Cited by 242Exercise and Physiological ResponsesMuscle Physiology and DisordersAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 176 of the 176 references it cites were found in a registry or an index.

The role of exercise-induced myokines in regulating metabolism

Huh, Joo Young·2018·Archives of Pharmacal Research

DOI 10.1007/s12272-017-0994-y

Open this paper in CoChat — free account

Abstract

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined therapeutic regimen of regular exercise and pharmaceutical treatment is often recommended. Exercise biology is complex and it involves various metabolic and molecular changes that translate into changes in substrate utilization, enzyme activation, and alternatively, improvement in exercise performance. Besides the effect of exercise on muscle metabolism, it has recently been discovered that contracting muscle can induce secretion of molecules called myokines. In the past few decades, a number of myokines have been discovered, such as interleukin-6, irisin, myostatin, interleukin-15, brain-derived neurotrophic factor, β-aminoisobutyric acid, meteorin-like, leukemia inhibitory factor, and secreted protein acidic and rich in cysteine, through secretome analysis. The existence of myokines has enhanced our understanding of how muscles communicate with other organs such as adipose tissue, liver, bone, and brain to exert beneficial effects of exercise at the whole body level. In this review, we focus on the role of these myokines in regulating local muscle metabolism as well as systemic metabolism in an autocrine/paracrine/endocrine fashion. The therapeutic potential of myokines and the natural or synthetic compounds known to date that regulate myokines are also discussed.

Integrity signals

Registry

Crossref · 10.1007/s12272-017-0994-y

Cites

176 of 176 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., & Lorenzo, M. (2008) · Diabetes · doi:10.2337/db07-1062 · Cited by 209
Retracted
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 1×
“In contrast, physical inactivity is associated with development of various diseases such as type 2 diabetes mellitus (T2DM), sarcopenia, osteoporosis, cardiovascular disease, and cancer (Tuomilehto et al. 2001; Monninkhof et al. 2007; Nocon et al. 2008; Wolin et al. 2009; Naseeb and Volpe 2017).”
Background
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388
Metabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · cited 2×
“liferator-activated receptor gamma coactivator 1-alpha (PGC1a) is a well-defined transcription factor responsible for mitochondrial biogenesis, transformation of muscle fiber type, and regulation of skeletal muscle metabolism (Wu et al. 1999; Lin et al. 2005).”
Background
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084

Show all 176 references

Sorted by citations

Items 101–200 of 242

Impact of diets rich in olive oil, palm oil or lard on myokine expression in rats
Gauze-Gnagne, C., Raynaud, F., Djohan, Y. F., Lauret, C., Feillet‐Coudray, C., Coudray, C., Monde, A., Koffi, G., Morena-Carrere, M., Camara-Cissé, M., et al. (2020) · Food & Function · doi:10.1039/d0fo01269f · Cited by 13
Move to Remember: The Role of Physical Activity and Exercise in Preserving and Enhancing Cognitive Function in Aging—A Narrative Review
Martín-Rodríguez, A., Dalamitros, A. A., Madrigal-Cerezo, R., Sánchez-Conde, P., Clemente‐Suárez, V. J., & Tornero-Aguilera, J. F. (2025) · Geriatrics · doi:10.3390/geriatrics10060143 · Cited by 16
Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet-induced obese mice
Cho, C., Ji, M., Cho, E., Yi, S., Kim, J. G., & Lee, S. (2023) · The Journal of Physiological Sciences · doi:10.1186/s12576-023-00864-6 · Cited by 14
Fndc5/irisin is regulated by myogenesis stage, irisin, muscle type and training.
Lavi, G., Horwitz, A., Einstein, O., Zipori, R., Gross, O., & Birk, R. Z. (2022) · PubMed Central · Cited by 13
Independent Link Between Peripheral Artery Disease and Muscle Wasting in Patients with Heart Failure
Ohori, K., Yano, T., Katano, S., Kouzu, H., Inoue, T. K., Takamura, Y., Nagaoka, R., Ishigo, T., Koyama, M., Nagano, N., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12951 · Cited by 12
Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects
Flis, M., Rodziewicz-Flis, E. A., Micielska, K., Kortas, J. A., Jaworska, J., Borkowska, A., Sansoni, V., Perego, S., Lombardi, G., & Ziemann, E. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/5015 · Cited by 16
The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract
Pinkas, M., & Brzozowski, T. (2024) · Antioxidants · doi:10.3390/antiox13040413 · Cited by 12
Does exercise-induced apelin affect sarcopenia? A systematic review and meta-analysis
Bae, J. H., Kwak, S. E., Lee, J. H., Yangjie, Z., & Song, W. J. (2019) · HORMONES · doi:10.1007/s42000-019-00157-x · Cited by 12
Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice
Wang, Z., Sim, H., Liu, W., Kim, J.-C., Lee, J., Kook, S., & Kim, S. H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0713 · Cited by 11
SOD2 mRNA as a potential biomarker for exercise: interventional and cross-sectional research in healthy subjects
Ogino, S., Ogino, N., Tomizuka, K., Eitoku, M., Okada, Y., Tanaka, Y., Suganuma, N., & Ogino, K. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-24 · Cited by 10
The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease
Mendes, S., Leal, D. V., Baker, L. A., Ferreira, A., Smith, A. C., & Viana, J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076017 · Cited by 12
Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential
Farrash, W. F., Phillips, B. E., Britton, S. L., Qi, N., Koch, L. G., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.645881 · Cited by 11
Insight into the role of myokines and myogenic regulatory factors under hypobaric hypoxia induced skeletal muscle loss
Srivastava, S., Rathor, R., Singh, S. N., & Suryakumar, G. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2112290 · Cited by 11
Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo
Kovanecz, I., Gelfand, R., Lin, G., Sharifzad, S., Ohanian, A., Ricks, R., Lue, T. F., & González-Cadavid, N. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164044 · Cited by 11
Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis
Feng, W., Wang, Y., Gu, X., Yu, D., & Liu, Z. (2025) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-025-01327-8 · Cited by 16
Voluntary Exercise-Mediated Protection in TNBS-Induced Rat Colitis: The Involvement of NETosis and Prdx Antioxidants
Almási, N., Török, S., Al-Awar, A., Veszelka, M., Király, L., Börzsei, D., Szabó, R., & Varga, C. (2023) · Antioxidants · doi:10.3390/antiox12081531 · Cited by 10
Assessment of causal effects of physical activity on the risk of osteoarthritis: a two-sample Mendelian randomization study
Wang, B., Liu, Y., Zhang, Y., Han, Z., Hou, J.-L., Chen, S., & Xiang, C. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01681-x · Cited by 11
Acute changes in free and extracellular vesicle-associated circulating miRNAs and myokine profile in professional sky-runners during the Gran Sasso d’Italia vertical run
Faraldi, M., Sansoni, V., Perego, S., Gomarasca, M., Gerosa, L., Ponzetti, M., Rucci, N., Banfi, G., & Lombardi, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.915080 · Cited by 10
Post-COVID-19 syndrome and type 2 diabetes: Primacy of exercise in prevention and management
Jayasinghe, S. U., Misra, A., & Hills, A. P. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.102379 · Cited by 10
Association of blood cadmium and physical activity with mortality: A prospective cohort study
Chen, Y., Zhen, C., Zeng, L., Feng, H., Wang, J., Ai, Q. Y. H., Ai, S., Zhang, J., Liang, Y. Y., Xue, H., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117541 · Cited by 9
The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes
Li, A., Zhou, Z., Li, D., Sha, P.-R., Hu, H., Lin, Y.-Q., Yue, B.-L., Li, J., & Xiong, Y. (2025) · Cells · doi:10.3390/cells14241954 · Cited by 10
Effect of single bout downhill running on the serum irisin concentrations in rats
Murao, M., Imano, T., Akiyama, J., 川上, 照., & Nakajima, M. (2019) · Growth Factors · doi:10.1080/08977194.2020.1742118 · Cited by 9
Latest developments in engineered skeletal muscle tissues for drug discovery and development
Ostrovidov, S., Ramalingam, M., Bae, H., Orive, G., Fujie, T., Shi, X., & Kaji, H. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2160438 · Cited by 9
Myokine levels after resistance exercise in young adults with Prader–Willi syndrome (PWS)
Hirsch, H. J., Gross‐Tsur, V., Sabag, Y., Nice, S., Genstil, L., Benarroch, F., & Constantini, N. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61391 · Cited by 10
Muskeltraining – ein universelles Medikament
Laube, W. (2021) · Manuelle Medizin · doi:10.1007/s00337-021-00801-x · Cited by 8
Downhill running exercise increases circulating level of myokine meteorin-like hormone in humans
ALIZADEH, A., & ALIZADEH, H. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.12246-7 · Cited by 8
Short- and long-term effects of concurrent aerobic and resistance training on circulating irisin levels in overweight or obese individuals: a systematic review and meta-analysis of randomized controlled trials
Cheng, Y., Ma, J., & Bo, S. (2024) · PeerJ · doi:10.7717/peerj.17958 · Cited by 10
cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells
Norikura, T., Kajiya, S., Sugawara, M., Kubo, M., Fukuyama, Y., & Sato, S. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103632 · Cited by 8
Association of Low Bone Mass with Decreased Skeletal Muscle Mass: A Cross-Sectional Study of Community-Dwelling Older Women
Nonaka, K., Murata, S., Nakano, H., Anami, K., Shiraiwa, K., Abiko, T., Goda, A., Iwase, H., & Horie, J. (2020) · Healthcare · doi:10.3390/healthcare8030343 · Cited by 8
Treadmill Training Effect on the Myokines Content in Skeletal Muscles of Mice With a Metabolic Disorder Model
Zakharova, A. N., Кироненко, Т. А., Милованова, К. Г., Орлова, А. А., Dyakova, E. Y., Kalinnikova, J. G., Kabachkova, A. V., Chibalin, A., & Капилевич, Л. В. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709039 · Cited by 9
CT-derived relationship between low relative muscle mass and bone damage in patients with multiple myeloma undergoing stem cells transplantation
Tagliafico, A. S., Rossi, F., Bignotti, B., Torri, L., Bonsignore, A., Belgioia, L., & Domineitto, A. (2021) · British Journal of Radiology · doi:10.1259/bjr.20210923 · Cited by 8
The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis: An Exploratory Study From the Osteoarthritis Initiative
Gong, Z., Li, S., Cao, P., Ruan, G., Zhang, Y., Zeng, Q., He, Z., Li, S., Chen, R., Zheng, P., et al. (2022) · The Journal of Rheumatology · doi:10.3899/jrheum.220538 · Cited by 8
Effects of Early Physical and Pulmonary Rehabilitation for Severely and Critically ill COVID-19 Patients: A Retrospective, Cohort, and Multicenter StudyPreprint
Qi, D., Yan, X., Xiang, J., Peng, J., Yu, Q., Tang, X., Tong, J., Feng, L., Yuan, J., Song, Y., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-66798/v1 · Cited by 8
Postmenopausal sarcopenia and Alzheimer's disease: The interplay of mitochondria, insulin resistance, and myokines
Farhana, F., Sultana, M. A., Hia, R. A., & Hegde, V. K. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106501 · Cited by 8
Aging‐Driven Inter‐Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty
Rao, X., & Cai, X. T. (2026) · The FASEB Journal · doi:10.1096/fj.202505069r · Cited by 8
Effects of In Vitro Muscle Contraction on Thermogenic Protein Levels in Co-Cultured Adipocytes
Nintou, E., Karligiotou, E., Vliora, M., Fatouros, I. G., Jamurtas, A. Z., Sakellaridis, N., DIMAS, K. S., & Flouris, A. D. (2021) · Life · doi:10.3390/life11111227 · Cited by 7
Identification of C-C motif chemokine ligand 5 as a heat-dependent myokine
Murata, K., Ishiuchi, Y., & Nedachi, T. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0611 · Cited by 7
Diagnostic and predictive abilities of myokines in patients with heart failure
Berezin, O. O., Berezina, T. A., Hoppe, U. C., Lichtenauer, M., & Berezin, A. Е. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.12.021 · Cited by 8
VEGF alleviates lower limb ischemia in diabetic mice by altering muscle fiber types
Jia, L., Zheng, P., Wang, H., Kang, L., Wu, H. J., & Fu, X. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11176 · Cited by 7
Aerobic Exercise and Neuropathic Pain: Insights from Animal Models and Implications for Human Therapy
Ruimonte-Crespo, J., Plaza‐Manzano, G., Díaz‐Arribas, M. J., Navarro‐Santana, M. J., López-Marcos, J. J., Fabero‐Garrido, R., Seijas-Fernández, T., & Valera‐Calero, J. A. (2023) · Biomedicines · doi:10.3390/biomedicines11123174 · Cited by 9
10 km running race induces an elevation in the plasma myokine level of nonprofessional runners
Marcucci-Barbosa, L. S., Júnior, F. D. A. D. M., Lobo, L. F., Morais, M. G., Moreira, J. M., Vieira, É. L. M., & Nunes-Silva, A. (2019) · Sport Sciences for Health · doi:10.1007/s11332-019-00608-3 · Cited by 7
Nonalcoholic fatty liver disease in lean subjects: is it all metabolic-associated fatty liver disease?
Machado, M. V. (2020) · Hepatoma Research · doi:10.20517/2394-5079.2020.90 · Cited by 7
The weight-lowering effect of low-intensity endurance training targeted at the level of maximal lipid oxidation (LIPOX max) lasts for more than 8 years, and is associated with improvements in body composition and blood pressure
Brun, J.-F., Myzia, J., Varlet-Marie, E., Mercier, J., & Raynaud de Mauverger, E. (2022) · Science & Sports · doi:10.1016/j.scispo.2022.03.002 · Cited by 6
The Association of Serum Calprotectin with Fitness Indicators and Biochemical Markers in High-Level Athletes: A Continuous Dynamic Monitoring during One Competitive Season
Bukvić, F., Ivković, A., Čičak, H., Dukić, L., Šimundić, A.-M., Marijančević, D., & Pašalić, D. (2023) · Sports · doi:10.3390/sports11120243 · Cited by 6
Concentrations of Circulating Irisin and Myostatin in Race and Endurace Purebred Arabian Horses—Preliminary Study
Kowalik, S., Wiśniewska, A., Kędzierski, W., & Janczarek, I. (2020) · Animals · doi:10.3390/ani10122268 · Cited by 7
The influence of nutrients on mechanical overload-induced changes to skeletal muscle mRNA content
Laskin, G. R., & Gordon, B. S. (2022) · Physiological Genomics · doi:10.1152/physiolgenomics.00075.2022 · Cited by 6
Body Composition, Fasting Blood Glucose and Lipidemic Indices Are Not Primarily Determined by the Nutritional Intake of Middle-Aged Endurance Trained Men—Another “Athletes’ Paradox”?
Methenitis, S. K., Feidantsis, K. G., Kaprara, A., Hatzitolios, A. I., Skepastianos, P., Papadopoulou, S. Κ., & Panayiotou, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11206057 · Cited by 6
Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease
Yang, B., Yang, X., Tan, X., Lu, L., Fan, W., Barbier‐Torres, L., Steggerda, J. A., Liu, T., & Yang, H. (2022) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2022/6799414 · Cited by 7
Potential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function
Kwak, S. E., Shin, H. E., Zhang, D. D., Lee, J., Yoon, K. J., Bae, J. H., Moon, H. Y., & Song, W. J. (2019) · Physical Activity and Nutrition · doi:10.20463/jenb.2019.0014 · Cited by 6
Skeletal muscle dysfunction in COPD: miRNAs, myokines and exercise
Maniscalco, M., Fuschillo, S., Ambrosino, P., Candia, C., Domenico, A. D., Lombardi, C., Motta, A., & Ambrosino, N. (2026) · ERJ Open Research · doi:10.1183/23120541.00887-2025 · Cited by 5
Exercise and exerkine upregulation: Brain-derived neurotrophic factor as a potential non-pharmacological therapeutic strategy for Parkinson’s disease
PRASAD, V. V., Samson, J. S., & Parvathi, V. D. (2024) · Biocell · doi:10.32604/biocell.2024.048776 · Cited by 6
Exercise for depression treatment. Exercise modalities and types
Gultyaeva, V. V., Zinchenko, M. I., Uryumtsev, D. Y., Krivoshchekov, S. G., & Aftanas, L. I. (2019) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2019119091136 · Cited by 6
Effects of Treadmill Running at Different Light Cycles in Mice with Metabolic Disorders
Zakharova, A. N., Милованова, К. Г., Орлова, А. А., Dyakova, E. Y., Kalinnikova, J. G., Kollantay, O. V., Shuvalov, I. Y., Chibalin, A., & Капилевич, Л. В. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015132 · Cited by 5
Interaction of the C2C12 myotube contractions and glucose availability on transcriptome and extracellular vesicle microRNAs
Lautaoja-Kivipelto, J. H., Karvinen, S. M., Korhonen, T.-M. K., O’Connell, T. M., Tiirola, M., Hulmi, J. J., & Pekkala, S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00401.2023 · Cited by 4
Meteorin-like/Metrnl: A pleiotropic cytokine implicated in metabolic, inflammatory and malignant disorders
Li, J., Ye, P., Si, J., & Xiang, G. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.12.003 · Cited by 4
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential
Aslam, M. A., Lee, J., Bowen, T. S., & Huh, J. Y. (2026) · Archives of Pharmacal Research · doi:10.1007/s12272-026-01624-x · Cited by 7
Self-citation
Effects of recreational SCUBA diving practiced once a week on neurohormonal response and myokines-mediated communication between muscles and the brain
Bratičević, M. N., Žarak, M., Šimac, B., Perović, A., & Dumić, J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1074061 · Cited by 4
Upregulation of CCL5/RANTES Gene Expression in the Diaphragm of Mice with Cholestatic Liver Disease
Morales, V., González, A., & Cabello‐Verrugio, C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-26163-3_11 · Cited by 4
Immediate effects of a real moderate interval-running training session on inflammatory profile
Azevedo, A. P. D. S., Nóbrega, C., Lima, J. D. C. C., de Matos‐Neto, E. M., Amadio, A. C., Seelaender, M. C. L., & Serrão, J. C. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155150 · Cited by 4
Impact of simple equation for estimating appendicular skeletal muscle mass in patients with stable coronary artery disease undergoing percutaneous coronary intervention
Nishio, R., Dohi, T., Fukase, T., Takeuchi, M., Takahashi, N., Endo, H., Doi, S., Okai, I., Iwata, H., Okazaki, S., et al. (2022) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2022.101163 · Cited by 6
The Hormone-like Myokines Irisin as Novel Biomarker for Cardiovascular Risk Stratification”,
Berezin, A. A., Myrnyi, D. P., Myrnyi, S. P., & Berezin, A. Е. (2021) · Pharmacophore · doi:10.51847/cx5vhf76yw · Cited by 4
Exercise-induced exerkines in multiple sclerosis: Emphasizing the pivotal role of myokines
Alifarsangi, A., Khaksari, M., Rajizadeh, M. A., Zadeh, N. A., & Rafie, F. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111565 · Cited by 3
Effects of exercise on cognitive function in older patients with Alzheimer’s disease: a meta-regression and meta-analysis
Xu, F., Zhang, Y., Tan, D., He, Y., Fei, Q., & Xu, K. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1793973 · Cited by 3
The Myokine Adaptome in Health and Disease: Exercise-Induced Cellular Signaling, Muscle–Organ Crosstalk, and Therapeutic Plasticity
Mănescu, D. C., Plastoi, C. D., Pîrvan, A., Dîrnu, R., Floroiu, E. A., & Popescu, A. (2026) · Cells · doi:10.3390/cells15141236 · Cited by 5
Myokines are one of the key elements of interaction between skeletal muscles and other systems of human body necessary for adaptation to physical loads
Tymochko-Voloshyn, R. I., Hashchyshyn, V., Параняк, Н., Boretsky, V. Y., Решетило, С., & Boretsky, Y. (2023) · Visnyk of Lviv University Biological series · doi:10.30970/vlubs.2023.88.01 · Cited by 4
Physical fitness level and the risk of severe COVID-19: A systematic review
Cardoso, F. J., Victor, D. R., da Silva, J. R., Guimarães, A., Leal, C. A., Taveira, M. R., & Alves, J. G. B. (2023) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2023.07.010 · Cited by 5
Myokines Produced by Cultured Bovine Satellite Cells Harvested from 3- and 11-Month-Old Angus Steers
Shira, K. A., Murdoch, B. M., Thornton, K. J., Reichhardt, C. C., Becker, G. M., Chibisa, G. E., & Murdoch, G. K. (2024) · Animals · doi:10.3390/ani14050709 · Cited by 3
Impact of myokines on chronic liver diseases: exploring the effects of metabolic dysfunction-associated steatotic liver disease (MASLD) on skeletal muscle. A narrative review
Aguirre, F. S., Valero‐Breton, M., Cabrera, D., Peñailillo, L., Otero, C., Fredes, C., & Cabello‐Verrugio, C. (2025) · European Journal of Translational Myology · doi:10.4081/ejtm.2025.13365 · Cited by 4
Exercise is medicine: Die Rolle von Zytokinen und Myokinen für Gesundheit und Krankheit
Wahl, P. (2018) · Sportphysio · doi:10.1055/a-0642-8160 · Cited by 3
Aerobic vs Resistance Exercise—An Endocrine Perspective
Bansal, N., Kotwal, N., & Kumar, S. (2020) · Journal of Medical Academics · doi:10.5005/jp-journals-10070-0057 · Cited by 3
Sport und Bewegungstherapie bei entzündlich rheumatischen Erkrankungen
HARTUNG, W. M., Sewerin, P., & Ostendorf, B. C. (2021) · Zeitschrift für Rheumatologie · doi:10.1007/s00393-021-00970-z · Cited by 3
Sporttherapie in der pädiatrischen Rheumatologie
Milatz, F., & Hartmann, M. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-60411-3_72-1 · Cited by 3
A New Approach Using BMI and FMI as Predictors of Cardio-Vascular Risk Factors among Mexican Young Adults
Salinas-Mandujano, R. G., Reynoso‐Camacho, R., Salgado, L. M., Ramos‐Gómez, M., Pérez‐Ramírez, I. F., Aguilar-Galarza, A., Moreno‐Celis, U., & Anaya‐Loyola, M. A. (2023) · European Journal of Investigation in Health Psychology and Education · doi:10.3390/ejihpe13100146 · Cited by 4
Inhibition of CX3CL1 by treadmill training prevents osteoclast-induced fibrocartilage complex resorption during TBI healing
Liu, X., Zhou, M., Tan, J., Ma, L., Tang, H., He, G., Tao, X., Guo, L., Kang, X., Tang, K., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295163 · Cited by 3
Exercise-mediated muscle-hypothalamus crosstalk: Improvement for cognitive dysfunction caused by disrupted circadian rhythm
Shi, J.-X., Wang, Z., Wang, S.-W., Shen, Q., & Tan, X. L. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123657 · Cited by 4
Combinación de entrenamiento de fuerza y aeróbico en adultos mayores: efectos en rendimiento funcional, fuerza, masa grasa y dolor (Combined resistance and aerobic training in Elderly: effects on functional performance, strength, fat mass and pain percep
Martínez, N., Bohórquez, C. P., & Sánchez-Canales, V. (2021) · Retos · doi:10.47197/retos.v43i0.86701 · Cited by 5
The increase of uncoupling protein-1 expression after moderate intensity continuous exercises in obese females
Sugiharto, S., Adji, B. S., Merawati, D., & Pranoto, A. (2021) · Jurnal SPORTIF Jurnal Penelitian Pembelajaran · doi:10.29407/js_unpgri.v7i2.15932 · Cited by 6
Rheumatoide Arthritis und Sport
Schütt, H., Sewerin, P., & Ostendorf, B. (2018) · Arthritis und Rheuma · doi:10.1055/s-0038-1669720 · Cited by 3
Evaluation of Irisin and Interleukin-6 Levels in Saliva Samples of Periodontally Healthy and Stage 3 Grade C Periodontitis Individuals
Sarıbaş, E., Kandemir, M., Erkan, R. E. C., & Tuncer, M. C. (2025) · Biology · doi:10.3390/biology14091188 · Cited by 2
PHYSICAL ACTIVITY AS A PRE-ANALYTICAL FACTOR AFFECTING LABORATORY TEST RESULTS
Isaković, A., Janković, G., Mazic, S. D., Stanojević, Ž., & Nešić, D. (2018) · Facta Universitatis Series Physical Education and Sport · doi:10.22190/fupes180925025i · Cited by 2
Working Out: The Molecular Biology of Exercise.
Eissenberg, J. C. (2022) · PubMed Central · Cited by 2
The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans
Траверсе, Г., Горошко, В. І., & Danylchenko, S. I. (2023) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs08.01.050 · Cited by 2
Exercise Prescription Principles among Physicians and Physical Therapists for Patients with Impaired Glucose Control: A Cross-Sectional Study
Petrie, M. A., Johnson, K. A., Dubey, O., & Shields, R. K. (2023) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk8030112 · Cited by 2
Metformin Protects Rat Skeletal Muscle from Physical Exercise-Induced Injury
Abbadessa, G., Maniscalco, E., Grasso, L., Popara, J., Scipio, F. D., Franco, F., Mancardi, D., Pigozzi, F., Borrione, P., Berta, G. N., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11092334 · Cited by 2
Integrated procedures for accelerating, deepening, and leading genetic inquiry: A first application on human muscle secretome
Bondi, D., Bevere, M., Piccirillo, R., Sorci, G., Felice, V. D., Cecconi, A. D. R., Damico, D. C. S., Pietrangelo, T., & Fulle, S. (2023) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2023.107705 · Cited by 2
Genetic Polymorphisms Associated with the Efficiency of Weight Loss: A Systematic Review
Egorova, E. S., & Ahmetov, I. I. (2023) · Russian Journal of Genetics · doi:10.1134/s1022795423080057 · Cited by 3
Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis
Franzoni, L., da Motta, S. B., Carvalho, G., Costa, R. R., Ahner, M. M., Saffi, M., Pereira, A. A., Pereira, A. H., da Silveira, A. D., & Stein, R. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x269909240320061952 · Cited by 2
ATPase Inhibitory Factor 1—A Novel Marker of Cellular Fitness and Exercise Capacity?
Domin, R., Pytka, M., Niziński, J., Żołyński, M., Zybek‐Kocik, A., Wrotkowska, E., Zieliński, J., Guzik, P., & Ruchała, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315303 · Cited by 2
Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women
Setiawan, H. K., Rejeki, P. S., Pranoto, A., Wigati, K. W., Muhammad, M., & Rahmanto, I. (2024) · Retos · doi:10.47197/retos.v55.103483 · Cited by 2
Sporttherapie in der pädiatrischen Rheumatologie
Milatz, F., & Hartmann, M. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-60410-6_72 · Cited by 1
Physical Activity and COVID-19 Vaccines
Gasmi, A., Nehaoua, A., Noor, S., Mujawdiya, P. K., & Bilstrom, D. (2023) · Springer eBooks · doi:10.1007/978-981-99-1802-7_5 · Cited by 1
Genetic Polymorphisms Associated with the Efficiency of Weight Loss: A Systematic Review
Egorova, E. S., & Ahmetov, I. I. (2023) · Генетика · doi:10.31857/s0016675823080052 · Cited by 1
Die Rolle des muskuloadipösen Status bei der Beurteilung des Risikoprofils vor Lebertransplantation
Deeb, A. A., Rauchfuß, F., & Settmacher, U. (2024) · Die Chirurgie · doi:10.1007/s00104-024-02111-z · Cited by 1
Sporda Dayanıklılık ve Aerobik Dayanıklılık Testleri
Atasever, G., & Kıyıcı, F. (2024) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub640.c2773 · Cited by 1
Egzersizde Protein Sentezi ve Etkileyen Faktörler
Akkuş, E. (2024) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub640.c2771 · Cited by 1
Apelin and Myostatin Levels in Adolescents With Type‐1‐Diabetes
Cohen, M., Weiss, L., Weiss, R., Shehadeh, N., & Khamaisi, M. (2025) · Pediatric Diabetes · doi:10.1155/pedi/1578938 · Cited by 1
Beta-aminoisobutyric acid attenuates doxorubicin-induced cardiotoxicity through the adenosine 5′-monophosphate-activated protein kinase-mediated pathway
Huang, J., Sun, M., Yu, J. H., Guo, Y., Li, B., Dai, L., Tang, Y., Wang, X., Han, S., & Lai, X. (2025) · Xenobiotica · doi:10.1080/00498254.2025.2520423 · Cited by 1
Molecular insights into irisin’s role in the regulation of programmed cell death: mechanisms and therapeutic potential
Yang, Y., Pullisaar, H., Reseland, J. E., & Ma, J. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02623-z · Cited by 1
Suppressed brain-derived neurotrophic factor response to 6 min walking exercise in mild cognitive impairment
Kang, M. C., Wandel, S. M. D., Perez, C. N., Deutz, N. E. P., & ENGELEN, M. P. K. J. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106561 · Cited by 1
Neuroligin-3: A Novel Exercise-Induced Secreted Factor Enhancing Insulin Sensitivity in Obese Insulin-Resistant Mice
Sinha, A., Patra, D., Mishra, S., Vashisth, A., Sharma, S., Dey, U., Ramprasad, P., Roy, S., Kumar, A., Tikoo, K., et al. (2026) · Diabetes · doi:10.2337/db25-0259 · Cited by 1

Authors: Huh, J. Y.
Affiliations: Chonnam National University (KR)
Corresponding author: Huh, Joo Young
ORCID: Huh, Joo Young
Venue: Archives of Pharmacal Research
Publisher: Springer Science and Business Media LLC
Published: 2017-11-25
Volume: 41
Issue: 1
Pages: 14-29
ISSN: 0253-6269 (ISSN-L)
1976-3786
DOI: 10.1007/s12272-017-0994-y
OpenAlex: W2770919725
Cited by: 242
References: 176
Citations by year: 2026: 15 · 2025: 20 · 2024: 27 · 2023: 39 · 2022: 34 · 2021: 34 · 2020: 31 · 2019: 29 · 2018: 13
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Archives of Pharmacal Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation of Korea (2015R1C1A1A02037367)
Chonnam National University (2014-2215, 2015-3035)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: muscle metabolism, systemic metabolism, interleukin-6, irisin, myostatin, IL-15, brain-derived neurotrophic factor, meteorin-like, leukemia inhibitory factor, SARC, metabolic disorders
MeSH terms: Aminoisobutyric Acids, Cysteine, Fibronectins, Humans, Exercise, Interleukin-6, Muscle, Skeletal, Brain-Derived Neurotrophic Factor, Interleukin-15, Myostatin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of exercise-induced myokines in regulating metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks