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Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
Abstract
Nitric oxide (NO) is a pivotal signaling messenger in the cardiovascular system. NO participates in regulatory functions including control of hemostasis, fibrinolysis, platelet and leukocyte interactions with the arterial wall, regulation of vascular tone, proliferation of vascular smooth muscle cells, and homeostasis of blood pressure. Diminished NO bioavailability and abnormalities in NO-dependent signaling are among central factors of vascular disease, although it is unclear whether this is a cause of, or result of endothelial dysfunction or both pathogenic events. Disturbances in NO bioavailability have been linked to cause endothelial dysfunction, leading to increased susceptibility to atherosclerotic lesion progression, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis and stroke.
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“Similarly, vascular disease, cardiovascular disease (CVD), and metabolic syndrome all share effective loss of NO function[23,35–39].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [35]
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Metadata
- Authors
- Napoli, C., & Ignarro, L. J.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Archives of Pharmacal Research
- Published
- 2009-08
- Volume
- 32
- Issue
- 8
- Pages
- 1103-1108
- ISSN
- 0253-6269 (ISSN-L)
- 1976-3786
- OpenAlex
- W2049131838
- Cited by
- 281
- References
- 37
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 9 · 2020: 15 · 2019: 16 · 2018: 18 · 2017: 20 · 2016: 9 · 2015: 18 · 2014: 23 · 2013: 17 · 2012: 24
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Pharmacal Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, NO bioavailability, endothelial dysfunction, vascular disease, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, thrombosis, stroke, vascular tone, vascular smooth muscle cell proliferation, hemostasis, fibrinolysis
- MeSH terms
- Animals, Humans, Nitric Oxide, Oxidation-Reduction, Vascular Diseases, Kruppel-Like Transcription Factors, Nitric Oxide Synthase Type III
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