Role of sGC-dependent NO signalling and myocardial infarction risk

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

(2002) · The Lancet · doi:10.1016/s0140-6736(02)11911-8 · Cited by 10,266 · see citing works

An integrated map of genetic variation from 1,092 human genomes

The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Nitric oxide: an endogenous modulator of leukocyte adhesion.

Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics

Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1× · see citing works

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154 · see citing works

Oral Sildenafil in the Treatment of Erectile Dysfunction

Goldstein, I., Lue, T. F., Padma-Nathan, H., Rosen, R. C., Steers, W. D., & Wicker, P. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805143382001 · Cited by 2,120 · see citing works

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070 · see citing works

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

The International Consortium for Blood Pressure Genome-Wide Association Studies (2011) · Nature · doi:10.1038/nature10405 · Cited by 2,033 · see citing works

Nitric oxide: A cytotoxic activated macrophage effector molecule

Hibbs, J. B., Taintor, R. R., Vavrin, Z., & Rachlin, E. M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80015-9 · Cited by 2,030 · see citing works

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.784 · Cited by 1,866 · see citing works

Large-scale association analysis identifies new risk loci for coronary artery disease

The CARDIoGRAMplusC4D Consortium, Deloukas, P., DIAGRAM Consortium, CARDIOGENICS Consortium, MuTHER Consortium, Wellcome Trust Case Control Consortium, Kanoni, S., Willenborg, C., Farrall, M., Assimes, T. L., et al. (2013) · Nature Genetics · doi:10.1038/ng.2480 · Cited by 1,614 · see citing works

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

Ghofrani, H. A., D’Armini, A. M., Grimminger, F., Hoeper, M. M., Jansa, P., Kim, N. H., Mayer, E., Simonneau, G., Wilkins, M. R., Fritsch, A., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1209657 · Cited by 1,393 · see citing works

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

Palmer, R. M. J., Rees, D. D., Ashton, D. S., & Moncada, S. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81362-7 · Cited by 1,348 · see citing works

Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

Lamas, S., Marsden, P. A., Li, G. K., Tempst, P., & Michel, T. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6348 · Cited by 982 · see citing works

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

Marsden, P. A., Heng, H. H., Scherer, S. W., Stewart, R. J., Hall, A. V., Shi, X.-M., Tsui, L.-C., & Schappert, K. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85359-0 · Cited by 871 · see citing works

Mortality from ischaemic heart disease by country, region, and age: Statistics from World Health Organisation and United Nations

Finegold, J. A., Asaria, P., & Francis, D. P. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.046 · Cited by 861 · see citing works

Cyclic GMP synthesis and function.

Waldman, S. A., & Murad, F. (1987) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06656-6 · Cited by 859 · see citing works

Enzyme-independent formation of nitric oxide in biological tissues

Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788 · see citing works

T −786 →C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm

Nakayama, M., Yasue, H., Yoshimura, M., Shimasaki, Y., Kugiyama, K., Ogawa, H., Motoyama, T., Saito, Y., Ogawa, Y., Miyamoto, Y., et al. (1999) · Circulation · doi:10.1161/01.cir.99.22.2864 · Cited by 777 · see citing works

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO

Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621 · see citing works

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage

Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · cited 1× · see citing works

Cardioprotective Function of Inducible Nitric Oxide Synthase and Role of Nitric Oxide in Myocardial Ischemia and Preconditioning: an Overview of a Decade of Research

Bolli, R. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1462 · Cited by 597 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Efficacy and Safety of Tadalafil for the Treatment of Erectile Dysfunction: Results of Integrated Analyses

Brock, G. B., McMahon, C. G., Chen, K. K., Costigan, T. M., Shen, W., Watkins, V., Anglin, G., & Whitaker, S. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64442-4 · Cited by 553 · see citing works

S-nitrosylation in health and disease

Foster, M. W., McMahon, T., & Stamler, J. S. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00028-5 · Cited by 552 · see citing works

STRUCTURE-FUNCTION ASPECTS IN THE NITRIC OXIDE SYNTHASES

Stuehr, D. J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.339 · Cited by 547 · see citing works

NO-independent regulatory site on soluble guanylate cyclase

Stasch, J., Becker, E. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Feurer, A., Gerzer, R., Minuth, T., Perzborn, E., Pleiß, U., et al. (2001) · Nature · doi:10.1038/35065611 · Cited by 546 · see citing works

Signal transduction mechanisms involving nitric oxide

Ignarro, L. J. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90618-f · Cited by 524 · see citing works

A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK

Hingorani, A. D., Liang, C. F., Fatibene, J., Lyon, A., Monteith, S., Parsons, A., Haydock, S. F., Hopper, R., Stephens, N. G., O’Shaughnessy, K. M., et al. (1999) · Circulation · doi:10.1161/01.cir.100.14.1515 · Cited by 522 · see citing works

Long-term Effects on Sexual Function of Five Antihypertensive Drugs and Nutritional Hygienic Treatment in Hypertensive Men and Women

Grimm, R. H., Grandits, G. A., Prineas, R. J., McDonald, R. H., Lewis, C. E., Flack, J. M., Yunis, C., Svendsen, K. H., Liebson, P. R., Elmer, P. J., et al. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.8 · Cited by 459 · see citing works

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

Hevel, J. M., White, K. A., & Marletta, M. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54421-5 · Cited by 455 · see citing works

Nitric Oxide Reversibly Inhibits the Migration of Cultured Vascular Smooth Muscle Cells

Sarkar, R., Meinberg, E., Stanley, J. C., Gordon, D., & Webb, R. C. (1996) · Circulation Research · doi:10.1161/01.res.78.2.225 · Cited by 419 · see citing works

The role of oxidized phospholipids in atherosclerosis

Berliner, J. A., Leitinger, N., & Tsimikas, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800074-jlr200 · Cited by 404 · see citing works

Inhibition of low‐density lipoprotein oxidation by nitric oxide Potential role in atherogenesis

Hogg, N., Kalyanaraman, B., Joseph, J., Struck, A. T., & Parthasarathy, S. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81706-6 · Cited by 400 · see citing works

Evidence of Association of the ecNOS Gene Polymorphism with Plasma NO Metabolite Levels in Humans

Tsukada, T., Yokoyama, K., Arai, T., Takemoto, F., Hara, S., Yamada, A., Kawaguchi, Y., 龍男, 細., & Igari, J. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8267 · Cited by 391 · see citing works

Evidence of Association of the ecNOS Gene Polymorphism with Plasma NO Metabolite Levels in Humans

塚田, 敏. (2000) · Medical Entomology and Zoology · doi:10.11501/3175141 · Cited by 364 · see citing works

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

Bryan, N. S., Calvert, J. W., Elrod, J. W., Gundewar, S., Ji, S. Y., & Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706579104 · Cited by 347 · see citing works

Riociguat for Patients With Pulmonary Hypertension Caused by Systolic Left Ventricular Dysfunction

Bonderman, D., Ghio, S., Felix, S. B., Ghofrani, H. A., Michelakis, E. D., Mitrović, V. L., Oudiz, R. J., Boateng, F., Scalise, A., Roessig, L., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001458 · Cited by 326 · see citing works

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

The Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Lu, X., Wang, L., Chen, S., He, L., Yang, X., Shi, Y., Cheng, J., Zhang, L., Gu, C. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2337 · Cited by 319 · see citing works

NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

Stasch, J., Schmidt, P. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Haerter, M., Heil, M., Minuth, T., Perzborn, E., Pleiß, U., et al. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704778 · Cited by 313 · see citing works

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

Ozaki, M., Kawashima, S., Yamashita, T., Hirase, T., Namiki, M., Inoue, N., Hirata, K., Yasui, H., Sakurai, H., Yoshida, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15215 · Cited by 312 · see citing works

Vardenafil for Treatment of Men With Erectile Dysfunction: Efficacy and Safety in a Randomized, Double‐Blind, Placebo‐Controlled Trial

Hellstrom, W. J. G., Gittelman, M., KARLIN, G. S., Segerson, T. P., Thibonnier, M., Taylor, T., & Padma-Nathan, H. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02332.x · Cited by 296 · see citing works

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

CARDIoGRAM, Erdmann, J., Stark, K. J., Esslinger, U. B., Rumpf, P. M., Koesling, D., de Wit, C., Kaiser, F. J., Braunholz, D., Medack, A., et al. (2013) · Nature · doi:10.1038/nature12722 · Cited by 287 · see citing works

Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases

Napoli, C., & Ignarro, L. J. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1801-1 · Cited by 281 · see citing works

Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System

Feil, R., Lohmann, S. M., de Jonge, H. R., Walter, U., & Hofmann, F. B. (2003) · Circulation Research · doi:10.1161/01.res.0000100390.68771.cc · Cited by 271 · see citing works

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

Ozaki, M., Kawashima, S., Yamashita, T., Hirase, T., Namiki, M., Inoue, N., Hirata, K.-I., Yasui, H., Sakurai, H., Yoshida, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215215 · Cited by 268 · see citing works

Long-term Treatment With Sildenafil Citrate in Pulmonary Arterial Hypertension

Rubin, L. J., Badesch, D. B., Fleming, T. R., Galiè, N., Simonneau, G., Ghofrani, H. A., Oakes, M., Layton, G. R., Serdarevic-Pehar, M., McLaughlin, V. V., et al. (2011) · CHEST Journal · doi:10.1378/chest.10-0969 · Cited by 258 · see citing works

Genetic Deficiency of Inducible Nitric Oxide Synthase Reduces Atherosclerosis and Lowers Plasma Lipid Peroxides in Apolipoprotein E–Knockout Mice

Kuhlencordt, P. J., Chen, J., Han, F., Astern, J., & Huang, P. L. (2001) · Circulation · doi:10.1161/01.cir.103.25.3099 · Cited by 252 · see citing works

Expression of Extracellular SOD and iNOS in Macrophages and Smooth Muscle Cells in Human and Rabbit Atherosclerotic Lesions

Luoma, J. S., Strålin, P., Marklund, S. L., Hiltunen, T. P., Särkioja, T., & Ylä‐Herttuala, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.2.157 · Cited by 238 · see citing works

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

Rybalkin, S. D., Rybalkina, I. G., Shimizu‐Albergine, M., Tang, X., & Beavo, J. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg051 · Cited by 234 · see citing works

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment

Ahluwalia, A., Foster, P., Scotland, R. S., McLean, P. G., Mathur, A., Perretti, M., Moncada, S., & Hobbs, A. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304264101 · Cited by 230 · see citing works

Soluble guanylate cyclase from rat lung exists as a heterodimer.

Kamisaki, Y., Saheki, S., Nakane, M., Palmieri, J. A., Kuno, T., Chang, B., Waldman, S. A., & Murad, F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38380-1 · Cited by 226 · see citing works

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

Thomas, M. K., Francis, S. H., & Corbin, J. D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77210-4 · Cited by 226 · see citing works

Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

Sayed, N., Baskaran, P., Ma, X., van den Akker, F., & Beuve, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703944104 · Cited by 221 · see citing works

Phosphodiesterase Type 5

Kass, D. A., Champion, H. C., & Beavo, J. A. (2007) · Circulation Research · doi:10.1161/circresaha.107.162511 · Cited by 217 · see citing works

Functional properties of a naturally occurring isoform of soluble guanylyl cyclase

Russwurm, M., Behrends, S., Harteneck, C., & Koesling, D. (1998) · Biochemical Journal · doi:10.1042/bj3350125 · Cited by 210 · see citing works

Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system

Mergia, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27657 · Cited by 198 · see citing works

Nitric Oxide Synthase: Non-Canonical Expression Patterns

Mattila, J. T., & Thomas, A. C. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00478 · Cited by 179 · see citing works

A Large Blood Pressure–Raising Effect of Nitric Oxide Synthase Inhibition in Humans

Sander, M., Chavoshan, B., & Victor, R. G. (1999) · Hypertension · doi:10.1161/01.hyp.33.4.937 · Cited by 176 · see citing works

Expression of soluble guanylyl cyclase

Harteneck, C., Koesling, D., Söling, A., Schultz, G., & Böhme, E. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80489-6 · Cited by 170 · see citing works

Blood Pressure Loci Identified with a Gene-Centric Array

Johnson, T., Gaunt, T. R., Newhouse, S., Padmanabhan, S., Tomaszewski, M., Meena Kumari, B., Morris, R. W., Tzoulaki, I., O'Brien, E. T., Poulter, N. R., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.10.013 · Cited by 164 · see citing works

Regulation and Functional Consequences of Endothelial Nitric Oxide Formation

Busse, R., & Fleming, I. (1995) · Annals of Medicine · doi:10.3109/07853899509002586 · Cited by 163 · see citing works

Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method

Humbert, P., Niroomand, F., FISCHER, G., Mayer, B., Koesling, D., Hinsch, K., Gausepohlꝉ, H., Frank, R. W., Schultz, G., & Böhme, E. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15572.x · Cited by 163 · see citing works

Molecular cloning and expression of a new α‐subunit of soluble guanylyl cyclase Interchangeability of the α‐subunits of the enzyme

Harteneck, C., Wedel, B. J., Koesling, D., Malkewitz, J., Böhme, E., & Schultz, G. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80871-y · Cited by 161 · see citing works

T−786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis

Nakayama, M., Yasue, H., Yoshimura, M., Shimasaki, Y., Ogawa, H., Kugiyama, K., Mizuno, Y., Harada, E., Nakamura, S., Ito, T., et al. (2000) · The American Journal of Cardiology · doi:10.1016/s0002-9149(00)01041-9 · Cited by 157 · see citing works

Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase

Salvi, E., Kutalik, Z., Glorioso, N., Benaglio, P., Frau, F., Kuznetsova, T., Arima, H., Hoggart, C., Tichet, J., IuP, N., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.181990 · Cited by 157 · see citing works

Phosphodiesterase regulation of nitric oxide signaling

KASS, D., Takimoto, E., Nagayama, T., & Champion, H. C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.02.031 · Cited by 156 · see citing works

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Siddiqi, N., Neil, C., Bruce, M., MacLennan, G., Cotton, S. C., Papadopoulou, S., Feelisch, M., Bunce, N. H., Lim, P. O., Hildick‐Smith, D., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu096 · Cited by 155 · see citing works

The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease

Thadani, U., Smith, W., Nash, S., Bittar, N., Glasser, S. P., Narayan, P., Stein, R. A., Larkin, S., Mazzu, A. L., Tota, R. R., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02563-9 · Cited by 144 · see citing works

Modulation of platelet aggregation by an l-arginine-nitric oxide pathway

Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90510-y · Cited by 136 · see citing works

Effects of Neuronal Nitric Oxide Synthase on Human Coronary Artery Diameter and Blood Flow In Vivo

Seddon, M. D., Melikian, N., Dworakowski, R., Shabeeh, H., Jiang, B., Byrne, J., Casadei, B., Chowienczyk, P., & Shah, A. M. (2009) · Circulation · doi:10.1161/circulationaha.108.822205 · Cited by 133 · see citing works

Association of a Polymorphism of the Endothelial Constitutive Nitric Oxide Synthase Gene With Myocardial Infarction in the Japanese Population

Ichihara, S., Yamada, Y., Fujimura, T., Nakashima, N., & Yokota, M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)10806-2 · Cited by 133 · see citing works

Neuronal Nitric Oxide Synthase Regulates Basal Microvascular Tone in Humans In Vivo

Seddon, M. D., Chowienczyk, P. J., Brett, S. E., Casadei, B., & Shah, A. M. (2008) · Circulation · doi:10.1161/circulationaha.107.744540 · Cited by 129 · see citing works

Tissue Distribution of the Human Soluble Guanylate Cyclases

Budworth, J., Meillerais, S., Charles, I. G., & Powell, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1444 · Cited by 123 · see citing works

Effect of Sildenafil on Cardiac Performance in Patients With Heart Failure

Hirata, K., Adji, A. I., Vlachopoulos, C. V., & O’Rourke, M. F. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.091 · Cited by 122 · see citing works

Nitrite Reduction and Cardiovascular Protection

Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121 · see citing works

Cardiovascular actions of a novel NO‐independent guanylyl cyclase stimulator, BAY 41‐8543: <i>in vivo</i> studies

Stasch, J., Dembowsky, K., Perzborn, E., Stahl, E., & Schramm, M. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704483 · Cited by 120 · see citing works

Localization of the Heme Binding Region in Soluble Guanylate Cyclase†

Zhao, Y., & Marletta, M. A. (1997) · Biochemistry · doi:10.1021/bi971825x · Cited by 119 · see citing works

Nitric oxide‐sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition

Dangel, O., Mergia, E., Karlisch, K., Groneberg, D., Koesling, D., & Friebe, A. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03806.x · Cited by 118 · see citing works

Evaluation of the effect of phosphodiesterase inhibitors on mortality in chronic heart failure patients

Nony, P., Boissel, J., Lièvre, M. M., Leizorovicz, A., Haugh, M. C., Fareh, S., & Breyne, B. D. (1994) · European Journal of Clinical Pharmacology · doi:10.1007/bf00192547 · Cited by 118 · see citing works

Effects of Cyclic GMP on Smooth Muscle Relaxation

Warner, T. D., Mitchell, J. A., Sheng, H., & Murad, F. (1994) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)60054-x · Cited by 117 · see citing works

Inhibition of low-density lipoprotein oxidation by nitric oxide

Hogg, N., Parthasarthy, S., & Kalyanaraman, B. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90278-3 · Cited by 115 · see citing works

Nitroglycerin-Induced S-nitrosylation and Desensitization of Soluble Guanylyl Cyclase Contribute to Nitrate Tolerance

Sayed, N., Kim, D. D., Fioramonti, X., Iwahashi, T., Durán, W. N., & Beuve, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175133 · Cited by 115 · see citing works

Structural and Functional Features in Human PDE5A1 Regulatory Domain That Provide for Allosteric cGMP Binding, Dimerization, and Regulation

Zoraghi, R., Bessay, E. P., Corbin, J. D., & Francis, S. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413611200 · Cited by 111 · see citing works

Randomized Phase 2 Trial of Intracoronary Nitrite During Acute Myocardial Infarction

Jones, D. A., Pellaton, C., Velmurugan, S., Rathod, K. S., Andiapen, M., Antoniou, S., van Eijl, S., Webb, A. J., Westwood, M. A., Parmar, M., et al. (2014) · Circulation Research · doi:10.1161/circresaha.116.305082 · Cited by 105 · see citing works

Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis

Melichar, V. O., Behr‐Roussel, D., Zabel, U., UTTENTHAL, L. O., Rodrigo, J., Rupin, A., Verbeuren, T. J., Kumar, A. H. S., & Schmidt, H. H. H. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405509101 · Cited by 102 · see citing works

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

Luo, C., Gangadharan, V., Bali, K. K., Xie, R., Agarwal, N., Kurejová, M., Tappe‐Theodor, A., Tegeder, I., Feil, S. C., Lewin, G. R., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001283 · Cited by 100 · see citing works

More answers to the still unresolved question of nitrate tolerance

Münzel, T. F., Daiber, A., & Gori, T. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht249 · Cited by 99 · see citing works

Association between IL-18 polymorphisms, serum levels, and HBV-related hepatocellular carcinoma in a Chinese population: a retrospective case–control study

Bao, J.-G., Yu, L., Deng, Y., Rong, C., Liu, Y., Huang, X., Song, L., Li, S., & Qin, X. Y. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0223-z · Cited by 99 · see citing works

Efficacy and safety of sildenafil citrate in men with erectile dysfunction and stable coronary artery disease

DeBusk, R. F., Pepine, C. J., Glasser, D. B., Shpilsky, A., Deriesthal, H., & Sweeney, M. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.030 · Cited by 99 · see citing works

Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury

Korkmaz, S., Radovits, T., Barnucz, E., Hirschberg, K., Neugebauer, P., Loganathan, S., Veres, G., Páli, S., Seidel, B., Zöllner, S. K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.870774 · Cited by 95 · see citing works

THERAPY OF ENDOCRINE DISEASE: Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis

Santi, D., Giannetta, E., Isidori, A. M., Vitale, C., Aversa, A., & Simoni, M. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0700 · Cited by 90 · see citing works

Phosphodiesterase Type 5 Inhibition Is a Novel Therapeutic Option in Raynaud Disease

Caglayan, E., Huntgeburth, M., Karasch, T., Weihrauch, J., Hunzelmann, N., Krieg, T., Erdmann, E., & Rosenkranz, S. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.2.231 · Cited by 87 · see citing works

The T allele of the missense Glu298Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile

Gardemann, A., Lohre, J., Cayci, S., Katz, N. R., Tillmanns, H., & Haberbosch, W. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00554-8 · Cited by 85 · see citing works

Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations.

Dosenko, V., Zagoriy, V., Haytovich, N. V., Gordok, O. A., & Moibenko, A. A. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3342 · Cited by 80 · see citing works

Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk

Lieb, W., Jansen, H., Loley, C., Pencina, M. J., Nelson, C. P., Newton‐Cheh, C., Kathiresan, S., Reilly, M. P., Assimes, T. L., Boerwinkle, E., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00275 · Cited by 79 · see citing works

Nitric Oxide-Induced Conformational Changes in Soluble Guanylate Cyclase

Underbakke, E. S., Iavarone, A. T., Chalmers, M. J., Pascal, B. D., Novick, S. J., Griffin, P. R., & Marletta, M. A. (2014) · Structure · doi:10.1016/j.str.2014.01.008 · Cited by 79 · see citing works

Long-Term Nitrate Treatment Increases Cardiac Events in Patients With Healed Myocardial Infarction

Ishikawa, K., Kanamasa, K., Ogawa, I., Takenaka, T., Naito, T., Kamata, N., Yamamoto, T., Nakai, S., Hama, J., Oyaizu, M., et al. (1996) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.60.779 · Cited by 74 · see citing works

A Variant of the α2 Subunit of Soluble Guanylyl Cyclase Contains an Insert Homologous to a Region within Adenylyl Cyclases and Functions as a Dominant Negative Protein

Behrends, S., Harteneck, C., Schultz, G., & Koesling, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21109 · Cited by 68 · see citing works

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

Methner, C., Lukowski, R., Grube, K., Loga, F., Smith, R. A. J., Murphy, M. P., Hofmann, F., & Krieg, T. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0337-1 · Cited by 62 · see citing works

Phosphodiesterases and Cyclic GMP Regulation in Heart Muscle

Lee, D. I., & Kass, D. A. (2012) · Physiology · doi:10.1152/physiol.00011.2012 · Cited by 59 · see citing works

Endothelial nitric oxide synthase gene polymorphisms -786T >C and 894G >T in coronary artery bypass graft surgery patients

Ragia, G., Nikolaidis, E., Tavridou, A., Arvanitidis, K. I., Kanoni, S., Dedoussis, G. V., Bougioukas, G., & Manolopoulos, V. G. (2010) · Human Genomics · doi:10.1186/1479-7364-4-6-375 · Cited by 57 · see citing works

Target Sequencing, Cell Experiments, and a Population Study Establish Endothelial Nitric Oxide Synthase ( eNOS ) Gene as Hypertension Susceptibility Gene

Salvi, E., Kuznetsova, T., Thijs, L., Lupoli, S., Stolarz‐Skrzypek, K., D’Avila, F., Tikhonoff, V., Astis, S. D., Barcella, M., Seidlerová, J., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01428 · Cited by 55 · see citing works

An open-label, long-term evaluation of the safety, efficacy and tolerability of avanafil in male patients with mild to severe erectile dysfunction

Belkoff, L. H., McCullough, A., Goldstein, I., Jones, L. A., Bowden, C. H., DiDonato, K. P., Trask, B. A., & Day, W. W. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12065 · Cited by 53 · see citing works

Endothelial nitric oxide gene polymorphisms, nitric oxide production and coronary artery disease risk in a South Indian population

Angeline, T., Isabel, W., & Tsongalis, G. J. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.08.009 · Cited by 53 · see citing works

Nitroglycerin Fails to Lower Blood Pressure in Redox-Dead Cys42Ser PKG1α Knock-In Mouse

Rudyk, O., Prysyazhna, O. D., Burgoyne, J. R., & Eaton, P. (2012) · Circulation · doi:10.1161/circulationaha.112.101287 · Cited by 52 · see citing works

Functional role of the soluble guanylyl cyclase α1 subunit in vascular smooth muscle relaxation☆

Nimmegeers, S., Sips, P. Y., Buys, E., Brouckaert, P., & VANDEVOORDE, J. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.06.002 · Cited by 52 · see citing works

Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction

Madigan, M. C., & Zuckerbraun, B. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00174 · Cited by 51 · see citing works

α1 Soluble Guanylyl Cyclase (sGC) Splice Forms as Potential Regulators of Human sGC Activity

Sharina, I. G., Jeleń, F., Bogatenkova, E., Thomas, A., Martin, E., & Murad, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710269200 · Cited by 49 · see citing works

Soluble Guanylate Cyclase α 1 and β 1 Gene Transfer Increases NO Responsiveness and Reduces Neointima Formation After Balloon Injury in Rats via Antiproliferative and Antimigratory Effects

Sinnaeve, P., Chiche, J., Nong, Z., Varenne, O., Pelt, N. V., Gillijns, H., Collen, D., Bloch, K. D., & Janssens, S. P. (2001) · Circulation Research · doi:10.1161/01.res.88.1.103 · Cited by 47 · see citing works

CCTη, a Novel Soluble Guanylyl Cyclase-interacting Protein

Hanafy, K. A., Martin, E., & Murad, F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404134200 · Cited by 46 · see citing works

Endothelial Nitric Oxide Synthase Gene G894T Polymorphism and Myocardial Infarction: A Meta-Analysis of 34 Studies Involving 21068 Subjects

Luo, J., Wen, J., Zhou, H., Chen, X., & Zhang, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087196 · Cited by 45 · see citing works

The majority of nitric oxide synthase in pig heart is vascular and not neural

Ursell, P., & Mayes, M. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.11.1920 · Cited by 43 · see citing works

Association of endothelial nitric oxide synthase gene polymorphisms with classical risk factors in development of premature coronary artery disease

El-Aziz, T. A. A., & Mohamed, R. H. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2380-7 · Cited by 43 · see citing works

Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction

Heltianu, C., Costache, G., Gafencu, A. V., Diaconu, M., Bodeanu, M., Cristea, C., Azibi, K., Poënaru, L., & Simionescu, M. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00343.x · Cited by 43 · see citing works

The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis

Jun-yan, L., Wu, X., Li, X., Feng, G., He, L., & Shi, Y. (2010) · Cardiology · doi:10.1159/000316063 · Cited by 42 · see citing works

Association between the −786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: A systematic review and meta-analysis

Liu, D., Jiang, Z., Dai, L., Zhang, X., Yan, C., & Han, Y. (2013) · Gene · doi:10.1016/j.gene.2013.09.099 · Cited by 41 · see citing works

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

Wang, H., Robinson, H. H., & Ke, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141614 · Cited by 40 · see citing works

Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis

Łukowski, R., Weinmeister, P., Bernhard, D., Feil, S. C., Gotthardt, M., Herz, J., Maßberg, S., Zernecke, A., Weber, C., Hofmann, F. B., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.166405 · Cited by 37 · see citing works

Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults

Kullo, I. J., Greene, M. T., Boerwinkle, E., Chu, J., Turner, S. T., & Kardia, S. L. R. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.02.008 · Cited by 36 · see citing works

The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial

Jones, D. A., Andiapen, M., Van-Eijl, T. J. A., Webb, A. J., Antoniou, S., SCHILLING, R. J., Ahluwalia, A., & Mathur, A. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002813 · Cited by 34 · see citing works

T–786C Polymorphism in the Endothelial Nitric Oxide Synthase Gene Is Associated with Increased Risk of Coronary Artery Disease in a Chinese Population

Han, Y., Xu, W., Zhang, W., Liu, N., & Ji, Y. (2010) · Pharmacology · doi:10.1159/000275135 · Cited by 31 · see citing works

Riociguat for Pulmonary Hypertension

Ghofrani, H. A., Simonneau, G., & Rubin, L. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1312903 · Cited by 31 · see citing works

Association of a polymorphism of the ecNOS gene with myocardial infarction in a subgroup of Turkish MI patients

Çine, N., Hatemı, A., & Erginel‐Ünaltuna, N. (2002) · Clinical Genetics · doi:10.1034/j.1399-0004.2002.610113.x · Cited by 28 · see citing works

Alternative splicing impairs soluble guanylyl cyclase function in aortic aneurysm

Martin, E., Golunski, E., Laing, S. T., Estrera, A. L., & Sharina, I. G. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00222.2014 · Cited by 23 · see citing works

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

Corbin, J. D., Zoraghi, R., & Francis, S. H. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.07.012 · Cited by 21 · see citing works

RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase

Sharina, I. G., Cote, G. J., Martin, E., Doursout, M., & Murad, F. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.08.001 · Cited by 19 · see citing works

Endothelial nitric oxide synthase gene polymorphisms and the risk of acute myocardial infarction in a South Indian population

Kumar, A. S. A., Umamaheswaran, G., Padmapriya, R., Balachandar, J., & Adithan, C. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2170-2 · Cited by 18 · see citing works

Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

Siddiqi, N., Bruce, M., Neil, C., Jagpal, B., MacLennan, G., Cotton, S. C., Papadopoulo, S. A., Bunce, N. H., Lim, P. O., Schwarz, K., et al. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-116 · Cited by 16 · see citing works

The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease

Ekmekçi, A., Özcan, K. S., Güngör, B., Abacı, N., Osmonov, D., Zencirci, A. E., Toprak, E., Dönmez, C., Üstek, D., Güleç, Ç., et al. (2013) · Acta cardiologica. Supplementum · doi:10.1080/ac.68.5.2994468 · Cited by 14 · see citing works

Sildenafil in primary pulmonary hypertension--is there a subset of patients who respond favourably?

Sayın, T., & Zenci, M. (2002) · PubMed · Cited by 14 · see citing works

Lack of association between Glu298Asp polymorphism and coronary artery disease in North Indians

Rai, H., Fitt, J., Sharma, A., Sinha, N., Kumar, S., Pandey, C. M., Agrawal, S. S., & Mastana, S. S. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1412-z · Cited by 10 · see citing works

Randomized Clinical Trials — Removing Obstacles

Reith, C., Landray, M., & Califf, R. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1312901 · Cited by 10 · see citing works

Molecular cloning of a novel variant of the rat soluble guanylate cyclase β2 subunit

Okamoto, H. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.08.003 · Cited by 9 · see citing works

Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse

Rudyk, O., Prysyazhna, O. D., & Eaton, P. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.288 · Cited by 3 · see citing works

Abstract 16274: Identification of Novel CAD Genetic Loci by 1000 Genomes-Based Imputation and a Non-Additive Discovery Screen

Nikpay, M., Goel, A., & Won, H. (2014) · Circulation · doi:10.1161/circ.130.suppl_2.16274 · Cited by 2 · see citing works

Abstract 19944: A PDE5A Gene Mutation Affecting Risk of Myocardial Infarction

Dang, T. A., Brænne, I., Aherrahrou, R., Tennstedt, S., Kessler, T., Hengstenberg, C., Erdmann, J., & Schunkert, H. (2014) · Circulation · doi:10.1161/circ.130.suppl_2.19944 · Cited by 1 · see citing works

Abstract 19823: Whole-Exome Sequencing in an Extended Family with Myocardial Infarction Identified a Potential Functional Mutation in PDE5A

Brænne, I., Medack, A., Stark, K. J., Field, S., Tuna, S., Deloukas, P., Samani, N. J., Hengstenberg, C., Schunkert, H., & Erdmann, J. (2012) · Circulation · doi:10.1161/circ.126.suppl_21.a19823 · Cited by 1 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

Emdin, C. A., Khera, A. V., Klarin, D. M., Natarajan, P., Zekavat, S. M., Nomura, A., Haas, M. E., Aragam, K. G., Ardissino, D., Wilson, J. G., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028021 · Cited by 119 · see citing works

Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus

Kessler, T., Wobst, J., Wolf, B. A., Eckhold, J., Vilne, B., Hollstein, R., von Ameln, S., Dang, T. A., Sager, H. B., Rumpf, P. M., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024152 · Cited by 98 · see citing works

Genetic alterations in the NO-cGMP pathway and cardiovascular risk

Wobst, J., Schunkert, H., & Kessler, T. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.019 · Cited by 48 · see citing works

MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

Czajka, P., Fitas, A., Jakubik, D., Eyileten, C., Gąsecka, A., Wicik, Z., Siller-Matula, J. M., Filipiak, K. J., & Postula, M. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.652579 · Cited by 43 · see citing works

Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress

Hiller, S., DeKroon, R. M., Hamlett, E. D., Xu, L., Osorio, C., Robinette, J. B., Winnik, W., Simington, S., Maeda, N., Álzate, Ó., et al. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.09.001 · Cited by 42 · see citing works

Neuroprotective potential of high-dose biotin

McCarty, M. F., & DiNicolantonio, J. J. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.10.012 · Cited by 40 · see citing works

GUCY1A1-LDHA Axis Suppresses Ferroptosis in Cardiac Ischemia-Reperfusion Injury

Yin, M., Su, L., Liu, M., Zhu, W., Chen, Y., Qiu, W., Li, Q., Li, Y., Chen, J., Zhou, Y., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.326029 · Cited by 28 · see citing works

Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants

Wobst, J., Ameln, S. V., Wolf, B. A., Wierer, M., Dang, T. A., Sager, H. B., Tennstedt, S., Hengstenberg, C., Koesling, D., Friebe, A., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0570-5 · Cited by 23 · see citing works

Genetics links between transforming growth factor β pathway and coronary disease

Zeng, L., Dang, T. A., & Schunkert, H. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.029 · Cited by 23 · see citing works

E-pharmacophore based virtual screening for identification of dual specific PDE5A and PDE3A inhibitors as potential leads against cardiovascular diseases

Maryam, A., Khalid, R. R., Siddiqi, A. R., & Ece, A. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1748718 · Cited by 21 · see citing works

BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells

Chen, P., Kuo, L.-M., Wu, Y.-H., Chang, Y., Lai, K.-H., & Hwang, T. (2020) · Biomedicines · doi:10.3390/biomedicines8090330 · Cited by 18 · see citing works

Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome

Singh, S., de Ronde, M. W. J., Creemers, E. E., van der Made, I., Meijering, R. A. M., Chan, M. Y., Tan, S. H., Chin, C. T., Richards, M., Troughton, R. W., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.017120 · Cited by 18 · see citing works

Cardiovascular events associated with nicorandil administration prior to primary percutaneous coronary intervention in patients with acute ST-segment elevated myocardial infarction: a systematic review and meta-analysis

Li, J., Xu, X., Zhou, X., Dai, J. M., Ma, L., Chen, C., Li, X., & Mao, W. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1617848 · Cited by 16 · see citing works

Nitric Oxide Production and Regulation in the Teleost Cardiovascular System

Giordano, D., Verde, C., & Corti, P. (2022) · Antioxidants · doi:10.3390/antiox11050957 · Cited by 17 · see citing works

Effect of myeloperoxidase modified LDL on bovine and human aortic endothelial cells

Elsamad, G., Bazzi, S. I., Karam, M., Boudjeltia, K. Z., Vanhamme, L., & Daher, J. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8109 · Cited by 13 · see citing works

Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension

Kreisel, W., Schaffner, D., Lazaro, A., Trebicka, J., Merfort, I., Schmitt-Graeff, A. H., & Deibert, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176223 · Cited by 11 · see citing works

sGC Activity and Regulation of Blood Flow in a Zebrafish Model System

Vishnolia, K. K., Raković, A., Hoene, C., Tarhbalouti, K., Aherrahrou, Z., & Erdmann, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.633171 · Cited by 7 · see citing works

Associations between GUCY1A3 genetic polymorphisms and large artery atherosclerotic stroke risk in Chinese Han population: a case-control study

Li, J., Liu, L., Jiang, D., Jiang, Y.-Y., Zhou, G.-Q., Mo, D.-C., & Luo, M. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1177-2 · Cited by 6 · see citing works

S-Nitrosylation: Mechanistic Links between Nitric Oxide Signaling and Atherosclerosis

Xu, W., Chen, D., & Zhou, H. (2025) · Current Atherosclerosis Reports · doi:10.1007/s11883-025-01321-y · Cited by 4 · see citing works

SNP associations in the L-citrulline metabolic pathway and vascular aging in the Japanese population

Nogimura, D., Moriyasu, K., Ishida, S., Kohda, M., Yazawa, T., & Morita, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323778 · Cited by 3 · see citing works

Repurposing PDE5-Inhibitors: Sildenafil Drives Arteriogenesis via Localized Regenerative Inflammation

Elbs, K., Bobrowski, L., Arnholdt, C., Kübler, M., Götz, P., Rohrmoser, M. R., Merkus, D., Lasch, M., & Deindl, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020985 · Cited by 1 · see citing works

Pharmacology of Gasotransmitters (Nitric Oxide and Carbon Monoxide) and Their Action

Deshmukh, R., Harwansh, R. K., Bandyopadhyay, N., Bandopadhyay, S., & Kumar, P. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_17 · Cited by 1 · see citing works

Nitric Oxide Donors in Brain Inflammation

Godínez-Rubí, M., & Ortuño‐Sahagún, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809275-0.00011-9

Genetics of (Premature) Coronary Artery Disease

Erdmann, J., & Schunkert, H. (2016) · Springer eBooks · doi:10.1007/978-3-319-44203-7_22

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Erdmann, J., & Schunkert, H. (2020) · Springer eBooks · doi:10.1007/978-3-030-45457-9_24

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Łukowski, R. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731776868.793537485

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Liu, W., Wang, M., Jiang, H., Chen, L., Hu, X., Ye, J., Rao, W., Zhang, J., Yan, W., Wu, W., et al. (2026) · Translational Vision Science & Technology · doi:10.1167/tvst.15.10.29

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Wobst, J., Schunkert, H., & Kessler, T. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.03.019 · Cited by 48 · see citing works

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Kessler, T. (2024) · doi:10.14293/cgmp.24000047.v1

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Dang, T. A., Schunkert, H., & Kessler, T. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000744 · Cited by 21 · see citing works

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Jamaiyar, A., Chen, J., & Feinberg, M. W. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00188-5 · Cited by 1 · see citing works

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Wang, X., Ye, Z.-X., Chen, J., He, S.-J., Chang, J. H., Yang, M.-W., Hong, F., Wang, Y., & Yang, S. (2018) · Cited by 1 · see citing works