3390/nu8070397 · Cited by 136
The Amphibian Skin Microbiome and Its Protective Role Against Chytridiomycosis
Rebollar, E. A., Martínez-Ugalde, E., & Orta, A. H. (2020) · Herpetologica · doi:10.1655/0018-0831-76.2.167 · Cited by 144
A Comparative Review on Microbiota Manipulation: Lessons From Fish, Plants, Livestock, and Human Research
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 134
Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings
Mukherjee, S., Joardar, N., Sengupta, S., & Babu, S. P. S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.010 · Cited by 129
The potential of probiotics in the amelioration of hyperuricemia
Zhao, H., Lu, Z., & Lu, Y. (2022) · Food & Function · doi:10.1039/d1fo03206b · Cited by 128
Anti-obesity effects of gut microbiota are associated with lactic acid bacteria
Tsai, Y.-T., Cheng, P.-C., & Pan, T. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5346-3 · Cited by 125
Reductions in intestinal Clostridiales precede the development of nosocomial Clostridium difficile infection
Vincent, C., Stephens, D. A., Loo, V. G., Edens, T. J., Behr, M. A., Dewar, K., & Manges, A. R. (2013) · Microbiome · doi:10.1186/2049-2618-1-18 · Cited by 123
Probiotics for the treatment of depressive symptoms: An anti-inflammatory mechanism?
Park, C., Brietzke, E. M., Rosenblat, J. D., Musial, N., Zuckerman, H., Ragguett, R., Pan, Z., Rong, C., Fus, D., & McIntyre, R. S. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.006 · Cited by 131
Effect of Long-Term Intake of Dietary Titanium Dioxide Nanoparticles on Intestine Inflammation in Mice
Mu, W., Wang, Y., Huang, C., Fu, Y., Li, J., Wang, H., Jia, X., & Ba, Q. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02391 · Cited by 120
Probiotic-directed modulation of gut microbiota is basal microbiome dependent
Hou, Q., Zhao, F., Liu, W., Lv, R., Khine, W. W. T., Han, J., Sun, Z., Lee, Y. K., & Zhang, H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1736974 · Cited by 127
Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers
Kabbani, T. A., Pallav, K., Dowd, S. E., Villafuerte-Galvez, J., Vanga, R. R., Castillo, N. E., Hansen, J., Dennis, M., Leffler, D. A., & Kelly, C. P. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1267890 · Cited by 115
Understanding the microbiome: Emerging biomarkers for exploiting the microbiota for personalized medicine against cancer
Rajpoot, M., Sharma, A. K., Sharma, A. K., & Gupta, G. K. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.02.003 · Cited by 119
The important role of polysaccharides from a traditional Chinese medicine-Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic
Cao, P., Wu, S., Wu, T., Deng, Y., Zhang, Q., Wang, K., & Zhang, Y. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116346 · Cited by 117
The adult intestinal core microbiota is determined by analysis depth and health status
Salonen, A., Salojärvi, J., Lahti, L., & de Vos, W. M. (2012) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2012.03855.x · Cited by 114
Comparative Analysis of Intestinal Tract Models
Williams, C. F., Walton, G., Jiang, L., Plummer, S. F., Garaiová, I., & Gibson, G. R. (2015) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022814-015429 · Cited by 123

Authors: Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M.
Affiliations: Wageningen University & Research (NL)
Radboud University Medical Center (NL)
Corresponding author: Gerritsen, Jacoline
ORCID: Gerritsen, Jacoline
Smidt, Hauke
Rijkers, Ger T.
Venue: Genes & Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2011-05-27
Volume: 6
Issue: 3
Pages: 209-240
ISSN: 1555-8932 (ISSN-L)
1865-3499
DOI: 10.1007/s12263-011-0229-7
PMC: PMC3145058
OpenAlex: W2116844657
Cited by: 724
References: 266
Citations by year: 2026: 13 · 2025: 40 · 2024: 60 · 2023: 35 · 2022: 50 · 2021: 54 · 2020: 69 · 2019: 63 · 2018: 70 · 2017: 75 · 2016: 63 · 2015: 49 · 2014: 32 · 2013: 32 · 2012: 15
FWCI: 10.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Genes & Nutrition (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Agentschap NL
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: gut microbiota, probiotics, dysbiosis, gut microbiota composition, gut microbiota diversity, gastrointestinal diseases, probiotic consumption

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intestinal microbiota in human health and disease: the impact of probiotics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks